Recursos de colección

University of Twente Publications (59.137 recursos)

University of Twente Repository provides publications of UT scientific staff, in many cases full text and publicly available.

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Mostrando recursos 1 - 20 de 12.483

  1. Brain-on-a-chip integrated neuronal networks

    Xie, Sijia

  2. Illuminating the structure of borides through X-ray absorption spectroscopy

    Huber, Sebastiaan Philippe

  3. Head-to-head comparison of anti-inflammatory performance of known natural products In Vitro

    Allijn, Iris E.; Vaessen, Stefan F.C.; Quarles van Ufford, Linda C.; Beukelman, Kees J.; Winther, Menno P.J. de; Storm, Gert; Schiffelers, R.M.
    Inflammation is an important therapeutic target. Due to their potency, steroidal drugs dominate the current treatment of inflammatory disorders. However, steroidal drugs can also exert a broad range of side effects and appear not always effective. This calls for the development of alternative drugs with a different mechanism of action, which are likely to be found in the field of natural products (NPs). For many NPs strong anti-inflammatory effects have been described, but usually investigating a single compound in a single assay. In this study, eight promising NPs were selected and tested against the strong anti-inflammatory drug prednisolone. For this...

  4. Comparison of pharmaceutical nanoformulations for curcumin: enhancement of aqueous solubility and carrier retention

    Allijn, Iris E.; Schiffelers, R.M.; Storm, Gert
    Curcumin, originally used in traditional medicine and as a spice, is one of the most studied and most popular natural products of the past decade. It has been described to be an effective anti-inflammatory and anti-cancer drug and protects against chronic diseases such as rheumatoid arthritis and atherosclerosis. Despite these promising pharmacological properties, curcumin is also very lipophilic, which makes its formulation challenging. Ideally the nanocarrier should additionally also retain the encapsulated curcumin to provide target tissue accumulation. In this study we aimed to tackle this aqueous solubility and carrier retention challenge of curcumin by encapsulating curcumin in different nanoparticles. We successfully loaded...

  5. Natural products to target inflammation

    Allijn, Iris Eva

  6. Cucurbit[8]uril ternary complexes for biomolecular assemblies in solution and at interfaces

    Cavatorta, Emanuela

  7. Engineering ferroelectric switching dynamics

    Ghosh, Anirban

  8. Early-time photodynamics of ruthenium-based photocatalysts for light-induced hydrogen generation

    Pan, Qing

  9. Bacteria Delay the Jamming of Particles at Microchannel Bottlenecks

    Sendekie, Zenamarkos Bantie; Gaveau, Arthur; Lammertink, Rob G.H.; Bacchin, Patrice
    Clogging of channels by complex systems such as mixtures of colloidal and biological particles is commonly encountered in different applications. In this work, we analyze and compare the clogging mechanisms and dynamics by pure and mixture suspensions of polystyrene latex particles and Escherichia coli by coupling fluorescent microscopic observation and dynamic permeability measurements in microfluidic filters. Pure particles filtration leads to arches and deposit formation in the upstream side of the microfilter while pure bacteria form streamers in the downstream zone. When mixing particle and bacteria, an unexpected phenomenon occurs: the clogging dynamics is significantly delayed. This phenomenon is related...

  10. Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels

    Henke, S.J.; Leijten, J.C.H.; Kemna, E.W.M.; Neubauer, M.; Fery, A.; Berg, A. van den; Apeldoorn, A.A. van; Karperien, H.B.J.
    Cell-laden micrometer-sized hydrogels (microgels) hold great promise for improving high throughput ex-vivo drug screening and engineering biomimetic tissues. Microfluidics is a powerful tool to produce microgels. However, only a limited amount of biomaterials have been reported to be compatible with on-chip microgel formation. Moreover, these biomaterials are often associated with mechanical instability, cytotoxicity, and cellular senescence. To resolve this challenge, dextran-tyramine has been explored as a novel biomaterial for on-chip microgel formation. In particular, dextran-tyramine is compared with two commonly used biomaterials, namely, polyethylene-glycol diacrylate (PEGDA) and alginate, which crosslink through enzymatic reaction, UV polymerization, and ionic interaction, respectively. Human...

  11. The lonely bystander: ostracism leads to less helping in virtual bystander situations

    Bommel, Marco van; Prooijen, Jan-Willem van; Elffers, Henk; Lange, Paul A.M. van
    People are less likely to help when they have been ostracized, or when they are in the presence of bystanders. In the current manuscript we test both these influences simultaneously. We postulated two opposing hypotheses: first, helping decreases after ostracism, even when intervention is already less likely due to bystander presence. Second, the bystander effect could be reversed, as helping may benefit one’s reputation, especially in the presence of others. After playing Cyberball to manipulate ostracism, participants could help others on either a crowded or empty internet forum. In support of the first hypothesis, we found two main effects: replicating...

