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UCL University College London Eprints (345,378 recursos)
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 1 - 20 de 345,087

1. Emotional Processing of Infants Displays in Eating Disorders. - Cardi, V; Corfield, F; Leppanen, J; Rhind, C; Deriziotis, S; Hadjimichalis, A; Hibbs, R; Micali, N; Treasure, J
Aim: The aim of this study is to examine emotional processing of infant displays in people with Eating Disorders (EDs). Background: Social and emotional factors are implicated as causal and maintaining factors in EDs. Difficulties in emotional regulation have been mainly studied in relation to adult interactions, with less interest given to interactions with infants. Method: A sample of 138 women were recruited, of which 49 suffered from Anorexia Nervosa (AN), 16 from Bulimia Nervosa (BN), and 73 were healthy controls (HCs). Attentional responses to happy and sad infant faces were tested with the visual probe detection task. Emotional identification of,...

2. A Relationship between the Transient Structure in the Monomeric State and the Aggregation Propensities of α-Synuclein and β-Synuclein - Allison, JR; Rivers, RC; Christodoulou, JC; Vendruscolo, M; Dobson, CM

3. Development and Validation of a Novel Method to Derive Central Aortic Systolic Pressure From the MR Aortic Distension Curve - Quail, MA; Steeden, JA; Knight, D; Segers, P; Taylor, AM; Muthurangu, V

4. Accuracy and Reproducibility of Right Ventricular Quantification in Patients with Pressure and Volume Overload Using Single-Beat Three-Dimensional Echocardiography - Knight, DS; Grasso, AE; Coghlan, JG; Davar, J; Quail, MA; Muthurangu, V; Taylor, AM; Toumpanakis, C; Caplin, ME
Background: The right ventricle is a complex structure that is challenging to quantify by two-dimensional (2D) echocardiography. Unlike disk summation three-dimensional (3D) echocardiography (3DE), single-beat 3DE can acquire large volumes at high volume rates in one cardiac cycle, avoiding stitching artifacts or long breath-holds. The aim of this study was to assess the accuracy and test-retest reproducibility of single-beat 3DE for quantifying right ventricular (RV) volumes in adult populations of acquired RV pressure or volume overload, namely, pulmonary hypertension (PH) and carcinoid heart disease, respectively. Three-dimensional and 2D echocardiographic indices were also compared for identifying RV dysfunction in PH. Methods:...

5. Novel hybrid positron emission tomography - magnetic resonance (PET-MR) multi-modality inflammatory imaging has improved diagnostic accuracy for detecting cardiac sarcoidosis - Wicks, EC; Menezes, L; Pantazis, A; White, S; O'meara, C; Booth, H; Moon, J; Mckenna, W; Groves, A; Elliott, PM

6. Feasibility and Significance of Preclinical Diagnosis in Hypertrophic Cardiomyopathy. - Efthimiadis, GK; Pagourelias, ED; Hadjimiltiades, S; Meditskou, S; Karvounis, H; McKenna, WJ
Preclinical diagnosis in hypertrophic cardiomyopathy (HCM) refers to the detection of functional or histopathological abnormalities in subjects who carry any HCM-causing gene mutation, before or even without the development of left ventricular hypertrophy [genotype(+) /phenotype(-) subjects]. The concept that HCM pathology, may exist in the absence of left ventricular hypertrophy is quite old but the ability to recognize the presence of early myocardial changes is quite new. Lessons from animal models have shown that in experimental human HCM, myocardial cell mechanical dysfunction precedes histopathological changes, such as myocyte disarray, fibrosis and hypertrophy. Several clinical reports have demonstrated that the majority...

7. Personalized in vitro cancer modeling — Fantasy or reality? - Bartlett, R; Everett, W; Lim, S; Natasha, G; Loizidou, M; Jell, G; Tan, A; Seifalian, AM
With greater technological advancements and understanding of pathophysiology, “personalized medicine” has become a more realistic goal. In the field of cancer, personalized medicine is the ultimate objective, as each cancer is unique and each tumor is heterogeneous. For many decades, researchers have relied upon studying the histopathology of tumors in the hope that it would provide clues to understanding the pathophysiology of cancer. Current preclinical research relies heavily upon two-dimensional culture models. However, these models have had limited success in recreating the complex interactions between cancer cells and the stroma environment in vivo. Thus, there is increasing impetus to shift...

