University of Twente Publications
University of Twente Repository provides publications of UT scientific staff, in many cases full text and publicly available.
Type = Article
Mostrando recursos 1 - 20 de 23,792
Predictors of satisfactory improvements in pain for patients with early rheumatoid arthritis in a treat-to-target study - Klooster, Peter M. ten; Vonkeman, Harald E.; Oude Voshaar, Martijn A.H.; Siemons, Liseth; Riel, Piet L.C.M. van; Laar, Mart A.F.J. van de
OBJECTIVE: The aim of this study was to identify baseline predictors of achieving patient-perceived satisfactory improvement (PPSI) in pain after 6 months of treat to target in patients with early RA. METHODS: Baseline and 6 month data were used from patients included in the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study. Simple and multivariable logistic regression analyses were used to identify significant predictors of achieving an absolute improvement of 30 mm or a relative improvement of 50% on a visual analogue scale for pain. RESULTS: At 6 months, 125 of 209 patients (59.8%) achieved an absolute PPSI and 130...
Sampling variability in forensic likelihood-ratio computation: A simulation study - Ali, Tauseef; Spreeuwers, Luuk; Veldhuis, Raymond; Meuwly, Didier
Recently, in the forensic biometric community, there is a growing interest to compute a metric called “likelihood- ratio” when a pair of biometric specimens is compared using a biometric recognition system. Generally, a biomet- ric recognition system outputs a score and therefore a likelihood-ratio computation method is used to convert the score to a likelihood-ratio. The likelihood-ratio is the probability of the score given the hypothesis of the prose- cution, Hp (the two biometric specimens arose from a same source), divided by the probability of the score given the hypothesis of the defense, Hd (the two biometric specimens arose from...
Impact of eye detection error on face recognition performance - Dutta, Abhishek; Günther, Manuel; El Shafey, Laurent; Veldhuis, Raymond; Spreeuwers, Luuk
The locations of the eyes are the most commonly used features to perform face normalisation (i.e. alignment of facial features), which is an essential preprocessing stage of many face recognition systems. In this study, the authors study the sensitivity of open source implementations of five face recognition algorithms to misalignment caused by eye localisation errors. They investigate the ambiguity in the location of the eyes by comparing the difference between two independent manual eye annotations. They also study the error characteristics of automatic eye detectors present in two commercial face recognition systems. Furthermore, they explore the impact of using different...
Low Mach number algorithm for droplet-laden turbulent channel flow including phase transition - Bukhvostova, A.; Kuerten, J.G.M.; Geurts, B.J.
In this study we propose a new numerical algorithm for droplet-laden turbulent channel flow with phase transitions at low Mach numbers. The carrier gas is treated as compressible flow. In order to avoid very small time steps at low Mach numbers that would arise from stability requirements associated with explicit time-stepping we propose a new semi-explicit time integration method, applied to the low Mach number compressible flow equations. We perform a perturbation analysis in powers of the Mach number of the system of governing equations. The obtained decomposition of pressure into a space-independent part and a hydrodynamic part permits to...
The Use of Polysymptomatic Distress Categories in the Evaluation of Fibromyalgia (FM) and FM Severity - Wolfe, Frederick; Walitt, Brian T.; Rasker, Hans; Katz, Robert S.; Häuser, Winfried
Objective The polysymptomatic distress (PSD) scale is derived from variables used in the 2010 American College of Rheumatology (ACR) fibromyalgia (FM) criteria modified for survey and clinical research. The scale is useful in measuring the effect of PSD over the full range of pain-related clinical symptoms, not just in those who are FM criteria-positive. However, no PSD scale categories have been defined to distinguish severity of illness in FM or in those who do not satisfy the FM criteria. We analyzed the scale and multiple covariates to develop clinical categories and to further validate the scale.
Methods FM was diagnosed...
PReVENT - protective ventilation in patients without ARDS at start of ventilation: study protocol for a randomized controlled trial - Simonis, Fabienne D.; Binnekade, Jan M.; Braber, Annemarije; Gelissen, Harry P.; Heidt, Jeroen; Horn, Janneke; Innemee, Gerard; Jonge, Evert de; Juffermans, Nicole P.; Spronk, Peter E.; Steuten, Lotte M.; Tuinman, Pieter Roel; Vriends, Marijn; Vreede, Gwendolyn de; Wilde, Rob B. de; Neto, Ary Serpa; Gama de Abreu, Marcelo; Pelosi, Paolo; Schultz, Marcus J.
It is uncertain whether lung-protective mechanical ventilation using low tidal volumes should be used in all critically ill patients, irrespective of the presence of the acute respiratory distress syndrome (ARDS). A low tidal volume strategy includes use of higher respiratory rates, which could be associated with increased sedation needs, a higher incidence of delirium, and an increased risk of patient-ventilator asynchrony and ICU-acquired weakness. Another alleged side-effect of low tidal volume ventilation is the risk of atelectasis. All of these could offset the beneficial effects of low tidal volume ventilation as found in patients with ARDS.
