Toirac, Ivette; Sanjuán, Julio; Aguilar, Eduardo J.; González, José C.; Artigas, Francesc; Rivero, Olga; Nájera, Carmen; Moltó, María D.; Frutos, Rosa de
[Objective]: Previous studies on a possible association between CCK-AR polymorphisms and schizophrenia have been controversial. The aim of the present study was to assess a potential association between schizophrenic patients with auditory hallucinations and polymorphisms of the CCK-AR gene.
Arroba, Ana I.; Revuelta-Cervantes, Jesús; González-Rodríguez, Águeda; Pardo, Virginia; Burks, Deborah J.; Valverde, Ángela M.
Botta-Orfila, Teresa; Tolosa, Eduardo; Gelpi, Ellen; Sánchez-Plà, Álex; Martí, María-José; Valldeoriola, Francesc; Fernandez, Manel; Carmona, Francesc; Ezquerra, Mario
LRRK2 mutations are the most common genetic cause of Parkinson's disease (PD). We performed a whole-genome RNA profiling of putamen tissue from idiopathic PD (IPD), LRRK2-associated PD (G2019S mutation), neurologically healthy controls and one asymptomatic LRRK2 mutation carrier, by using the Genechip Human Exon 1.0-ST Array. The differentially expressed genes found in IPD revealed an alteration of biological pathways related to long-term potentiation (LTP), GABA receptor signalling, and calcium signalling pathways, among others. These pathways are mainly related with cell signalling cascades and synaptic plasticity processes. They were also altered in the asymptomatic LRRK2 mutation carrier but not in the...