Mostrando recursos 1 - 20 de 26

  1. Proprioceptive deficits in Parkinson’s disease : from clinical data to animal experimentation

    Santos, Letícia Ribeiro da Silva dos; Souza, Tadeu Mello e; Araujo, Lisiane Bizarro; Oliveira Junior, Alcyr Alves de
    Parkinson’s disease (PD) is characterized by the manifestation of akinesia, slowness to initiate movement, muscle rigidity, and tremors. However, recent evidence indicates that this pathology also causes alterations in proprioception. Disturbances in proprioceptive mechanisms directly affect postural control and the ability to calculate the velocity and amplitude of movement, suggesting that these alterations are related to the motor symptoms of PD. This article reviews the clinical data on these symptoms and presents evidence of a connection between proprioceptive deficits and the physiology of PD. The identification of proprioceptive impairments in different forms of Parkinsonism can provide valuable clues on the...

  2. Access to treatment for phenylketonuria by judicial means in Rio Grande do Sul, Brazil


    Treatment of phenylketonuria (PKU) includes the use of a metabolic formula which should be provided free of charge by the Unified Health System (SUS). This retrospective, observational study sought to characterize judicial channels to obtain PKU treatment in Rio Grande do Sul (RS), Brazil. Lawsuits filed between 2001– 2010 and having as beneficiaries PKU patients requesting treatment for the disease were included. Of 20 lawsuits filed, corresponding to 16.8% of RS patients with PKU, 19 were retrieved for analysis. Of these, only two sought to obtain therapies other than metabolic formula. In all the other 17 cases, prior treatment requests...

  3. Access to treatment for phenylketonuria by judicial means in Rio Grande do Sul, Brazil


    Treatment of phenylketonuria (PKU) includes the use of a metabolic formula which should be provided free of charge by the Unified Health System (SUS). This retrospective, observational study sought to characterize judicial channels to obtain PKU treatment in Rio Grande do Sul (RS), Brazil. Lawsuits filed between 2001– 2010 and having as beneficiaries PKU patients requesting treatment for the disease were included. Of 20 lawsuits filed, corresponding to 16.8% of RS patients with PKU, 19 were retrieved for analysis. Of these, only two sought to obtain therapies other than metabolic formula. In all the other 17 cases, prior treatment requests...

  4. The seed bank of subtropical grasslands withcontrasting land-use history in southern Brazil

    Vieira, Mariana de Souza; Bonilha, Camila Leal; Boldrini, Ilsi Iob; Overbeck, Gerhard Ernst
    The expansion of land use for agriculture is among the main reasons for the reduction of natural grasslands around the world, and little is known about the recovery potential of original native grassland vegetation from seed banks. The aim of this study was to assess the seed bank potential of grassland areas with or without history of cultivation in southern Brazil. Specifically, we aimed at evaluating if agricultural use allowed for the persistence of species typical of natural grasslands in soil seed banks. We analyzed seed banks in two areas with a history of cultivation and in two natural grasslands....

  5. Mandibular condylar hyperplasia : diagnosis and management. Case report

    Pinto, Isabel; Fonseca, Júlio; Vinagre, Alexandra; Ângelo, David; Sanz, David; Grossmann, Eduardo
    BACKGROUND AND OBJECTIVES: Mandibular condylar hyperplasia is a disease where excessive growth of mandibular condyle, ramus and body elicits facial asymmetry. Its therapeutic management is not a consensus and, due to its complexity, is a challenge for maxillofacial surgeons and orthodontists. This study aimed at discussing clinical, diagnostic and therapeutic aspects of the management of this disease, and at explaining the role of condylectomy. CASE REPORT: Female patient, 19 years old, Caucasian, looked for maxillofacial surgeon assistance due to facial asymmetry and pain on right temporomandibular joint. Patient had no medical, gestational or family history of facial deformity, or history...

  6. Cognition and functioning in bipolar depression

    Kapczinski, Natalia Soncini; Narvaez, Joana Corrêa de Magalhães; Magalhães, Pedro Vieira da Silva; Bücker, Joana; Peuker, Ana Carolina Wolf Baldino; Loredo, Ana C.; Troiano, Federico; Czepielewski, Letícia Sanguinetti; Rosa, Adriane Ribeiro; Fries, Gabriel Rodrigo; Gama, Clarissa Severino
    Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test. Results: In patients, severe depression was associated...

