DSpace at MIT
This site is a university repository providing access to the publication output of the institution. Registered users can set up email alerts to notify them of newly added relevant content. A certain level of encryption and security is embedded in the site which may cause some users accessibility problems.
Mechanical Engineering - Master's degree
Mostrando recursos 1 - 20 de 3,056
Timber tower : a flexible fabrication method for reconfigurable housing - Coleman, James (James Richard)
"Prefabricating Housing...again", this time it's going to be different. Fabrication machine functionality is bracketed by the physical configuration and componentry of the system. Traditionally, a machine designer engineers a system to deliver a specified range of operational metrics such as speed, stiffness, and accuracy. The end goal of this process being that these metrics satisfy a desired functionality. This work-flow generates specific machines for specific tasks. Task specific machines require thorough design, engineering and testing. Once this process is complete, these highly specialized machines most often do not lend themselves well to alternative or non specified use. Multi purpose tooling...
Elastography using optical coherence tomography : development and validation of a novel technique - Chau, Alexandra H. (Alexandra Hung), 1980-
Atherosclerosis is an inflammatory disease characterized by an accumulation of lipid and fibrous tissue in the arterial wall. Postmortem studies have characterized rupture-prone atherosclerotic plaques by the presence of a large lipid-rich core covered by a thin fibrous cap. Studies employing finite element analysis (FEA) based on ex vivo plaque geometry have found that most plaques rupture at sites of high circumferential stress, thus diagnosis of plaque vulnerability may be enhanced by probing the mechanical behavior of individual plaques. Elastography is a method of strain imaging in which an image sequence of the artery undergoing deformation is acquired, pixel motion...
Streamlining data management in drug product commercialization and manufacturing - Anderson, Spencer C. (Spencer Clark)
Effective execution and alignment of data management across development and manufacturing teams is essential for Amgen's Drug Product Technology group to realize its main goals of shortening the development timeline and ensuring robust commercial manufacturing. The right data management strategy can help address these goals by accelerating development work and regulatory filing as well as improving commercial manufacturing efficiency. In the face of challenges associated with rapid growth and an expanding product pipeline, Amgen's commitment to standardizing development work and digitizing both clinical and commercial manufacturing has introduced many opportunities for new data management initiatives, improvements, and a revamped overall...