8. Optical Coherence Tomography to Assess Neurodegeneration in Multiple Sclerosis. - Petzold, A
Retinal spectral domain optical coherence tomography (OCT) has emerged as a clinical and research tool in multiple sclerosis (MS) and optic neuritis (ON). This chapter summarizes a short OCT protocol as included in international consensus guidelines. The protocol was written for hands-on style such that both clinicians and OCT technicians can make use of it. The protocol is suitable for imaging of the optic nerve head and macular regions as a baseline for follow-up investigations, individual layer segmentation, and diagnostic assessment.

9. Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography (Ophthalmology 2014;121:573-9). - Oberwahrenbrock, T; Balk, L; Petzold, A; Brandt, AU; Albrecht, P

10. COMPULSIVE VERSIFYING IN TRANSIENT EPILEPTIC AMNESIA - Woollacott, IOC; Fletcher, PD; Massey, LA; Pasupathy, A; Rossor, MN; Rohrer, JD; Warren, JD

11. Climate threats to the earth-built heritage of Scotland - Parkin, SJ; Adderley, WP; Kennedy, CJ; Aktas, YD; D Ayala, D; Erkal, A

12. Laboratory testing of non-standard original historic building materials and related implications for conservation - Erkal, A; D Ayala, D

13. Allosteric signalling in the outer membrane translocation domain of PapC usher. - Farabella, I; Pham, T; Henderson, NS; Geibel, S; Phan, G; Thanassi, DG; Delcour, AH; Waksman, G; Topf, M
PapC ushers are outer-membrane proteins enabling assembly and secretion of P pili in uropathogenic E. coli. Their translocation domain is a large β-barrel occluded by a plug domain, which is displaced to allow the translocation of pilus subunits across the membrane. Previous studies suggested that this gating mechanism is controlled by a β-hairpin and an α-helix. To investigate the role of these elements in allosteric signal communication we developed a method combining evolutionary and molecular dynamics studies of the native translocation domain and mutants lacking the β-hairpin and/or α-helix. Analysis of a hybrid residue interaction network suggests distinct regions (residue...

14. Editorial overview: Membranes: Recent methods in the study of membrane protein structure. - Gonen, T; Waksman, G

15. Reprint of "Biogenesis and adhesion of type 1 and P pili" - Lillington, J; Geibel, S; Waksman, G
Uropathogenic Escherichia coli (UPEC) cause urinary tract infections (UTIs) in approximately 50% of women. These bacteria use type 1 and P pili for host recognition and attachment. These pili are assembled by the chaperone-usher pathway of pilus biogenesis.

16. Bacterial surface appendages as targets for novel antibacterial therapeutics. - Steadman, D; Lo, A; Waksman, G; Remaut, H
The rise of multidrug resistant bacteria is a major worldwide health concern. There is currently an unmet need for the development of new and selective antibacterial drugs. Therapies that target and disarm the crucial virulence factors of pathogenic bacteria, while not actually killing the cells themselves, could prove to be vital for the treatment of numerous diseases. This article discusses the main surface architectures of pathogenic Gram-negative bacteria and the small molecules that have been discovered, which target their specific biogenesis pathways and/or actively block their virulence. The future perspective for the use of antivirulence compounds is also assessed.

17. Biogenesis and adhesion of type 1 and P pili. - Lillington, J; Geibel, S; Waksman, G
Uropathogenic Escherichia coli (UPEC) cause urinary tract infections (UTIs) in approximately 50% of women. These bacteria use type 1 and P pili for host recognition and attachment. These pili are assembled by the chaperone-usher pathway of pilus biogenesis.

18. Electrophysiological Analysis of PapC Mutants Provides Insights into the Mechanism of Plug Displacement - Pham, T; Henderson, NS; Phan, G; Volkan, E; Hultgren, S; Waksman, G; Thanassi, DG; Delcour, AH

19. Ordered and ushered; the assembly and translocation of the adhesive type I and p pili. - Lillington, J; Waksman, G
Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit folding and maintains them in a polymerization-competent state, and an outer membrane-spanning nanomachine, the usher, which choreographs their assembly into a pilus and drives their secretion through the membrane. In this review, recent structures and kinetic studies are combined to examine the mechanism of type I and P pili assembly, as it is currently known. We also investigate how the knowledge of pilus...

20. Infectious respiratory disease in non-HIV immunocompromised patients. - Jose, RJ; Dickey, BF; Brown, JS
This review summarizes current knowledge regarding frequently encountered infectious respiratory complications in adult immunocompromised hosts (excluding those with human immunodeficiency virus (HIV) infection). It discusses the clinical approach to these patients, the usual patterns of disease and the most important pathogens.

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