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PubMed Central (PMC3 - NLM DTD) (2.007.004 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Mostrando recursos 1 - 20 de 9.483

1. Microtubule Regulation in Mitosis: Tubulin Phosphorylation by the Cyclin-dependent Kinase Cdk1D? - Fourest-Lieuvin, Anne; Peris, Leticia; Gache, Vincent; Garcia-Saez, Isabel; Juillan-Binard, Céline; Lantez, Violaine; Job, Didier
Cdk1 phosphorylates a number of microtubule- or tubulin-binding proteins but, hitherto, tubulin itself has not been detected as a Cdk1 substrate.

2. Conditional Dominant Mutations in the Caenorhabditis elegans Gene act-2 Identify Cytoplasmic and Muscle Roles for a Redundant Actin IsoformD?V? - Willis, John H.; Munro, Edwin; Lyczak, Rebecca; Bowerman, Bruce
Animal genomes each encode multiple highly conserved actin isoforms that polymerize to form the microfilament cytoskeleton.

3. Phosphorylation of the Chromosomal Passenger Protein Bir1 Is Required for Localization of Ndc10 to the Spindle during Anaphase and Full Spindle Elongation - Widlund, Per O.; Lyssand, John S.; Anderson, Scott; Niessen, Sherry; Yates, John R.; Davis, Trisha N.
The Saccharomyces cerevisiae inhibitor of apoptosis (IAP) repeat protein Bir1 localizes as a chromosomal passenger.

4. The Slow Wallerian Degeneration Protein, WldS, Binds Directly to VCP/p97 and Partially Redistributes It within the NucleusD? - Laser, Heike; Conforti, Laura; Morreale, Giacomo; Mack, Till G.M.; Heyer, Molly; Haley, Jane E.; Wishart, Thomas M.; Beirowski, Bogdan; Walker, Simon A.; Haase, Georg; Celik, Arzu; Adalbert, Robert; Wagner, Diana; Grumme, Daniela; Ribchester, Richard R.; Plomann, Markus; Coleman, Michael P.
We report direct binding of N70 to valosin-containing protein (VCP; p97/Cdc48), a protein with diverse cellular roles including a pivotal role in the ubiquitin proteasome system.

5. Ena/VASP Proteins Can Regulate Distinct Modes of Actin Organization at Cadherin-adhesive ContactsD?V? - Scott, Jeanie A.; Shewan, Annette M.; den Elzen, Nicole R.; Loureiro, Joseph J.; Gertler, Frank B.; Yap, Alpha S.
Functional interactions between classical cadherins and the actin cytoskeleton involve diverse actin activities, including filament nucleation, cross-linking, and bundling.

6. Shiga Toxin Regulates Its Entry in a Syk-dependent Manner - Lauvrak, Silje Ugland; Wälchli, Sébastien; Iversen, Tore-Geir; Slagsvold, Hege Holte; Torgersen, Maria Lyngaas; Spilsberg, Bjørn; Sandvig, Kirsten
Stx was found to activate Syk and induce rapid tyrosine phosphorylation of several proteins, one protein being clathrin heavy chain.

7. Role of a Cdc42p Effector Pathway in Recruitment of the Yeast Septins to the Presumptive Bud SiteD?V? - Iwase, Masayuki; Luo, Jianying; Nagaraj, Satish; Longtine, Mark; Kim, Hyong Bai; Haarer, Brian K.; Caruso, Carlo; Tong, Zongtian; Pringle, John R.; Bi, Erfei
In the yeast Saccharomyces cerevisiae, the septins are recruited to the presumptive bud site at the cell cortex, where they form a ring through which the bud emerges.

8. Dynamic Nature of Cleavage Bodies and Their Spatial Relationship to DDX1 Bodies, Cajal Bodies, and Gems - Li, Lei; Roy, Ken; Katyal, Sachin; Sun, Xuejun; Bléoo, Stacey; Godbout, Roseline
DDX1 bodies, cleavage bodies, Cajal bodies (CBs), and gems are nuclear suborganelles that contain factors involved in RNA transcription and/or processing.

9. Identification of Novel In Vivo Raf-1 Phosphorylation Sites Mediating Positive Feedback Raf-1 Regulation by Extracellular Signal-regulated Kinase - Balan, Vitaly; Leicht, Deborah T.; Zhu, Jun; Balan, Karina; Kaplun, Alexander; Singh-Gupta, Vinita; Qin, Jun; Ruan, Hong; Comb, Michael J.; Tzivion, Guri
Although the exact mechanisms underlying Raf-1 regulation remain incompletely understood, phosphorylation has been proposed to play a critical role in this regulation.

