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Article no. bjoc.1999.0770 The role of endogenous interleukin-2 in proliferation of human - Te Reichert; Y Kashii; J Stanson; A Zeevi; Tl Whiteside
Summary Interleukin (IL-2) and IL-2Rβ/γ have been shown to be expressed in human carcinomas in culture and in situ. Recently, expression of endogenous IL-2 and IL-2R in the cytoplasm was found to be up-regulated in tumour cells undergoing mitosis. This observation suggested that similar to its role in lymphocytes, the IL-2/IL-R pathway is involved in the regulation of carcinoma cell proliferation. Metabolic labelling followed by immunoprecipitation and Western blot results showed that IL-2 in carcinomas was identical to that in human lymphocytes. However, tumour cells did not secrete IL-2 detectable by immunoassays, although membrane-associated IL-2 was detectable on a proportion...
Dispensaries in counties Armagh and Down in the pre-Famine years - G M Beale
This paper traces the development of dispensaries in the counties of Armagh and Down in the decades prior to the Great Famine. It examines the number and distribution of dispensaries and discusses their management, finance and daily administration. The role of dispensary doctors, their conditions of employment and the diseases which they treated are also considered.
ARTICLE The Journal of General Physiology - Gustavo Frindt; Zuhal Ergonul; Lawrence G. Palmer
Expression of epithelial Na channel (ENaC) protein in the apical membrane of rat kidney tubules was assessed by biotinylation of the extracellular surfaces of renal cells and by membrane fractionation. Rat kidneys were perfused in situ with solutions containing NHS-biotin, a cell-impermeant biotin derivative that attaches covalently to free amino groups on lysines. Membranes were solubilized and labeled proteins were isolated using neutravidin beads, and surface � and � ENaC subunits were assayed by immunoblot. Surface � ENaC was assessed by membrane fractionation. Most of the � ENaC at the surface was smaller in molecular mass than the full-length subunit,...
$rec.titulo - D Gisselsson; L Gorunova; P Elfving
www.bjcancer.com Telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas
Benefits of Data Sharing for - Heather A. Piwowar; Michael J. Becich; Howard Bilofsky; Rebecca S. Crowley
health care data is important but difficult. Recognizing this, many initiatives facilitate, fund, request, or require researchers to share their data [1–5]. These initiatives address the technical aspects of data sharing, but rarely focus on incentives for key stakeholders . Academic health centers (AHCs) have a critical role in enabling, encouraging, and rewarding data sharing. The leaders of medical schools and academic-affiliated hospitals can play a unique role in supporting this transformation of the research enterprise. We propose that AHCs can and should lead the transition towards a culture of biomedical data sharing.
Epilepsy, E/I balance and GABA A - Receptor Plasticity
receptors mediate most of the fast inhibitory transmission in the CNS. They form heteromeric complexes assembled from a large family of subunit genes. The existence of multiple GABA A receptor subtypes differing in subunit composition, localization and functional properties underlies their role for fine-tuning of neuronal circuits and genesis of network oscillations. The differential regulation of GABA A receptor subtypes represents a major facet of homeostatic synaptic plasticity and contributes to the excitation/inhibition (E/I) balance under physiological conditions and upon pathological challenges. The purpose of this review is to discuss recent findings highlighting the significance of GABA A receptor heterogeneity...
ORIGINAL ARTICLE - Margaretha M. Koudijs; J. Fred; Nagelkerke Jan; M. C. Junggeburt
Celecoxib inhibits growth of tumors in a syngeneic rat liver metastases model for colorectal cancer
Macrophage - Robert Kleemann; Susanne Zadelaar; Teake Kooistra
Cytokines and atherosclerosis: a comprehensive
Updated Three-Stage Model for the Peopling of the Americas - Connie J. Mulligan; Andrew Kitchen; Michael M. Miyamoto
Background: We re-assess support for our three stage model for the peopling of the Americas in light of a recent report that identified nine non-Native American mitochondrial genome sequences that should not have been included in our initial analysis. Removal of these sequences results in the elimination of an early (i.e.,40,000 years ago) expansion signal we had proposed for the proto-Amerind population. Methodology/Findings: Bayesian skyline plot analysis of a new dataset of Native American mitochondrial coding genomes confirms the absence of an early expansion signal for the proto-Amerind population and allows us to reduce the variation around our estimate of...
.<>-~-3.3--.o3- n-O i_3-ULSTER::iMEIA JOURNAL PUBLISHED ON BEHALF OF THE ULSTER MEDICAL SOCIETY
TO BE elected President of this august Society is a very great honour. However it also carries certain responsibilities and duties. The first hurdle and probably the most daunting is the presentation of a presidential address. On examining the list of presidents who have held office since I first became a member of the Ulster Medical Society thirty-one years ago I discovered, as I anticipated, that they represented the main branches of our profession. There were nine surgeons, six physicians, six general practitioners, four obstetricians, three pathologists, two medical administrators and one medically qualified dentist. On reading through their presidential...
Hepatitis delta virus infection in Northern - R A Curran; H J O'neill; J H Connolly
The incidence of hepatitis delta virus (HD V) infection in Northern Ireland (1970-1989) was tested by enzyme linked immunosorbent assay in 401 hepatitis B surface antigen (HBsAg) positive sera. Hepatitis delta antigen (HDAg) was tested in 388 patients and antibody to delta antigen (anti-HD) in 401 patients. Four patients (1-03 %) were HDAg positive. Nine patients (2-24 %) were positive for anti- HD and after acid pre- treatment of sera from eight of these patients, five were positive for HDAg. The overall incidence ofHDV markers was 3-27%, which reflects the low incidence in HBsAg carriers in Northern Ireland (who were...