  7. Shortened telomere length in bipolar disorder : a comparison of the early and late stages of disease

    Barbé-Tuana, Florencia María; Parisi, Mariana Migliorini; Panizzutti, Bruna Schilling; Fries, Gabriel Rodrigo; Grun, Lucas Kich; Guma, Fátima Theresinha Costa Rodrigues; Kapczinski, Flávio Pereira; Berk, Michael; Gama, Clarissa Severino; Rosa, Adriane Ribeiro
    Objective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. Methods: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. Results: Telomere length...

  8. Internacionalização da produção científica brasileira : políticas, estratégias e medidas de avaliação

    Santin, Dirce Maria; Vanz, Samile Andrea de Souza; Stumpf, Ida Regina Chitto
    A internacionalização da produção científica tem reflexos significativos na ciência contemporânea e na inserção internacional dos países em desenvolvimento. Apesar dos esforços empreendidos pelo Brasil nas últimas décadas, a produção científica nacional ainda enfrenta entraves em relação ao alcance e ao impacto internacional das publicações. Este artigo aborda as políticas e as estratégias voltadas à internacionalização da produção científica brasileira e apresenta algumas medidas de avaliação. A internacionalização da produção é discutida com base nos aspectos difusão, colaboração e impacto internacional, com vistas a refletir sobre as possibilidades de ampliar a projeção da ciência brasileira no meio científico internacional.

  9. Differential effect of solution conditions on the conformation of the Actinoporins Sticholysin II and Equinatoxin II

    Vargas Filho, Edson Fauth; Cilli, Eduardo M.; Braun, Rodrigo Ligabue; Verli, Hugo
    Actinoporins are a family of pore-forming proteins with hemolytic activity. The structural basis for such activity appears to depend on their correct folding. Such folding encompasses a phosphocholine binding site, a tryptophan-rich region and the activity-related N-terminus segment. Additionally, different solution conditions are known to be able to influence the pore formation by actinoporins, as for Sticholysin II (StnII) and Equinatoxin II (EqtxII). In this context, the current work intends to characterize the influence of distinct solution conditions in the conformational behavior of these proteins through molecular dynamics (MD) simulations. The obtained data offer structural insights into actinoporins dynamics in...

  10. Are bovine teeth a suitable substitute for human teeth in in vitro studies to assess endotoxin load in root canals?

    Melo, Tiago André Fontoura de; Gründling, Grasiela Sabrina Longhi; Montagner, Francisco; Scarparo, Roberta Kochenborger; Figueiredo, Jose Antonio Poli de; Vier-Pelisser, Fabiana Vieira
    The present study aimed to determine the feasibility of using bovine teeth as a suitable alternative for human teeth, in experiments involving in vitro endotoxin contamination. Twenty bovine central incisors and 20 human single-root premolars had their dental crowns removed and root lengths set at 16 mm. Root canals were prepared up to #60 K-file size and sterilized with cobalt-60 gamma irradiation (20 kGy, 6 h). The teeth were randomly divided into four groups: G1-bovine teeth (bovine negative control, n = 10), G2-human teeth (human negative control, n = 10), G3-bovine teeth, inoculated with Escherichia coli (055:B55) LPS, and G4-human...

  11. Evaluation of sexual dimorphism and the relationship between craniofacial, dental arch and masseter muscle characteristics in mixed dentition

    Marquezin, Maria Carolina Salomé; Andrade, Annicele da Silva; De Rossi, Moara; Gameiro, Gustavo Hauber; Gavião, Maria Beatriz Duarte; Castelo, Paula Midori
    Purpose: to evaluate sexual dimorphism and the relationship between craniofacial characteristics, dental arch morphology and masseter muscle thickness in children in the mixed dentition stage. Methods: the study sample comprised 32 children, aged 6-10 years (14♀/18♂) with normal occlusion. Craniofacial characteristics, dental morphology and masseter muscle thickness were evaluated by means of posteroanterior cephalometric radiographs, dental cast evaluation and ultrasound exam, respectively. The results were analyzed using Shapiro-Wilk test, Mann-Whitney/t-test and stepwise linear regression to assess the relation between face width and age, gender, body mass index, masseter thickness, distances between first molars and canines on dental casts (between cusps/cervical...

