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UCL University College London Eprints (411.881 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 101 - 120 de 66.741

  1. Rhetoric and Reality: You Protect Competitors, We Protect Competition Except When We Protect Competitors

    Wagner-von Papp, F

  2. An optimized strategy to measure protein stability highlights differences between cold and hot unfolded states.

    Alfano, C; Sanfelice, D; Martin, SR; Pastore, A; Temussi, PA
    Macromolecular crowding ought to stabilize folded forms of proteins, through an excluded volume effect. This explanation has been questioned and observed effects attributed to weak interactions with other cell components. Here we show conclusively that protein stability is affected by volume exclusion and that the effect is more pronounced when the crowder's size is closer to that of the protein under study. Accurate evaluation of the volume exclusion effect is made possible by the choice of yeast frataxin, a protein that undergoes cold denaturation above zero degrees, because the unfolded form at low temperature is more expanded than the corresponding...

  3. Actin cortex architecture regulates cell surface tension.

    Chugh, P; Clark, AG; Smith, MB; Cassani, DAD; Dierkes, K; Ragab, A; Roux, PP; Charras, G; Salbreux, G; Paluch, EK
    Animal cell shape is largely determined by the cortex, a thin actin network underlying the plasma membrane in which myosin-driven stresses generate contractile tension. Tension gradients result in local contractions and drive cell deformations. Previous cortical tension regulation studies have focused on myosin motors. Here, we show that cortical actin network architecture is equally important. First, we observe that actin cortex thickness and tension are inversely correlated during cell-cycle progression. We then show that the actin filament length regulators CFL1, CAPZB and DIAPH1 regulate mitotic cortex thickness and find that both increasing and decreasing thickness decreases tension in mitosis. This...

  4. SOLUBLE CD163, A MARKER OF MACROPHAGE ACTIVATION, IS INCREASED IN EARLY ALLOGRAFT DYSFUNCTION AFTER LIVER TRANSPLANTATION

    Thomsen, KL; Jalan, R; Robertson, FP; Holland-Fischer, P; Davidson, BR; Mookerjee, R; Moller, HJ; Gronbaek, H

  5. Addressing the Psychology of Financial Markets

    Tuckett, D

  6. A Psychoanalytic Interpretation of Dot.com Stock Valuations

    Tuckett, D; Taffler, RJ

  7. A Psychoanalytic Interpretation of Dot.com Stock Valuations

    Taffler, RJ; Tuckett, D

  8. ‘My Facebook is a bit of a multiple personality at the minute’: Social Media and the Transition to New Motherhood

    Newhouse, NI; Blandford, A

  9. Becoming Mother: Designing Online Resources That Support And Empower

    Newhouse, NI; Blandford, A

  10. DepthCut: Improved Depth Edge Estimation Using Multiple Unreliable Channels

    Guerrero, P; Winnemöller, H; Li, W; Mitra, NJ
    In the context of scene understanding, a variety of methods exists to estimate different information channels from mono or stereo images, including disparity, depth, and normals. Although several advances have been reported in the recent years for these tasks, the estimated information is often imprecise particularly near depth discontinuities or creases. Studies have however shown that precisely such depth edges carry critical cues for the perception of shape, and play important roles in tasks like depth-based segmentation or foreground selection. Unfortunately, the currently extracted channels often carry conflicting signals, making it difficult for subsequent applications to effectively use them. In...

  11. AUTOMATED ACTIN FILAMENT SEGMENTATION, TRACKING AND TIP ELONGATION MEASUREMENTS BASED ON OPEN ACTIVE CONTOUR MODELS.

    Li, H; Shen, T; Smith, MB; Fujiwara, I; Vavylonis, D; Huang, X
    This paper presents an automated method for actin filament segmentation and tracking for measuring tip elongation rates in Total Internal Reflection Fluorescence Microscopy (TIRFM) images. The main contributions of the paper are: (i) we use a novel open active contour model for filament segmentation and tracking, which is fast and robust against noise; (ii) different strategies are proposed to solve the filament intersection problem, which is shown to be the main difficulty in filament tracking; and (iii) this fully automated method avoids the need of human interaction and thus reduces required time for the entire elongation measurement process on an...

