Mostrando recursos 1 - 20 de 13.890

  1. Trumpets and drums in the night: the 1956 Berliner Ensemble season in London and its aftermath

    Bull, John

  2. Enhancing learning with effective practical science 11-16

    Abrahams, Ian; Reiss, Michael J.

  3. No rehearsal is necessary: The man who flew into space from his apartment

    Pinchbeck, Michael
    : The man who flew into space from his apartment is inspired by an installation of the same name by the Russian artist Ilya Kabakov. The performance draws on notions of escape and makes a journey, like Kabakov, between east and west, flying and falling, attempt and failure. Using found slides and an old slide projector, I present a slideshow for an empty gallery space to be performed by a guest performer in front of an audience of 10 people. The audience becomes the Ten Characters in Kabakov’s work. The guest performer follows prerecorded instructions on headphones that take him or her on a journey into the unknown like the man...

  4. Art, philosophy, and non-standard aesthetics

    Sutherland, Thomas
    Going as far back as Heraclitus (although perhaps exemplified by the writings of Plato, wherein he sought to expel cordon off all art, be it poetry or painting, from the domain of philosophical truth), aesthetics has been frequently viewed by the metaphysical tradition as a disruptive supplement to its ideal purity, always in some sense secondary and inadequate in relation to its a priori categories. Yet simultaneously, these same metaphysics seem to actually draw upon art in order to illustrate such a priori facta, even though the latter are then posited in a transcendent manner such that they may legislate...

  5. Stuck for words: multimodal representations of children’s ideas in science

    Callinan, Carol
    Research which has aimed to understand how children come to acquire ideas about different science concepts has had a long history [1, 2, 3]. However, these studies have explored conceptual knowledge largely through verbal reports. Whilst these approaches have been successful in revealing what children know the bias towards language and linguistic capabilities at the expense of other forms of communication may prevent a comprehensive understanding of knowledge growth particularly if children are not able to clearly or fully articulate their ideas [4]. This paper uses the results to recent study to discuss how children use gestures and other forms...

  6. Selective anti-malarial minor groove binders

    Scott, Fraser J.; Khalaf, Abedawn I.; Duffy, Sandra; Avery, Vicky M.; Suckling, Colin J.
    A set of 31 DNA minor groove binders (MGBs) with diverse structural features relating to both physical chemical properties and DNA binding sequence preference has been evaluated as potential drugs to treat Plasmodium falciparum infections using a chloroquine sensitive strain (3D7) and a chloroquine resistant strain (Dd2) in comparison with human embryonic kidney (HEK) cells as an indicator of mammalian cell toxicity. MGBs with an alkene link between the two N-terminal building blocks were demonstrated to be most active with IC50 values in the range 30 – 500 nM and therapeutic ratios in the range 10 - > 500. Many...

  7. An evaluation of Minor Groove Binders as anti-lung cancer therapeutics

    Scott, Fraser J.; Puig-Sellart, Mireia; Khalaf, Abedawn I.; Henderson, Catherine J.; Westrop, Gareth; Watson, David G.; Carter, Katharine; Grant, M. Helen; Suckling, Colin J.
    A series of 47 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for anti-lung cancer activity by screening against the melanoma cancer cell line B16-F10. Five compounds have been found to possess significant activity, more so than a standard therapy, Gemcitabine. Moreover, one compound has been found to have an activity around 70-fold that of Gemcitabine and has a favourable selectivity index of greater than 125. Furthermore, initial studies have revealed this compound to be metabolically stable and thus it represents a lead for further optimisation towards a novel treatment for lung cancer.

  8. An investigation into students’ difficulties in numerical problem solving questions in high school biology using a numeracy framework

    Scott, Fraser
    The ‘mathematics problem’ is a well-known source of difficulty for students attempting numerical problem solving questions in the context of science education. This paper illuminates this problem from a biology education perspective by invoking Hogan’s numeracy framework. In doing so, this study has revealed that the contextualisation of mathematics within the domain of biology is not the main source of difficulty for students but rather more fundamental mathematical skills.

  9. To DAPS or to IAPS: that is the question

    Abrahams, Ian; Reiss, Michael; Sharpe, Rachael
    This article reviews how practical work, including practical skills, is currently summatively assessed in school science in a number of countries and makes comparisons with how other subjects, such as music and geography, summatively assess skills. Whilst practical skills in school science are clearly valued as being of importance, there is a lack of clarity as to what these skills actually are and how they might, most effectively, be validly assessed. Countries vary greatly in the extent to which they employ what we term ‘Direct Assessment of Practical Skills’ (DAPS) or ‘Indirect Assessment of Practical Skills’ (IAPS). Each of these...

  10. Applications of p-deficiency and p-largeness

    Button, J. O.; Thillaisundaram, A.; Howie, J.
    We use Schlage-Puchta's concept of p-deficiency and Lackenby's property of p-largeness to show that a group having a finite presentation with p-deficiency greater than 1 is large, which implies that Schlage-Puchta's infinite finitely generated p-groups are not finitely presented. We also show that for all primes p at least 7, any group having a presentation of p-deficiency greater than 1 is GolodShafarevich, and has a finite index subgroup which is GolodShafarevich for the remaining primes. We also generalize a result of Grigorchuk on Coxeter groups to odd primes. © 2011 World Scientific Publishing Company.

  11. A note on p-central groups

    Camina, Rachel; Thillaisundaram, Anitha
    A group G is n-central if Gn � Z(G), that is the subgroup of G generated by n-powers of G lies in the centre of G. We investigate p k -central groups for p a prime number. For G a finite group of exponent pk , the covering group of G is pk -central. Using this we show that the exponent of the Schur multiplier of G is bounded by p�c/p-1�, where c is the nilpotency class of G. Next we give an explicit bound for the order of a finite pk -central p-group of coclass r. Lastly, we establish...