PReVENT is a national...
MMT-inzetcriteria, (g)een abc'tje? - Bogt, Nancy C.W. ter; Egberink, Rolf; Eenennaam, Fred L.; Wit, Ralph J. de
In Nederland heeft elke veiligheidsregio een eigen meldkamer van waaruit de hulpdiensten
worden aangestuurd. Aan de hand van de openingsvraag kunnen 112-bellers aangeven om
welke hulpverlener wordt gevraagd. In het geval van gezondheidsproblemen wordt de melding
doorgeschakeld naar de Meldkamer Ambulancezorg (MKA). Vervolgens wordt de triage
uitgevoerd door een centralist, in de meeste gevallen een verpleegkundige. In korte tijd moet
de centralist op basis van de beschrijving van de situatie en de patiënt door een omstander
middels een triagemethodiek de urgentie bepalen en het soort inzet. Naast de inzet van een
ambulance kan de centralist ter aanvulling op de reguliere ambulancezorg ook een Mobiel
Medisch Team (MMT) oproepen
On device architectures, subthreshold swing, and power consumption of the piezoelectric field-effect transistor (π-FET) - Hueting, Raymond J.E.; Hemert, Tom van; Kaleli, Buket; Wolters, Rob A.M.; Schmitz, Jurriaan
This paper describes the potential of tunable strain in field-effect transistors to boost performance of digital logic. Voltage-controlled strain can be imposed on a semiconductor body by the integration of a piezoelectric material improving transistor performance. In this paper, we derive the relations governing the subthreshold swing in such devices to improve the understanding. Using these relations and considering the mechanical and technological boundary conditions, we discuss possible device architectures that employ this principle. Further, we review the recently published experimental and modeling results of this device, and give analytical estimates of the power consumption.
Elasto-capillary folding using stop-programmable hinges fabricated by 3D micro-nachining - Legrain, Antoine; Berenschot, Erwin J.W.; Tas, Niels R.; Abelmann, Leon
We show elasto-capillary folding of silicon nitride objects with accurate folding angles be- tween flaps of (70.6 ± 0.1)° and demonstrate the feasibility of such accurate micro-assembly with a final folding angle of 90°. The folding angle is defined by stop-programmable hinges that are fabricated starting from silicon molds employing accurate three-dimensional corner lithography. This nano-patterning method exploits the conformal deposition and the subse- quent timed isotropic etching of a thin film in a 3D shaped silicon template. The technique leaves a residue of the thin film in sharp concave corners which can be used as an inversion mask in...
Liquefaction of lignocellulose: Do basic and acidic additives help out? - Kumar, S.; Lange, J.P.; Rossum, G. van; Kersten, S.R.A.
Lignocellulosic feedstock can be converted to bio-oil by direct liquefaction in a phenolic solvent such as guaiacol. The bio-oil could then be further upgraded to transportation fuel using conventional oil refining process. The production of heavy components (molecular weight >1000 Da) was found to be a major hurdle in this process as it hinders the efficiency of recycling the bio-oil as liquefaction medium. This paper studies the effect of bases and acids on the liquefaction of biomass and their effectiveness in reducing the formation of heavy components. Acid was found to have a negative effect while all the bases showed...
Muscle Activity during Walking Measured Using 3D MRI Segmentations and FDG-PET - Kolk, Sjoerd; Klawer, E.M.E.; Schepers, Jan; Weerdesteyn, Vivian; Visser, Eric P.; Verdonschot, N.J.J.
AB Purpose: This study aimed to determine the contribution of each muscle of the lower limb to walking using positron emission tomography (PET) with [18F]-Fluorodeoxyglucose (FDG). Furthermore, we compared our results obtained with volumetric analysis of entire muscles to a more traditional approach considering the uptake in only one slice in each segment. Methods: Ten healthy subjects walked on a treadmill at self-selected comfortable walking speed for a total of 90 minutes, 60 minutes before and 30 minutes after intravenous injection of 50 MBq FDG. A PET/CT scan of the lower limb was made subsequently. The three-dimensional contours of 39...
Momentum conserving Brownian dynamics propagator for complex soft matter fluids - Padding, J.T.; Briels, W.J.
We present a Galilean invariant, momentum conserving first order Brownian dynamics scheme for coarse-grained simulations of highly frictional soft matter systems. Friction forces are taken to be with respect to moving background material. The motion of the background material is described by locally averaged velocities in the neighborhood of the dissolved coarse coordinates. The velocity variables are updated by a momentum conserving scheme. The properties of the stochastic updates are derived through the Chapman-Kolmogorov and Fokker-Planck equations for the evolution of the probability distribution of coarse-grained position and velocity variables, by requiring the equilibrium distribution to be a stationary solution....
