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1. Interpreting DNA Evidence: A Review - Foreman, L.A.; Champod, C.; Evett, I.W.; Lambert, J.A.; Pope, S.
The paper provides a review of current issues relating to the use of DNA profiling in forensic science. A short historical section gives the main statistical milestones that occurred during a rapid development of DNA technology and operational uses. Greater detail is then provided for interpretation issues involving STR DNA profiles, including: ¶ methods that take account of population substructure in DNA calculations; ¶ parallel work carried out by the US National Research Council; ¶ the move away from multiple independence testing in favour of experiments that demonstrate the robustness of casework procedures; ¶ the questionable practice of source attribution `with reasonable scientific certainty'; ¶ the effect on the...

2. The Statistical Interpretation of Forensic Glass Evidence - Curran, James M.
When examining a sample of glass fragments recovered from a suspect in a forensic case, many questions arise: "Did this man break that window?", "Are these fragments from the crime scene source?", "Do the fragments recovered from the suspect come from more than one source?", "How common is it to find glass on someone unrelated with crime?" etc. Such questions are usually answered with the help of statistical methods. This paper reviews some of the statistical solutions and problems encountered in the interpretation and evaluation of forensic glass evidence.

3. Questioning a Courtroom Proof of the Uniqueness of Fingerprints - Kaye, David H.
Forensic scientists or analysts concerned with "individualization" often presume that features such as fingerprint minutia are unique to each individual. In the United States, defendants in criminal cases have been demanding proof of such assumptions. In at least two cases, the government of the United States has successfully relied on an unpublished statistical study prepared specifically for litigation to demonstrate the uniqueness of fingerprints. This article suggests that the study is neither designed nor executed in a way that can show whether an individual's fingerprint impressions are unique.

4. Sentencing Illicit Drug Traffickers: How do the Courts Handle Random Sampling Issues? - Izenman, Alan J.
While many European justice systems distinguish between possession of and trafficking in illicit drugs, sentencing in drug cases in those countries tends not to depend (at least formally) upon the quantity of drugs seized from a defendant, but rather on the circumstances in which the defendant was found with drugs. Courts in the United States, on the other hand, penalize those convicted of drug crimes through an elaborate system of sentencing rules and guidelines. These sentences depend only upon the amount of drugs (possibly adjusted for circumstances) and the defendant's criminal history. Because of the enormous amount of work needed to determine drug type and quantity in...

5. Copyright Damages and Statistics - Basmann, Robert L.; Slottje, Daniel J.
This paper discusses the statistical issues that arise in conducting an economic damages analysis in the context of a litigation matter involving copyrights. Calculating damages in copyright cases turns out to be a natural application for econometric modelling methods. Surprisingly, elementary statistical issues can be a source of significant debate between the experts in such matters. In this paper, we present a case study and illustrate how issues such as interpretation of $p$-values and what "rejection of the null hypothesis" really "means" in such matters.

6. Statistical Issues Arising in Disparate Impact Cases and the Use of the Expectancy Curve in Assessing the Validity of Pre-Employment Tests - Gastwirth, Joseph L.; Miao, Weiwen; Zheng, Gang
Disparate impact cases concern the potential adverse effect seemingly neutral employment practices, such as passing a pre-employment test or possessing a fixed level of education, have on minority applicants. Their purpose is to eliminate discrimination by subterfuge, i.e., imposing a requirement that eliminates many minority individuals who could do the job but who do not meet the requirement. When a significantly higher fraction of applicants from minority groups fail the requirement compared to majority applicants, the requirement needs to be shown to be job-related. Statistical techniques used at the various stages of a disparate impact claim are described. Properties of the expectancy curve, which describes the utility...

7. Multiple Imputation: Theory and Method - Zhang, Paul
In this review paper, we discuss the theoretical background of multiple imputation, describe how to build an imputation model and how to create proper imputations. We also present the rules for making repeated imputation inferences. Three widely used multiple imputation methods, the propensity score method, the predictive model method and the Markov chain Monte Carlo (MCMC) method, are presented and discussed.

