Recursos de colección

Estudo Geral - Universidade de Coimbra (19.630 recursos)

ESTUDO GERAL é a designação do repositório digital da produção científica da Universidade de Coimbra, com o objectivo de divulgar conteúdos digitais de natureza científica de autores ligados à Universidade de Coimbra. A sua criação insere-se no movimento de Acesso Livre à Literatura científica (Open Access), ao qual o Conselho de Reitores das Universidades Portuguesas aderiu em 2006 e que a Universidade de Coimbra subscreveu. À semelhança de outras grandes universidades nacionais e internacionais, a UC tem o maior interesse em aumentar a sua presença na rede informática mundial, sendo cada vez mais - e também por essa via - um emissor de conhecimento e cultura.

FCTUC Zoologia - Teses de Doutoramento

Mostrando recursos 1 - 20 de 240

  1. Regulation of Mitochondrial Function in Ischemia/Reperfusion: Looking for Therapeutic Strategies in Fatty Livers

    Varela, Ana Teresa Inácio Ferreira
    Non-alcoholic fatty liver diseases (NAFLD) are associated with obesity and type II diabetes, which are rapidly increasing worldwide due to a fat rich diet and lack of exercise. Fatty liver is characterized by the accumulation of fat in the cytoplasm of hepatocytes derived from adipocytes, intestinal absorption or hepatic lipogenesis. Clinical data has shown that fatty livers are more susceptible to ischemia/ reperfusion (I/R) injury, leading to diminished liver function. Different hypothesis, such as impaired ATP synthesis, microcirculation, Kupffer cell dysfunction and increased leukocytical adhesion have been proposed for the increased susceptibility of fatty organs to ischemic injury. Fatty degeneration, which induces a series of alterations in mitochondria, renders these organelles...

  2. The Role of Transmembrane AMPA Receptor Regulatory Proteins (TARPs) in Synapse Remodeling and Homeostatic Plasticity

    Louros, Susana Ribeiro dos
    Durante o desenvolvimento do sistema nervoso central o refinamento dos circuitos neuronais é primariamente controlado por mecanismos de plasticidade de Hebb. No entanto, esta plasticidade tende a destabilizar os circuitos neuronais, levando a um descontrolo da excitabilidade neuronal. Existem evidências convincentes na literatura do controlo homeostático da excitabilidade neuronal em diversos sistemas. Conhecem-se algumas das vias de sinalização que controlam a plasticidade homeostática, mas os mecanismos moleculares que regulam este processo permanecem uma área de investigação activa. Neste trabalho testámos o papel da stargazina, uma proteína da família das proteínas transmembranares que interagem com os receptores do glutamato do tipo AMPA (TARPs), na plasticidade sináptica homeostática. Para isso, investigámos de que...

  3. Zebrafish caudal fin regeneration : the effect of repeated amputations and ageing

    Azevedo, Ana Sofia Rodrigues dos Santos
    Whilst all organisms developed schemes to respond to injury and illness, their capacity to recover from severe loss or damage of organs and appendages diverge quite a lot. A vertebrate organism that retained regenerative capacity is the zebrafish (Danio rerio). Its amenability to molecular and genetic manipulation turned it into a powerful regeneration model. In particular, zebrafish caudal fin regeneration has emerged as an ideal model to further study vertebrate regeneration due its accessibility and simple anatomical structure. The caudal fin is composed of several segmented bony rays. Each bony ray, with the exception of the most lateral, is bifurcated...

  4. Interplay between Alpha-Synuclein and Oxidative Stress in Parkinson´s Disease Cell Models

    Perfeito, Rita Catarina Gonçalves
    Parkinson’s disease (PD) is the most common motor and age-related neurodegenerative disorder affecting more than 1% of the population above age 65. Neurologically, PD patients present symptoms of progressive deterioration of tremor, rigidity of movements, bradykinesia and postural instability. The major neuropathological features of the disease are characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SN) and the formation of intracytoplasmic inclusions, called Lewy bodies (LBs), which are mainly composed by alpha-synuclein (alpha-syn). Despite the efforts over the years, the etiopathogenesis of PD is still not fully understood. 95% of cases are sporadic and result from a combination of environmental factors and...

