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MIT Open Access Articles

Mostrando recursos 41 - 60 de 23.998

  1. Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells

    Shelley, Brandon C.; Mandefro, Berhan; Sareen, Dhruv; Svendsen, Clive N.; Milani, Pamela; Escalante, Renan A.; Patel-Murray, Natasha Leanna; Xin, Xiaofeng; Adam, Miriam; Fraenkel, Ernest
    In recent years, the assay for transposase-accessible chromatin using sequencing (ATAC-Seq) has become a fundamental tool of epigenomic research. However, it is difficult to perform this technique on frozen samples because freezing cells before extracting nuclei can impair nuclear integrity and alter chromatin structure, especially in fragile cells such as neurons. Our aim was to develop a protocol for freezing neuronal cells that is compatible with ATAC-Seq; we focused on a disease-relevant cell type, namely motor neurons differentiated from induced pluripotent stem cells (iMNs) from a patient affected by spinal muscular atrophy. We found that while flash-frozen iMNs are not...

  2. Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging

    Wang, Taejun; Jang, Won Hyuk; Lee, Seunghun; Yoon, Calvin J.; Lee, Jun Ho; Kim, Bumju; Hwang, Sekyu; Hong, Chun-Pyo; Yoon, Yeoreum; Lee, Gilgu; Le, Viet-Hoan; Bok, Seoyeon; Ahn, G-One; Lee, Jaewook; Gho, Yong Song; Chung, Euiheon; Kim, Sungjee; Jang, Myoung Ho; Myung, Seung-Jae; Kim, Myoung Joon; Kim, Ki Hean; So, Peter T. C.
    Multiphoton microscopy (MPM) is a nonlinear fluorescence microscopic technique widely used for cellular imaging of thick tissues and live animals in biological studies. However, MPM application to human tissues is limited by weak endogenous fluorescence in tissue and cytotoxicity of exogenous probes. Herein, we describe the applications of moxifloxacin, an FDA-approved antibiotic, as a cell-labeling agent for MPM. Moxifloxacin has bright intrinsic multiphoton fluorescence, good tissue penetration and high intracellular concentration. MPM with moxifloxacin was demonstrated in various cell lines, and animal tissues of cornea, skin, small intestine and bladder. Clinical application is promising since imaging based on moxifloxacin labeling...

  3. A Novel Analysis Method for Paired-Sample Microbial Ecology Experiments

    Techtmann, Stephen M.; Fortney, Julian L.; Bastidas-Oyanedel, Juan R.; Rodríguez, Jorge; Hazen, Terry C.; Alm, Eric J; Olesen, Scott Wilder; Vora, Suhani Deepak
    Many microbial ecology experiments use sequencing data to measure a community’s response to an experimental treatment. In a common experimental design, two units, one control and one experimental, are sampled before and after the treatment is applied to the experimental unit. The four resulting samples contain information about the dynamics of organisms that respond to the treatment, but there are no analytical methods designed to extract exactly this type of information from this configuration of samples. Here we present an analytical method specifically designed to visualize and generate hypotheses about microbial community dynamics in experiments that have paired samples and...

  4. Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling

    Yun, Sanguk; Budatha, Madhusudhan; Coon, Brian G.; Cameron, Ryan T.; Baillie, George; Schwartz, Martin A.; Dahlman, James; Langer, Robert S; Anderson, Daniel Griffith
    Atherosclerosis is primarily a disease of lipid metabolism and inflammation; however, it is also closely associated with endothelial extracellular matrix (ECM) remodelling, with fibronectin accumulating in the laminin–collagen basement membrane. To investigate how fibronectin modulates inflammation in arteries, we replaced the cytoplasmic tail of the fibronectin receptor integrin α5 with that of the collagen/laminin receptor integrin α2. This chimaera suppressed inflammatory signalling in endothelial cells on fibronectin and in knock-in mice. Fibronectin promoted inflammation by suppressing anti-inflammatory cAMP. cAMP was activated through endothelial prostacyclin secretion; however, this was ECM-independent. Instead, cells on fibronectin suppressed cAMP via enhanced phosphodiesterase (PDE) activity,...

