Predictors of satisfactory improvements in pain for patients with early rheumatoid arthritis in a treat-to-target study - Klooster, Peter M. ten; Vonkeman, Harald E.; Oude Voshaar, Martijn A.H.; Siemons, Liseth; Riel, Piet L.C.M. van; Laar, Mart A.F.J. van de
OBJECTIVE: The aim of this study was to identify baseline predictors of achieving patient-perceived satisfactory improvement (PPSI) in pain after 6 months of treat to target in patients with early RA. METHODS: Baseline and 6 month data were used from patients included in the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study. Simple and multivariable logistic regression analyses were used to identify significant predictors of achieving an absolute improvement of 30 mm or a relative improvement of 50% on a visual analogue scale for pain. RESULTS: At 6 months, 125 of 209 patients (59.8%) achieved an absolute PPSI and 130...
Polymer foam comprising a polymer and nanoparticles, and nanoparticles for the manufacture of such foam. - Vancso, G.J.
A polymer foam is produced comprising a polymer and nanoparticles having a maximum dimensionof 750 nm, which foam has cells with an average cell size of at most 1 µm and a cell density of at least 1012 cells/ml, wherein polymeric grafts have been attached to the nanoparticles. The nanoparticles may be particles with a solid core or porous hollow core-shell particles. The foam can be manufactured by dispersing the nanoparticles in a polymer to yield a dispersion; by adding a blowing agent to the dispersion to obtain an expandable mixture; and by foaming the expandable mixture to obtain the...
The Use of Polysymptomatic Distress Categories in the Evaluation of Fibromyalgia (FM) and FM Severity - Wolfe, Frederick; Walitt, Brian T.; Rasker, Hans; Katz, Robert S.; Häuser, Winfried
Objective The polysymptomatic distress (PSD) scale is derived from variables used in the 2010 American College of Rheumatology (ACR) fibromyalgia (FM) criteria modified for survey and clinical research. The scale is useful in measuring the effect of PSD over the full range of pain-related clinical symptoms, not just in those who are FM criteria-positive. However, no PSD scale categories have been defined to distinguish severity of illness in FM or in those who do not satisfy the FM criteria. We analyzed the scale and multiple covariates to develop clinical categories and to further validate the scale.
Methods FM was diagnosed...
PReVENT - protective ventilation in patients without ARDS at start of ventilation: study protocol for a randomized controlled trial - Simonis, Fabienne D.; Binnekade, Jan M.; Braber, Annemarije; Gelissen, Harry P.; Heidt, Jeroen; Horn, Janneke; Innemee, Gerard; Jonge, Evert de; Juffermans, Nicole P.; Spronk, Peter E.; Steuten, Lotte M.; Tuinman, Pieter Roel; Vriends, Marijn; Vreede, Gwendolyn de; Wilde, Rob B. de; Neto, Ary Serpa; Gama de Abreu, Marcelo; Pelosi, Paolo; Schultz, Marcus J.
It is uncertain whether lung-protective mechanical ventilation using low tidal volumes should be used in all critically ill patients, irrespective of the presence of the acute respiratory distress syndrome (ARDS). A low tidal volume strategy includes use of higher respiratory rates, which could be associated with increased sedation needs, a higher incidence of delirium, and an increased risk of patient-ventilator asynchrony and ICU-acquired weakness. Another alleged side-effect of low tidal volume ventilation is the risk of atelectasis. All of these could offset the beneficial effects of low tidal volume ventilation as found in patients with ARDS.
PReVENT is a national...
MMT-inzetcriteria, (g)een abc'tje? - Bogt, Nancy C.W. ter; Egberink, Rolf; Eenennaam, Fred L.; Wit, Ralph J. de
In Nederland heeft elke veiligheidsregio een eigen meldkamer van waaruit de hulpdiensten
worden aangestuurd. Aan de hand van de openingsvraag kunnen 112-bellers aangeven om
welke hulpverlener wordt gevraagd. In het geval van gezondheidsproblemen wordt de melding
doorgeschakeld naar de Meldkamer Ambulancezorg (MKA). Vervolgens wordt de triage
uitgevoerd door een centralist, in de meeste gevallen een verpleegkundige. In korte tijd moet
de centralist op basis van de beschrijving van de situatie en de patiënt door een omstander
middels een triagemethodiek de urgentie bepalen en het soort inzet. Naast de inzet van een
ambulance kan de centralist ter aanvulling op de reguliere ambulancezorg ook een Mobiel
Medisch Team (MMT) oproepen
Liquefaction of lignocellulose: Do basic and acidic additives help out? - Kumar, S.; Lange, J.P.; Rossum, G. van; Kersten, S.R.A.
