Mostrando recursos 1 - 20 de 4.585

  1. Genetic rescue of absence seizures

    McCafferty, Cian; Connelly, William M.; Celli, Roberta; Ngomba, Richard T.; Nicoletti, Ferdinando; Crunelli, Vincenzo
    Crossbreeding GABAAR δ subunit knockout mice with stargazer mice removes the absence seizure phenotype Thalamic tonic GABAA current is similarly abolished Rescue also occurs with acute siRNA knockdown of δ subunit Ataxic phenotype of stargazer is partially ameliorated

  2. Yearning to belong: finding a "home" for the right to academic freedom in the UN human rights covenants

    Beiter, Klaus; Karran, Terence; Appiagyei-Atua, Kwadwo
    Academic freedom is generally considered a human right, both nationally and internationally. However, no legally binding international human rights instrument—neither at the global nor the regional level—provides express protection for this right; this includes the two most important global human rights treaties, the International Covenant on Civil and Political Rights and the International Covenant on Economic, Social and Cultural Rights, both of 1966. This begs the question: Does the right to academic freedom not—even so—have a “home” in either or both of the U.N. Human Rights Covenants? Can and should academic freedom be protected as part of the right to...

  3. Self-disclosure with dogs: dog owners’ and non-dog owners’ willingness to disclose emotional topics

    Evans-Wilday, Aislinn S.; Hall, Sophie S.; Hogue, Todd E.; Mills, Daniel S.
    Many owners talk to their pets about a wide range of issues, but there is very little research that has considered the content of this, or its impact on owner wellbeing. Verbal disclosure brings a range of potential health benefits, yet a number of factors may prevent individuals from confiding in their partners or friends (confidants). As such, in some circumstances, dogs may provide a more favorable alternative focus for disclosure. In a survey, we assessed dog owners’ (n = 286) and non-dog owners’ (n = 64) self-reported willingness to talk to their dog (dog owners only), their partner and...

  4. Changing nature and emerging patterns of domestic violence in global contexts: dowry abuse and the transnational abandonment of wives in India

    Anitha, Sundari; Yalamarty, Harshita; Roy, Anupama
    This paper argues for the need to understand dowry-related abuse through a lens that focuses not only on micro-and meso-level gendered socio-cultural milieus and economic norms but also on macro-level formal-legal structures and global power asymmetries. Based on life-history narratives of 57 women in India and 21 practitioner interviews, this paper documents a growing phenomenon whereby men who are resident in another country abuse their Indian-origin wives, appropriate their dowry and abandon them. While dowry-related abuse in such marriages is part of a continuum of domestic violence prevalent in South Asia and the South Asian diaspora, we explore how gender...

  5. A defining moment in personal tutoring: reflections on personal tutoring definitions and their implications

    Walker, Ben W.
    Despite personal tutoring being a highly important area, it has a contested nature. One contention concerns its definition: in simple terms, what personal tutoring is and, by extension, what effective personal tutoring is. A book on personal tutoring (Stork and Walker, 2015) I co-authored entitled Becoming an Outstanding Personal Tutor - which aims to define the role of the personal tutor in further education as well as explain and demonstrate how to carry out the role effectively) - raises a number of questions to be explored further. These have been brought into sharper focus by both my journey from further...

  6. Improvements in marble protection by means of innovative photocatalytic nanocomposites

    Gherardi, Francesca; Goidanich, Sara; Toniolo, Lucia
    The application of photocatalytic and self-cleaning nanomaterials in the field of architectural heritage is an encouraging strategy for stone conservation and particularly for marble elements. In the present research, self‐cleaning nanocomposites were set-up by mixing water dispersions of TiO2 nanoparticles in commercial protective treatments based on organosiloxanes, fluoropolyethers and functionalized SiO2. The pure anatase phase nanoparticles used for their preparation are photoactive under solar light, in addition to UV radiation, due to their benzyl surface capping resulting in an increase of their efficiency in the degradation of pollutants. The nanomaterials applied on Carrara marble specimens show better performance in terms...

