UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
Recent Advances in Clinical Cellular Immunotherapy - Morris, EC; Lowdell, M
This new edition of Practical Transfusion Medicine benefits from even more international authorship than the previous two editions and is an invaluable resource for trainee doctors, scientists, technicians and other staff in haematology and ...
Portable and wearable dialysis devices for the treatment of patients with end-stage kidney failure: Wishful thinking or just over the horizon? - Davenport, A
Dialysis is a life-sustaining treatment for patients with end-stage kidney disease. In a different context, for many patients this treatment is the focal point around which their life revolves, not only due to the time spent travelling to and from treatment sessions and the time dedicated to the dialysis treatment itself, but also due to the accompanying dietary and fluid restrictions and medication burden. Wearable and portable dialysis devices could potentially improve patient quality of life by allowing patients to continue with their daily activities of life while undergoing dialysis, as well as by loosening-or removing entirely-dietary and fluid restrictions...
Predialysis NTproBNP Predicts Magnitude of Extracellular Volume Overload in Haemodialysis Patients. - Nongnuch, A; Panorchan, K; Davenport, A
Introduction: Increased natriuretic peptides are associated with increased cardiovascular and all-cause mortality for haemodialysis (HD) patients. However, debate continues whether these biomarkers are increased by extracellular water (ECW) excess and can be used to aid clinical assessment of volume status and help determine target weight. Methods: We measured N terminal probrain natriuretic peptide (NT-proBNP) predialysis in 375 stable haemodialysis outpatients with corresponding pre and postdialysis multifrequency bioelectrical impedance assessments (MFBIA) of (ECW)/total body water (TBW). Results: Median age 64 (51-75), 63.9% male, 42.9% diabetic, 43.2% Caucasoid, 14.4% with a history of myocardial infarction, 8.4% coronary artery bypass surgery, dialysis vintage...
How can dialyzer designs improve solute clearances for hemodialysis patients? - Davenport, A
Improvements in dialyzer technology and design have led to a reduction in both dialyzer size and cost, but also dialysis session treatment times as hemodialysis has evolved from using the cellulosic coiled drum dialyzer to the flat plate Kiil, to the current generation of hollow fiber capillary dialyzers. Newer manufacturing techniques have led to smoother, more consistent pore sizes and larger pore sizes increasing middle molecule clearances with the development of higher permeability dialyzers, and changing polymer composition to increase hydraulic permeability. Modifications to the dialyzer casing and capillary fibers can also increase the efficiency of solute clearances. Although very...
The role of bioimpedance and biomarkers in helping to aid clinical decision-making of volume assessments in dialysis patients - Davies, SJ; Davenport, A
Bioimpedance analysis (BIA) derives two main pieces of information - total tissue fluid content, which when referring to the whole patient is equivalent to the total body water (TBW), and cell mass, which in the limbs mainly reflects muscle. The relationship between these measures, expressed in different ways, is abnormal in dialysis patients due to muscle wasting combined with tissue overhydration. In both dialysis modalities this is associated with aging, comorbidity, and inflammation, and there is a conflict between achieving euvolemia to improve blood pressure control and prevent left ventricular hypertrophy on one hand, but risking episodes of hypovolemia and...
Perceived age discrimination in older adults - Rippon, I; de Oliveira, C; Demakakos, P; Steptoe, A; Kneale, D
Objectives: to examine perceived age discrimination in a large representative sample of older adults in England. Methods: this cross-sectional study of over 7,500 individuals used data from the fifth wave of the English Longitudinal Study of Ageing (ELSA), a longitudinal cohort study of men and women aged 52 years and older in England. Wave 5 asked respondents about the frequency of five everyday discriminatory situations. Participants who attributed any experiences of discrimination to their age were treated as cases of perceived age discrimination. Multivariable logistic regression analysis was used to estimate the odds ratios of experiencing perceived age discrimination in...
The (in)operative power: architecture and the reclaim of social relevance - Boano, C; Talocci, G
The following contribution sits in the complex debate around power and architecture and wishes to confront architecture's comfort zone, bringing ‘uncertainty in place of purity’. Acknowledging a new ‘social’ call to arms – reconfiguring architecture’s ethical shift and revitalising participatory neologisms and design activisms – and the expansion of the role of architect, the paper wishes to offer a renewed perspective on design, suggesting a reorientation between politics and aesthetics that would not simply reorder power relations, but create new political subjects too. What follows reflect on the direct experiences of the authors in a research by design activity undertaken...
Sequential digital elevation models of active lava flows from ground-based stereo time-lapse imagery - James, MR; Robson, S
We describe a framework for deriving sequences of digital elevation models (DEMs) for the analysis of active lava flows using oblique stereo-pair time-lapse imagery. A photo-based technique was favoured over laser-based alternatives due to low equipment cost, high portability and capability for network expansion, with images of advancing flows captured by digital SLR cameras over durations of up to several hours. However, under typical field scale scenarios, relative camera orientations cannot be rigidly maintained (e.g. through the use of a stereo bar), preventing the use of standard stereo time-lapse processing software. Thus, we trial semi-automated DEM-sequence workflows capable of handling...