Lignocellulosic feedstock can be converted to bio-oil by direct liquefaction in a phenolic solvent such as guaiacol. The bio-oil could then be further upgraded to transportation fuel using conventional oil refining process. The production of heavy components (molecular weight >1000 Da) was found to be a major hurdle in this process as it hinders the efficiency of recycling the bio-oil as liquefaction medium. This paper studies the effect of bases and acids on the liquefaction of biomass and their effectiveness in reducing the formation of heavy components. Acid was found to have a negative effect while all the bases showed...
Opportunities, Constraints and Perceptions of Rural Communities Regarding Their Potential to Contribute to Forest Landscape Transitions Under REDD+: Case Studies from Mexico - Skutsch, M.; Borrego, A.; Morales-Barquero, L.; Paneque-Gálvez, J.; Salinas Melgoza, M.A.; Ramirez, M.I.; Perez-Salicrup, D.; Benet, D.; Monroy, S.; Gao, Y.
In Mexico, REDD+ is being presented as a win-win policy enabling forest communities to benefit financially and diversify their income sources while preserving and increasing their forest carbon stocks through more sustainable management. Under the national programme, it is expected that forest communities will have opportunities to tailor their own approaches. However, to date there is little understanding about what opportunities and constraints exist in reality for forest communities to contribute to REDD+, and even less about how their members perceive these opportunities. We assess potential and constraints at community level and investigate perceptions about opportunities in REDD+ and strategies...
Correcting for differential item functioning in multi-level regression models in cross-national surveys - Jehangir, K.; Berg, S.M. van den; Glas, C.A.W.
Results of the PISA project have shown that the school average socio-economic status is an important background variable that explains a lot of variance in the student results. However, if the socio-economic variable which is measured at the student level is biased across countries due to a cultural bias, then the aggregated variable (at school level) is also subject to error. In this article, DIF (Differential Item Functioning, i.e., item bias) is mitigated using country specific item parameters. The effect of using this approach is studied on the results from multilevel regression for different measurement models and person parameter estimation...
Exploring teacher roles and pupil outcomes in technology-rich early literacy learning - Cviko, A.; Mckenney, Susan; Voogt, J.M.
The present study focused on the involvement of Dutch kindergarten teachers in curriculum (design and) implementation of PictoPal activities in three different roles: executor-only, re-designer, and co-designer. PictoPal refers to ICT-rich on- and off-computer activities for early literacy. In the executor-only role, teachers were not involved in design; they implemented ready-made PictoPal activities in their classes. The re-designer and co-designer roles involved teams of teachers in a purposeful act of adjusting, respectively designing and implementing PictoPal. The aim of this study was to understand how teacher roles influence implementation of PictoPal and pupil learning outcomes. Case studies were used to...
Online co-creating the future of education - Vollenbroek, Wouter; Vries, Sjoerd de
Education in the 21st century must constantly adapt to new situations. New technologies, new legislations, shrinking budgets and increasing commitment of parents affect the current educational structure. Schools at all levels try to make a virtue instead of this problem. They try to seek opportunities, more and more found through collaboration. We propose that networks of educational professionals and stakeholders with common interests and intentions can complement each other in the development of new or improved didactics and teaching methods. In this article we describe this phenomenon by means of examples and identify, classify and analyse the characteristics that determine...
Force limited vibration testing: an evaluation of the computation of C2 for real load and probabilistic source - Wijker, J.J.; Boer, A. de; Ellenbroek, M.H.M.
To prevent over-testing of the test-item during random vibration testing Scharton proposed and discussed the force limited random vibration testing (FLVT) in a number of publications. Besides the random vibration specification, the total mass and the turn-over frequency of the load (test item), is a very important parameter for FLVT. A number of computational methods to estimate are described in the literature, i.e., the simple and the complex two degrees of freedom system, STDFS and CTDFS, respectively. The motivation of this work is to evaluate the method for the computation of a realistic value of to perform a representative random...