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Computation and Systems Biology (CSB)

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  1. A Distributed Computational Architecture for Integrating Multiple Biomolecular Pathways

    Ayyadurai, Shiva; Dewey, C. Forbes
    Biomolecular pathways are building blocks of cellular biochemical function. Computational biology is in rapid transition from diagrammatic representation of pathways to quantitative and predictive mathematical models, which span time-scales, knowledge domains and spatial-scales. This transition is being accelerated by high-throughput experimentation which isolates reactions and their corresponding rate constants. A grand challenge of systems biology is to model the whole cell by integrating these emerging quantitative biomolecular pathway models. Current integration approaches do not scale. A new parallel and distributed computational architecture, CytoSolve, directly addresses this scalability issue. Results are presented in the solution of a concrete biological model: the...
    (143075 bytes; application/pdf) - 23-jun-2010

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