8. Proper and Improper Multiple Imputation - Feodor Nielsen, Soren
Multiple imputation has become viewed as a general solution to missing data problems in statistics. However, in order to lead to consistent asymptotically normal estimators, correct variance estimators and valid tests, the imputations must be proper. So far it seems that only Bayesian multiple imputation, i.e.\ using a Bayesian predictive distribution to generate the imputations, or approximately Bayesian multiple imputations has been shown to lead to proper imputations in some settings. In this paper, we shall see that Bayesian multiple imputation does not generally lead to proper multiple imputations. Furthermore, it will be argued that for general statistical use, Bayesian multiple imputation is inefficient even when it is proper.

9. Dimension Reduction with Linear Discriminant Functions Based on an Odds Ratio Parameterization - van der Linde, Angelika
The association of two random elements with positive joint probability density function is given by an odds ratio function. The covariance is an adequate description only in the case of two jointly Gaussian variables. The impact of the association structure on the set-up and solution of problems of linear discrimination is investigated, and the results are related to standard techniques of multivariate analysis, particularly to canonical correlation analysis, analysis of contingency tables, discriminant analysis and multidimensional scaling.

10. Introduction - Balding, David J.; Gastwirth, Joseph L.
The word "statistics" derives from the collection and use of data to assist in the administration of a state (nation). The justice system is one of the fundamental pillars of a state, and is central to the political life of most countries. Ideas from probability and statistics have been used to try to model and improve methods of legal decision-making since the earliest days of our discipline in the 16th and 17th centuries. More recently, the debate over the Bayesian statistical paradigm, rooted in probability theory, as a model for legal reasoning has not subsided since being ignited by Finkelstein & Farley (1970); see Balding (1998) for...

11. Environmental Statistics---A Personal View - Guttorp, Peter
The field of environmental statistics is one of rapid growth at the moment. Environmental decision-making is prevalent in much of the world, and politicians and other decision makers are requesting new tools for understanding the state of the environment. In this paper, three case studies involving water pollution, air pollution, and climate change assessment are presented, together with brief descriptions of some other areas of environmental statistics. A discussion of future directions of the field concludes the paper.

12. \bf Hierarchical Models in Environmental Science - Wikle, Christopher K.
Environmental systems are complicated. They include very intricate spatio-temporal processes, interacting on a wide variety of scales. There is increasingly vast amounts of data for such processes from geographical information systems, remote sensing platforms, monitoring networks, and computer models. In addition, often there is a great variety of scientific knowledge available for such systems, from partial differential equations based on first principles to panel surveys. It is argued that it is not generally adequate to consider such processes from a joint perspective. Instead, the processes often must be considered as a coherently linked system of conditional models. This paper provides a brief overview of hierarchical approaches applied to environmental processes. The...

13. Statistical Assessment of Numerical Models - Fuentes, Montserrat; Guttorp, Peter; Challenor, Peter
Evaluation of physically based computer models for air quality applications is crucial to assist in control strategy selection. The high risk of getting the wrong control strategy has costly economic and social consequences. The objective comparison of modeled concentrations with observed field data is one approach to assessment of model performance. For dry deposition fluxes and concentrations of air pollutants there is a very limited supply of evaluation data sets. We develop a formal method for evaluation of the performance of numerical models, which can be implemented even when the field measurements are very sparse. This approach is applied to a current U.S. Environmental Protection Agency air quality model. In other...

14. Sequential Data Assimilation Techniques in Oceanography - Bertino,, Laurent; Evensen, Geir; Wackernagel, Hans
We review recent developments of sequential data assimilation techniques used in oceanography to integrate spatio-temporal observations into numerical models describing physical and ecological dynamics. Theoretical aspects from the simple case of linear dynamics to the general case of nonlinear dynamics are described from a geostatistical point-of-view. Current methods derived from the Kalman filter are presented from the least complex to the most general and perspectives for nonlinear estimation by sequential importance resampling filters are discussed. Furthermore an extension of the ensemble Kalman filter to transformed Gaussian variables is presented and illustrated using a simplified ecological model. The described methods are designed for predicting over geographical regions using a high spatial resolution...

