Recursos de colección

RUA (124.683 recursos)

Este sitio es un repositorio institucional para facilitar el acceso a las publicaciones producidas por los miembros de la universidad. La interfaz del sitio está disponible en parte en español y en parte en Inglés. Un canal RSS está disponible para que los usuarios se mantengan al día con los nuevos materiales añadidos. El sitio dispone de ayuda en español solamente.

INV - TSB - Artículos de Revistas

Mostrando recursos 1 - 2 de 2

  1. Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines

    Mata Balaguer, Trinidad; Gómez-Martínez, Ángeles; García Morales, Pilar; Lacueva, Javier; Calpena, Rafael; Rocamora Reverte, Lourdes; López Riquelme, Natividad; Martínez Lacaci, Isabel; Ferragut, José A.; Saceda, Miguel
    Background. It has been reported that the histone deacetylase inhibitor (iHDAc) trichostatin A (TSA) induces an increase in MDR1 gene transcription (ABCB1). This result would compromise the use of iHDACs in combination with other cytotoxic agents that are substrates of P-glycoprotein (Pgp). It has also been reported the use of alternative promoters by the ABCB1 gene and the existence of a traslational control of Pgp protein. Finally, the ABCB1 gene is located in a genetic locus with the nested gene RUNDC3B in the complementary DNA strand, raising the possibility that RUNDC3B expression could interfere with ABCB1 alternative promoter regulation. Methods....
    - 17-may-2018

  2. Isochore chromosome maps of the human genome

    Oliver, Jose-Luis; Carpena, Pedro; Román Roldán, Ramón; Mata Balaguer, Trinidad; Mejías Romero, Andrés; Hackenberg, Michael; Bernaola Galván, Pedro
    The human genome is a mosaic of isochores, which are long DNA segments (z.Gt;300 kbp) relatively homogeneous in G+C. Human isochores were first identified by density-gradient ultracentrifugation of bulk DNA, and differ in important features, e.g. genes are found predominantly in the GC-richest isochores. Here, we use a reliable segmentation method to partition the longest contigs in the human genome draft sequence into long homogeneous genome regions (LHGRs), thereby revealing the isochore structure of the human genome. The advantages of the isochore maps presented here are: (1) sequence heterogeneities at different scales are shown in the same plot; (2) pair-wise...
    - 25-may-2018

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