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University of Twente Publications (58.714 recursos)

University of Twente Repository provides publications of UT scientific staff, in many cases full text and publicly available.

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Mostrando recursos 1 - 20 de 27.110

  1. Compatibilization of Silica-filled Natural Rubber Compounds by Functionalized Low Molecular Weight Polymer

    Saramolee, P.; Sahakaro, K.; Lopattananon, N.; Dierkes, W.K.; Noordermeer, J.W.M.

  2. Magnetic anisotropies in epitaxial Fe3O4/GaAs(100) patterned structures

    Zhang, W.; Wong, P.K.J.; Zhang, D.; Yuan, S.J.; Huang, Z.S.; Zhai, Y.; Wu, J.; Xu, Y.B.
    Previous studies on epitaxial Fe3O4 rings in the context of spin-transfer torque effect have revealed complicated and undesirable domain structures, attributed to the intrinsic fourfold magnetocrystalline anisotropy in the ferrite. In this Letter, we report a viable solution to this problem, utilizing a 6-nm-thick epitaxial Fe3O4 thin film on GaAs(100), where the fourfold magnetocrystalline anisotropy is negligible. We demonstrate that in the Fe3O4 planar wires patterned from our thin film, such a unique magnetic anisotropy system has been preserved, and relatively simple magnetic domain configurations compared to those previous reports can be obtained.

  3. Splitting high-dose oral Methotrexate improves biovailability: a pharmacokinetic study in patients with rheumatoid Arthritis

    Hoekstra, Monique; Haagsma, Cees; Neef, Cees; Proost, Johannes; Knuif, Antonius; Laar, Mart van de
    OBJECTIVE: To study the bioavailability of a divided higher oral dose of methotrexate (MTX), in comparison to a single dose, in adult patients with rheumatoid arthritis (RA). METHODS: A pharmacokinetic analysis was performed in 10 patients with RA taking a stable dose (25-35 mg weekly) of MTX. Separated by one week, a pharmacokinetic analysis was performed in each patient after an oral single dose, and after an equal but split dose separated by 8 hours. MTX serum concentrations were measured by a fluorescence polarization immunoassay technique. Analysis was performed by calculation of the area under the curve (AUC) by the trapezoidal rule and...

  4. The burden of informal caregivers for people with rheumatoid arthritis in Egypt and the Netherlands

    El-Mansoury, Tarek M.; Taal, Erik; Riemsma, Robert P.; Abdel Nasser, Ahmed; Rasker, Johannes J.
    Objectives: To study the burden as experienced by informal caregivers for people with Rheumatoid Arthritis (RA) in Egypt and the Netherlands and to determine which factors are related to this burden. Methods: A total of 99 Dutch and 30 Egyptian females with RA and their caregivers participated in the study. Data were collected by means of questionnaires including the amount of help provided, mental health and subjective burden as experienced by the caregiver, patient demographic and health status, social support, self-efficacy expectations and caregiver characteristics. Differences between Egypt and the Netherlands were analysed with ANCOVA, controlled for age and disease duration. Variables related...

  5. Possession of assistive devices is related to improved psychological well-being in patients with rheumatic conditions

    Veehof, Martine; Taal, Erik; Rasker, Johannes; Lohmann, Johannes; Laar, Mart van de
    OBJECTIVE: To investigate the relationship between the possession of assistive devices and psychological well-being in patients with rheumatic conditions. METHODS: Patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) were selected from rheumatology outpatient clinics in 2 adjacent regions in The Netherlands and Germany. A total of 142 patients completed a questionnaire on the possession of assistive devices and psychological well-being. Questions on sociodemographics, clinical status, and health status were included. Hierarchical multiple linear regression analysis was used to determine the unique association between the number of assistive devices per patient and psychological well-being, controlling for confounding variables. RESULTS: Univariately, the number of assistive...

  6. The symptom intensity scale, fibromyalgia, and the meaning of fibromyalgia-like symptoms

    Wolfe, Frederick; Rasker, Johannes J.
    OBJECTIVE: To characterize a scale for the measurement of fibromyalgia (FM)-like symptoms; to investigate whether FM is a discrete disorder; to understand the significance of FM-like symptoms; and to investigate causal and noncausal factors in the development of such symptoms. METHODS: We evaluated 25,417 patients with rheumatic disease using the Symptom Intensity (SI) Scale, a self-report scale that combines a count of pain in 19 nonarticular regions with a visual analog scale for fatigue. We studied this scale in relation to demographics, clinical symptoms, and serious outcomes, including serious medical illnesses, hospitalization, work disability, and death. RESULTS: Compared with other rheumatic disease assessments, the SI...