  7. Investigating head movements induced by "riloid" patterns in migraine and control groups using a virtual reality display

    O'Hare, Louise; Sharp, Alex; Dickinson, Patrick; Richardson, Graham; Shearer, John
    Certain striped patterns can induce illusory motion, such as those used in op-art. The visual system and the vestibular system work together closely, and so it is possible that illusory motion from a visual stimulus can result in uncertainty in the vestibular system. This increased uncertainty may be measureable in terms of the magnitude of head movements. Head movements were measured using a head-mounted visual display. Results showed that stimuli associated with illusory motion also seems to induce greater head movements when compared to similar stimuli. Individuals with migraine are more susceptible to visual discomfort, and this includes illusory motion...

  8. Chemical diversity in a metal-organic framework revealed by fluorescence lifetime imaging

    Schrimpf, Waldemar; Jiang, Juncong; Ji, Zhe; Hirschle, Patrick; Lamb, Don C.; Yaghi, Omar M.; Wuttke, Stefan
    The presence and variation of chemical functionality and defects in crystalline materials, such as metal–organic frameworks (MOFs), have tremendous impact on their properties. Finding a means of identifying and characterizing this chemical diversity is an important ongoing challenge. This task is complicated by the characteristic problem of bulk measurements only giving a statistical average over an entire sample, leaving uncharacterized any diversity that might exist between crystallites or even within individual crystals. Here we show that by using fluorescence imaging and lifetime analysis, both the spatial arrangement of functionalities and the level of defects within a multivariable MOF crystal can...

  9. It’s the news, stupid!

    Winston, Brian
    George the Fifth, by the Grace of God, of the United Kingdom of Great Britain and Ireland etc etc…. To all whom these Presents shall come Greeting! etc etc.... AND WHEREAS…. more than two million persons in our United Kingdom…. have applied for and taken out Licenses to instal and operate apparatus for wireless telegraphy for the purposes of receiving Broadcast programmes…. We believe that it would greatly…. be of public benefit if a Corporation…were created by the exercise of Our Royal Prerogative and certain knowledge and of Our special grace and knowledge and mere motion…. The King thus willed...

  10. Chitosan nanoparticle antigen uptake in epithelial monolayers can predict mucosal but not systemic in vivo immune response by oral delivery

    Cole, Hannah; Bryan, Donna; Lancaster, Lorna; Mawas, Fatme; Vllasaliu, Driton
    This study compared in vitro and in vivo antigen delivery effects of ultrapure chitosan (CS) chloride. CS nanoparticles were formulated to incorporate ovalbumin (OVA) as a model antigen and characterised for size, charge, OVA complexation and release. The effect of CS:OVA nanoparticles on cell viability, epithelial tight junctions and transepithelial permeation of OVA was tested on Caco-2 monolayer in vitro intestinal model. The system’s ability to elicit immune responses was subsequently tested in vivo. The work confirmed that CS complexes with OVA into nano-size entities. Nanocomplexes displayed favourable delivery properties, namely OVA release and no notable cytotoxicity. CS:OVA markedly enhanced...

  11. Mapping the location of terrestrial impacts and extinctions onto the spiral arm structure of the Milky Way

    Gillman, Michael; Erenler, Hilary; Sutton, Phil
    High density regions within the spiral arms are expected to have profound effects on passing stars. Understanding of the potential effects on the Earth and our Solar System is dependent on a sufficient dynamic model of arm passage. Using a novel combination of data we derive a model of the timings of the Solar System through the spiral arms and the relationship to arm tracers such as methanol masers. This reveals that asteroid/comet impacts are significantly clustered near the spiral arms and within specific locations of an average arm structure. The end-Permian and end-Cretaceous extinctions are shown to be located...

  12. On the tidal environment of an outwardly migrated F ring

    Sutton, Phil
    Saturn’s F-ring is a unique narrow ring that lies radially close to the tidally disruptive Roche limit of Saturn for water ice. Significant work has been done on the system that shows it to be one of the most dynamic places in the Solar System. Aggregates fortunate enough to form constantly battle against the strong tidal forces of Saturn and the nearby moons Prometheus and Pandora, which act to gravitationally stir up ring material. Planetary rings are also known to radially spread, with the outer ring edge migrating outwards. As the F ring lies at the edge of the main...

