PubMed Central (PMC3 - NLM DTD)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
Mostrando recursos 1 - 20 de 242
Aneurysmal Coronary Artery Fistulae: How Big is Big Enough? - Jaiswal, Abhishek; Park, Chong H.
Coronary artery fistula (CAF) is the most common congenital anomaly of coronary arteries. Management strategies for CAF causing symptoms and large shunting are well described. With growing use of noninvasive imaging modalities, the diagnosis of asymptomatic CAF has increased. This poses challenge on the management of CAF with high-risk features as therapeutic strategy of incidentally found CAF remains open to debate. The actual risk of complications in such cases is mere speculations based on small studies and need to be revisited. We describe the case of an asymptomatic 78-year-old woman with a large saccular coronary aneurysm associated with coronary artery...
Case Report and Review of Literature: Late Retrograde Type A Aortic Dissection With Rupture after Repair of Type B Aortic Dissection with a GORE TAG Endovascular Prosthesis - Manetta, Frank; Ajakaiye, Bayo; Scheinerman, S. Jacob; Yu, Pey-Jen
Acute aortic dissection is the most common catastrophic condition of the aorta. Treatment options include open surgery and thoracic endovascular aortic reconstruction (TEVAR). We present a late Type A dissection as a complication of the management of descending aortic dissections with TEVAR and a review of the literature. TEVAR of the thoracic aorta is a viable treatment option for the management of complicated descending thoracic aortic dissections. Careful patient selection is necessary as medical therapy successfully treats the majority of uncomplicated Type B dissections. TEVAR should be reserved for patients with complicated Type B dissections or those who fail nonoperative...
Aiming at One-Stage Corrective Surgery for Extended Thoracic Aortic Dilatation - Niinimaki, Eetu; Kajander, Henri; Paavonen, Timo; Sioris, Thanos; Mennander, Ari
Definitive treatment of extended thoracic aortic dilatation is a major surgical challenge. Histopathology of resected thoracic aortic wall may reveal undiagnosed aortitis affecting outcome. We sought to investigate the benefit of thorough histopathology after one-stage corrective surgery for the treatment of extended thoracic aortic dilatation. Five patients underwent one-stage corrective surgery using the hybrid open arch repair by the frozen elephant trunk together with endovascular aortic grafting. A representative sample of the resected aortic arch was procured for histology. T- and B-lymphocytes, plasma cells, macrophages, and immunoglobulin G4 (IgG4) positivity were evaluated by immunohistochemistry. The mean preoperative maximum aortic diameter...
Rapamune Does Not Attenuate High Cholesterol-Induced Atherosclerosis in Rabbits - Attia, Ahmed; Ahmed, Mohamed; Ng, Siew Hon; Prasad, Kailash; Shoker, Ahmed
Solid-organ transplant recipients are prone to develop atherosclerosis. The objectives of this study were to investigate the effects of Rapamune (Wyeth Canada, Saint-Larent, QC, Canada) on the rabbit model of atherosclerosis. The rabbits were assigned to four groups: group I, regular diet (control); group II, 1% cholesterol diet; group III, control with Rapamune (1 mg/kg/d orally); and group IV, high cholesterol diet with Rapamune. Blood samples for serum lipids (triglycerides [TG], total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C]), as well as malondialdehyde, and protein carbonyls, the indices of oxidative stress were collected at the end of...
Impact of Renal Artery Stent Implantation on Hypertension in Patients with Hemodialysis - Hikita, Hiroyuki; Kojima, Keisuke; Kimura, Shigeki; Takahashi, Atsushi; Isobe, Mitsuaki
The benefit from renal artery stent implantation to treat atherosclerotic renal artery stenosis (ARAS) is not well understood in hemodialysis patients. We sought to evaluate the effects of renal artery stenting on hypertension of hemodialysis patients. Renal artery stent implantation was successfully performed on eight hypertensive hemodialysis patients with ARAS (mean ± SD, 66 ± 10 years; men 6, women 2). Blood pressure was measured by automated oscillometric recordings just before hemodialysis. Mean values of the blood pressure, measured 12 times a month, were used for blood pressure analysis. Values of systolic blood pressure decreased at 6 months after renal artery stent implantation (162.6 ± 29.7...
Isolated Single Coronary Artery Presenting as Acute Coronary Syndrome: Case Report and Review - Mahapatro, Anil K.; Patro, A. Sarat K.; Sujatha, Vipperala; Sinha, Sudhir C.
Congenital single coronary artery is commonly associated with complex congenital heart diseases and manifests in infancy or childhood. But isolated single coronary artery is a rare congenital anomaly which can present as acute coronary syndrome in adults. The aim of the work is to discuss on isolated single coronary artery in two adults presenting as acute coronary syndrome. The first case underwent coronary angiography (CAG) through right radial route, but switched over to femoral for confirmation of diagnosis and due to radial spasm. An aortic root angiogram was done to rule out presence of any other coronary ostia. It revealed...
