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Mostrando recursos 1 - 20 de 166

  1. Hydrogenase Inhibition by O2: Density Functional Theory/Molecular Mechanics Investigation

    Dogaru, Daniela
    [Fe-Fe]-hydrogenases are enzymes that reversibly catalyze the reduction of protons to molecular hydrogen, which occurs in anaerobic media. In living systems, [Fe-Fe]-hydrogenases shift the reversible reaction towards H2 formation. The [Fe-Fe]-hydrogenase H-cluster is the active site, which contains two iron atoms (Fep-Fed, i.e., proximal and distal iron). Because most experimental and theoretical investigations confirm that the structure of di-iron air inhibited species is FepII-FedII-O-O-H-, O2 has to be prevented from binding to Fed in all di-iron subcluster oxidation states in order to retain a catalytically active enzyme. By understanding the catalytic processes of metalloenzymes, researches are enabled to produce an...

  2. Tenuous Legitimacy: The Administrative State, the Anti-Government Movement and Constitutional Democracy

    Peffer, Shelly L.
    The public administration literature is inundated with books and articles despairing about the legitimacy crisis in the field. There have been numerous bases proposed for legitimizing the administrative state, including expertise, virtue or public service, and leadership and vision. Yet the issue remains contested, and the lack of agreement has wide reaching implications. One under-examined implication is the role that this tenuous legitimacy has in weakening the administrative state's ability to temper anti-government sentiment. This dissertation explores the connections and patterns in the ideologies, actions, and philosophical foundations of strongly held views that the administrative state is an illegitimate democratic...

  3. ROTOR POSITION AND VIBRATION CONTROL FOR AEROSPACE FLYWHEEL ENERGY STORAGE DEVICES AND OTHER VIBRATION BASED DEVICES

    Alexander, BXS
    Flywheel energy storage has distinct advantages over conventional energy storage methods such as electrochemical batteries. Because the energy density of a flywheel rotor increases quadratically with its speed, the foremost goal in flywheel design is to achieve sustainable high speeds of the rotor. Many issues exist with the flywheel rotor operation at high and varying speeds. A prominent problem is synchronous rotor vibration, which can drastically limit the sustainable rotor speed. In a set of projects, the novel Active Disturbance Rejection Control (ADRC) is applied to various problems of flywheel rotor operation. These applications include rotor levitation, steady state rotation at high speeds and accelerating operation. Several models such...

  4. MASS SPECTROMETRY-BASED HIGH THROUGHPUT APPROACH FOR IDENTIFICATION OF MOLECULAR MODIFICATION OF OXIDATIVE PROCESS IN RESPIRATORY

    Song, Wei
    Eosinophil peroxidase (EPO) and myeloperoxidase (MPO) have been implicated in generating reactive species and promoting oxidative modifications in numerous diseases. The detection and identification of potential pathways has been proven extremely challenge due to evanescence nature of these reactive species. An alternative approach to study the involvement of oxidative modification is to detect and quantify the stable molecular fingerprints, like oxidized tyrosine species, in biological matrices. Previously reported analytical methods for quantifying oxidized amino acids have typically been limited by: low sensitivity, specificity and the failure of detection potential oxidation products generated during sample handling. Using GC/MS in combination with...

  5. A Study of Resiliency in African-American Middle School Boys

    Celico, Andrea
    While our nation claims that we provide “equal learning opportunities” for all, the Black-White achievement gap still exists. This leads to a variety of political, economic, and social ramifications for our students. With this said, seldom are studies conducted that disprove the countless theories that explain why African-American students are at-risk for academic success. As an attempt to determine environmental factors that contribute to the achievement gap between African-American and Caucasian students, it is important to gain a greater understanding of how academically successful African-American students have managed to translate their struggles and experiences of oppression into academic success...

  6. Robust and Decentralized Control of Web Winding Systems

    Zhou, Wankun
    This research addresses the velocity and tension regulation problems in web handling, including those found in the single element of an accumulator and those in the large-scale system settings. A continuous web winding system is a complex large-scale interconnected dynamics system with numerous tension zones to transport the web while processing it. A major challenge in controlling such systems is the unexpected disturbances that propagate through the system and affect both tension and velocity loops along the way. To solve this problem, a unique active disturbance rejection control (ADRC) strategy is proposed. Simulation results show remarkable disturbance rejection capability of...