  13. Determinants of livelihood choices and artisanal entrepreneurship in Nigeria

    Igwe, Paul Agu; Madichie, Nnamdi O.; Newbery, Robert
    Purpose – This study provides fresh insights into rural artisanal activities in a developing world context. It highlights key determinants of the decision to engage in an artisanal business and the challenges that impact upon the growth of these activities. Design/methodology/approach – The study adopts a mix-method research approach to explore a rural setting where most respondents (81 percent) combine farm and non-farm livelihood activities. Quantitatively, a multi-nominal regression is used to examine the determinants of diversified artisanal livelihoods. It modelled the differences between farming livelihoods that have not diversified, compared to those also involved in the artisanal activity or wage...

  14. The welfare of the vulnerable in the late 18th and early 19th centuries: Gilbert’s Act of 1782

    Shave, Samantha
    This article explores the adoption of Gilbert's Act (1782) to establish workhouses in the south of England. It examines how they operated, what their purpose was and how this changed over time.

  15. The dependent poor? (Re)constructing individuals’ lives ‘on the parish’ in rural Dorset, 1800-1832

    Shave, Samantha A.
    Social commentators in the early decades of the nineteenth century considered the ‘poor classes’ to be a homogenous sub-group of society dependent on parish poor relief. Whilst in recent decades studies of the Old Poor Law have added much to our understandings of the complexity of poor relief practices, the concept of dependency has proved remarkably durable. This article challenges this central assumption by focusing upon the very individuals who constituted this supposedly homogenous dependent group. The relief histories of eight individuals from two cohorts who resided in the Dorset parish of Motcombe are (re)constructed and linked to demographic data...

  16. The impact of Sturges Bourne's Poor Law reforms in rural England

    Shave, Samantha
    England was blighted by frequent agricultural depressions in the late eighteenth and early nineteenth centuries. Recurrent crises brought poor law reform to the parliamentary agenda and led to the passage of two non-compulsory pieces of legislation, Sturges Bourne's Acts of 1818 and 1819. These permissory acts allowed parishes to ‘tighten up’ the distribution of poor relief through two vital tools: the formation of select vestries, and the appointment of waged assistant overseers. Whilst previous studies have tended to represent the legislation as a failing reform in the dying days of the old poor law, we know remarkably little about the...

  17. The Carnegie dietary survey of interwar Britain

    Shave, Samantha
    This research note describes an under-used collection of papers which document interwar income, nutrition and health in Britain which were created in the administration of the Carnegie Dietary Survey by John Boyd-Orr in the Rowett Institute with funding from the Carnegie United Kingdom Trust. The survey was conducted in 16 rural and urban places across England and Scotland between 1937-9, and are now held at the Specialist Collections Centre at the University of Aberdeen. While the importance of the survey in informing knowledge about nutrition and the development of rationing has been acknowledged in the field of social medicine, the...

  18. The new Poor Law: local and regional perspectives [Introduction]

    Hinde, Andrew; Shave, Samantha A.
    A special edition of Local Population Studies

  19. Composition of bird nests is a species-specific characteristic

    Biddle, Lucia; Broughton, Robyn; Goodman, Adrian; Deeming, Charles
    Bird nests represent an extended phenotype of individuals expressed during reproduction and so exhibit variability in composition, structure and function. Descriptions of nests based on qualitative observations suggest that there is interspecific variation in size and composition but there are very few species in which this has been confirmed. For these species, data of the amounts of different materials indicate that nest construction behaviour is plastic and affected by a variety of factors, such as prevailing temperature, geographic location, and availability of materials. The lack of data on nest composition is hampering our understanding of how nests achieve their various...

  20. Nation, nationhood and theatre [introduction to special issue]

    Bull, John
    There is, for me at least, a delightful irony in the fact that I should be writing the introduction to this collection of essays based on the proceedings of the 26th annual Contemporary Drama in English conference, on “Nation, Nationalism and Theatre,” held at the University of Reading (UK) in June/July 2017. For John Bull is, or more realistically was, regarded as the popular iconic figure epitomising the robust and patriotic cheerfulness of the English people.1 It is an identification that goes back to 1712, when he first made an appearance in John Arbuthnot’s The History of John Bull, an...

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