  5. Impact of H9c2 Cardiomyoblast Differentiation on Isoproterenol Toxicity: Different Modulation of Signaling Pathways

    Branco, Ana Filipa Roque
    The chronic exposure of cardiomyocytes to catecholamines is associated with pathologic alterations. Stress conditions and tissue insults trigger the activation of neurohormonal systems and catecholamine synthesis is consequently increased. The binding of circulating catecholamines to adrenergic receptors normally incurs in physiological responses that comprises increasing contractile force, heart rate, metabolic activity, among other effects that affect cardiac performance. However, hyperadrenergic stimulation, resulting from sustained activation of β- adrenergic receptors (β-AR), is thought to be directly involved in cardiomyocyte apoptosis. Over-activation of specific signaling pathways results in several cellular processes which lead to progressive myocardium deterioration and contribute toward decompensated heart failure. In this regard, the present work addresses the mechanisms by which cardiac cells...

  6. Role of Kainate Receptors in Neuronal Development

    Marques, Joana Medeiros Vieira
    Tese de doutoramento em Biologia, na especialidade de Biologia Celular, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra

  7. Impact of H9c2 cardiomyoblast differentiation on isoproterenol toxicity : different modulation of signaling pathways

    Branco, Ana Filipa Roque
    The chronic exposure of cardiomyocytes to catecholamines is associated with pathologic alterations. Stress conditions and tissue insults trigger the activation of neurohormonal systems and catecholamine synthesis is consequently increased. The binding of circulating catecholamines to adrenergic receptors normally incurs in physiological responses that comprises increasing contractile force, heart rate, metabolic activity, among other effects that affect cardiac performance. However, hyperadrenergic stimulation, resulting from sustained activation of β- adrenergic receptors (β-AR), is thought to be directly involved in cardiomyocyte apoptosis. Over-activation of specific signaling pathways results in several cellular processes which lead to progressive myocardium deterioration and contribute toward decompensated heart failure. In this regard, the present work addresses the mechanisms by which cardiac cells...

  8. Infertilidade equina : múltiplas fragilidades ou um "fado" do espermatozóide

    Gamboa, Sandra Cristina de Oliveira Pinto
    As raças autóctones portuguesas de equinos estão representadas pelos Puro Sangue Lusitano (PSL), Garrano e Sorraia, sendo o PSL a que assume maior expressão. O Sorraia corresponde a um tipo equino com elevados níveis de consanguinidade que se encontra classificado como mantido de forma crítica. Para PSL e Sorraia, falta definir o padrão espermático e a capacidade dos seus espermatozóides (SPZ) suportarem as tecnologias de conservação ex situ. Além disto, os equinos são uma espécie de reprodução sazonal de dias longos não se sabendo, à nossa latitude, como varia a qualidade espermática ao longo do ano. Em produção animal, a predição do potencial de fertilidade do macho...

  9. Pathways for the Synthesis and Hydrolysis of some Compatible Solutes in the Bacterium Rubrobacter xylanophilus and in the Plant Selaginella moellendorffii : characterization of some recombinant enzymes

    Nobre, Ana Luísa Nabais Gomes
    Organisms that face osmotic stress have long been known to accumulate small organic molecules that do not perturb cell function, even when at high concentrations. Such molecules are typically called ‘compatible’ solutes and permit cells to adjust the turgor pressure required for metabolism and survival of organisms. Compatible solutes are fundamental molecules, accumulated or synthesized by cells, in the response several stress conditions and are viewed as general stress protectants. Rubrobacter xylanophilus is known to accumulate a rare combination of compatible solutes, being trehalose and mannosylglycerate the major solutes and constitutively accumulated. The present work describes the biochemical characterization of three enzymes...