15. Health Effects of Air Pollution:\\ A Statistical Review - Dominici, Francesca; Sheppard, Lianne; Clyde, Merlise
We critically review and compare epidemiological designs and statistical approaches to estimate associations between air pollution and health. More specifically, we aim to address the following questions: \begin{enumerate} \item[1.]{\bfWhich epidemiological designs and statistical methods are available to estimate associations between air pollution and health?} \item[2.]{\bfWhat are the recent methodological advances in the estimation of the health effects of air pollution in time series studies?} \item[3.]{\bfWhat are the the main methodological challenges and future research opportunities relevant to regulatory policy?} \end{enumerate} In question 1, we identify strengths and limitations of time series, cohort, case-crossover and panel sampling designs. In question 2, we focus on time series studies and we review statistical methods for: 1)...

16. Reflections on Fourteen Cryptic Issues Concerning the Nature of Statistical Inference - Kardaun, O.J.W.F.; Salomé, D.; Schaafsma, W.; Steerneman, A.G.M.; Willems, J.C.; Cox, D.R.
The present paper provides the original formulation and a joint response of a group of statistically trained scientists statisticians to fourteen cryptic issues for discussion, which were handed out to the public by Professor Dr. D.R. Cox after his Bernoulli Lecture 1997 at Groningen University. ¶ footnote: Part of this work was funded by a collaboration between IPP and Euratom. The contents of this work is the sole responsibility of the authors. In particular, the views expressed therein are not to be construed as being official and do not necessarily reflect those of the European Commission or the Max-Planck-Gesellschaft.

17. Statistical Regularity and Free Will:\\ L.A.J. Quetelet and P.A. Nekrasov - Seneta, Eugene
In the 19th century, causes of empirically observed stability of averages in settings relating to human behaviour were a topic of intense discussion in western Europe. This followed an extensive study of empirical stability by the founder of modern statistics (and of the International Statistical Institute) L.A.J. Quetelet, published in 1835, in what he called "Social Physics''. The eminent mathematician of strong probabilistic and philosophical inclination and Russian Orthodox religious belief, P.A. Nekrasov, took up and modified Quetelet's Social Physics in 1902, with (social) independence seen as prime cause of statistical regularity. Our paper focuses on the role free will plays in the statistical writings of Quetelet and...

18. Bridging the Gap between Different Statistical Approaches: An Integrated Framework for Modelling - Kuhnert, Petra M.; Mengersen, Kerrie; Tesar, Peter
This paper proposes a template for modelling complex datasets that integrates traditional statistical modelling approaches with more recent advances in statistics and modelling through an exploratory framework. Our approach builds on the well-known and long standing traditional idea of `good practice in statistics' by establishing a comprehensive framework for modelling that focuses on exploration, prediction, interpretation and reliability assessment, a relatively new idea that allows individual assessment of predictions. ¶ The integrated framework we present comprises two stages. The first involves the use of exploratory methods to help visually understand the data and identify a parsimonious set of explanatory variables. The second encompasses a two step modelling process, where the use of non-parametric...

19. A Bayesian Formulation of Exploratory Data Analysis and Goodness-of-fit Testing - Gelman, Andrew
Exploratory data analysis (EDA) and Bayesian inference (or, more generally, complex statistical modeling)---which are generally considered as unrelated statistical paradigms---can be particularly effective in combination. In this paper, we present a Bayesian framework for EDA based on posterior predictive checks. We explain how posterior predictive simulations can be used to create reference distributions for EDA graphs, and how this approach resolves some theoretical problems in Bayesian data analysis. We show how the generalization of Bayesian inference to include replicated data $y^{\rm rep}$ and replicated parameters $\theta^{\rm rep}$ follows a long tradition of generalizations in Bayesian theory. ¶ On the theoretical level, we present a predictive Bayesian formulation of goodness-of-fit testing, distinguishing between $p$-values...

20. Some Aspects Of Neutral To Right Priors - Dey, Jyotirmoy; Erickson, R.V.; Ramamoorthi, R.V.
Neutral to right priors are generalizations of Dirichlet process priors that fit in well with right-censored data. These priors are naturally induced by increasing processes with independent increments which, in turn, may be viewed as priors for the cumulative hazard function. This connection together with the L\'{e}vy representation of independent increment processes provides a convenient means of studying properties of \nr\ priors. ¶ This article is a review of the theoretical aspects of \nr\ priors and provides a number of new results on their structural properties. Notable among the new results are characterizations of \nr\ priors in terms of the posterior and the cumulative hazard function. We also show that...

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