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DSpace at MIT (104.280 recursos)

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Biological Engineering (20) - Archived

Mostrando recursos 1 - 12 de 12

  1. 20.430J / 2.795J / 6.561J / 10.539J / HST.544J Fields, Forces, and Flows in Biological Systems (BE.430J), Fall 2004

    Lauffenburger, Douglas; Grodzinsky, Alan
    This course covers the following topics: conduction, diffusion, convection in electrolytes; fields in heterogeneous media; electrical double layers; Maxwell stress tensor and electrical forces in physiological systems; and fluid and solid continua: equations of motion useful for porous, hydrated biological tissues. Case studies considered include membrane transport; electrode interfaces; electrical, mechanical, and chemical transduction in tissues; electrophoretic and electroosmotic flows; diffusion/reaction; and ECG. The course also examines electromechanical and physicochemical interactions in biomaterials and cells; orthopaedic, cardiovascular, and other clinical examples.

  2. 2.797J / 3.053J / 6.024J / 20.310J Molecular, Cellular, and Tissue Biomechanics, Fall 2006

    Lang, Matthew; Kamm, Roger D.
    This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. The class also examines experimental methods for probing structures at the tissue, cellular, and molecular levels.

  3. HST.523J / 2.785J / 3.97J / 20.411J Cell-Matrix Mechanics, Spring 2004

    Yannas, Ioannis; Spector, Myron
    Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine.

  4. 7.91J / 7.36J / 20.490J Foundations of Computational and Systems Biology, Spring 2004

    Burge, Christopher; Yaffe, Michael; Woolf, Peter; Keating, Amy
    Serving as an introduction to computational biology, this course emphasizes the fundamentals of nucleic acid and protein sequence analysis, structural analysis, and the analysis of complex biological systems. The principles and methods used for sequence alignment, motif finding, structural modeling, structure prediction, and network modeling are covered. Students are also exposed to currently emerging research areas in the fields of computational and systems biology.

  5. 20.201 Mechanisms of Drug Actions, Fall 2005

    Dedon, Peter; Tannenbaum, Steven
    This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.

  6. 20.320 Biomolecular Kinetics and Cell Dynamics, Spring 2006

    Lauffenburger, Douglas; White, Forest
    This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

  7. 20.109 Laboratory Fundamentals in Biological Engineering, Spring 2006

    Engelward, Bevin; Endy, Drew; Kuldell, Natalie; Lerner, Neal; Belcher, Angela M.; Banuazizi, Atissa
    This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Rigorous quantitative data collection, statistical analysis, and conceptual understanding of instrumentation design and application form the underpinnings of this course. The four discovery based modules include DNA Engineering, Protein Engineering, Systems Engineering, and Biomaterials Engineering. Additional information is available on the course Wiki (hosted on OpenWetWare.) Teaching Fellows Reshma Shetty Maria Foley Eileen Higham Yoon Sung Nam

  8. 20.441 / 2.79J / 3.96J / HST.522J Biomaterials-Tissue Interactions (BE.441), Fall 2003

    Yannas, Ioannis; Spector, Myron
    This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Topics include methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. It also covers mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Other areas include tissue and organ regeneration; design of implants and prostheses based on control of biomaterials-tissue interactions; comparative analysis of intact, biodegradable, and...

  9. 20.453J / 2.771J / HST.958J Biomedical Information Technology (BE.453J), Spring 2005

    Dewey, C. Forbes (Clarence Forbes)
    The objective of this subject is to teach the design of contemporary information systems for biological and medical data. These data are growing at a prodigious rate, and new information systems are required. This subject will cover examples from biology and medicine to illustrate complete life cycle information systems, beginning with data acquisition, following to data storage and finally to retrieval and analysis. Design of appropriate databases, client-server strategies, data interchange protocols, and computational modeling architectures will be covered. Students are expected to have some familiarity with scientific application software and a basic understanding of at least one contemporary programming...

  10. 2.782J / 3.961J / 20.451J / HST.524J Design of Medical Devices and Implants, Spring 2003

    Yannas, Ioannis V.; Spector, Myron
    Solution of clinical problems by use of implants and other medical devices. Systematic use of cell-matrix control volumes. The role of stress analysis in the design process. Anatomic fit: shape and size of implants. Selection of biomaterials. Instrumentation for surgical implantation procedures. Preclinical testing for safety and efficacy: risk/benefit ratio assessment. Evaluation of clinical performance: design of clinical trials. Project materials drawn from orthopedic devices, soft tissue implants, artificial organs, and dental implants.

  11. 20.462J / 3.962J Molecular Principles of Biomaterials (BE.462J), Spring 2003

    Irvine, Darrell J.
    Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.

  12. 3.051J / 20.340J Materials for Biomedical Applications, Spring 2004

    Mayes, Anne M.
    Introduction to the interactions between cells and surfaces of biomaterials. Surface chemistry and physics of selected metals, polymers, and ceramics. Surface characterization methodology. Modification of biomaterials surfaces. Quantitative assays of cell behavior in culture. Biosensors and microarrays. Bulk properties of implants. Acute and chronic response to implanted biomaterials. Topics in biomimetics, drug delivery, and tissue engineering. Laboratory demonstrations.

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