  5. Poly(Limonene Thioether) Scaffold for Tissue Engineering

    Fischer, Kristin McKeon; Morgan, Kathy Ye; Hearon II, Michael Keith; Sklaviadis, Demetra; Tochka, Zachary L; Fenton, Owen S.; Anderson, Daniel Griffith; Langer, Robert S; Freed, Lisa E
    A photocurable thiol-ene network polymer, poly(limonene thioether) (PLT32o), is synthesized, characterized, fabricated into tissue engineering scaffolds, and demonstrated in vitro and in vivo. Micromolded PLT32o grids exhibit compliant, elastomeric mechanical behavior similar to grids made of poly(glycerol sebacate) (PGS), an established biomaterial. Multilayered PL32o scaffolds with regular, geometrically defined pore architectures support heart cell seeding and culture in a manner similar to multilayered PGS scaffolds. Subcutaneous implantation of multilayered PLT32o scaffolds with cultured heart cells provides long-term 3D structural support and retains the exogenous cells, whereas PGS scaffolds lose both their structural integrity and the exogenous cells over 31 d...

  6. A low-dissipation, pumpless, gravity-induced flow battery

    Chen, Xinwei; Hopkins, Brandon James; Helal, Ahmed H.; Fan, Frank Yongzhen; Smith, Kyle; Li, Zheng; Slocum Jr., Alexander H; McKinley, Gareth H; Carter, W Craig; Chiang, Yet-Ming
    Redox flow batteries have the potential to provide low-cost energy storage to enable renewable energy technologies such as wind and solar to overcome their inherent intermittency and to improve the efficiency of electric grids. Conventional flow batteries are complex electromechanical systems designed to simultaneously control flow of redox active fluids and perform electrochemical functions. With the advent of redox active fluids with high capacity density, i.e., Faradaic capacity significantly exceeding the 1–2 M concentration equivalents typical of aqueous redox flow batteries, new flow battery designs become of interest. Here, we design and demonstrate a proof-of-concept prototype for a “gravity-induced flow...

  7. Designing Robust Hierarchically Textured Oleophobic Fabrics

    Truong, Quoc T.; Sieber, Michael; Kleingartner, Justin Alan; Srinivasan, Siddarth; Cohen, Robert E; McKinley, Gareth H
    Commercially available woven fabrics (e.g., nylon- or PET-based fabrics) possess inherently re-entrant textures in the form of cylindrical yarns and fibers. We analyze the liquid repellency of woven and nanotextured oleophobic fabrics using a nested model with n levels of hierarchy that is constructed from modular units of cylindrical and spherical building blocks. At each level of hierarchy, the density of the topographical features is captured using a dimensionless textural parameter D[subscript n][superscript *]. For a plain-woven mesh comprised of chemically treated fiber bundles (n = 2), the tight packing of individual fibers in each bundle (D[subscript 2][superscript *] ≈...

  8. Investigation into the Formation and Adhesion of Cyclopentane Hydrates on Mechanically Robust Vapor-Deposited Polymeric Coatings

    Gleason, Karen K.; Sojoudi, Hossein; Gleason, Karen K; McKinley, Gareth H
    Blockage of pipelines by formation and accumulation of clathrate hydrates of natural gases (also called gas hydrates) can compromise project safety and economics in oil and gas operations, particularly at high pressures and low temperatures such as those found in subsea or arctic environments. Cyclopentane (CyC5) hydrate has attracted interest as a model system for studying natural gas hydrates, because CyC5, like typical natural gas hydrate formers, is almost fully immiscible in water; and thus CyC5 hydrate formation is governed not only by thermodynamic phase considerations but also kinetic factors such as the hydrocarbon/water interfacial area, as well as mass...

  9. Robotic manipulation of micro/nanoparticles using optical tweezers with velocity constraints and stochastic perturbations

    Yan, Xiao; Cheah, Chien Chern; Pham, Quang-Cuong; Slotine, Jean-Jacques E
    Various control approaches have been developed for micro/nanomanipulations using optical tweezers. Most existing methods assume that the micro/nanoparticles stay trapped during manipulations, and stochastic perturbations (Brownian motion) are usually ignored for the simplification of model dynamics. However, the trapped particles could escape from the optical traps especially in motion due to several possible reasons: small trapping stiffness, stochastic perturbations, and kinetic energy gained during manipulation. This paper investigates the conditions under which micro/nanoparticles will stay trapped while in motion. The dynamics of the trapped particles subject to stochastic perturbations is analyzed. Dynamic trapping is considered and the maximum manipulation velocity...

