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DSpace at MIT (77,612 recursos)
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Mechanical Engineering - Master's degree

Mostrando recursos 1 - 20 de 3,081

1. Streamlining data management in drug product commercialization and manufacturing - Anderson, Spencer C. (Spencer Clark)
Effective execution and alignment of data management across development and manufacturing teams is essential for Amgen's Drug Product Technology group to realize its main goals of shortening the development timeline and ensuring robust commercial manufacturing. The right data management strategy can help address these goals by accelerating development work and regulatory filing as well as improving commercial manufacturing efficiency. In the face of challenges associated with rapid growth and an expanding product pipeline, Amgen's commitment to standardizing development work and digitizing both clinical and commercial manufacturing has introduced many opportunities for new data management initiatives, improvements, and a revamped overall...

2. Tactical planning optimization for campaign scheduling of active pharmaceutical ingredient production based on monoclonal antibodies - Assia, Shai
Monoclonal Antibodies (mAb's) are the fastest growing segment in the biopharmaceutical industry. They are used today as therapeutics and diagnostics for several medical applications, including various types of cancer, rheumatoid arthritis, psoriasis, severe asthma macular degeneration, multiple sclerosis and more. In recent years, industry trends and market pressure have driven pharmaceutical companies to focus efforts on increasing operational efficiency in order to reduce the financial burden associated with drug manufacturing. Consequentially, Novartis Pharma Technical Operations' is currently engaging in efforts to obtain Class "A" Manufacturing Resource Planning (MRP II). This project was chosen to analyze and address the current Integrated...

3. Creating a corporate strategy for utilizing supply chain simulation, optimization and visualization - Chou, David (David Hancheng)
Computer based supply chain simulation, optimization, and visualization capability have changed significantly in the past 45 years, expanding capability in lockstep with increases in computational power. The increase in accessibility of relatively cheap and powerful hardware has led to the development of a multitude of supply chain simulation, optimization, and visualization programs catered towards reducing corporate supply chain costs. Some of these programs are commercial business to business offerings, while a significant set are developed internally within the corporation. Expertise in this field is increasingly seen as an area of competitive advantage for modern goods based corporations. However, the danger...

4. Improving sales and operations planning in an engineer-to-order environment - Christogiannis, Andreas
A pragmatic approach is taken at analyzing and improving Sales and Operations Planning in a project based, engineer-to-order product line. Variability of product and components configurations and long lead times of the sales process and of material procurement during project execution place additional planning challenges in comparison with a standardized high volume product business. The study focuses on improving the visibility on future customer orders and on reducing the procurement lead time of project material. Due to the nature of the market and the customers of the studied product line, incoming orders timing is very uncertain when viewed on a...

5. Extracting product opportunities from intellectual property portfolios : from patent to product idea - Cooper-Davis, Sarah
Companies and research institutes maintain large intellectual property portfolios, which are considered company assets and require significant investments to maintain. This thesis looks at the potential to extract value from such portfolios through new product development to offset this capital investment. Traditionally the IP protects existing products or excludes competitors from entering a given market. Alternatively this process looks to move from intellectual property (IP) to product ideas (PI), hereafter referred to as the IP2PI process ... [figure 1]. As outlined in Figure 1 the IP2PI process starts with intellectual property as the main input. Next the IP2PI process itself...

6. Improving the inbound supply chain through dynamic pickup windows - Cummings, Charles R., III (Charles Ronald)
Amazon is one of the world's largest retailers with revenues of $74.5 billion in 2013 and 22% growth over 2012. As Amazon continues to grow and offer greater selection, more products are flowing through an expanding inbound network. While this growth has added complexity for the inbound transportation organization, it has also created opportunities to reduce transportation cost and improve performance. Inbound transportation managed by Amazon currently represents 60% of the company's inbound freight. For this freight, Amazon uses automated shipment-planning systems to select a carrier for all shipments. The systems run once per day, selecting carriers for a set...

7. Quality improvement strategy in a dynamic aerospace manufacturing environment - English, Orion T. (Orion Tyler)
In the manufacturing of any complex product it is a generally accepted phenomenon that defects will occur at various stages in the process. In aircraft modification and repair facilities, the low levels of automation and high degree of manual labor results in a significant increase in the rate of errors and defects caused throughout the production cycle. This results in a significant amount of unplanned rework that is scheduled and executed along with the previously planned work. This thesis presents a project carried out during an internship at Boeing focused on developing and implementing a quality management strategy targeting improvement...

8. Technology maturity analysis for assessing capacity and schedule risk of future automation projects - Frackleton, Conor J
The need to improve risk assessment methods for automation projects within United States manufacturers exists due to a shift toward increased in factory automation stemming from industry pressure to reduce manufacturing costs and increase production rates. This study explores the hypothesis that a risk assessment method, based on technology maturity analysis, can be used to reduce the time to decision, reduce the influence of personal bias, and improve the estimation of risk impact when evaluating proposed automation systems. The risk assessment method is based on the Technology Readiness Level (TRL) framework, coupled with a mathematical simulation of the manufacturing process....

9. Optimizing procurement and handling costs in a utility - Genser, Bradley Philip
We propose a novel method to quantify the cost of activities involved in the picking portion of order fulfillment. We adapt the general method of picking cost quantification to the specific situation of TP&G, a publicly held utility, to build a simulation model which calculates total cost (procurement purchasing costs + material handling costs) across TP&G's Construction Materials Supply Chain (CMSC) . We use the simulation model to demonstrate the effect of case pack quantities and various disputed (within TP&G) material handling policies on supply chain costs. Finally. we move beyond the descriptive results of the simulation model and build...