Endovascular Repair of a Large Ruptured Abdominal Aortic Aneurysm Using Monitored Anesthesia Care and Local Anesthesia - Franz, R. W.; Nardy, V. J.; Burkdoll, D.
Over the last decade, there has been a paradigm shift in the treatment of ruptured abdominal aortic aneurysm (AAA) from open repair to endovascular aneurysm repair (EVAR). Regardless of the method used during emergent rupture, open verses endovascular repair, the overall mortality remains high. Recent studies have compared patient outcomes using different types of anesthesia during elective EVAR procedures. The data show that during an elective EVAR, monitored anesthesia care (MAC) with local anesthesia is not only just as safe as general anesthesia, but it offers other potential benefits as well. There is limited data in regards to patient outcomes...
The Role of Imaging in Hypertensive Heart Disease - Hoey, Edward T. D.; Pakala, Vijayabhaskar; Teoh, Jun K.; Simpson, Helen
Hypertensive heart disease (HHD) describes a spectrum of target organ response that includes left ventricular hypertrophy, systolic, and diastolic dysfunction. A variety of imaging techniques can be used to assess the various aspects of HHD. Echocardiography has for many years been the main imaging technique in the evaluation of HHD, but there is an increasing role for cardiovascular magnetic resonance (CMR) imaging due to its ability to provide an unrestricted field of view and noninvasive tissue characterization. This article reviews the current role of imaging for HHD with particular focus on echocardiography and CMR applications.
Transradial Approach to Cardiovascular Interventions: An Update - Sachdeva, Shilpa; Saha, Sibu
Background Since the first cardiac catheterization in 1929, the procedure has continually evolved with advances in understanding, capabilities, and ease of operation. Though historically performed by cut down of the brachial artery, cardiologists soon learned that transfemoral access was both easier to perform and more efficacious with regard to patient outcome. In the last 20 years, the transradial approach has been adopted, and is being utilized with increasing frequency.
Predictors and Prognostic Implications of Major Adverse Cardiovascular Events after Renal Transplant: 10 Years Outcomes in 321 Patients - Aftab, Waqas; Varadarajan, Padmini; Rasool, Shuja; Pai, Ramdas G.
Renal transplantation is the treatment of choice in patients with end-stage renal disease. Major adverse cardiac events (MACE) are common after renal transplant, especially in the perioperative period, leading to excess morbidity and mortality. The predictors and long-term prognostic implications of MACE are poorly understood. We analyzed predictors and implications of MACE in a cohort of 321 consecutive adult patients, who received renal allograft transplantation between 1995 and 2003 at our institution. The characteristics of 321 patients were: age at transplant 44 ± 13 years, 60% male, 36% diabetes mellitus (DM), left ventricular ejection fraction (LVEF) 60 ± 16%. MACE occurred in 21 patients...
Coronary Arteriovenous Fistulae: A Review - Challoumas, Dimitris; Pericleous, Agamemnon; Dimitrakaki, Inetzi A.; Danelatos, Christos; Dimitrakakis, Georgios
Coronary arteriovenous fistulae are a coronary anomaly, presenting in 0.002% of the general population. Their etiology can be congenital or acquired. We present a review of recent literature related to their epidemiology, etiology, pathophysiology, clinical presentation, diagnostic approach, and therapeutic management.
Improvements of Venous Tone with Pycnogenol in Chronic Venous Insufficiency: An Ex Vivo Study on Venous Segments - Belcaro, Gianni; Dugall, Mark; Luzzi, Roberta; Hosoi, M.; Corsi, Marcello
This study evaluated the stretching and dilatation of venous segments ex vivo in subjects with primary varicose veins in comparison with comparable segments from subjects that used the supplement Pycnogenol (150 mg/d) for 3 months before surgery. Subjects with varicose veins and chronic venous insufficiency voluntarily used Pycnogenol for a period of at least 3 months. The segments of veins removed with surgery (in 30 subjects that had used Pycnogenol and in 10 comparable control subjects that had not used the supplement) were compared with normal, unused vein segments harvested for bypass grafting. The segments were suspended and a weight...
Catheter Aspiration after Every Stage during Primary Percutaneous Angioplasty; ADMIT Trial - Turgeman, Yoav; Bushari, Limor Ilan; Antonelli, Dante; Feldman, Alexander; Yahalom, Malka; Bloch, Lev; Suleiman, Khalid
We assess the epicardial and microcirculation flow characteristics, and clinical outcome by using catheter aspiration after each stage of primary percutaneous coronary intervention (PPCI). Conflicting data are reported regarding early and late benefit of using aspiration catheter in the initial phase PPCI.