  12. The Leadership Role of the Ethicist: Balancing between the Authoritative and the Passive

    Wynsberghe, Aimee van
    The pervasive presence of Information and Communication technologies has profound effects on cultural norms and values. This relationship is most commonly referred to in terms of values embedded in a technology (Nissenbaum, 2001). To mitigate potential threats to values, researchers from a variety of disciplines advocate in favor of incorporating ethics into research and design processes. As Boenink (2013) rightly points out, however, there is little work done that outlines exactly what it is that the ethicist does when engaged in ‘ethics in the lab'. This paper aims to fill the gap that Boenink has identified and to contribute to...

  13. Virtually good?: Disclosing the presuppositions behind the claimed inferiority of virtual worlds

    Søraker, J.H.
    Modern technology has changed the way we live, work, play, communicate, fight, love, and die. Yet few works have systematically explored these changes in light of their implications for individual and social welfare. How can we conceptualize and evaluate the influence of technology on human well-being? Bringing together scholars from a cross-section of disciplines, this volume combines an empirical investigation of technology and its social, psychological, and political effects, and a philosophical analysis and evaluation of the implications of such effects.

  14. Introduction

    MacLeod, Miles; Sumillera, Rocio G.; Surman, Jan; Smirnova, Ekaterina

  15. How language became a tool: The reconceptualisation of language and the empirical turn in seventeenth-century Britain

    MacLeod, Miles

  16. Guest editorial: Knowledge intensive organisations: on the frontiers of knowledge management

    Millar, Carla C.J.M.; Lockett, Martin; Mahon, John F.
    Purpose This paper aims to further research on leadership and knowledge management through formal knowledge strategies in knowledge-intensive organizations (KIOs), and analyse knowledge management challenges and approaches within KIOs, especially tacit knowledge. Design/methodology/approach This paper is based on conceptual and literature research. Findings Managing knowledge as an organizational asset involves how knowledge is obtained, stored and organized, and accessed and shared when needed. This is crucial for KIOs. Knowledge that is not captured, understood and transferred, throughout the organization, is useless. This requires the integration of systems and processes with people and leadership. Tacit knowledge generation and transfer is especially important in KIOs. In particular,...

  17. The team absorptive capacity triad: a configurational study of individual, enabling, and motivating factors

    Löwik, Sandor; Kraaijenbrink, Jeroen; Groen, Aard
    Purpose The paper aims to understand how knowledge-intensive teams can develop and enhance their team absorptive capacity (ACAP) level, by exploring whether individual and organizational factors are complements or substitutes for team ACAP. Design/methodology/approach The study applies a configurational approach using fuzzy-set qualitative comparative analysis to identify combinations of individual and team factors that are associated with team ACAP. Data were gathered through a survey among 297 employees of four medium-sized Dutch firms, working in 48 functional teams. Findings The primary finding is that knowledge-intensive team ACAP depends on a triad of complementary factors: team members’ individual ACAP, factors that enable knowledge integration and factors...

  18. Understanding researchers’ strategic behaviour in knowledge production: a case of social science and nanotechnology researchers

    Zalewska-Kurek, Kasia
    Purpose This paper seeks to understand the strategic behaviour of researchers when producing knowledge in two scientific fields – nanotechnology and social sciences. Design/methodology/approach The author conducted semi-structured interviews with 43 researchers to analyse the needs for strategic interdependence (resource-sharing) and for organisational autonomy (decision-making) in knowledge production. When aligned, these two concepts form three modes of behaviour: mode1, mode2 and mode3. Findings The empirical study results show that, besides well-studied differences in various publications, there are large behaviour differences between social science and nanotechnology researchers. While nanotechnology researchers’ behaviours are mostly in mode3 (sharing resources; highly autonomous), social science researchers’ behaviours tend to be...

  19. Paul Benneworth; Columnist

    Benneworth, Paul
    IWAS cycling to work this morning through the misty forest when I was overtaken by a Nissan Leaf. It gave me a sneaking sense of pride to know that a car in the eastern Netherlands had been made in Sunderland, in one of Europe's most modern, productive factories....

  20. Why after years living abroad I am suddenly fearful for my native North East

    Benneworth, Paul
    Coming home this summer was the first time I experienced serious homesickness as a migrant. I’ve lived happily in the Netherlands for seven years, and coming back home three times a year means it never really feels like we’ve left. It’s a big contrast with my university days, when coming back from Oxford’s stuffy spires and forelock-tugging feudalism brought an upwelling of massive relief. From the moment we leave the ferry at North Shields, it all feels so normal....

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