University of Twente Publications
University of Twente Repository provides publications of UT scientific staff, in many cases full text and publicly available.
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Focal salvage iodine-125 brachytherapy for prostate cancer recurrences after primary radiotherapy: a retrospective study regarding toxicity, biochemical outcome and quality of life - Peters, Max; Maenhout, Metha; Voort van Zyp, Jochem R.N. van der; Moerland, Marinus A.; Moman, Maaike R.; Steuten, Lotte M.G.; Deursen, Marijke J.H. van; Vulpen, Marco van
Whole-gland salvage for recurrent prostate cancer (PCa) shows high failure and toxicity rates. Early and adequate localization of recurrences enables focal salvage, thereby potentially improving functional outcomes, while maintaining cancer control.
Materials and methods
Retrospective analysis yielded 20 focal salvage I125 brachytherapy patients for locally recurrent PCa after primary radiotherapy. Tumor was defined by multiparametric MRI and correspondence with transrectal biopsies. Dose data were obtained intra-operatively. The tumor was prescribed ⩾144 Gy. Toxicity was scored by the Common Terminology Criteria for Adverse Events version 4 (CTCAE-4). Biochemical failure (BF) was defined using the Phoenix criteria (PSA-nadir + 2.0 ng/ml). Quality of life...
De datateam® methode: Een concrete aanpak voor onderwijsverbetering - Schildkamp, Kim; Handelzalts, Adam; Poortman, Cindy; Leusink, Hanadie; Meerdink, M.A.; Smit, Maaike; Ebbeler, Johanna; Hubers, Mireille
Hoe kan ik ervoor zorgen dat de meerderheid van mijn leerlingen volgende keer wel een voldoende haalt voor geschiedenis? Hoe krijgen we de toetsresultaten Engels omhoog? Welke nieuwe methode moeten we aanschaffen voor wiskunde? Geven we eigenlijk wel voldoende feedback aan onze leerlingen? Hoe verbeteren we de doorstroom van klas 4 naar klas 5? Is de 6 die ik geeft echt een 6? Elke dag staan schoolleiders en docenten voor tal van beslissingen om de kwaliteit van het onderwijs te bewaken en te verbeteren. Veel van deze beslissingen worden ad hoc en (te) snel genomen, op basis van aannames, anekdotes...
Is an accelerating robot perceived as energetic or as gaining in speed? - Noordzij, Matthijs L.; Schmettow, Martin; Lorijn, Melle R.
Previous studies have found that basic movement characteristics of a robot influence the emotional attributes people perceive independent of the embodiment of the motion (e.g. iCat vs. Roomba). Here, with a very simple LEGO robot, we replicate these associations between levels of acceleration and curvature and the extent to which positive and negative emotions are attributed. Importantly, we also show that these associations might not be valid. Prior to the emotional questionnaires participants were asked neutral questions on what they deemed relevant observations pertaining to the different robot motions. Only 3% of the remarks coincided with the emotional terms found...
What drives the geeks? Linking computer enthusiasm to achievement goals - Schmettow, Martin
The personality construct of geekism is introduced as the tendency to act out one's need for cognition in the domain of computing technology. Achievement goal theory is introduced, and we ask, what drives geeks in terms of achievement. In a questionnaire study, it is shown that geekism is related to achievement motivation in imagined situations with technology. Need for cognition showed strong association with self-oriented achievement goals. A newly created scale for computer enthusiasm seems to reflect performance oriented achievement goals
Optimizing Usability Studies by Complementary Evaluation Methods - Schmettow, Martin; Bach, Cedric; Scapin, Dominique
This paper examines combinations of complementary evaluation methods as a strategy for efficient usability problem discovery. A data set from an earlier study is re-analyzed, involving three evaluation methods applied to two virtual environment applications. Results of a mixed-effects logistic regression suggest that usability testing and inspection discover rather disjunctive sets of problems. A resampling analysis reveals that mixing inspection and usability testing sessions in equal parts finds 20% more problems with the same number of sessions
Internal and external spatial attention examined with lateralized EEG power spectra - Lubbe, Rob H.J. van der; Bundt, Carsten; Abrahamse, Elger L.
Several authors argued that retrieval of an item from visual short term memory (internal spatial attention) and focusing attention on an externally presented item (external spatial attention) are similar. Part of the neuroimaging support for this view may be due to the employed experimental procedures. Furthermore, as internal spatial attention may have a more induced than evoked nature some effects may not have been visible in event related analyses of the electroencephalogram (EEG), which limits the possibility to demonstrate differences. In the current study, a colored frame cued which stimulus, one out of four presented in separate quadrants, required a...
A randomized controlled trial of an Internet-based cognitive–behavioural intervention for non-specific chronic pain: An effectiveness and cost-effectiveness study - Boer, M.J. de; Versteegen, G.J.; Vermeulen, K.M.; Sanderman, R.; Struys, M.M.R.F.
Cognitive–behavioural treatment can nowadays be delivered through the Internet. This form of treatment can have various advantages with regard to availability and accessibility. Previous studies showed that Internet-based treatment for chronic pain is effective compared to waiting-list control groups.
We conducted a randomized controlled trial comparing an Internet-based cognitive–behavioural intervention with e-mail therapist contact to a face-to-face cognitive–behavioural group intervention. Of the 72 participants who were randomly assigned to an Internet or a group course, 50 participants completed the intervention. Participants were assessed at baseline (T0), immediately after the 7-week course (T1) and at the booster session 2 months later (T2)....