  10. Closure Schemes for Nonlinear Bistable Systems Subjected to Correlated Noise: Applications to Energy Harvesting from Water Waves

    Joo, Han Kyul; Sapsis, Themistoklis P.
    The moment equation closure minimization (MECM) method has been developed for the inexpensive approximation of the steady-state statistical structure of bistable systems, which have bimodal potential shapes and which are subjected to correlated excitation. Our approach relies on the derivation of moment equations that describe the dynamics governing the two-time statistics. These are then combined with a closure scheme that arises from a non-Gaussian probability density function (PDF) representation for the joint response-excitation statistics. We demonstrate its effectiveness through the application on a bistable nonlinear single-degree-of-freedom (SDOF) ocean wave energy harvester with linear damping, and the results compare favorably with direct Monte...

  11. Impurity transport, turbulence transitions and intrinsic rotation in Alcator C-Mod plasmas

    Holland, C.; Howard, N. T.; White, Anne E.; Greenwald, Martin J; Rice, John E
    Linear and nonlinear gyrokinetic simulations are used to probe turbulent impurity transport in intrinsically rotating tokamak plasmas. For this simulation-based study, experimental input parameters are taken from a pair of ICRF heated Alcator C-Mod discharges exhibiting a change in the sign of the normalized toroidal rotation gradient at mid-radius (i.e. a change from hollow to peaked intrinsic rotation profiles). The simulations show that there is no change in the peaking of the calcium impurity between the plasmas with peaked and hollow rotation profiles, suggesting that the impurity transport and the shape of the rotation do not always change together. Furthermore,...

  12. A strain tensor method for three-dimensional Michell structures

    Jacot, Benjamin; Mueller, Caitlin T
    In the design of discrete structures such as trusses and frames, important quantitative goals such as minimal weight or minimal compliance often dominate. Many numerical techniques exist to address these needs. However, an analytical approach exists to meet similar goals, which was initiated by Michell (1904) and has been mostly used for two-dimensional structures so far. This paper develops a method to extend the existing mainly two-dimensional approach to apply to three-dimensional structures. It will be referred as the Michell strain tensor method (MSTM). First, the proof that MSTM is consistent with the existing theory in two dimensions is provided....

  13. Reliability Based Factors of Safety for VIV Fatigue Using NDP Riser High Mode VIV Tests

    Tognarelli, M.; Constantinides, Y.; Oakley, O.; Fontaine, Ebraheem I; Marcollo, Hayden; Vandiver, Kathleen; Triantafyllou, Michael S; Larsen, Gretchen K.
    Understanding the level of conservatism in a riser system design for vortex-induced vibration (VIV) fatigue is an important issue for operators. This study represents a demonstration of the calibration methodology to derive consistent values for the Factor of Safety (FoS). The exercise is performed here based on medium scale VIV data and utilizing the most commonly used VIV prediction software by industry. The results emphasize the need for (i) a coherent approach to estimate the FoS to be used and (ii) monitoring/measurement of software improvements as this may increase risk of failure if the influence of such improvements on the...

  14. Partial Strake Coverage Vortex-Induced Vibration Benchmarking Using SHEAR7v4.5

    Marcollo, Hayden; Vandiver, John Kim
    A VIV benchmarking study was undertaken using SHEAR7v4.5 against NDP high mode VIV response laboratory data. The purpose of which was to derive an improved set of modeling parameters for partial strake coverage cases whilst not comprising previous accuracy of shear flow bare riser response predictions. Fifty percent (50%) partial strake coverage experimental data was utilized from both uniform and shear flow conditions while bare data was also included in the activity for reference purposes. The results showed that such an activity can derive an improved set of modeling parameters that significantly improve the ability to match experimental results and...