10. Barrier-to-Autointegration Factor Phosphorylation on Ser-4 Regulates Emerin Binding to Lamin A In Vitro and Emerin Localization In VivoD? - Bengtsson, Luiza; Wilson, Katherine L.
Barrier-to-autointegration factor (BAF) is a conserved 10-kDa chromatin protein essential in proliferating cells.

11. Sphingoid Base Is Required for Translation Initiation during Heat Stress in Saccharomyces cerevisiaeD? - Meier, Karsten D.; Deloche, Olivier; Kajiwara, Kentaro; Funato, Kouichi; Riezman, Howard
Sphingolipids are required for many cellular functions including response to heat shock.

12. Cip1 and Cip2 Are Novel RNA-Recognition-Motif Proteins That Counteract Csx1 Function during Oxidative Stress - Martín, Victoria; Rodríguez-Gabriel, Miguel A.; McDonald, W. Hayes; Watt, Stephen; Yates, John R.; Bähler, Jürg; Russell, Paul
Eukaryotic cells reprogram their global patterns of gene expression in response to stress.

13. Balance between Transcription and RNA Degradation Is Vital for Saccharomyces cerevisiae Mitochondria: Reduced Transcription Rescues the Phenotype of Deficient RNA Degradation - Rogowska, Agata T.; Puchta, Olga; Czarnecka, Anna M.; Kaniak, Aneta; Stepien, Piotr P.; Golik, Pawel
The Saccharomyces cerevisiae SUV3 gene encodes the helicase component of the mitochondrial degradosome (mtEXO), the principal 3?-to-5.

14. Cdc42 and Actin Control Polarized Expression of TI-VAMP Vesicles to Neuronal Growth Cones and Their Fusion with the Plasma MembraneV? - Alberts, Philipp; Rudge, Rachel; Irinopoulou, Theano; Danglot, Lydia; Gauthier-Rouvière, Cécile; Galli, Thierry
Here, we demonstrate that TI-VAMP, but not synaptobrevin 2, concentrates in the peripheral, F-actin-rich region of the growth cones of hippocampal neurons in primary culture.

15. Deregulation of HEF1 Impairs M-Phase Progression by Disrupting the RhoA Activation Cycle - Dadke, Disha; Jarnik, Michael; Pugacheva, Elena N.; Singh, Mahendra K.; Golemis, Erica A.
The focal adhesion-associated signaling protein HEF1 undergoes a striking relocalization to the spindle at mitosis, but a function for HEF1 in mitotic signaling has not been demonstrated.

16. Distinct Ceramide Synthases Regulate Polarized Growth in the Filamentous Fungus Aspergillus nidulansD? - Li, Shaojie; Du, Liangcheng; Yuen, Gary; Harris, Steven D.
Here, we employ a chemical genetic approach to demonstrate that ceramide synthesis is necessary for the formation of a stable polarity axis in the model fungus Aspergillus nidulans.

17. An Essential Role for SNX1 in Lysosomal Sorting of Protease-activated Receptor-1: Evidence for Retromer-, Hrs-, and Tsg101-independent Functions of Sorting Nexins - Gullapalli, Anuradha; Wolfe, Breann L.; Griffin, Courtney T.; Magnuson, Terry; Trejo, JoAnn
Sorting nexin 1 (SNX1) and SNX2 are the mammalian homologues of the yeast Vps5p retromer component that functions in endosome-to-Golgi trafficking.

18. Rapid, Diffusional Shuttling of Poly(A) RNA between Nuclear Speckles and the NucleoplasmD? - Politz, Joan C. Ritland; Tuft, Richard A.; Prasanth, Kannanganattu V.; Baudendistel, Nina; Fogarty, Kevin E.; Lifshitz, Larry M.; Langowski, Jörg; Spector, David L.; Pederson, Thoru
Speckles are nuclear bodies that contain pre-mRNA splicing factors and polyadenylated RNA.

19. KEL-8 Is a Substrate Receptor for CUL3-dependent Ubiquitin Ligase That Regulates Synaptic Glutamate Receptor Turnover - Schaefer, Henry; Rongo, Christopher
To identify genes that regulate AMPAR synaptic abundance, we screened for mutants that accumulate high synaptic levels of the AMPAR subunit GLR-1 in Caenorhabditis elegans.

20. Involvement of Src Family Kinases in N-Cadherin Phosphorylation and ?-Catenin Dissociation during Transendothelial Migration of Melanoma CellsD? - Qi, Jianfei; Wang, Junfu; Romanyuk, Olena; Siu, Chi-Hung
N-cadherin is recruited to the heterotypic contact during transendothelial migration of melanoma cells in a coculture system with tumor cells seeded on top of a monolayer of endothelial cells.

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