Distinct Effect of TCF4 on the NFκB Pathway in Human Primary Chondrocytes and the C20/A4 Chondrocyte Cell Line - Landman, E.B.M.; Periyasamy, P.C.; Blitterswijk, C.A. van; Post, J.N.; Karperien, M.
Objective: Previous studies indicated a difference in crosstalk between canonical WNT pathway and nuclear factor-κB (NFκB) signaling in human and animal chondrocytes. To assess whether the differences found were dependent on cell types used, we tested the effect of WNT modulation on NFκB signaling in human primary articular chondrocytes in comparison with the immortalized human costal chondrocyte cell line C20/A4. Design: We used gene expression analysis to study the effect of WNT modulation on IL1β-induced matrix metalloproteinase (MMP) expression as well as on WNT and NFκB target gene expression. In addition, we tested the involvement of RelA and TCF4 on...
Multipotent Stromal Cells Outperform Chondrocytes on Cartilage-Derived Matrix Scaffolds - Benders, K.E.M.; Boot, W.; Cokelaere, S.M.; Weeren, P.R. van; Gawlitta, D.; Bergman, H.J.; Saris, D.B.F.; Dhert, W.J.A.; Malda, J.
Objective. Although extracellular matrix (ECM)–derived scaffolds have been extensively studied and applied in a number of clinical applications, the use of ECM as a biomaterial for (osteo)chondral regeneration is less extensively explored. This study aimed at evaluating the chondrogenic potential of cells seeded on cartilage-derived matrix (CDM) scaffolds in vitro. Design. Scaffolds were generated from decellularized equine articular cartilage and seeded with either chondrocytes or multipotent stromal cells (MSCs). After 2, 4, and 6 weeks of in vitro culture, CDM constructs were analyzed both histologically (hematoxylin and eosin, Safranin-O, collagen types I and II) and biochemically (glycosaminoglycan [GAG] and DNA...
Towards an international taxonomy of integrated primary care: a Delphi consensus approach - Valentijn, Pim P.; Vrijhoef, Hubertus J.M.; Ruwaard, Dirk; Boesveld, Inge; Arends, Rosa Y.; Bruijnzeels, Marc A.
Developing integrated service models in a primary care setting is considered an essential strategy for establishing a sustainable and affordable health care system. The Rainbow Model of Integrated Care (RMIC) describes the theoretical foundations of integrated primary care. The aim of this study is to refine the RMIC by developing a consensus-based taxonomy of key features.
First, the appropriateness of previously identified key features was retested by conducting an international Delphi study that was built on the results of a previous national Delphi study. Second, categorisation of the features among the RMIC integrated care domains was assessed in a second...
Relation between speckle decorrelation and optical phase conjugation (OPC)- based turbidity suppression through dynamic scattering media: a study on in vivo mouse skin - Jang, Mooseok; Ruan, Haowen; Vellekoop, Ivo M.; Judkewitz, Benjamin; Chung, Euiheon; Yang, Changhuei
Light scattering in biological tissue significantly limits the accessible depth for localized optical interrogation and deep-tissue optical imaging. This challenge can be overcome by exploiting the time-reversal property of optical phase conjugation (OPC) to reverse multiple scattering events or suppress turbidity. However, in living tissue, scatterers are highly movable and the movement can disrupt time-reversal symmetry when there is a latency in the OPC playback. In this paper, we show that the motion-induced degradation of the OPC turbidity-suppression effect through a dynamic scattering medium shares the same decorrelation time constant as that determined from speckle intensity autocorrelation – a popular...
Mothering, fathering, and externalizing behavior in toddler boys - Verhoeven, Marjolein; Junger, Marianne; Aken, Chantal van; Dekovic, Maja; Aken, Marcel A.G. van
This study examined the effects of reported maternal and paternal support, psychological control, and spanking on externalizing behavior of toddler boys. Questionnaires were administered to both parents of 104 two-parent families with a 3-year-old son. Both maternal and paternal psychological control was related to boys' externalizing behavior. Interaction effects were found, in that the association between maternal spanking and boys' externalizing behavior was stronger when levels of maternal support were high. High levels of paternal support strengthened the association between maternal support and boys' externalizing behaviors. Results suggest that the associations between specific parenting dimensions and children's externalizing behavior need...
A short-term longitudinal study of the development of self-reported patenting during toddlerhood - Verhoeven, M.; Junger, M.; Aken, C. van; Dekovic, M.; Aken, M.A.G.
Objective: This study examined four types of stability (factorial equivalence over time, mean-level stability, rank-order stability, and individual-level stability) in five facets of parenting (support, structure, positive discipline, psychological control, and physical punishment) during toddlerhood for both mothers and fathers. Design: Mothers and fathers from 108 intact Dutch families with a son reported about their parenting behavior in three measurement waves when the child was 17, 23, and 29 months of age. Results: Confirmatory factor analyses showed that all five parenting facets measured as invariant over time and across mothers and fathers (factorial equivalence). Support, structure, and physical punishment displayed...