  15. Geometry-based estimation of stability region for a class of structure preserving power grids

    Vu, Thanh Long; Turitsyn, Konstantin
    The increasing development of the electric power grid, the largest engineered system ever, to an even more complicated and larger system requires a new generation of stability assessment methods that are computationally tractable and feasible in real-time. In this paper we first extend the recently introduced Lyapunov Functions Family (LFF) transient stability assessment approach, that has potential to reduce the computational cost on large scale power grids, to structure-preserving power grids. Then, we introduce a new geometry-based method to construct the stability region estimate of power systems. Our conceptual demonstration shows that this new method can certify stability of a...

  16. Optimal generation of spatially coherent soft X-ray isolated attosecond pulses in a gas-filled waveguide using two-color synthesized laser pulses

    Jin, Cheng; Lin, C. D.; Hong, Kyung-Han
    We numerically demonstrate the generation of intense, low-divergence soft X-ray isolated attosecond pulses in a gas-filled hollow waveguide using synthesized few-cycle two-color laser waveforms. The waveform is a superposition of a fundamental and its second harmonic optimized such that highest harmonic yields are emitted from each atom. We then optimize the gas pressure and the length and radius of the waveguide such that bright coherent high-order harmonics with angular divergence smaller than 1 mrad are generated, for photon energy from the extreme ultraviolet to soft X-rays. By selecting a proper spectral range enhanced isolated attosecond pulses are generated. We study how...

  17. Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds

    Hajjarian, Zeinab; Nia, Hadi Tavakoli; Ahn, Shawn; Nadkarni, Seemantini K.; Grodzinsky, Alan J; Jain, Rakesh Kumar
    Natural and synthetic hydrogel scaffolds exhibit distinct viscoelastic properties at various length scales and deformation rates. Laser Speckle Rheology (LSR) offers a novel, non-contact optical approach for evaluating the frequency-dependent viscoelastic properties of hydrogels. In LSR, a coherent laser beam illuminates the specimen and a high-speed camera acquires the time-varying speckle images. Cross-correlation analysis of frames returns the speckle intensity autocorrelation function, g[subscript 2](t), from which the frequency-dependent viscoelastic modulus, G*(ω), is deduced. Here, we establish the capability of LSR for evaluating the viscoelastic properties of hydrogels over a large range of moduli, using conventional mechanical rheometry and atomic force...

  18. Output-feedback control of nonlinear systems using control contraction metrics and convex optimization

    Manchester, Ian; Slotine, Jean-Jacques E
    Control contraction metrics (CCMs) are a new approach to nonlinear control design based on contraction theory. The resulting design problems are expressed as pointwise linear matrix inequalities and are and well-suited to solution via convex optimization. In this paper, we extend the theory on CCMs by showing that a pair of “dual” observer and controller problems can be solved using pointwise linear matrix inequalities, and that when a solution exists a separation principle holds. That is, a stabilizing output-feedback controller can be found. The procedure is demonstrated using a benchmark problem of nonlinear control: the Moore-Greitzer jet engine compressor model.

  19. Expectation Management in a Global Collaboration Project Using a Deterministic Design Approach

    Ichikawa, Tetsuo; Ito, Teruaki; Hanumara, Nevan Clancy; Slocum, Alexander H
    Expectation management in product engineering design aims at setting achievable goals for both customers and designers, while leaving room for creativity and passion. This is especially challenging in the global workplace. Using an example of a design project, the Dental Headrest project (DHR), this paper reviews how expectations were managed in a successful, collaborative project between the University of Tokushima (UT) and Massachusetts Institute of Technology (MIT). The goal of the project was to design an innovative mechanism for the positioning a dental chair headrest so satisfy both the needs of a patient for comfort and a clinician for flexibility...