  7. Incorporating the patient perspective into outcome assessment in rheumatoid arthritis - progress at OMERACT 7

    Kirwan, John R.; Hewlett, Sarah E.; Heiberg, Turid; Hughes, Rod A.; Carr, Maggie; Hehir, Maggie; Kvien, Tore K.; Minnock, Patricia; Newman, Stanton P.; Quest, Enid M.; Taal, Erik; Wale, Janney
    The Patient Perspective Workshop at OMERACT 7 addressed the question of assessing the outcomes of intervention in rheumatoid arthritis (RA) from the perspective of those who experience the disease. A particular emphasis at this workshop was placed on fatigue, but other areas included well-being, real-time assessment, patient priorities, and needs in early and late disease. Through a series of overview presentations, discussion groups, and plenary sessions, workshop participants (who included 19 patients) clarified what is known and what are the outstanding issues for future research. The importance of further work on clarifying the validity of fatigue measurements in RA has...

  8. Parenteral gold preparations. Efficacy and safety of therapy after switching from aurothioglucose to aurothiomalate

    Roon, Eric N. van; Laar, Martin A.F.J. van de; Janssen, Matthijs; Kruijsen, Marijn W.M.; Jansen, Tim L.T.A.; Brouwers, Jacobus R.B.J.
    OBJECTIVE: For reasons of insufficient quality of the raw material, aurothioglucose was withdrawn from the Dutch market at the end of 2001. Aurothiomalate became available as an alternative preparation. We followed a cohort of patients during the first year after switching from aurothioglucose to aurothiomalate to study efficacy and tolerability. METHODS: Patients were observed at baseline and at 3 and 12 months after switching. At each visit, data on adverse drug reactions (ADR), withdrawal, and disease activity were collected. RESULTS: In total 120 patients were included [age 63(SD 15) yrs, 68% female, 93% with rheumatoid arthritis, duration of disease 15 (SD 9) years, 82% IgM...

  9. The design and evaluation of psychoeducational/self-management interventions

    Mulligan, Kathleen; Newman, Stanton P.; Taal, Erik; Hazes, Mieke; Rasker, Johannes J.
    A large number of interventions have been developed with the aim of improving patient self-management of arthritis. These interventions are complex, usually including multiple components, and have certain key features including participants' awareness of the arms of the study and their often having clear preferences for one or other arm. Because of these and other differences the randomized controlled trial is not necessarily ideal for studies of self-management interventions. This special interest group (SIG) considered designs that may be more appropriate. Self-management interventions use a wide range of outcome measures, which are often assessed at a range of time periods...

  10. Bioavailability of higher dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis

    Hoekstra, Monique; Haagsma, Cees; Neef, Cees; Proost, Johannes; Knuif, Antonius; Laar, Mart van de
    OBJECTIVE: To determine the bioavailability of higher oral doses of methotrexate (MTX) in adult patients with rheumatoid arthritis (RA). METHODS: A pharmacokinetic analysis was performed in 15 patients with RA taking a stable dose of MTX (> or = 25 mg weekly). Separated by 2 weeks, a pharmacokinetic analysis was performed in each patient after oral and subcutaneous administration of the same dose of MTX. MTX serum concentrations were measured by a fluorescence polarization immunoassay. Pharmacokinetic analysis was performed with an iterative 2-stage Bayesian population procedure, obtaining population and individual pharmacokinetic parameters. RESULTS: The median MTX dose was 30 mg weekly (range 25-40 mg). A...

  11. Disseminated primary varicella infection during infliximab treatment

    Vonkeman, Harald; Napel, Chris ten; Rasker, Johannes J.; Laar, Mart van de
    A young man developed a serious disseminated varicella infection, necessitating antiviral treatment, after being treated with anti-tumor necrosis factor-alpha therapy for rheumatoid arthritis.

  12. Outcome after 40 years with rheumatoid arthritis: a prospective study of function, disease activity, and mortality

    Minaur, Nicola J.; Jacoby, Richard K.; Cosh, John A.; Taylor, Gordon; Rasker, Johannes J.
    In an inception cohort of 100 patients with rheumatoid arthritis (RA) we studied course and outcome after 40 years, regarding function, disease activity, cause and age of death, and prognostic factors. Function, joint count, erythrocyte sedimentation rate (ESR), hemoglobin (Hb), rheumatoid factor (RF), and the number of orthopedic operations were measured in 100 consecutive referrals between 1957 and 1963 with either definite or classical RA at one year after onset of symptoms. Subjects have been followed for a mean of 40 years, or until death. In May 1999, 84 subjects had died. Of the 16 survivors, 8 (50%) were severely...