  7. Plasma Biomarkers for Age-Related Macular Degeneration

    NI, JIAQIAN
    The goal of this thesis research was to develop methods to predict susceptibility to age-related macular degeneration (AMD). Age-related macular degeneration (AMD) is the most common cause of legal blindness in the elderly in developed countries, and early identification of susceptibility is important for preventing this progressive disease. New and original evidence was found supporting the prognostic potential of plasma advanced glycation endproducts (AGEs) as possible biomarkers for AMD, specifically the oxidative protein modifications Nε-(carboxymethyl)lysine (CML) and pentosidine. Quantitative analyses of plasma from AMD (n = 60) and normal control (n = 30) donors showed that mean CML and pentosidine...

  8. Sarah Kane's Cruelty: Subversive Performance and Gender

    Dluback, Rebecca L.
    Sarah Kane uses cruelty in her plays Blasted and Cleansed to shock the audience out of their indifference, which will then allow Kane to subvert gender norms, through performed acts on stage, and the heterosexual patriarchal authority that creates the Other in society. Kane uses the theories of Antonin Artaud and Judith Butler to create a new style that melds these two theories while bringing a fresh take to the theater. Kane was twenty-three when her first play, Blasted, opened at the Royal Court Theater Upstairs on January 12, 1995. It was met with hostility by the critics when it...

  9. The Role of Acceptance and Pain Intensity in Chronic Pain Disability and Physical Functioning

    Ferguson, Lisa Lukwinski
    Chronic pain is a wide spread, debilitating disorder. With the development of Relational Frame Theory, the pathological nature of avoidance behaviors has been brought to the forefront of chronic pain research and acceptance based therapies are being extensively studied. Although interdisciplinary chronic pain rehabilitation programs draw from a variety of disciplines, they incorporate many components of acceptance therapy. The purpose of the present study was to examine the relationship between chronic pain acceptance, pain intensity, disability, and physical functioning. This study sought to answer the following questions: 1) Do patients who complete an interdisciplinary chronic pain rehabilitation program differ from...

  10. The Effects of Opiod and Benzodiazepine Weaning on Cognitive Ability in the Context of a Chronic Pain Rehabilitation Program

    Fishman, Daniel M.
    Pain is a component of many disease processes; however in some cases, when pain becomes a chronic condition it can become the problem itself. It can be a debilitating condition which is emotionally and economically costly to the individual, his or her family, and societies as a whole. Theories of pain have evolved over the last several decades to incorporate a Biopsychosocial Model of Pain. The biological portion of the model relies on The Gate Control Theory of Pain, although some emerging research points to a Neuromatrix model. As is suggested by the term, Biopsychosocial Model of Pain, the biologic...

  11. OCCUPATIONS, A DIASPORA, AND THE DESIGN OF LOCAL GOVERNMENTS FOR A PALESTINIAN STATE

    Al-Habil, Wasim
    The forces that shape administrative structures include the goals and objectives of minority and majority groups, modern management principles, and a legacy or history in which domestic political factions have gradually accepted rules and roles for mutual tolerance and inclusion. However, this process can be muted or redefined in societies where centuries of occupation and dispersion “short-circuit” maturation processes and introduce non-indigenous systems externally imposed without any level of popular acceptance or active citizenship participation. In these environments, as new states emerge, their task of building local government institutions requires a clear understanding of indigenous systems and institutions. What must...

  12. Old Beginnings: The Re-Inscription of Masculine Domination at the New Millennium in Margaret Atwood’s Oryx and Crake

    Semenovich, Lacie M.
    This essay analyzes the role of masculine domination in the twenty-first century as portrayed in Margaret Atwood’s 2003 novel of speculative fiction, Oryx and Crake. I argue that Atwood’s uncharacteristic choice of male primary characters highlights the masculine/feminine and the human/nature binaries in order to critique the destructiveness of a continued masculine domination of nature and the feminine. I utilize Donna Haraway’s theory of speculative fiction as an alternative space in which we can begin to explore new relationships with nature to critique Atwood’s novel. In my first chapter, I posit that Atwood utilizes Judeo-Christian allusions to situate the novel...

  13. Public sector seforms and managing change in Botswana: The case of Performance Management System (PMS)

    Mothusi, Bashi
    Although public sector reforms have been embraced voluntarily in Botswana, no attempt has been made by scholars and practioners to assess the effect of such interventions and their relationship with the culture that shapes and influences people's behaviour within public organizations. The evaluation of programs and policies formulated and implemented since the attainment of political independence in September 1966 rarely makes reference to the manner in which organizational culture affects the attainment of goals and objectives specified under such interventions. Hence, this study sought to understand the relationship between public sector reforms undertaken in Botswana, particularly Performance Management System (PMS)...