  12. Gm and Inv allotypes of brazilian Cayapo indians

    Salzano, Francisco Mauro; Steinberg, A. G.; Tepfenhart, Mary A.
    Data from 440 individuals belonging to four populations of Brazilian Cayapo Indians are reported. About 99% of them are Gm (1, 21) or Gm (1, 2, 21), while the frequency of sera with Inv (1) varies from 59%7 to 75%. These values are generally in accordance with those previously obtained among other South American Indians. The four populations can be separated into two groups if the distribution of Gm' 21 and Gm 2, 21 is considered, but this distinction is not apparent in the frequencies of Inv'. A surprisingly high number of samples showed antibody activity against the sensitized red...

  13. Molecular docking and molecular dynamicsof semi-synthetic piperidine alkaloids as acetylcholinesterase inhibitors

    Danuello, Amanda; Romeiro, Nelilma C.; Giesel, Guilherme Menegon; Pivatto, Marcos; Viegas Junior, Claudio; Verli, Hugo; Barreiro, Eliezer J.; Fraga, Carlos A.M.; Castro, Newton Gonçalves de; Bolzani, Vanderlan da Silva
    A mistura dos derivados semissintéticos cloridrato da (–)-3-O-acetil-cassina e cloridrato da (–)-3-O-acetil-espectalina, preparada a partir da mistura dos alcalóides (–)-cassina e (–)-espectalina (4:1) obtida de Senna spectabilis, é um potente inibidor da acetilcolinesterase (AChE), assim justificando mais estudos moleculares. Neste sentido, estudos de docking e dinâmica moleculares foram conduzidos neste trabalho com o objetivo de adquirir uma compreensão mais profunda de todos os aspectos estruturais das moléculas cloridratos da (–)-3-O-acetil-cassina e (–)-3-O-acetil-espectalina, as quais diferem em seus potenciais inibidores de AChE. Os dois derivados em estudo apresentaram diversas interações com o sítio periférico aniônico dentro da cavidade catalítica de AChE...

  14. Estrutura sinusial dos componentes herbáceo e arbustivo de uma floresta costeira subtropical

    Muller, Sandra Cristina; Waechter, Jorge Luiz
    As sinusias herbaceas e arbustivas sao componentes de comunidades florestais pouco pesquisados nas regibes tropicais e subtropicais. Neste trabalho foram estudadas a composicao floristica e a estrutura fitossociologica destas sinasias em uma floresta arenosa (restinga) da Planicie Costeira do Rio Grande do Sul, Brasil. Os dados fitossociologicos foram obtidos em 30 parcelas de 2 x 2 m. Em cads parcela anotou-se a presenca e a altura maxima das especies herbaceas e arbutivas, e a cobertura foi estimada pela escala de Causton. A composicao floristica total da area compreende 61 especies, 52 generos e 33 familias. As familias que apresentaram mais...

  15. Association between floral bud size and developmental stage in soybean microspores

    Lauxen, Mozart da Silva; Santos, Eliane Kaltchuk dos; Hu, Ching Yeh; Callegari-Jacques, Sidia Maria; Bodanese-Zanettini, Maria Helena
    Este estudo visa estabelecer a associação entre o tamanho do botão floral e o estágio de desenvolvimento dos micrósporos em cultivares brasileiras de soja. A distribuição dos estágios de desenvolvimento dos micrósporos foi analisada, nos anos de 1995 e 1997, em botões florais jovens das cultivares Década, IAS5 e RS7. Os dados indicam que, para um dado intervalo de tamanho do botão floral, os micrósporos das diferentes cultivares estavam em distintos estágios de desenvolvimento, com as cultivares RS7 e Década exibindo estágios anteriores àqueles observados na cultivar IAS5. A distribuição dos estágios dos micrósporos entre as dez anteras de um...

