Recursos de colección

Digital.CSIC (78.117 recursos)

Repositorio institucional del Consejo Superior de Investigaciones Científicas. Digital.CSIC es un depósito de documentos digitales, cuyo objetivo es organizar, archivar, preservar y difundir en modo de acceso abierto la producción intelectual resultante de la actividad investigadora del CSIC.

(IBMCC) Comunicaciones congresos

Mostrando recursos 1 - 4 de 4

  1. Sirtuin 1 is a key regulator of the IL-12 p70/IL-23 balance in human dendritic cells (DC)

    Alvarez, Yolanda; Rodríguez, Mario; Municio, Cristina; Hugo, Etzel; Alonso, Sara; Ibarrola, Nieves; Fernández, Nieves; Sánchez Crespo, Mariano
    Stimulation of DC with the fungal surrogate zymosan produces IL-23 and a low amount of IL-12 p70. Trans-repression of il12a transcription, which encodes IL-12 p35 chain, by proteins of the Notch family and lysine deacetylation reactions have been reported as the underlying mechanisms, but this has not been fully addressed. Zymosan induced the association of SIRT1 with the il12a promoter, increased the nuclear concentration of the SIRT1 cosubstrate NAD+, and decreased chromatin accessibility in the nucleosome 1 of il12a. The involvement of deacetylation reactions in the inhibition of il12a transcription was supported by the absence of Ac-K14-histone H3 in DC...
    - 25-jun-2015

  2. Genome-wide screenings and subcellular localization analyses uncover major events in the mechanism of action of antitumor lipids in Saccharomyces cerevisiae

    Cuesta-Marbán, Álvaro; Botet, Javier; Cacharro, Luis M.; Gajate, Consuelo; Hornillos, Valentín; Amat-Guerri, Francisco; Revuelta, José L.; Acuña, A. Ulises; Mollinedo, Faustino
    Trabajo presentado al "8th International Meeting on Yeast apoptosis" celebrado en Kent del 2 al 6 de mayo de 2011.-- et al.
    - 31-ene-2014

  3. Unique genetic profile of sporadic colorectal cancer liver metastasis versus primary tumors by SNP-Arrays

    Sayagués, José María; Fontanillo, Celia; González González, María; García, Eva; Abad, María del Mar; De Las Rivas, Javier; Orfao, A.
    Trabajo presentado como póster al XXVI Congreso Nacional de Genética Humana y a la XIX Reunión Anual de la SEGCD celebradas en Murcia del 30 de marzo al 1 de abril del 2011.-- et al.
    - 27-mar-2014

  4. Combining dissimilarity based classifiers for cancer prediction using gene expression profiles

    Blanco, Ángela; Martín-Merino, Manuel; De Las Rivas, Javier
    DNA Microarrays allow us to monitor the expression level of thousands of genes simultaneously across a collection of related samples. This technology has been applied to the prediction of cancer considering the gene expression profiles in both, normal and cancer samples.
    (186342 bytes; application/pdf) - 22-ene-2013

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