  14. An Analysis of “THE REAL,” As Reflected in Conrad's HEART OF DARKNESS

    Joyce, Beverly Rose
    Heart of Darkness, as a framed narrative, questions perception and authenticity. It is difficult to discern Marlow's individual voice, for it is buried within a layering of narration. Critics ascribe the words of the text to Marlow, claiming he is the one who, in Achebe's words, dehumanizes Africans. Yet, the quotation marks suggest otherwise. Perception is relevant to an analysis of Heart of Darkness, for it is unclear whose point of view constructs the text, that of Kurtz, Marlow, or the frame narrator. Since the narrative is likely composed of multiple perspectives, it is difficult to determine whose reality it...

  15. A Cross-National Comparison of Corporate Web-Site Communications: An Examination of the Services Sector

    LaRosa, Richard J.
    Despite the trend toward increased marketing in the electronic medium, there is still a lack of comprehensive research. Especially noteworthy is the lack of research on equivalence of electronic information across both industries and national boundaries. The literature is replete with findings from studies surrounding consumer and B2B goods advertising promoted through print and TV mediums; however, this study suggests that previous findings and methods may not be directly transferrable to service advertisers in an electronic medium. The specific design characteristics inherent with the web medium combined with the inherent limitations surrounding cultural indices suggest that new methods and measures...

  16. Of Earth And Sky: Lev Tolstoy As Poet And Prophet

    Cliffe, Alan
    In this study I consider Lev Tolstoy's life and thought by reference to their national and historical context. My purposes here, of course, have to do with understanding that context as well as with understanding Tolstoy. In Chapter II, I consider and try to evoke the nineteenth-century Russian landscape to which Tolstoy was born. Also in Chapter II, I introduce, for comparative purposes, a figure from a generation of Russians later than Tolstoy's, a man very different from Tolstoy who nonetheless admired him greatly. I am referring to the man who became known as Lenin. I extend and expand the Tolstoy/Lenin comparison...

  17. Slurry Based Coatings on Silicon Based Ceramics

    Khaja Abdul, Sameer K.
    The use of advanced structural ceramics, such as Si3N4 (SN282), SiC, and SiC/SiC composites, is a promising technology to accomplish the high performance goals for advanced turbine applications. These materials exhibit excellent corrosion resistance by forming a dense silica scale. However, severe degradation of the silica scale has been observed due to the presence of certain environmental species, like alkali salts and water vapors, limiting the long-term reliability of structural ceramics. Presence of water vapor in the turbine environment leads to the formation of a gaseous silicon hydroxide species (Si(OH)4) via a reaction with silica layer, SiO2(s) + 2H2O(g) =...

  18. Health Monitoring of Cracked Rotor Systems using External Excitation Techniques

    Wroblewski, Adam Christopher
    Cracked rotors present a significant safety and loss hazard in nearly every application of modern turbomachinery. This thesis focuses on the health monitoring, modeling, and analysis of machines with transverse breathing cracks, which open and close due to the self-weight of the rotor. After considering the modeling of cracked rotors, the thesis investigates an active structural health monitoring approach, focusing on the application of an active magnetic actuator to apply a specially designed external force excitation to the rotating shaft. Extensive experimental data has been collected and analyzed utilizing advanced diagnostic techniques. The presented results demonstrate that the use of...

  19. A casein kinase 2 inhibitor is a potent anti-cancer drug candidate

    Ciocea, Alieta
    Cancer is so widespread and lethal that it can be considered the biggest health problem of our century. Cancer drug development is a real challenge. Efforts outlined in this work were directed towards showing solid evidence that casein kinase 2 inhibitors can be used as a starting point for the development of potential cancer therapy. We first studied the effect of a specific CK2 inhibitor, DMAT, in a malignant megakaryoblastic leukemia cell line (MEG-01). Treated cells grew at a significantly lower rate than non-treated cells. Apoptosis was induced by DMAT in MEG-01 cells, dose and time dependent. When stimulated with DMAT,...

  20. World War I Posters and the Female Form: Asserting Ownership of the American Woman

    Rother, Laura M.
    Like Britain and continental Europe, the United States would utilize the war poster to garner both funding and public support during World War I. While war has historically been considered a masculine endeavor, a relatively large number of these posters depict the female form. Although the use of women in American World War I propaganda may not initially seem problematic, upon further inspection it becomes clear that her presence often served to promote racial and national pretentiousness. Based on the works of popular pre-war illustrators like Howard Chandler Christy and Charles Dana Gibson, the American woman was the most attractive woman...

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