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  1. The crystal structure of a junction between Two Z-DNA helices

    de Rosa, Matteo; de Sanctis, Daniele; Rosario, Ana Lucia; Archer, Margarida; Rich, Alexander; Athanasiadis,Alekos; Carrondo, Maria Armenia
    The double helix of DNA, when composed of dinucleotide purine - pyrimidine repeats, can adopt a left-handed helical structure called Z-DNA. For reasons not entirely understood, such dinucleotide repeats in genomic sequences have been associated with genomic instability leading to cancer. Adoption of the left handed conformation results in the formation of conformational junctions: a B to Z junction is formed at the boundaries of the helix, while a Z to Z junction is commonly formed in sequences where the dinucleotide repeat is interrupted by single base insertions or deletions that bring neighbouring helixes out of phase. B-Z junctions are...
    (application/msword; application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/vnd.openxmlformats-officedocument.wordprocessingml.document; image/tiff; image/tiff; image/tiff; image/tiff; image/jpeg) - 24-jun-2010

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