Recursos de colección

Digital.CSIC (162.855 recursos)

Repositorio institucional del Consejo Superior de Investigaciones Científicas. Digital.CSIC es un depósito de documentos digitales, cuyo objetivo es organizar, archivar, preservar y difundir en modo de acceso abierto la producción intelectual resultante de la actividad investigadora del CSIC.

(IIBB) Artículos post-print

Mostrando recursos 1 - 3 de 3

  1. Association between CCK-AR gene and schizophrenia with auditory hallucinations

    Toirac, Ivette; Sanjuán, Julio; Aguilar, Eduardo J.; González, José C.; Artigas, Francesc; Rivero, Olga; Nájera, Carmen; Moltó, María D.; Frutos, Rosa de
    [Objective]: Previous studies on a possible association between CCK-AR polymorphisms and schizophrenia have been controversial. The aim of the present study was to assess a potential association between schizophrenic patients with auditory hallucinations and polymorphisms of the CCK-AR gene.
    - 15-nov-2017

  2. Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice

    Arroba, Ana I.; Revuelta-Cervantes, Jesús; González-Rodríguez, Águeda; Pardo, Virginia; Burks, Deborah J.; Valverde, Ángela M.
    et al.
    - 19-dic-2017

  3. Microarray expression analysis in idiopathic and LRRK2-associated Parkinson's disease

    Botta-Orfila, Teresa; Tolosa, Eduardo; Gelpi, Ellen; Sánchez-Plà, Álex; Martí, María-José; Valldeoriola, Francesc; Fernandez, Manel; Carmona, Francesc; Ezquerra, Mario
    LRRK2 mutations are the most common genetic cause of Parkinson's disease (PD). We performed a whole-genome RNA profiling of putamen tissue from idiopathic PD (IPD), LRRK2-associated PD (G2019S mutation), neurologically healthy controls and one asymptomatic LRRK2 mutation carrier, by using the Genechip Human Exon 1.0-ST Array. The differentially expressed genes found in IPD revealed an alteration of biological pathways related to long-term potentiation (LTP), GABA receptor signalling, and calcium signalling pathways, among others. These pathways are mainly related with cell signalling cascades and synaptic plasticity processes. They were also altered in the asymptomatic LRRK2 mutation carrier but not in the...
    - 12-jul-2018

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