Brako, F; Raimi-Abraham, B; Mahalingam, S; Craig, DQM; Edirisinghe, M
Nanofibres from mucoadhesive polymers could combine their material properties with
unique structural characteristics for superior drug delivery performance. However, due
to their chain structure a significant proportion of mucoadhesive polymers such as polysac-
charides cannot be easily spun into fibres. In this study, we demonstrate the possibility of
using polymer blends for the preparation of nanofibres that offer substantial mucoadhesive
capabilities. Fibres from four different polymers were obtained by pressurised gyration at
different working pressures and a rotation speed of 24,000 rpm. Electron microscopy indi-
cates that structurally well-defined fibres with diameters from less than 100 nm upwards
were successfully produced. Quantitative relationships between the physical properties
Grubb, M; Duong, M; Chapuis, T
This paper reviews evidence that technical change in the energy sector has historically responded to external pressures (rather than being an autonomous process) and presents a preliminary analysis of how optimal responses to climate change may alter if abatement efforts induce technology development. This is linked with the inertia that characterises energy system dynamics. An optimising model is developed which takes these dimensions explicitly into account in a highly simplified manner. The model optimises the emissions trajectory given abatement costs which are related explicitly to both the degree and the rate of abatement. Altering the coefficients associated with each of...
Burman, E; Hansbo, P
We extend our results on fictitious domain methods for Poisson’s problem to the case of incompressible elasticity, or Stokes’ problem. The mesh is not fitted to the domain boundary. Instead boundary conditions are imposed using a stabilized Nitsche type approach. Control of the non-physical degrees of freedom, i.e., those outside the physical domain, is obtained thanks to a ghost penalty term for both velocities and pressures. Both inf-sup stable and stabilized velocity pressure pairs are considered.
Evans, SE; Matsumoto, R
© Palaeontological Association July 2015.The Early Cretaceous deposits of the Tetori Group of western Japan have yielded a diverse wetland vertebrate fauna including both aquatic and terrestrial components. The latter include several lizards, three of which have been named and described in detail: Kaganaias hakusanensis, a long-bodied aquatic lizard; Kuwajimalla kagaensis, a herbivorous borioteiioid; and Sakurasaurus shokawensis, a relative of the Chinese Jehol genus Yabeinosaurus. Here we describe lizard material from the Shiramine locality representing five or six additional taxa, three of which are named herein: a small lizard represented by two associations, but of unresolved phylogenetic position; a slightly...
Matsumoto, R; Manabe, M; Evans, SE
A longirostrine choristoderan reptile is described from the Early Cretaceous Tetori Group on the basis of an associated specimen from the Kuwajima Formation, Ishikawa Prefecture. This is the first report of Neochoristodera from Japan. However, the brevirostrine Monjurosuchus has already been reported from the same deposit, and the long-necked Shokawa was recovered from the Okurodani Formation, which is a lateral equivalent of the Kuwajima Formation. This new material demonstrates that the three known choristoderan morphotypes (short-necked longirostrine, short-necked brevirostrine and long-necked brevirostrine) were all present in the Early Cretaceous deposits of the Tetori Group. Until now, the Jiufotang Formation of...
Ólafsdóttir, HF; Barry, C; Saleem, AB; Hassabis, D; Spiers, HJ
Dominant theories of hippocampal function propose that place cell representations are formed during an animal's first encounter with a novel environment and are subsequently replayed during off-line states to support consolidation and future behaviour. Here we report that viewing the delivery of food to an unvisited portion of an environment leads to off-line pre-activation of place cells sequences corresponding to that space. Such 'preplay' was not observed for an unrewarded but otherwise similar portion of the environment. These results suggest that a hippocampal representation of a visible, yet unexplored environment can be formed if the environment is of motivational relevance...
Cuff, AR; Randau, M; Head, J; Hutchinson, JR; Pierce, SE; Goswami, A
The evolution of body mass is a fundamental topic in evolutionary biology, because it is closely linked to manifold life history and ecological traits and is readily estimable for many extinct taxa. In this study, we examine patterns of body mass evolution in Felidae (Placentalia, Carnivora) to assess the effects of phylogeny, mode of evolution, and the relationship between body mass and prey choice in this charismatic mammalian clade. Our data set includes 39 extant and 26 extinct taxa, with published body mass data supplemented by estimates based on condylobasal length. These data were run through 'SURFACE' and 'bayou' to...
Thiruppathy, K; Bajwa, A; Kuan, KG; Murray, C; Cohen, R; Emmanuel, A
Horga, A; Tomaselli, PJ; Gonzalez, MA; Laurà, M; Muntoni, F; Manzur, AY; Hanna, MG; Blake, JC; Houlden, H; Züchner, S; Reilly, MM
OBJECTIVE: To describe the genetic and clinical features of a simplex patient with distal hereditary motor neuropathy (dHMN) and lower limb spasticity (Silver-like syndrome) due to a mutation in the sigma nonopioid intracellular receptor-1 gene (SIGMAR1) and review the phenotypic spectrum of mutations in this gene. METHODS: We used whole-exome sequencing to investigate the proband. The variants of interest were investigated for segregation in the family using Sanger sequencing. Subsequently, a larger cohort of 16 unrelated dHMN patients was specifically screened for SIGMAR1 mutations. RESULTS: In the proband, we identified a homozygous missense variant (c.194T>A, p.Leu65Gln) in exon 2 of...
Loreti, A; Kadokura, R; Fayer, SE; Kövér, A; Laricchia, G
Using a purely positron beam, the total cross section of positrons scattering from H2O has been measured for the first time with a high angular discrimination (≃1°) against forward scattered projectiles. Results are presented in the energy range (10-300) eV. Significant deviations from previous measurements are found which are, if ascribed entirely to the angular acceptances of various experimental systems, in quantitative accord with ab initio theoretical predictions of the differential elastic scattering cross section.