  10. Elementos para uma Antropologia da Psiquiatria: Transtorno Mental cos CAPS - Centros de Atenção Psicossocial de Natal - Rio Grande do Norte - Brasil

    Souza, Bertulino José de
    Tese de doutoramento em Antropologia, no ramo de especialização de Antropologia Social e Cultural, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra

  11. Insights on the Accumulation and Biosynthetic Pathway for Mannosylglucosylglycerate in the Deep-branching Phylum Planctomycetes

    Cunha, Ana Sofia Ventura
    Tese de doutoramento em Bioquímica, na especialidade de Microbiologia, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra

  12. Beyond the Visible World. Bridging Macroscopic and Paleohistopathological Techniques in the Study of Periosteal new Bone Formation in Human Skeletal Remains

    Assis, Sandra Sofia Domingos
    Tese de mestrado em Antropologia, na especialidade de Antropologia Biológica, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra

  13. The Immune Response to Mycobacteria of Distinct Virulence

    Barroso, Manuel António Afonso Pereira
    Tese de doutoramento em Bioquímica, na especialidade de Microbiologia, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra

  14. The interplay between vascular and mitochondrial abnormalities in type 2 diabetes and Alzheimer's disease

    Carvalho, Cristina Isabel Marques Maurício de
    Tese de doutoramento em Biologia, na especialidade de Biologia Celular, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra

  15. A Link Between Metabolic Signaling and Cognition: The Hippocampal Function of Ghrelin

    Ribeiro, Luís Filipe da Silva
    Tese de doutoramento em Biologia, na especialidade de Biologia Celular, apresentada à Faculdade de Ciências e Tecnologias da Universidade de Coimbra

  16. Regulation of the Formation of Microtubule Organizing Centers

    Leal, Filipe Miguel de Sousa Marques
    Tese de doutoramento em Bioquímica, na especialidade de Biologia Molecular, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra

  17. A Metabolic Switch for Cell Differentiation

    Pereira, Sandro Lino Cardoso
    Tese de doutoramento em Biologia, na especialidade de Biologia Celular, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra

  18. The role of individual foraging specialization in the trophic relationships between seabirds and the marine environment

    Ceia, Filipe
    Trophic relationships are central in ecology and play a crucial role in species survival, as availability of food resources varies over time and space. The spatio-temporal variation in food sources at sea has many ecological implications on marine top predators such as seabirds. However, most ecological studies of resource use and population dynamics treat conspecific individuals as ecologically equivalent, but intra-specific variation in individual foraging strategies can be large and many apparently generalized populations are in fact composed of specialized individuals that use a small subset of the available resources over time (individual consistency). Studies on the incidence of individual...

  19. Multimodal Imaging Probes for the Diagnostics of Alzheimer’s Disease

    Martins, Andre Ferreira
    Alzheimer’s disease (AD) is the most frequent form of intellectual deterioration in elderly individuals, characterized by the brain deposition of amyloid plaques and neurofibrillary tangles. Early detection of the β-amyloid (Aβ) deposits in vivo is very difficult. Recently 11C-radiolabeled small-molecules have been developed, capable of entering the brain and specifically targeting amyloid plaques for imaging with PET, such as several Thioflavin T derivatives. In particular, the uncharged analogue 6-OH-BTA-1 (Pittsburgh compound B- PiB) is highly efficient both in crossing the BBB and in selective binding to AD amyloid aggregates. The use of Aβ marker linked to a MRI CA would...

  20. Novel Noninvasive Imaging Biomarkers for Liver Steatosis, Inflammation and Fibrosis

    Leitão, Helena Cristina Gil Cardeira dos Santos
    As hepatites virais e a doença hepática gorda não alcoólica são actualmente as causas mais frequentes de doença hepática crónica. Qualquer uma destas patologias é caracterizada pela presença no parênquima hepático de esteatose, inflamação e fibrose, que podem agravar-se e levar a uma situação clínica de insuficiência hepática, causando não só considerável morbilidade mas também mortalidade, e igualmente um real incremento nos custos nacionais com a saúde. A capacidade de deteção precoce, por rotina, de estádios ligeiros/moderados de inflamação e fibrose e a quantificação da esteatose através de meios de imagem não invasivos, poderá trazer vantagens clínicas importantes para estes...

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