  20. Directional Limits on Persistent Gravitational Waves from Advanced LIGO’s First Observing Run

    Abbott, B. P.; Abbott, R.; Abbott, T. D.; Abernathy, M. R.; Acernese, F.; Ackley, K.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R. X.; Adya, V. B.; Affeldt, C.; Agathos, M.; Agatsuma, K.; Aguiar, O. D.; Aiello, L.; Ain, A.; Ajith, P.; Allen, B.; Allocca, A.; Altin, P. A.; Ananyeva, A.; Anderson, S. B.; Anderson, W. G.; Appert, S.; Arai, K.; Araya, M. C.; Areeda, J. S.; Arnaud, N.; Arun, K. G.; Ascenzi, S.; Ashton, G.; Ast, M.; Aston, S. M.; Astone, P.; Aufmuth, P.; Aulbert, C.; Avila-Alvarez, A.; Babak, S.; Bacon, P.; Bader, M. K. M.; Baker, P. T.; Baldaccini, F.; Ballardin, G.; Ballmer, S. W.; Barayoga, J. C.; Barclay, S. E.; Barish, B. C.; Barker, D.; Barone, F.; Barr, B.; Barsuglia, M.; Barta, D.; Bartlett, J.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J. C.; Baune, C.; Bavigadda, V.; Bazzan, M.; Beer, C.; Bejger, M.; Belahcene, I.; Belgin, M.; Bell, A. S.; Berger, B. K.; Bergmann, G.; Berry, C. P. L.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Bhagwat, S.; Bhandare, R.; Bilenko, I. A.; Billingsley, G.; Billman, C. R.; Birch, J.; Birney, R.; Birnholtz, O.; Biscoveanu, A. S.; Bisht, A.; Bitossi, M.; Biwer, C.; Bizouard, M. A.; Blackburn, J. K.; Blackman, J.; Blair, C. D.; Blair, D. G.; Blair, R. M.; Bloemen, S.; Bock, O.; Boer, M.; Bogaert, G.; Bohe, A.; Bondu, F.; Bonnand, R.; Boom, B. A.; Bork, R.; Boschi, V.; Bose, S.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P. R.; Braginsky, V. B.; Branchesi, M.; Brau, J. E.; Briant, T.; Brillet, A.; Brinkmann, M.; Brisson, V.; Brockill, P.; Broida, J. E.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brunett, S.; Buchanan, C. C.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cabero, M.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Calderón Bustillo, J.; Callister, T. A.; Calloni, E.; Camp, J. B.; Campbell, W.; Canepa, M.; Cannon, K. C.; Cao, H.; Cao, J.; Capano, C. D.; Capocasa, E.; Carbognani, F.; Caride, S.; Casanueva Diaz, J.; Casentini, C.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C. B.; Cerboni Baiardi, L.; Cerretani, G.; Cesarini, E.; Chamberlin, S. J.; Chan, M.; Chao, S.; Charlton, P.; Chassande-Mottin, E.; Cheeseboro, B. D.; Chen, H. Y.; Chen, Y.; Cheng, H.-P.; Chincarini, A.; Chiummo, A.; Chmiel, T.; Cho, H. S.; Cho, M.; Chow, J. H.; Christensen, N.; Chu, Q.; Chua, A. J. K.; Chua, S.; Chung, S.; Ciani, G.; Clara, F.; Clark, J. A.; Cleva, F.; Cocchieri, C.; Coccia, E.; Cohadon, P.-F.; Colla, A.; Collette, C. G.; Cominsky, L.; Constancio, M.; Conti, L.; Cooper, S. J.; Corbitt, T. R.; Cornish, N.; Corsi, A.; Cortese, S.; Costa, C. A.; Coughlin, E.; Coughlin, M. W.; Coughlin, S. B.; Coulon, J.