  13. Ten-year radiographic outcome in patients with rheumatoid factor positive rheumatoid arthritis treated with aggressive immunosuppressive combination therapy

    Darmawan, John; Rasker, Johannes J.; Nuralim, Hendri
    We observed 10-year radiographic outcomes in patients with rheumatoid factor positive rheumatoid arthritis prospectively. Group I, II, and III comprised 87, 125, and 89 consecutive subjects with disease duration at presentation of less than 4, 4-24, and 25-255 months, respectively. Initial therapy was with combinations of pulse intravenous (i.v.) methylprednisolone (0-125 mg), cyclophosphamide (100-200 mg), methotrexate (MTX, 5-15 i.v. mg/week) and simultaneous oral cyclosporin A (CSA, 25 mg bid/tid). After disease was controlled i.v. therapy was tapered and switched to oral MTX + CSA. Outcomes from the Larsen Index and Erosive Joint Count were compared in cases and in dropouts...

  14. Weather effects in rheumatoid arthritis: from controversy to consensus. A review

    Patberg, Wiebe R.; Rasker, Johannes J.
    OBJECTIVE: To review and evaluate the evidence for the widespread view that signs and symptoms of rheumatoid arthritis (RA) are influenced, or even caused, by the weather. METHODS: A literature search from 1985 to April 2003 was performed using the PubMed database of the US National Library of Medicine. Additional relevant articles were identified from the bibliographies, and from our own archives. Methods and findings of the studies were critically reviewed. RESULTS: Only temperature and humidity appear to have clear influences on the symptoms of RA, although the reported findings do not agree. In many cases, the apparent controversies can be explained by the intimate...

  15. Outcomes from the Patient Perspective Workshop at OMERACT 6

    Kirwan, John; Heiberg, Turid; Hewlett, Sarah; Hughes, Rod; Kvien, Tore; Ahlmen, Monica; Boers, Maarten; Minnock, Patricia; Saag, Kenneth; Shea, Beverley; Suarez Almazor, Maria; Taal, Erik
    The objective of the Patient Perspective Workshop at OMERACT 6 was to address the question of assessing the outcomes of intervention in rheumatoid arthritis (RA) from the perspective of those who experience the disease themselves. This was done by reviewing the current state of research in the area, identifying the requirements for the development of valid instruments, delineating a research agenda that can attain these requirements, and motivating participants to undertake the appropriate research. Through a series of meetings and discussion sessions a research agenda emerged that includes: exploring subjective experiences of RA identified by patients as important but not...

  16. Reduced burden of disease and improved outcome of patients with rheumatoid factor positive rheumatoid arthritis compared with dropouts. A 10 year observational study

    Darmawan, John; Rasker, Johannes J.; Nuralim, Hendri
    Our objective was to determine outcome and burden of disease in a 10 year study of patients with rheumatoid factor positive rheumatoid arthritis (RF+ RA) compared with study dropouts. Three hundred and one consecutive subjects with disease duration of 3-255 months at presentation were enrolled. The acute (as measured by C-reactive protein, CRP) and chronic (by erythrocyte sedimentation rate, ESR) phases of RF+ RA were suppressed by pulse intravenous (IV) combination of low dose methylprednisolone (MPS) + cyclophosphamide (CYC) for 3 consecutive days and weekly intravenous methotrexate (MTX) with simultaneous oral cyclosporine (CSA) + mycophenolate mofetil (MPM). After achieving negative...

  17. The effect of control and self-medication of chronic gout in a developing country. Outcome after 10 years

    Darmawan, John; Rasker, Johannes J.; Nuralim, Hendri
    Objective:: We describe a 10 year observation of the effect of control of hyperuricemia compared with self-medication alone in patients with chronic gout. Methods: We studied 299 consecutively self-referred Malayo-Polynesian men with chronic gout, mean age 35 ± 14.3 SD years. Subjects comprised 228 cases with chronic gout without tophi or urolithiasis (Group 1) and 71 with those complications (Group 2). Attacks of acute gouty arthritis were treated with nonsteroidal antiinflammatory drugs (NSAID) and/or corticosteroids. After acute arthritis had settled, urate-lowering drugs were instituted in both groups combined with low dose colchicine and/or low dose NSAID for at least 0.5–2 years. Urate levels were...

  18. Beneficial effect of being outdoors in rheumatoid arthritis

    Patberg, Wiebe R.; Rasker, Johannes J.

  19. Globalization of rheumatology: activities of ILAR. Think global - act local

    Dequeker, Jan; Rasker, J.J. (Hans); El-Hadidi, Tahsin
    In 1997 a distinguished EULAR rheumatologist involved in the development of biologics asked somewhat ironically, “What is ILAR [International League of Associations for Rheumatology] doing?” Now, 3 years later, we are in a position to review ILAR’s activities in recent years and its plans for the future. The current ILAR Executive in its global mission statement outlined 5 areas of special interest: (1) confirming the importance of rheumatology as a specialty; (2) stimulating better education; (3) initiating and updating World Wide Web information on rheumatology; (4) continuing stimulation and support of transregional projects; and (5) tightening the links with WHO...

  20. Dual effect of alcohol on pain in rheumatoid arthritis

    Patberg, Wiebe R.; Rasker, Johannes J.; Wiel, Albert van de

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