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Health Sciences and Technology (HST) - Archived

Mostrando recursos 1 - 20 de 24

  1. 20.430J / 2.795J / 6.561J / 10.539J / HST.544J Fields, Forces, and Flows in Biological Systems (BE.430J), Fall 2004

    Lauffenburger, Douglas; Grodzinsky, Alan
    This course covers the following topics: conduction, diffusion, convection in electrolytes; fields in heterogeneous media; electrical double layers; Maxwell stress tensor and electrical forces in physiological systems; and fluid and solid continua: equations of motion useful for porous, hydrated biological tissues. Case studies considered include membrane transport; electrode interfaces; electrical, mechanical, and chemical transduction in tissues; electrophoretic and electroosmotic flows; diffusion/reaction; and ECG. The course also examines electromechanical and physicochemical interactions in biomaterials and cells; orthopaedic, cardiovascular, and other clinical examples.

  2. 10.547J / 7.547J / 15.136J / HST.920J Principles and Practice of Drug Development, Fall 2005

    Cooney, Charles; Rubin, Robert; Finkelstein MD, Stan; Allen, Tom; Sinskey, Anthony
    This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

  3. HST.523J / 2.785J / 3.97J / 20.411J Cell-Matrix Mechanics, Spring 2004

    Yannas, Ioannis; Spector, Myron
    Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine.

  4. 8.592J / HST.452J Statistical Physics in Biology, Spring 2005

    Mirny, Leonid; Kardar, Mehran
    Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution.

  5. HST.184 Health Information Systems to Improve Quality of Care in Resource-Poor Settings, Spring 2011

    Fraser, Hamish; Celi, Leo; Szolovits, Peter
    This course is a collaborative offering of Sana, Partners in Health, and the Institute for Healthcare Improvement (IHI). The goal of this course is the development of innovations in information systems for developing countries that will (1) translate into improvement in health outcomes, (2) strengthen the existing organizational infrastructure, and (3) create a collaborative ecosystem to maximize the value of these innovations. The course will be taught by guest speakers who are internationally recognized experts in the field and who, with their operational experiences, will outline the challenges they faced and detail how these were addressed.

  6. 20.441 / 2.79J / 3.96J / HST.522J Biomaterials-Tissue Interactions (BE.441), Fall 2003

    Yannas, Ioannis; Spector, Myron
    This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Topics include methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. It also covers mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Other areas include tissue and organ regeneration; design of implants and prostheses based on control of biomaterials-tissue interactions; comparative analysis of intact, biodegradable, and...

  7. HST.950J / 6.872J Engineering Biomedical Information: From Bioinformatics to Biosurveillance, Fall 2005

    Kohane, Isaac; Ramoni, Marco
    This course provides an interdisciplinary introduction to the technological advances in biomedical informatics and their applications at the intersection of computer science and biomedical research.

  8. HST.921 / HST.922 Information Technology in the Health Care System of the Future, Spring 2007

    Bergeron, Bryan; Sands, Daniel; Blander, Jeffrey; Yoo, Julie; Locke, Steven
    This course will show how information technologies (IT) shape and redefine the health care marketplace. Students will learn how IT enhances medical care through: 1) improved economies of scale, 2) greater technical efficiencies in the delivery of care, 3) advanced tools for patient education and self-care, 4) network-integrated decision support tools for clinicians, and 5) opportunities for e-health delivery over the internet. Students will work in interdisciplinary teams to design an innovative solution to a current or future health care problem. Students' proposed solutions will draw upon understanding of tools and principles acquired and will be presented as an application...

  9. HST.725 Music Perception and Cognition, Spring 2004

    Tramo, Mark J., M.D. Ph.D.; Cariani, Peter; Oxenham, Andrew
    Survey of perceptual and cognitive aspects of the psychology of music, with special emphasis on underlying neuronal and neurocomputational representations and mechanisms. Basic perceptual dimensions of hearing (pitch, timbre, consonance/roughness, loudness, auditory grouping) form salient qualities, contrasts, patterns and streams that are used in music to convey melody, harmony, rhythm and separate voices. Perceptual, cognitive, and neurophysiological aspects of the temporal dimension of music (rhythm, timing, duration, temporal expectation) are explored. Special topics include comparative, evolutionary, and developmental psychology of music perception, biological vs. cultural influences, Gestaltist vs. associationist vs. schema-based theories, comparison of music and speech perception, parallels between...

