Recursos de colección

Caltech Authors (160.010 recursos)

Repository of works by Caltech published authors.

Type = Patent

Mostrando recursos 1 - 20 de 27

  1. Human immunodeficiency virus neutralizing antibodies and methods of use thereof [APPLICATION]

    Scheid, Johannes; Nussenzweig, Michel; Bjorkman, Pamela J.; Diskin, Ron
    The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection.

  2. Antibodies directed toward the HIV-1 GP120 CD4 binding site with increased potency and breadth

    Diskin, Ron; Bjorkman, Pamela J.; Nussenzweig, Michel; Scheid, Johannes
    Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution in the heavy chain at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4 and an amino acid substitution in the light chain, these antibodies having improved potency and breadth.

  3. Antibodies directed toward the HIV-1 GP120 CD4 binding site with increased potency and breadth

    Diskin, Ron; Bjorkman, Pamela J.; Nussenzweig, Michel; Scheid, Johannes
    Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution in the heavy chain at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4 and an amino acid substitution in the light chain, these antibodies having improved potency and breadth.

  4. Plants having modified response to ethylene by transformation with an ETR nucleic acid

    Meyerowitz, Elliot M.; Chang, Caren; Bleecker, Anthony B.
    The invention includes transformed plants having at least one cell transformed with a modified ETR nucleic acid. Such plants have a phenotype characterized by a decrease in the response of at least one transformed plant cell to ethylene as compared to a plant not containing the transformed plant cell. Tissue and/or temporal specificity for expression of the modified ETR nucleic acid is controlled by selecting appropriate expression regulation sequences to target the location and/or time of expression of the transformed nucleic acid. The plants are made by transforming at least one plant cell with an appropriate modified ETR nucleic acid,...

  5. Molecular sieves for improved hydrocarbon traps

    Davis, Mark E.; Okubo, Tatsuya
    Molecular sieves and the use of such materials as hydrocarbon traps, particularly for reducing the emissions associated with the combustion of hydrocarbon fuels are described. Specifically, the use of molecular sieves such as zeolites as adsorbents for hydrocarbon gases, especially exhaust gases such as are formed during the combustion of hydrocarbons, and more particularly to the adsorption of hydrocarbon gases formed during the cold start operation of an internal combustion engine is described. In one embodiment, a method of treating exhaust gas that comprises a hydrocarbon combustion product is provided, the method comprising contacting the exhaust gas with a CON...

  6. Beam-forming concentrating solar thermal array power systems

    Cwik, Thomas A.; Dimotakis, Paul E.; Hoppe, Daniel J.
    The present invention relates to concentrating solar-power systems and, more particularly, beam-forming concentrating solar thermal array power systems. A solar thermal array power system is provided, including a plurality of solar concentrators arranged in pods. Each solar concentrator includes a solar collector, one or more beam-forming elements, and one or more beam-steering elements. The solar collector is dimensioned to collect and divert incoming rays of sunlight. The beam-forming elements intercept the diverted rays of sunlight, and are shaped to concentrate the rays of sunlight into a beam. The steering elements are shaped, dimensioned, positioned, and/or oriented to deflect the beam...

  7. Congestion window control based on queuing delay and packet loss

    Jin, Cheng; Liu, Victor; Low, Steven; Gururajan, Santosh Rao; Yang, Lingfeng
    A method of controlling size of a congestion window, includes, at a transmitting device, transmitting a plurality of data packets over a communication channel from the transmitting device to a receiver, determining a queuing delay and a loss rate of the transmission, comparing the queuing delay to a threshold queuing delay, comparing the loss rate to a threshold loss rate, and in response to a determination that the queuing delay is greater than the threshold queuing delay and the loss rate is greater than the threshold loss rate, resetting the size of the congestion window in accordance with a function...

  8. Systems and Methods for Convex Relaxations and Linear Approximations for Optimal Power Flow in Multiphase Radial Networks

    Gan, Lingwen; Low, Steven H.
    Centralized node controllers in accordance with embodiments of the invention enable linear approximation of optimal power flow. One embodiment includes a centralized node controller including: a network interface, a processor, and a memory containing: a centralized power control application a network topology, where the network is multiphase unbalanced and comprises a plurality of connected nodes; wherein the processor is configured by the centralized controller application to: request node operating parameters from the plurality of connected nodes; calculate network operating parameters using a linear approximation of optimal power flow and the node operating parameters from the plurality of connected nodes; send...

  9. Distributed Gradient Descent for Solving Optimal Power Flow in Radial Networks

    Gan, Lingwen; Low, Steven H.
    Node controllers and power distribution networks in accordance with embodiments of the invention enable distributed power control, One embodiment includes a node controller comprising a memory containing: a plurality of node operating parameters; and a plurality of node operating parameters describing operating parameters for a set of at least one node selected from the group consisting of at least one downstream node and at least one upstream node; wherein the processor is configured by the node controller application to: receive and store in memory a plurality of coordinator parameters describing operating parameters of a node coordinator by the network interface;...

  10. Dynamical bandwidth adjustment of a link in a data network

    Walid, Anwar I.; Gan, Lingwen; Low, Steven
    An apparatus includes a first node configured to receive the data packets from a plurality of source nodes of the data network and to selectively route some of the received data packets to a link via a port of the first node. The apparatus also includes a link-input buffer that is located in the first node and is configured to store the some of the received data packets for transmission to the link via the port. The first node is configured to power off hardware for transmitting received data packets to the link in response to a fill level of...