-P.; Countryman, S. T.; Couvares, P.; Covas, P. B.; Cowan, E. E.; Coward, D. M.; Cowart, M. J.; Coyne, D. C.; Coyne, R.; Creighton, J. D. E.; Creighton, T. D.; Cripe, J.; Crowder, S. G.; Cullen, T. J.; Cumming, A.; Cunningham, L.; Cuoco, E.; Dal Canton, T.; Danilishin, S. L.; D’Antonio, S.; Danzmann, K.; Dasgupta, A.; Da Silva Costa, C. F.; Dattilo, V.; Dave, I.; Davier, M.; Davies, G. S.; Davis, D.; Daw, E. J.; Day, B.; Day, R.; De, S.; DeBra, D.; Debreczeni, G.; Degallaix, J.; De Laurentis, M.; Deléglise, S.; Del Pozzo, W.; Denker, T.; Dent, T.; Dergachev, V.; De Rosa, R.; DeRosa, R. T.; DeSalvo, R.; Devenson, J.; Devine, R. C.; Dhurandhar, S.; Díaz, M. C.; Di Fiore, L.; Di Giovanni, M.; Di Girolamo, T.; Di Lieto, A.; Di Pace, S.; Di Palma, I.; Di Virgilio, A.; Doctor, Z.; Dolique, V.; Dooley, K. L.; Doravari, S.; Dorrington, I.; Douglas, R.; Dovale Álvarez, M.; Downes, T. P.; Drago, M.; Drever, R. W. P.; Driggers, J. C.; Du, Z.; Ducrot, M.; Dwyer, S. E.; Edo, T. B.; Edwards, M. C.; Effler, A.; Eggenstein, H.-B.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Etienne, Z.; Etzel, T.; Evans, T. M.; Everett, R.; Factourovich, M.; Fafone, V.; Fair, H.; Fairhurst, S.; Fan, X.; Farinon, S.; Farr, B.; Farr, W. M.; Fauchon-Jones, E. J.; Favata, M.; Fays, M.; Fehrmann, H.; Fejer, M. M.; Ferrante, I.; Ferreira, E. C.; Ferrini, F.; Fidecaro, F.; Fiori, I.; Fiorucci, D.; Fisher, R. P.; Flaminio, R.; Fletcher, M.; Fong, H.; Forsyth, S. S.; Fournier, J.-D.; Frasca, S.; Frasconi, F.; Frei, Z.; Freise, A.; Frey, R.; Frey, V.; Fries, E. M.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Gabbard, H.; Gadre, B. U.; Gaebel, S. M.; Gair, J. R.; Gammaitoni, L.; Gaonkar, S. G.; Garufi, F.; Gaur, G.; Gayathri, V.; Gehrels, N.; Gemme, G.; Genin, E.; Gennai, A.; George, J.; Gergely, L.; Germain, V.; Ghonge, S.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S.; Giaime, J. A.; Giardina, K. D.; Giazotto, A.; Gill, K.; Glaefke, A.; Goetz, E.; Goetz, R.; Gondan, L.; González, G.; Gonzalez Castro, J. M.; Gopakumar, A.; Gorodetsky, M. L.; Gossan, S. E.; Gosselin, M.; Gouaty, R.; Grado, A.; Graef, C.; Granata, M.; Grant, A.; Gray, C.; Greco, G.; Green, A. C.; Groot, P.; Grote, H.; Grunewald, S.; Guidi, G. M.; Guo, X.; Gupta, A.; Gupta, M. K.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Hacker, J. J.; Hall, B. R.; Hall, E. D.; Hammond, G.; Haney, M.; Hanke, M. M.; Hanks, J.; Hanna, C.; Hannam, M. D.; Hanson, J.; Hardwick, T.; Harms, J.; Harry, G. M.; Harry, I. W.; Hart, M. J.; Hartman, M. T.; Haster, C.-J.; Haughian, K.; Healy, J.; Heidmann, A.; Heintze, M. C.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Hennig, J.; Henry, J.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hoak, D.; Hofman, D.; Holt, K.; Holz, D. E.; Hopkins, P.; Hough, J.; Houston, E. A.; Howell, E. J.; Hu, Y. M.; Huerta, E. A.; Huet, D.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh-Dinh, T.; Indik, N.; Ingram, D. R.; Inta, R.; Isa, H. N.; Isac, J.-M.; Isi, M.; Iyer, B. R.; Izumi, K.; Jacqmin, T.; Jani, K.; Jaranowski, P.; Jawahar, S.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Junker, J.; Kalaghatgi, C. V.; Kalogera, V.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Karki, S.; Karvinen, K. S.; Kasprzack, M.; Katzman, W.; Kaufer, S.; Kaur, T.; Kawabe, K.; Kéfélian, F.; Keitel, D.; Kelley, D. B.; Kennedy, R.; Key, J. S.; Khalili, F. Y.; Khan, I.; Khan, S.; Khan, Z.; Khazanov, E. A.; Kijbunchoo, N.; Kim, Chunglee; Kim, J. C.; Kim, Whansun; Kim, W.; Kim, Y.