  10. 20.453J / 2.771J / HST.958J Biomedical Information Technology (BE.453J), Spring 2005

    Dewey, C. Forbes (Clarence Forbes)
    The objective of this subject is to teach the design of contemporary information systems for biological and medical data. These data are growing at a prodigious rate, and new information systems are required. This subject will cover examples from biology and medicine to illustrate complete life cycle information systems, beginning with data acquisition, following to data storage and finally to retrieval and analysis. Design of appropriate databases, client-server strategies, data interchange protocols, and computational modeling architectures will be covered. Students are expected to have some familiarity with scientific application software and a basic understanding of at least one contemporary programming...

  11. HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis, Fall 2006

    Gollub, Randy L.; Banzett, Robert B.; Bolar, Divya S.; Buckner, Randy; Dickerson, Bradford; Gabrieli, John D. E.; Whitfield-Gabrieli, Susan; Greve, Doug; Hadjikhani, Nouchine; Helmer, Karl; Kanwisher, Nancy; Kennedy, David N. (David Nelson), 1962-; Mandeville, Joe; Manoach, Dara; Melcher, Jennifer R.; Moore, Christopher; Napadow, Vitaly; Pujol, Sonia; Rosen, Bruce Robert; Salat, David; Savoy, Robert; Sodickson, Dan; Sorensen, A. Gregory; Triantafyllou, Christina; Vangel, Mark Geoffrey; Wald, Lawrence; Yendiki, Anastasia
    This team taught, multidisciplinary course covers the fundamentals of magnetic resonance imaging relevant to the conduct and interpretation of human brain mapping studies. The challenges inherent in advancing our knowledge about brain function using fMRI are presented first to put the work in context. The course then provides in depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include fMRI experimental design including block design, event related and...

  12. 22.00J / 1.021J / 2.030J / 3.021J / 10.333J / 18.361J / HST.558J Introduction to Modeling and Simulation, Spring 2006

    Yip, Sidney; Beers, Kenneth J.; Buehler, Markus J.; Hadjiconstantinou, Nicolas G (Nicholas George); Mirny, Leonid A.; Bazant, Martin Z.; Marzari, Nicola; Powell, Adam C.; Radovitzky, Raul A.; Rosales, Rodolfo; Ulm, F.-J. (Franz-Josef)
    Basic concepts of computer modeling in science and engineering using discrete particle systems and continuum fields. Techniques and software for statistical sampling, simulation, data analysis and visualization. Use of statistical, quantum chemical, molecular dynamics, Monte Carlo, mesoscale and continuum methods to study fundamental physical phenomena encountered in the fields of computational physics, chemistry, mechanics, materials science, biology, and applied mathematics. Applications drawn from a range of disciplines to build a broad-based understanding of complex structures and interactions in problems where simulation is on equal-footing with theory and experiment. Term project allows development of individual interest. Student mentoring by a coordinated...

  13. HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis, Fall 2004

    Gollub, Randy L.; Savoy, Robert; Wald, Lawrence; Banzett, Robert B.; Dickerson, Bradford C; Melcher, Jennifer R.; Kennedy, David N. (David Nelson), 1962-; Tuch, David Solomon, 1973-; Jovicich, Jorge; Greve, Doug; Mandeville, Joe; Vangel, Mark Geoffrey; Hoge, Rick; Blood, Anne; Hadjikhani, Nouchine; Moore, Christopher; Salat, David; Sigalovsky, Irina S., 1972-; Stufflebeam, Steven M; Zalesky, Martin
    Provides information relevant to the conduct and interpretation of human brain mapping studies. Provides in-depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include fMRI experimental design including block design, event related and exploratory data analysis methods, and building and applying statistical models for fMRI data. Human subject issues including informed consent, institutional review board requirements and safety in the high field environment are also presented. Probability, linear...

  14. 2.782J / 3.961J / 20.451J / HST.524J Design of Medical Devices and Implants, Spring 2003

    Yannas, Ioannis V.; Spector, Myron
    Solution of clinical problems by use of implants and other medical devices. Systematic use of cell-matrix control volumes. The role of stress analysis in the design process. Anatomic fit: shape and size of implants. Selection of biomaterials. Instrumentation for surgical implantation procedures. Preclinical testing for safety and efficacy: risk/benefit ratio assessment. Evaluation of clinical performance: design of clinical trials. Project materials drawn from orthopedic devices, soft tissue implants, artificial organs, and dental implants.

  15. HST.921 / HST.923 Information Technology in the Health Care System of the Future, Spring 2003

    Locke, Steven E. (Steven Elliot); Bergeron, Bryan P.; Sands, Daniel Z.; Blander, Jeffrey
    The healthcare system in the US has been in the midst of a rapid transition in response to changing trends and patterns of care. The growing emphasis on evidence-based medical practice, continuous quality improvement, clinical and cost-effectiveness, and risk management have led to a sea change in medical practice that has been stressful for clinicians, patients, and administrators. As care becomes more tightly managed, it becomes a challenge for clinicians, administrators, and patients to balance time, money, resources, and clinical outcomes. Can emerging technologies help solve these complex problems? How has the demise of the dot.com industry effected these trends...