  12. Automated brain tumour detection and segmentation using superpixel-based extremely randomized trees in FLAIR MRI

    Soltaninejad, Mohammadreza; Yang, Guang; Lambrou, Tryphon; Allinson, Nigel; Jones, Timothy; Barrick, Thomas; Howe, Franklyn; Ye, Xujiong
    Purpose: We propose a fully automated method for detection and segmentation of the abnormal tissue associated with brain tumour (tumour core and oedema) from Fluid Attenuated Inversion Recovery (FLAIR) Magnetic Resonance Imaging (MRI). Methods: The method is based on superpixel technique and classification of each superpixel. A number of novel image features including intensity-based, Gabor textons, fractal analysis and curvatures are calculated from each superpixel within the entire brain area in FLAIR MRI to ensure a robust classification. Extremely randomized trees (ERT) classifier is compared with support vector machine (SVM) to classify each superpixel into tumour and non-tumour. Results: The proposed method is evaluated...

  13. Pedagogies of pluriversality

    Amsler, Sarah
    The creation of alternatives to market-driven higher institutions, including higher education, is necessary for social justice, ecological survival and human flourishing. In this paper, I explore how such alternatives are being created in a subaltern ecosystem of counter-systemic educational practices and institutions around the world. I begin with a critical reading of recent university policies in the UK to illustrate how the dominant forms of the ‘globalization of higher education’ are not only undesirable but entangled within a broader system of Eurocentric colonial-capitalist ‘monocultures’ (Santos 2014) which both destroy human and ecological possibility and render existing and emerging forms of...

  14. Other learning is possible

    Amsler, Sarah
    This talk offers a brief introduction to some diverse forms of higher education now being practiced around the world and considers the light these shed on the politics of education in Britain today. It asks why new imaginaries of egalitarian, autonomous, co-operative and post-capitalist education remain marginal in the ‘education debate’ here despite decades of professional opposition to the marketization of education, extensive evidence of its exclusionary consequences, and the rise of global education movements which demonstrate that other learning is possible. The talk will argue that both the mainstream education debate and institutionalized educational practice in the UK are...

  15. Educating radical democracy: theorising counter-capitalist possibility in neoliberal social systems

    Amsler, Sarah
    In this talk, I explore themes in a project to understand the politics of possibility in dominating social systems, with particular interest in claims that prefigurative, autonomous and radical democratic politics are effective strategies for resisting neoliberal power and appropriate methods for generating viable counter-capitalist forms of life. After briefly outlining some common endorsements and critiques of radical democracy, I argue that in conditions of advanced neoliberal hegemony we must move beyond asking why the ‘balance of social forces is very powerfully against hope’, as Stuart Hall once described it, and towards understanding how certain kinds of political possibility are...

  16. Pedagogies of autonomy, self-management and cooperation

    Amsler, Sarah
    My contribution to this workshop takes the form of questions that have arisen through my experience of working with autonomous (and relatively autonomous), self-organized and co-operative organizations in education and research. Some of these address the reading of Marx’s and Marxists’ work in contemporary activist projects and movements, as this is focus of the workshop. As my practical experience in self-organization and struggles for autonomy inside and outside heteropatriarchal and capitalist institutions has often not focused on the reading of this work, or has focused on the problems of reading this work, some of my questions also relate to issues...

  17. Higher education for social justice

    Amsler, Sarah
    One of the things least discussed in the everyday lifeworld of higher education in England today is the role that universities have played in the ascendance and consolidation of national and global capitalism, and that they play in legitimising and normalising the many injustices of this system in this country and in our everyday lives and communities. Equally little discussed, however, is how certain forms of radically democratic and autonomous learning can help us understand and resist concrete forms of power and powerlessness within these institutions, and can enable the production of economic, social and cultural infrastructures that place both...

  18. Other learnings are possible: autonomous education, decolonization and radical democracy

    Amsler, Sarah
    This talk offers a brief introduction to some diverse forms of education now being practiced around the world and considers the light these shed on the politics of counter-capitalist educational projects in Britain today. It asks why radical imaginaries of autonomous, egalitarian, co-operative and post-capitalist education remain marginal in educational discourses and politics here despite decades of opposition to the marketization of society, extensive academic and experiential evidence of its exclusionary consequences, and the growth of global education movements which demonstrate the liberatory potential of counter-hegemonic epistemological and pedagogical practices. The talk will argue that mainstream education debates, institutionalized educational...

  19. Indebted servitude – the work of ‘the calling’ in the new feudal professions

    Amsler, Sarah
    This paper argues that, far from supporting an educational ‘calling’ in structural terms, the academic life (like many professions) is both a form of wage labour and, in certain cases, part of a neo-feudal economy in which growing numbers of working people remain permanently indebted to landlords and financial institutions, and increasingly accountable to both markets and the state. At the same time, however, many of those who work as academics in universities continue to cultivate and defend traditional principles of scholarly activity and aspire to pursue what remains for them an intellectual, social or moral vocation. Drawing on recent...

  20. University rankings and the consolidation of elite networked institutions in an era of global capital

    Amsler, Sarah; Bolsmann, Chris
    In this paper we explore the dual role of global university rankings in the creation of a new, knowledge-identified, transnational capitalist class and in facilitating new forms of social exclusion. We examine how and why the practice of ranking universities has become widely defined by national and international organisations as an important instrument of political and economic policy. We consider the development of university rankings into a global business combining social research, marketing and public relations, as a tangible policy tool that narrowly redefines the social purposes of higher education itself. Finally, it looks at how the influence of rankings...

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