  11. System and methods for computer clock synchronization

    Mallada, Enrique; Tang, Ao
    A clock synchronization system and methods including an algorithm, or protocol, that synchronizes to any source of time without the need of estimating frequency errors and only performing frequency adaptions. Specifically, a clock synchronization protocol synchronizes networked nodes without explicit estimation of the clock skews and steep corrections on the time. The algorithm is guaranteed to converge even in the presence of timing loops which allow different clients to share timing information and even collectively outperform individual clients when the time source has large jitter.

  12. System and methods for computer clock synchronization

    Mallada, Enrique; Tang, Ao
    A clock synchronization system and methods including an algorithm, or protocol, that synchronizes to any source of time without the need of estimating frequency errors and only performing frequency adaptions. Specifically, a clock synchronization protocol synchronizes networked nodes without explicit estimation of the clock skews and steep corrections on the time. The algorithm is guaranteed to converge even in the presence of timing loops which allow different clients to share timing information and even collectively outperform individual clients when the time source has large jitter.

  13. Adaptive Charging Algorithms for a Network of Electric Vehicles

    Low, Zhi H.; Low, Steven H.
    Electric vehicle node controllers in accordance with embodiments of the invention enable adaptive charging. One embodiment includes one or more centralized computing systems; a communications network; a plurality of electric vehicle node controllers, where each electric vehicle node controller in the plurality of node controllers contains: a network interface; a processor; a memory containing: an adaptive charging application; a plurality of electric vehicle node parameters describing charging parameters of an electric vehicle node in the electric vehicle charging network; where the processor is configured by the adaptive charging application to: send electric vehicle node parameters to the one or more...

  14. Systems and Methods for Optimal Power Flow on a Radial Network

    Low, Steven H.; Peng, Qiuyu
    Node controllers and power distribution networks in accordance with embodiments of the invention enable distributed power control. One embodiment includes a node controller including a distributed power control application; a plurality of node operating parameters describing the operating parameter of a node and a set of at least one node selected from the group consisting of an ancestor node and at least one child node; wherein send node operating parameters to nodes in the set of at least one node; receive operating parameters from the nodes in the set of at least one node; calculate a plurality of updated node...

  15. Dynamic adjustment of receive window utilized by a transmitting device

    Jin, Cheng; Lee, George S.; Low, Steven; Ng, Darren; Witt, Ryan
    A method of controlling size of a receive window includes transmitting packets over a communication channel from a transmitting device to a receiver, and receiving acknowledgment packets from the receiver, the received acknowledgement packets from the receiver including an advertised receive window size. The method further includes determining a backlog parameter for the receiver in accordance with the advertised receive window size, determining a queuing delay in accordance the received acknowledgment packets, resetting a size of a congestion window in accordance with a function of a current size of the congestion window and a factor proportional to the queuing delay,...

  16. Imidazo bibyclic imminium compounds as antitumor agents

    Chen, James; Kato, Tomoyo Sakata; Ondrus, Alison Evelynn
    The invention relates to imidazobicycles having a quaternary nitrogen that are inhibitors of the Hedgehog pathway and therefore useful as antitumor agents and as probes of the function of Hedgehog-dependent systems.

  17. Anonymous credit card transactions

    Low, Steven Hwye; Maxemchuk, Nicholas Frank; Paul, Sanjoy
    Techniques for performing credit-card transactions without disclosing the subject matter of the transaction to the institution providing the credit card. The techniques include the use of a communications exchange so that information and funds may be transferred without the destination for the transfer knowing the source of the information or funds and the use of public key encryption so that each party to the transaction and the communications exchange can read only the information the party or the exchange needs for its role in the transaction. Also disclosed are techniques for authenticating a card holder by receiving personal information from...

  18. Method and apparatus for network congestion control

    Jin, Cheng; Low, Steven H.; Wei, Xiaoliang (David)
    The present invention is a delay based model and in fact uses queuing delay as a congestion measure, providing advantages over prior art loss based systems. One advantage is that queuing delay can be more accurately estimated than loss probability. This is because packet losses in networks with large bandwidth-delay product are rare events under TCP Reno and its variants (probability on the order 10.sup.-7 or smaller), and because loss samples provide coarser information than queuing delay samples. Indeed, measurements of delay are noisy, just as those of loss probability. Thus, another advantage of the present invention is that each...

  19. Method and apparatus for network congestion control using queue control and one-way delay measurements

    Jin, Cheng; Low, Steven H.; Wei, David X.; Wydrowski, Bartek; Tang, Ao; Choe, Hyojeong
    The invention provides a congestion control scheme that is a delay based scheme that includes a scalable queue size and one-way queueing delay measurement to reduce network congestion. Queue size is managed by queue control, a scalable utility function, dynamic alpha tuning, and/or randomized alpha tuning. One-way queueing delay is accomplished by measuring backward queueing delay management using various methods of estimating the receiver clock period. Embodiments include estimating the receiver clock period using single sample and multiple sample periods. The system includes a method for detecting route change.

  20. Document copying deterrent method

    Brassil, John T; Low, Steven H.; Maxemchuk, Nicholas F.; O'Gorman, Lawrence P.
    The present invention is directed to a method of deterring the illicit copying of electronically published documents. It includes utilizing a computer system to electronically publish a plurality of copies of a document having electronically created material thereon for distribution to a plurality of subscribers and operating programming within the computer system so as to perform the identification code functions. The steps are to encode the plurality of copies each with a separate, unique identification code, the identification code being based on a unique arrangement of the electronically created material on each such copy; and, creating a codebook to correlate...

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