Factors Associated with Completion of Pre–Kidney Transplant Evaluations - Siskind, Eric; Alex, Asha; Alexander, Mohini; Akerman, Meredith; Mathew, Christine; Fishbane, Lara; Thomas, Jisha; Israel, Ezra; Fana, Melissa; Evans, Cory; Godwin, Andrew; Agorastos, Stergiani; Mellace, Barbara; Rosado, Jesus; Rajendran, Prejith P.; Krishnan, Prathik; Ramadas, Poornima; Flecha, Antonette; Kiernan, Lisa; Morgan, Ruth M.; Ali, Nicole; Sachdeva, Mala; Calderon, Kellie; Hong, Susana; Kaur, Jasmeet; Basu, Amit; Nicastro, Jeffrey; Coppa, Gene; Bhaskaran, Madhu; Molmenti, Ernesto
This study sought to examine various factors that may prevent transplant candidates from completing their transplant workup prior to listing. We reviewed the records of 170 subjects (cases = 100, controls 70) who were either on dialysis or had less than 20 mL/min creatinine clearance and were therefore candidates for preemptive transplantation. Approximately, 56% of preemptive patients completed their workup, while only 36% of patients on dialysis completed their workup. Our data revealed that factors contributing toward completion of workup included intrinsic motivation (four times more likely), lack of specific medical comorbidities (three times more likely), and preemptive status (two times more...
Low Levels of Serum Soluble Receptors for Advanced Glycation End Products, Biomarkers for Disease State: Myth or Reality - Prasad, Kailash
Advanced glycation end products (AGEs) interact with the receptor for AGEs (RAGE) on the membrane and induce deleterious effects via activation of nuclear factor kappa-B, and increased oxidative stress and inflammatory mediators. AGEs also combine with circulating soluble receptors (endogenous secretory RAGE [esRAGE] and soluble receptor for RAGE [sRAGE]) and sequester RAGE ligands and act as a cytoprotective agent. esRAGE is secreted from the cells and is a spliced variant of RAGE. The sRAGE on the other hand is proteolytically cleaved from cell surface receptor via matrix metalloproteinase (MMPs). sRAGE is elevated in type 1 and type 2 diabetes and...
Successful Treatment of Myocardial Bridge with Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy - Sunbul, Murat; Kepez, Alper; Tigen, Kursat; Erdogan, Okan; Mutlu, Bulent
Hypertrophic obstructive cardiomyopathy (HOCM) is characterized by left ventricular hypertrophy of various morphologies, with variety of clinical manifestations and hemodynamic dysfunctions. Myocardial bridge (MB) is frequently seen in HOCM patients and the decrease of flow in the coronary artery segment going intramurally through the myocardium beneath a muscle bridge is also associated with angina, myocardial ischemia, arrhythmia, and sudden death in these patients. We present here a rare case of successful treatment of MB with alcohol septal ablation in hypertrophic cardiomyopathy which has not been reported previously.
Chronic Total Artery Occlusions in Noninfarct-Related Coronary Arteries - Ozeke, Ozcan; Gungor, Mutlu; Topaloglu, Serkan; Aras, Dursun; Ozer, Can
It has been rarely encountered some patients in clinical practice with coronary artery chronic total occlusion (CTO) on angiography but no any clinical history or electrocardiographic, echocardiographic, or left ventriculographic evidence of previous myocardial infarction. These noninfarct-related artery CTO (non-IRA CTO) lesions may be used as a clinical role model of endogenous cardioprotective mechanisms in addition to continuing the process of atherosclerosis. The objective of this study was to characterize the clinical characteristics of patients with non-IRA CTO patients and compared them to those with infarct-related CTO (IRA-CTO). We reviewed our invasive cardiology database searching for the CTO of any...
Is Radial Access and Transradial Cardiac Catheterization Feasible without the Use of Any Vasodilator? - Izgi, Cemil; Feray, Hasan
This is a “proof of concept” study to assess feasibility of transradial access without use of vasodilators. Radial artery spasm (RAS) is an important cause of patient discomfort and procedural failure with use of radial access. Vasodilators are routinely used to prevent RAS. However, the use of vasodilators may not be appropriate in substantial groups of patients. These include patients with myocardial infarction and low blood pressure who will benefit from radial access the most. No specific recommendations about use of vasodilators in these settings are stated on consensus documents on radial access. During a short period of shortage of...
Predicting the Occurrence of Oxygenation Impairment in Patients with Type-B Acute Aortic Dissection - Tomita, Kazunori; Hata, Noritake; Kobayashi, Nobuaki; Shinada, Takuro; Shirakabe, Akihiro
Complicated respiratory failure requiring mechanical ventilation in patients with type-B acute aortic dissection (AAD) has been previously reported, and inflammatory reactions have been found to be associated with the occurrence of oxygenation impairment (OI). However, the possibility of predicting the occurrence of OI in patients with type-B AAD has not yet been evaluated. This study was performed to investigate the possibility of predicting the occurrence of OI in type-B AAD. In this study, 79 type-B AAD patients were enrolled to investigate the possibility of predicting the occurrence of OI. OI was defined as Po
2 ≤ 200. Patient characteristics, type of AAD,...