  16. Insulin stimulation of Akt/PKB phosphorylation in the placenta of preeclampsia patients=Estimulação com insulina da fosforilação da Akt/PKB em placenta de pacientes com pré-eclâmpsia

    Ferreira, Gustavo Dias; Orcy, Rafael Bueno; Costa, Sergio Hofmeister de Almeida Martins; Ramos, José Geraldo Lopes; Brum, Ilma Simoni; Corleta, Helena von Eye; Capp, Edison
    CONTEXTO E OBJETIVO: Pré-eclâmpsia (PE) é uma doença multissistêmica das mais frequentes e graves durante a gestação. A ligação da insulina inicia a fosforilação e ativação de substratos citoplasmáticos, tais como fosfatidil-inositol 3 quinase (PI3K). A fosforilação do fosfoinositol 2 (PIP2) da membrana em fosfoino- siltol 3 (PIP3) pela PI3K inicia a ativação da Akt/PKB. Defeitos na fosforilação do receptor de insulina e seus substratos têm papel importante na resistência à insulina. Estudos demonstraram que resistência à insulina está associada com pré-eclâmpsia e sua patofisiologia. O objetivo foi investigar a via de estimulação com insulina da Akt/PKB em placenta de...

  17. Biocompatibility of RealSeal, its primer and AH Plus implanted in subcutaneous connective tissue of rats

    Grecca, Fabiana Soares; Kopper, Patrícia Maria Poli; Santos, Regis Burmeister dos; Fossati, Anna Christina Medeiros; Carrard, Vinícius Coelho; Acasigua, Gerson Arisoly Xavier; Figueiredo, Jose Antonio Poli de
    Objective: This study tested rat connective tissue response to RealSeal, RealSeal primer or AH Plus after 7, 15, 30, 60 and 90 days of implantation. Material and methods: Thirty Wistar rats had subcutaneous sockets created on their back and received four implants each of polyethylene tubes containing one of the materials tested according to the groups: AH (AH Plus Sealer); RS (RealSeal Sealer); RP (RealSeal Primer); CG (control group – empty tube). After histological processing, sections were analyzed to identify the presence of neutrophils, lymphocytes and plasma cells, eosinophils, macrophages and giant cells, as well as fibrous capsule and abscesses,...

  18. Interference of partial visual analysis of root filling quality and apical status on retreatment decisions

    Morgental, Renata Dornelles; Santos, Regis Burmeister dos; Rösing, Cassiano Kuchenbecker; Chanin, Taís do Amaral; Figueiredo, Jose Antonio Poli de
    Objective: The presence of periapical radiolucency has been used as a criterion for endodontic treatment failure. However, in addition to the inherent limitations of radiographic examinations, radiographic interpretations are extremely subjective. Thus, this study investigated the effect of partial analysis of root filling quality and periapical status on retreatment decisions by general dentists. Material and Methods: Twelve digitalized periapical radiographs were analyzed by 10 observers. The study was conducted at three time points at 1-week intervals. Radiographs edited with the Adobe Photoshop CS4 software were analyzed at three time points: first, only root filling quality was analyzed ; second, only...

  19. Radiographic evaluation of furcal perforations sealed with different materials in dogs' teeth

    Vanni, José Roberto; Della Bona, Alvaro; Figueiredo, Jose Antonio Poli de; Pedro, Giovani; Voss, Douglas; Kopper, Patrícia Maria Poli
    Objective: The objective of this work was to evaluate, using radiographic images, the behavior of four materials used to repair root perforations in dogs’ teeth. Material and Methods: Second and third premolars of 6 dogs were used. The 48 teeth were andomly divided into 4 groups (n=12) and the perforations were sealed with one of the following materials: MTA, AH Plus, Vitremer and gutta-percha. Dogs were submitted to general anesthesia, teeth were radiographed and pulp was accessed. Perforations were done, at the maximum curve of the pulp floor, sealed and the acessed coronal cavity was filled with glass ionomer cement...

  20. Cartas ao editor : [O Serviço de Genética Médica do Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, é um centro de referência internacional para o diagnóstico e tratamento das Mucopolissacaridosis (MPS) ...] :

    Marinho, Diane Ruschel; Azevedo, Ana Cecília Medeiros Mano; Rymer, Samuel; Giugliani, Roberto; Schwartz, Ida Vanessa Doederlein

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