  12. Is FiLaC the answer for more complex perianal fistula?

    Chand, M; Tozer, P; Cohen, RC

  13. Alert to opportunities

    Franklin, BD

  14. Studies on the efficacy of child psychoanalysis.

    Fonagy, P; Moran, GS

  15. TypeLoader: A fast and efficient automated workflow for the annotation and submission of novel full-length HLA alleles.

    Surendranath, V; Albrecht, V; Hayhurst, JD; Schöne, B; Robinson, J; Marsh, SGE; Schmidt, AH; Lange, V
    Recent years have seen a rapid increase in the discovery of novel allelic variants of the human leukocyte antigen (HLA) genes. Commonly, only the exons encoding the peptide binding domains of novel HLA alleles are submitted. As a result, the IPD-IMGT/HLA Database lacks sequence information outside those regions for the majority of known alleles. This has implications for the application of the new sequencing technologies, which deliver sequence data often covering the complete gene. As these technologies simplify the characterization of the complete gene regions, it is desirable for novel alleles to be submitted as full-length sequences to the database....

  16. Equilibrium Scour-Depth Prediction around Cylindrical Structures

    Tavouktsoglou, NS; Harris, JM; Simons, RR; Whitehouse, RJS

  17. Echo-sounder profiles 2D analysis on scour around marine foundations in mixed and layered sediments

    Ferradosa, TF; Taveira-Pinto, F; Oliveira, B; Simons, RR
    Offshore structures, such as wind farms, are usually subject to local scour phenomena, which tend to generate several stability problems. Complex configurations of marine soils, such as layered and mixed configurations, can often be found in offshore foundations. A sustainable solution to this problem implies a deep understanding of its influence in seabed morphology. A laboratory study is presented in this paper in order to analyse the bathymetry’s behaviour during the scour phenomenon in non-cohesive, layered and mixed foundation soils.

  18. Is it time to loosen the restrictions on athletes with cardiac disorders competing in sport?

    Providência, R; Teixeira, C; Segal, O; Ullstein, A; Mueser, KT; Lambiase, P

  19. Catheter ablation for ventricular tachycardia in patients with cardiac sarcoidosis: a systematic review.

    Papageorgiou, N; Providência, R; Bronis, K; Dechering, DG; Srinivasan, N; Eckardt, L; Lambiase, PD
    Aims: Cardiac sarcoidosis (CS) is associated with a poor prognosis. Important features of CS include heart failure, conduction abnormalities, and ventricular arrhythmias. Ventricular tachycardia (VT) is often refractory to antiarrhythmic drugs (AAD) and immunosuppression. Catheter ablation has emerged as a treatment option for recurrent VT. However, data on the efficacy and outcomes of VT ablation in this context are sparse. Methods and results: A systematic search was performed on PubMed, EMBASE, and Cochrane database (from inception to September 2016) with included studies providing a minimum of information on CS patients undergoing VT ablation: age, gender, VT cycle length, CS diagnosis...

  20. Emotion Regulation and Depression: Maintaining Equilibrium between Positive and Negative Affect

    Rice, F; Davidovich, S; Dunsmuir, S
    In this chapter we describe the main features of depression in children and adolescents in terms of symptomatology, epidemiology and risk factors. One way of viewing depression is as an imbalance of positive and negative affect systems. We take a broad view of emotional regulation as comprising responses to, interpretations of and control of emotional material that affect the balance between positive and negative affect and can therefore influence a person’s thoughts and beliefs about themselves and the world around them. We describe cognitive behavioural therapy and behavioural activation as psychological interventions that primarily aim to alter negative and positive...

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