Recursos de colección PubMed Central (PMC3 - NLM DTD) (2.002.009 recursos) Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
Mostrando recursos 1 - 20 de 84
1. Induction of revertant fibres in the mdx mouse using antisense oligonucleotides - Fall, Abbie M; Johnsen, Russell; Honeyman, Kaite; Iversen, Pat; Fletcher, Susan; Wilton, Stephen D 2. Characterization of the ribonuclease activity on the skin surface - Probst, Jochen; Brechtel, Sonja; Scheel, Birgit; Hoerr, Ingmar; Jung, Günther; Rammensee, Hans-Georg; Pascolo, Steve The rapid degradation of ribonucleic acids (RNA) by ubiquitous ribonucleases limits the efficacy of new therapies based on RNA molecules. 3. Long term physiologic modification using rAAV in utero gene-therapy - Garrett, Deiadra J; Cohen, J Craig; Larson, Janet E 4. The recombinant adeno-associated virus vector (rAAV2)-mediated apolipoprotein B mRNA-specific hammerhead ribozyme: a self-complementary AAV2 vector improves the gene expression - Zhong, Shumei; Sun, Shihua; Teng, Ba-Bie 5. The significance of controlled conditions in lentiviral vector titration and in the use of multiplicity of infection (MOI) for predicting gene transfer events - Zhang, Bing; Metharom, Pat; Jullie, Howard; Ellem, Kay AO; Cleghorn, Geoff; West, Malcolm J; Wei, Ming Q 6. A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma - Söling, Ariane; Theiß, Christian; Jungmichel, Stephanie; Rainov, Nikolai G 7. Attenuation of dengue virus infection by adeno-associated virus-mediated siRNA delivery - Zhang, Weidong; Singam, Rajeswari; Hellermann, Gary; Kong, Xiaoyuan; Juan, Homero San; Lockey, Richard F; Wu, Shuen-Ju; Porter, Kevin; Mohapatra, Shyam S 8. The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery - Anson, Donald S Retroviral vector-mediated gene transfer has been central to the development of gene therapy. 9. Comparison of bovine leukemia virus (BLV) and CMV promoter-driven reporter gene expression in BLV-infected and non-infected cells - Harms, Jerome S; Eakle, Kurt A; Kuo, Lillian S; Bremel, Robert D; Splitter, Gary A 10. Human cytokine-induced killer cells have enhanced in vitro cytolytic activity via non-viral interleukin-2 gene transfer - Nagaraj, Srinivas; Ziske, Carsten; Schmidt-Wolf, Ingo GH Modulation of the immune system by genetically modified immunological effector cells is of potential therapeutic value in the treatment of malignancies. 11. Durable cytotoxic immune responses against gp120 elicited by recombinant SV40 vectors encoding HIV-1 gp120 ± IL-15 - McKee, Hayley J; T'sao, Patricia Y; Vera, Maria; Fortes, Puri; Strayer, David S 12. Skipping the co-expression problem: the new 2A "CHYSEL" technology - de Felipe, Pablo However, any realistic hope of gene therapy treatment for those diseases needs first to address the problem of co-ordinately co-expressing several transgenes. 13. Improved gene delivery to human saphenous vein cells and tissue using a peptide-modified adenoviral vector - Work, Lorraine M; Reynolds, Paul N; Baker, Andrew H The establishment of efficient gene delivery to target human tissue is a major obstacle for transition of gene therapy from the pre-clinical phases to the clinic. 14. Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC - Ebert, Oliver; Wilbert, Dorothee; Buttgereit, Peter; Ziske, Carsten; Flieger, Dimitri; Schmidt-Wolf, Ingo GH 15. In vivo gene targeting of IL-3 into immature hematopoietic cells through CD117 receptor mediated antibody gene delivery - Chapel, Alain; Deas, Olivier; Bensidhoum, Morad; François, Sabine; Mouiseddine, Moubarak; Poncet, Pascal; Dürrbach, Antoine; Aigueperse, Jocelyne; Gourmelon, Patrick; Gorin, Norbert C; Hirsch, François; Thierry, Dominique 16. DNA vaccines: designing strategies against parasitic infections - Ivory, Catherine; Chadee, Kris The versatility of DNA vaccination provides new perspectives. 17. Human cytomegalovirus plasmid-based amplicon vector system for gene therapy - Mahmood, Kutubuddin; Prichard, Mark N; Duke, Gregory M; Kemble, George W; Spaete, Richard R We have constructed and evaluated the utility of a helper-dependent virus vector system that is derived from Human Cytomegalovirus (HCMV). 18. Electroporation by nucleofector is the best nonviral transfection technique in human endothelial and smooth muscle cells - Iversen, Nina; Birkenes, Baard; Torsdalen, Kari; Djurovic, Srdjan 19. Evaluation of the VP22 protein for enhancement of a DNA vaccine against anthrax - Perkins, Stuart D; Flick-Smith, Helen C; Garmory, Helen S; Essex-Lopresti, Angela E; Stevenson, Freda K; Phillpotts, Robert J 20. Production and characterization of amplified tumor-derived cRNA libraries to be used as vaccines against metastatic melanomas - Carralot, Jean-Philippe; Weide, Benjamin; Schoor, Oliver; Probst, Jochen; Scheel, Birgit; Teufel, Regina; Hoerr, Ingmar; Garbe, Claus; Rammensee, Hans-Georg; Pascolo, Steve