  16. 6.021J / 2.791J / 2.794J / 6.521J / BE.370J / BE.470J / HST.541J Quantitative Physiology: Cells and Tissues, Fall 2002

    Freeman, Dennis M.; Weiss, Thomas Fischer; Poe, Mya
    Principles of mass transport and electrical signal generation for biological membranes, cells, and tissues. Mass transport through membranes: diffusion, osmosis, chemically mediated, and active transport. Electric properties of cells: ion transport; equilibrium, resting, and action potentials. Kinetic and molecular properties of single voltage-gated ion channels. Laboratory and computer exercises illustrate the concepts. For juniors and seniors. Students engage in extensive written and oral communication exercises. Meets with graduate subject 6.521J, but assignments differ.

  17. HST.071 Human Reproductive Biology, Fall 2002

    Klapholz, Henry; Benacerraf, Beryl; Burke, Louis; Davis, Ann; Holmes, Lewis; Klipstein, Sigal; Lim, Kee-Hak; Morentaler, Abraham; Oskowitz, Selwyn; Penzias, Alan; Reindollar, Richard; Richardson, Douglas; Zand, Sarvenaz; Bonventre, Joseph B.
    Lectures and clinical case discussions designed to provide the student with a clear understanding of the physiology, endocrinology, and pathology of human reproduction. Emphasis is on the role of technology in reproductive science. Suggestions for future research contributions in the field are probed. Students become involved in the wider aspects of reproduction, such as prenatal diagnosis, in vitro fertilization, abortion, menopause, contraception and ethics relation to reproductive science. (Only HST students may register under HST.070, graded P/D/F.) From the course home page: Course Description Lectures, laboratory sessions, and clinical case discussions designed to provide the student with a clear understanding...

  18. HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis, Fall 2002

    Gollub, Randy L.; Bird, Stephanie J.; Brown, E. N. (Emery N.); Fischl, Bruce; Kanwisher, Nancy; Kennedy, David N. (David Nelson), 1962-; Manoach, Dara; Melcher, Jennifer R.; Moore, Christopher; Wald, Lawrence; Dale, Anders; Schmitt, F. (Franz), 1953-; Greve, Doug; Hoge, Rick; Jovicich, Jorge; Mandeville, Joe; Rosen, Bruce Robert; Savage, Cary; Savoy, Robert; Sorensen, A. Gregory; Tuch, David Solomon, 1973-; Vanduffel, Wim; Vangel, Mark Geoffrey; Bush, George
    Provides information relevant to the conduct and interpretation of human brain mapping studies. Provides in-depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include fMRI experimental design including block design, event related and exploratory data analysis methods, and building and applying statistical models for fMRI data. Human subject issues including informed consent, institutional review board requirements and safety in the high field environment are also presented. Probability, linear...

  19. HST.121 Gastroenterology, Fall 2002

    Carey, Martin C.; Schapiro, Robert; Badizadegan, Kamran; Chung, Raymond T.; Glickman, Jonathan N.
    Presents the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and associated pancreatic, liver, and biliary systems. Emphasis on the molecular and pathophysiological basis of disease where known. Covers gross and microscopic pathology and clinical aspects. Formal lectures given by core faculty, with some guest lectures by local experts. Selected seminars conducted by students with supervision of faculty. Permission of instructor required. (Only HST students may register under HST.120, graded P/D/F.) From the course home page: Course Description The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic,...

  20. HST.151 Principles of Pharmacology, Spring 2003

    Rosow, Carl E. (Carl Elliott), 1947-; Standaert, David; Strichartz, G. R. (Gary R.), 1943-; Dershwitz, Mark; Di Salvo, Thomas; Ko, Dickens; Kufe, Donald; Langer, Robert S.; Lees, Robert S.; Rubin, Robert H., 1941-; Ruskin, Jeremy N.; Tepper, Robert; Walsh, Carol T.; Weinblatt, Michael E.; Zapol, Warren M., 1942-
    An introduction to pharmacology. Topics include mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interactions, and substance abuse. Selected agents and classes of agents examined in detail. (Only HST students may register under HST.150, graded P/D/F.) From the course home page: Course Description The objective of this course is to teach and approach to the study of pharmacologic agents. It is not intended to be a review of the pharmacopoeia nor is it intended to be a replace dicussions of relevant drugs in the organ systems HST pathophysiology courses.

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