10. Rugged field-service computing : a product development case study at Dell Inc. - Giese, Jeremy M
In the face of challenging market conditions, Dell, Inc. is in the process of shifting from focusing on electronics hardware development and sales to focusing on providing complete IT solutions to business clients. Part of this process involves determining what products and services Dell can provide beyond its current offerings, and then developing these new offerings internally or through acquisition. This thesis will use the internal development of one such offering as an in-depth case study to examine an accelerated version of Dell's standard new product development processes. Additionally, it will use the case study to identify pain points in...

11. Complexity cost quantification and modeling for strategic portfolio management - Ma, Jan, S.M. Massachusetts Institute of Technology
This project explores portfolio management and planning through effectively reducing complexity within operations. We apply this to a major healthcare company (referred to as Company X). The anticipated launch of new molecules and formulations into the existing high mix product portfolio presents significant challenges to contain cost and maintain the standard service level of Company X. Complexity costs associated with manufacturing and supply chain activities are not entirely accounted for in direct production costs. Having transparency to these costs at a brand or SKU level would allow significant improvements in strategic decision making throughout the life cycle of a product....

12. Framework and strategies for reducing aircraft lead time - Marsh, John Andrew, S.M. Massachusetts Institute of Technology
Aircraft are complex machines consisting of tens of thousands of parts and assemblies. Due to special engineering requirements, processes, and materials, the lead time for many of the parts can be several months resulting in a long aircraft lead time. During periods of high demand long aircraft lead time is less of a concern since manufacturers often have a large backlog, which is greater than the lead time, allowing them to build the aircraft to order. However, during periods of low demand, manufacturers may need to forecast demand and make the decision to start building aircraft before having a committed...

13. Carbon footprint measurement and analysis of a multi-modal logistics network - Miller, Adam J. (Adam James)
General Motors (GM) is one of the world's largest automobile manufacturing companies and does business in over 120 countries, requiring a complex operations network. Operating with a focus on environmental impact has become a strategic pillar within the company, both in its products and in its supply chain. Specifically, the GM global logistics organization is driving toward greater emissions visibility and the identification of carbon dioxide reduction opportunities within its network. Key objectives of this thesis work include creating business tools and processes to record global logistics emissions data, which will allow GM to more accurately report logistics emissions and...

14. Multi-echelon inventory strategies for a retail replenishment business model - Polak, Benjamin M. (Benjamin Michael)
The mission of the Always Available retail replenishment business at NIKE is to ensure consumer-essential products are in-stock at retailers at all times. To achieve this goal, NIKE has developed a forecast-driven, make-to-stock supply chain model which allows retailers to place weekly orders to an on-hand inventory position in a distribution center. The challenge facing the business is how to design an inventory strategy that achieves a high level of service to its customers while minimizing inventory holding cost. Specifically, safety stock holding cost is targeted as it accounts for the majority of on-hand inventory and can be reduced without...

15. Inventory management for perishable goods using simulation methods - Tan, Nicola
Amazon.com is the world's largest online retailer, and continues to grow its business by expanding into new markets and new product lines that have not traditionally been sold online. These product categories create new challenges to inventory and operations management. One example of this new type of products sold online includes the category of perishable goods. Perishable goods provide a unique inventory challenge due to the fact that products may expire at unknown times while in stock, making them unavailable for the customer to purchase. This thesis discusses a method for managing perishable goods inventory by characterizing the key variables...

16. Forecasting linehaul transit times & on time delivery probability using quantile regression forests - Truong, Gold
with delays on the road and variabilities introduced by the major participants in the process, ie: distribution centers, drivers, etc. These sources of variability also make it difficult to measure the impact changes in transit time have on on-time performance. This paper focuses on trying to identify indicators of variability and incorporates them into quantile regression forest, a black box forecasting model, that will provide estimated scheduled transit times for a given probability of on-time arrival at the destination. With the use of Amazon's Q1 & Q2 2013 linehaul data, an analysis on performance trends based on length of haul...

17. A practical application of simulation for production planning in a flexible pharmaceutical manufacturing environment - Wilson, Christopher J. (Christopher James)
In pursuit of Novartis Pharmaceutical's vision to "Make Quality Medicine-On Time, Every Time" Novartis Ringaskiddy Limited (NRL), is pursuing Class A Manufacturing (MRP II) certification. Achieving Class A certification requires production plans be established and met with great accuracy. The Multi Synthesis Production Unit (MSPU) at NRL sets rolling eighteen month production commitments on a semi-annual basis. During planning a rudimentary tool is used to allocate production campaigns for over 40 different Active Pharmaceutical Ingredients (API) and intermediate products across roughly 200 pieces of equipment. This manual tool is time intensive to operate, prone to errors, and requires extensive knowledge...

18. Development of a medical bougie with integral force transducer - Wiseman, Brian M. (Brian Michael)
by Brian M. Wiseman.

19. Manipulation of a rigid body with a flexible sheet and its application to a rehabilitation bed - Roy, Binayak, 1979-
by Binayak Roy.

20. The development of an in vitro model of coronary lesion thrombosis - Kolandaivelu, Kumaran
by Kumaran Kolandaivelu.

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