Quality assurance in the European policy arena - Enders, Jürgen; Westerheijden, Don F.
Our paper investigates the emergence, development and contested nature of quality assurance (QA) in the European policy arena as part and parcel of the Bologna Process. We conceptualise our paper on the background of the study of multi-level and multi-actor dynamics between national, inter-governmental and supranational policies; we discuss the changing ideational framing of QA in the European policy arena, and attempts at European norm-setting and standardisation. QA in the Bologna Process moved from a non-binding inter-governmental agreement towards monitored coordination and became embedded in the competitive turn in European higher education policy stressing an instrumental view of the university....
How to interest people for the hare instead of the chase, an exploration of open script design to change consumer behaviour - Stam, Liesbeth; Eggink, Wouter
In this paper we raise the question: does our consumer behaviour make us happy? The infinite source of consumer desires seems to be the justification of an ever increasing amount of products that inundate our lives. Consumption itself is set free from any functional bond, bringing our current consumption levels to the point that it is ecologically destructive and unsustainable. By examining philosophical theories of well-being we argue that consumer satisfaction does not of necessity lead to happiness, and we reach the conclusion that it is in the act of appropriation -fitting the acquired artefacts into our lives- that consumption...
What's Holding Back Social Entrepreneurship? Removing the Impediments to Theoretical Advancement - Mueller, Susan; D'Intino, Robert S.; Walske, Jennifer; Ehrenhard, Michel L.; Newbert, Scott L.; Robinson, Jeffrey A.; Senjem, Jason C.
This article summarizes four contributions that were presented in a professional development workshop at the 2013 Academy of Management conference. The goal of the workshop was to discuss impediments to the theoretical advancement of social entrepreneurship. This paper's first two contributors discuss assumptions and boundaries of social entrepreneurship, exhibiting contrasting views of whether theory should be aggregated or disaggregated. The other two scholars focus on specific topics that advance social entrepreneurship research, specifically, studying the implicit normative underpinning of social entrepreneurship and social innovation processes. This is part three of a three-part series dealing with the future of social entrepreneurship...
Unravelling the secret of successful brand extensions: a case study to explore consumer response - Mulder-Nijkamp, Maaike; Eggink, Wouter
In this paper we try to disentangle the design of successful brand extensions and test this with two case studies. Earlier research revealed that typicality and novelty are related to the aesthetic preference of products. Despite the fact these two predictors are also each other’s suppressors, the equilibrium of both will determine aesthetically preferred products. When dealing with brand extensions we assume this effect is even bigger. We discern two approaches to explain this process. On the one hand the new product category with respect to the known brand can be seen as the novel experience of the design. On...
Where's my robot? Integrating human technology relations in the design curriculum - Eggink, Wouter
In today’s society, and in almost every forecast for the future, technology development plays a major role. From theories in Science & Technology Studies we learn that the development of new technology cannot be meaningful unless there are users that successfully adapt the products and services to their own lives. As a result, it is important that designers learn to explore the interrelationships between engineering and behavioural, cultural and social issues. Within our Industrial Design Engineering curriculum we therefore emphasise the influence of technology on human behaviour and vice-versa. Although every specific product and context demands for a specific relation,...
Why designers and philosophers should meet in school - Stam, Liesbeth; Eggink, Wouter
Many scholars who study user-technology relations have shown from different perspectives that such relations are mutually constructive: users shape technology, and technology shapes users. This awareness raises questions about the part a designer plays in the workings of society. Are designers responsible for the social role of their products? Can designers promote the well-being of users and society at large? These questions are still largely absent in design education. In this paper we argue the importance and benefit of integrating concepts from Philosophy of Technology and the related field of Science and Technology Studies (STS) in design education. We will...
Using prior risk-related knowledge to support risk management decisions: lessons learnt from a tunneling project - Chivatá Cárdenas, I.C.; Al-Jibouri, Saad S.H.; Halman, J.I.M.; Linde, W. van de; Kaalberg, F.
The authors of this article have developed six probabilistic causal models for critical risks in tunnel works. The details of the models' development and evaluation were reported in two earlier publications of this journal. Accordingly, as a remaining step, this article is focused on the investigation into the use of these models in a real case study project. The use of the models is challenging given the need to provide information on risks that usually are both project and context dependent. The latter is of particular concern in underground construction projects. Tunnel risks are the consequences of interactions between site-...
Characterizing nanoscale morphologic and mechanical properties of α-synuclein amyloid fibrils with atomic force microscopy - Sweers, K.K.M.; Stöckl, M.T.; Bennink, M.L.; Subramaniam, V.
We have used atomic force microscopy (AFM) to image wild-type and disease-related mutant α-synuclein (aS) amyloid fibrils deposited on various hard and soft surfaces, ranging from freshly cleaved mica to two different supported lipid bilayers: phosphatidylcholine (POPC) and a mixture of POPC and phosphatidylglycerol (POPG). Quantitative morphologic analyses show that fibrils deposited on freshly cleaved mica, gold and glass substrates appeared to have similar heights and lengths, suggesting that the surface–fibril interaction in these cases does not influence the fibril morphology. When the same fibril sample is deposited on HOPG or quartz, the aS fibrils appear shorter in length and...