Lane, N; Bhattacharya, S
Deep learning has revolutionized the way sensor data are analyzed and interpreted. The accuracy gains these approaches offer make them attractive for the next generation of mobile, wearable and embedded sensory applications. However, state-of-the-art deep learning algorithms typically require a significant amount of device and processor resources, even just for the inference stages that are used to discriminate high-level classes from low-level data. The limited availability of memory, computation, and energy on mobile and embedded platforms thus pose a significant challenge to the adoption of these powerful learning techniques. In this paper, we propose SparseSep, a new approach that leverages...
Georgiev, P; Lane, ND; Rachuri, KK; Mascolo, C
Mobile apps that use sensors to monitor user behavior often employ resource heavy inference algorithms that make computational offloading a common practice. However, existing schedulers/off loaders typically emphasize one primary offloading aspect without fully exploring complementary goals (e.g., heterogeneous resource management with only partial visibility into underlying algorithms, or concurrent sensor app execution on a single resource) and as a result, may overlook performance benefits pertinent to sensor processing. We bring together key ideas scattered in existing offloading solutions to build LEO - a scheduler designed to maximize the performance for the unique workload of continuous and intermittent mobile sensor...
Mathur, A; Lane, ND; Kawsar, F
In this paper, we examine the potential of using mobile context to model user engagement. Taking an experimental approach, we systematically explore the dynamics of user engagement with a smartphone through three different studies. Specifically, to understand the feasibility of detecting user engagement from mobile context, we first assess an EEG artifact with 10 users and observe a strong correlation between automatically detected engagement scores and user's subjective perception of engagement. Grounded on this result, we model a set of application level features derived from smartphone usage of 10 users to detect engagement of a usage session using a Random...
The dynamics and statistical mechanics of N chaotically evolving point vortices in the doubly periodic domain are revisited. The selection of the correct microcanonical ensemble for the system is first investigated. The numerical results of Weiss and McWilliams [Phys. Fluids A 3, 835 (1991)], who argued that the point vortex system with N=6 is nonergodic because of an apparent discrepancy between ensemble averages and dynamical time averages, are shown to be due to an incorrect ensemble definition. When the correct microcanonical ensemble is sampled, accounting for the vortex momentum constraint, time averages obtained from direct numerical simulation agree with ensemble...
Brede, JL; Orgeta, V
Coughtrey, AE; Pistrang, N
Objectives The telephone is increasingly used to deliver psychological therapies for common mental health problems. This review addressed the following question: are evidence-based psychological therapies for adults with depression and/or anxiety effective in reducing psychological symptoms when delivered over the telephone? Method A systematic search for articles published over a 25-year period (January 1991-May 2016) was performed using the databases PsycINFO, PubMed and Web of Science. Citation searches, manual searches of bibliographies of relevant papers, and hand searches of key journals were also conducted. The quality of the studies included for review was assessed using the Effective Public Health Practice...
Rosello Gilchrist, A; Hayward, AC; Hopkins, S; Horner, C; Ironmonger, D; Hawkey, PM; Deeny, SR
BACKGROUND: Long-term care facilities (LTCFs) are thought to be important reservoirs of antimicrobial-resistant (AMR) bacteria; however, there is no routine surveillance of resistance in LTCF residents, or large population-based studies comparing AMR in LTCFs with the community, so the relative burden of AMR in LTCFs remains unknown.
OBJECTIVES: To compare the frequency of antibiotic resistance of urinary tract bacteria from residents of LTCFs for the elderly and adults aged 70 years or older living in the community.
METHODS: Positive urine specimens reported to any diagnostic microbiology laboratory in the West Midlands region (England) from 1 April 2010 to 31 March 2014 collected...
Sohn, JM; Kim, SJ; Seo, JK; Kim, BJ; Paik, JK
Offshore installations are exposed to hydrocarbon explosions and/or fire accidents. Especially, explosions lead to serious damages to human, safety, and environment. To minimise and prevent the damage from explosions, blast walls are generally installed in oil and gas production structures. Typical blast walls are classified into flat, corrugated, and stiffened types. Among them, corrugated blast walls are frequently used for reasons such as construction, cost, and energy absorption.
However, it has been known that a corrugated type of blast wall buckles between the web and flange under the explosion loads, and loses its stiffness. It means that the buckling phenomenon of...
Rahman, MA; Leggoe, J; Thiagarajan, K; Mohd, MH; Paik, JK
This paper presents a computational fluid dynamics (CFD) study of vortex-induced vibration (VIV) for different aspect ratio (L/D) cylinder. Of particular interest was to measure hydrodynamic forces and numerically investigate the wake behaviour of VIV while varying the aspect ratio. The simulation models represented the actual experimental conditions with idealised free-surface boundary condition to capture the responses from fluid-structure interaction phenomenon. The simulations were performed in the subcritical flow region (7.4×103 < Re < 2×105), corresponding to a range of reduced velocity (Ur) from 2 to 14. The results of the cases studied were discussed and compared with the experimental...
Sohn, JM; Bae, DM; Bae, SY; Paik, JK
This paper is a sequel to the paper dealing with quasi-static responses previously studied by the authors. The structural failure of membrane-type liquefied natural gas carrier (LNGC) cargo tank is an important issue in the construction of ultra-large an LNG carrier. However, quasi-static analysis to investigate the structural failure is difficult and tends to give conservative results. To compensate the weak points of the quasi-static analysis, a procedure for the dynamic analysis was developed to assess the structural failure using nonlinear finite element method. A nonlinear finite element method is employed to model metal membrane, insulation and surface contacts. Various...