-M.; Kimbrell, S. J.; King, E. J.; King, P. J.; Kirchhoff, R.; Kissel, J. S.; Klein, B.; Kleybolte, L.; Klimenko, S.; Koch, P.; Koehlenbeck, S. M.; Koley, S.; Kondrashov, V.; Korobko, M.; Korth, W. Z.; Kowalska, I.; Kozak, D. B.; Krämer, C.; Kringel, V.; Królak, A.; Kuehn, G.; Kumar, P.; Kumar, R.; Kuo, L.; Kutynia, A.; Lackey, B. D.; Landry, M.; Lang, R. N.; Lange, J.; Lantz, B.; Lartaux-Vollard, A.; Lasky, P. D.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lebigot, E. O.; Lee, C. H.; Lee, H. K.; Lee, H. M.; Lee, K.; Lehmann, J.; Lenon, A.; Leonardi, M.; Leong, J. R.; Leroy, N.; Letendre, N.; Levin, Y.; Li, T. G. F.; Littenberg, T. B.; Liu, J.; Lockerbie, N. A.; Lombardi, A. L.; London, L. T.; Lord, J. E.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J. D.; Lousto, C. O.; Lovelace, G.; Lück, H.; Lundgren, A. P.; Ma, Y.; Macfoy, S.; Machenschalk, B.; Macleod, D. M.; Magaña-Sandoval, F.; Majorana, E.; Maksimovic, I.; Malvezzi, V.; Man, N.; Mandic, V.; Mangano, V.; Mansell, G. L.; Manske, M.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markosyan, A. S.; Maros, E.; Martelli, F.; Martellini, L.; Martin, I. W.; Masserot, A.; Massinger, T. J.; Masso-Reid, M.; Mastrogiovanni, S.; Matas, A.; Matone, L.; Mazumder, N.; McCarthy, R.; McClelland, D. E.; McCormick, S.; McGrath, C.; McGuire, S. C.; McIntyre, G.; McIver, J.; McManus, D. J.; McRae, T.; McWilliams, S. T.; Meacher, D.; Meadors, G. D.; Meidam, J.; Melatos, A.; Mendell, G.; Mendoza-Gandara, D.; Mercer, R. A.; Merilh, E. L.; Merzougui, M.; Meshkov, S.; Messenger, C.; Messick, C.; Metzdorff, R.; Meyers, P. M.; Mezzani, F.; Miao, H.; Michel, C.; Middleton, H.; Mikhailov, E. E.; Milano, L.; Miller, A. L.; Miller, A.; Miller, B. B.; Millhouse, M.; Minenkov, Y.; Ming, J.; Mirshekari, S.; Mishra, C.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; 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M.; Buikema, Aaron; Donovan, Frederick J; Essick, Reed Clasey; Evans, Matthew J; Fernandez Galiana, Alvaro-Miguel; Fritschel, Peter K; Gras, Slawomir; Isogai, Tomoki; Katsavounidis, Erotokritos; Kontos, Antonios; Lanza Jr, Robert K; Libson, Adam A.; Lynch, Ryan Christopher; MacInnis, Myron E; Martynov, Denis; Mason, Kenneth R; Matichard, Fabrice; Mavalvala, Nergis; Miller, John; Mittleman, Richard K; Ray Pitambar Mohapatra, Satyanarayan; Oelker, Eric Glenn; Shoemaker, David H; Tse, Maggie; Vitale, Salvatore; Weiss, Rainer; Yam, William; Yu, Hang; Yu, Haocun; Zucker, Michael E
    We employ gravitational-wave radiometry to map the stochastic gravitational wave background expected from a variety of contributing mechanisms and test the assumption of isotropy using data from the Advanced Laser Interferometer Gravitational Wave Observatory’s (aLIGO) first observing run. We also search for persistent gravitational waves from point sources with only minimal assumptions over the 20–1726 Hz frequency band. Finding no evidence of gravitational waves from either point sources or a stochastic background, we set limits at 90% confidence. For broadband point sources, we report upper limits on the gravitational wave energy flux per unit frequency in the range F[subscript α,Θ](f)<(0.1–56)×10[superscript -8] erg cm[superscript−2] s[superscript−1]...

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