Sunday, May 24, 2015

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía
 

rss_1.0 Recursos de colección

UCL University College London Eprints (354,301 recursos)
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 141 - 160 de 353,913

141. Development of novel pyrrolobenzodiazepines for treatment of skin cancer and actinic keratosis - Haque, T
The pyrrolobenzodiazepines (PBDs) are members of a family of DNA minor-groove binding anticancer agents. Some PBD compounds have very potent in vitro cytotoxicity and in vivo antitumour activities. Topical dosage forms in some cases offer more advantages than oral or parenteral dosage forms as more localised delivery of drug is possible with comparatively lower side effects. However, there are only a few anticancer topical formulations currently available for the treatment of skin cancer. Therefore, the main objective of this project was to develop topical formulations using PBD compounds for the palliative treatment of late stage melanoma patients, and for the...

142. Crowding out the Archivist? Implications of online user participation for archival theory and practice. - Eveleigh, AMM
This thesis charts a course through an emerging landscape of online user participation in archives, focusing upon user involvement at the point of practice known to professional archivists as archival description. Recent years have seen significant growth in participatory initiatives in the archive sector, and the application of Web 2.0 technologies — augmenting traditions of user engagement and volunteering — has been widely heralded as a new opportunity to ‘democratise’ archival practice. The study considers a spectrum of online initiatives which have sought to benefit from the skills or knowledge of diverse user groups: from mass participation ‘crowdsourcing’ transcription projects,...

143. Developing a recombinant model of the P2Y1 and P2Y11 receptor interactions mediating relaxation in gut smooth muscle - Farran, B
ATP and ADP mediate gut smooth muscle relaxation through two receptors, P2Y1 and P2Y11. This project aims to investigate the interaction between these two receptors by developing a recombinant model of the P2Y receptors expressed in gut smooth muscle cells (SMCs) by transfecting the human P2Y11 receptor cDNA into CHO-K1 cells, which express an endogenous P2Y1 receptor. Individual clonal cell lines expressing different densities of hP2Y11 were isolated from this stably-transfected CHO-K1:P2Y11 pool and characterized. A clone expressing a “high” density of hP2Y11 (13) and a clone expressing a “low” density of hP2Y11 (6) were selected for further study. Control...

144. New strategies for protein-to-protein conjugation - Farys, M
Chimeric proteins (e.g. fusion proteins, bispecific antibodies) often have more than one therapeutic function. All of the clinically validated examples (e.g. Enbrel®) are produced using recombinant strategies. Considering the recombinant fusion of two different proteins, there is a need to consider the design of the construct, specifically the polypeptide linker. Challenges remain to make small families of chimeric proteins for preclinical studies as well as to produce these proteins at manufacturing scale. A possible alternative strategy is a recombinant-chemical conjugation approach using separate proteins and heterobifunctional reagents. The concept of conjugating two proteins together has been known for several decades,...

145. The Integration of Magnetic Resonance Imaging in the Diagnostic and Therapeutic Pathway for Localised Prostate Cancer - Dickinson, CL
The current clinical pathway for localised prostate cancer firstly involves serum PSA testing, through screening programmes or ad hoc testing in highrisk or symptomatic men. If the PSA is raised, a transrectal-ultrasound guided biopsy is performed for histological diagnosis for suspected cancer. However, serum Prostate Specific Antigen (PSA) levels are inaccurate in selecting an ‘at-risk’ group for malignancy, and transrectal-ultrasound guided biopsy is a morbid procedure in which approximately 30% of men are under-diagnosed (through missing the disease) or misdiagnosed (through underestimating the true disease burden), therefore misinforming on appropriate management. A proportion of men are ‘over-diagnosed’ with low risk...

146. Heat metering: socio-technical challenges in district-heated social housing - Morgenstern, P; Lowe, R; Chiu, LF
Individual heat metering and charging (IMC) are seen as promising methods to reduce domestic heating and hot water use through the provision of financial incentives. The heat consumption measured by meters is influenced by both the dwelling characteristics and the behaviour of the occupant, but heating charges would ideally relate to occupant behaviour only. This dilemma can be especially relevant under two circumstances: if the thermal performance of the dwelling is poor and/or if heating costs represent a substantial part of the occupants’ income, i.e. in social housing. The case of a district-heated council block in London is presented where...

147. Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. - Naville, M; Ishibashi, M; Ferg, M; Bengani, H; Rinkwitz, S; Krecsmarik, M; Hawkins, TA; Wilson, SW; Manning, E; Chilamakuri, CS; Wilson, DI; Louis, A; Lucy Raymond, F; Rastegar, S; Strähle, U; Lenhard, B; Bally-Cuif, L; van Heyningen, V; FitzPatrick, DR; Becker, TS; Roest Crollius, H
Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage. Here we test this concept experimentally using the human X chromosome. We describe a scoring method to identify evolutionary maintenance of linkage between conserved noncoding elements and neighbouring genes. Chromatin marks associated with enhancer function are strongly correlated with this linkage score. We test >1,000 putative enhancers by transgenesis assays in zebrafish to ascertain the identity of the target gene. The majority of active enhancers drive a transgenic expression in...

148. Molecular chaperones and neuronal proteostasis. - Smith, HL; Li, W; Cheetham, ME
Protein homeostasis (proteostasis) is essential for maintaining the functionality of the proteome. The disruption of proteostasis, due to genetic mutations or an age-related decline, leads to aberrantly folded proteins that typically lose their function. The accumulation of misfolded and aggregated protein is also cytotoxic and has been implicated in the pathogenesis of neurodegenerative diseases. Neurons have developed an intrinsic protein quality control network, of which molecular chaperones are an essential component. Molecular chaperones function to promote efficient folding and target misfolded proteins for refolding or degradation. Increasing molecular chaperone expression can suppress protein aggregation and toxicity in numerous models of...

149. Nano and microcarrier drug delivery systems for the treatment of ocular diseases - Elsaid, N
Background and purpose: Biodegradable polymers, such as PLGA, are delivery vehicles used to treat posterior segment eye disease, but suffer from poor drug loading and initial burst release. This thesis describes a ‘system-within-system’, PLGA microparticles incorporating chitosan-based nanoparticles, for ranibizumab delivery, and chitosan-containing micelles for transscleral rapamycin delivery. Methods: Synthesis of chitosan-N-acetyl-L-cysteine (CNAC) and octanoyl-chitosan-poly (ethylene glycol) (OChiPEG) were confirmed using spectroscopy. Chitosan/TPP, chitosan/TPP-HA, CNAC and CNAC/TPP nanoparticles containing ranibizumab were prepared then incorporated in PLGA microparticles and characterised for their size, zeta potential, morphologies, solid-state properties, morphology, protein loading, stability, release, in vivo antiangiogenic activity and effects on cell...

150. Romantic-Gothic Sepulchres: Intersections of Death, Memory, and Mourning in Film (1907-1958) - De Amil Da Costa Jacob Ramalho, JR
In this study, I explore the representation of death, memory, mourning, and oneirism in specific transnational cinematic works from 1907 to 1958. Looking beyond psychoanalytic theories, I revise current theorisations of the Gothic through a formal-aesthetic methodological lens and propose new, cross-cultural avenues that have been heretofore neglected. I suggest that Romanticism and the Gothic have become catch-all terms whose usage may seem convenient to speak and write about film, but that nonetheless overlook the unique way the Gothic and Romantic doctrines meet and meld on the screen. I work towards an assessment of this singular relationship in cinema—which I...

151. Semiconductor nanowires grown by molecular beam epitaxy for electronics applications - Isakov, I
One-dimensional nanostructures such as semiconductor nanowires are very attractive for application in next generation electronics. This work presents an experimental study of InAs-based and ZnO-based nanowires grown by molecular beam epitaxy for electronics applications. InAs, InAsP and InAsSb nanowires were grown self-catalytically on silicon. Phosphorus incorporation was studied by means of HRTEM, XRD, EDX and PL. The phosphorus incorporation rate was shown to be 10 times smaller than that of arsenic. InAs and InAsP nanowires exhibit the wurtzite structure with a high density of stacking faults and phase boundaries. Conversely, InAsSb nanowires exhibit the zincblende structure with the density of...

152. Illicit Tobacco: Policy Responses, Consumption and Attitudes - Iringe-Koko, IB
The existence of the illicit tobacco trade has serious implications for tobacco control efforts as it encourages smoking by providing tobacco products at a cheaper price. Although this illicit trade has serious ramifications for public health in England, there is very limited data on its nature, the extent of its use and smokers’ views on illicit tobacco. This thesis aimed to address this by utilising a mixed methodology approach which consisted of population based surveys of English smokers and in-depth face-to-face interviews with smokers. Prevalence of illicit tobacco use appeared to decrease between 2007-8 and 2012, but there was an...

153. The sexual health of young British Pakistanis in London: social and cultural influences - Griffiths, C
Background: Pakistanis are the second largest ethnic minority group in the UK. However, there is a paucity of sexual health research among this group. In contrast to their parents’ generation, other South Asians are beginning to have premarital (sexual) relationships. This change may be occurring among young Pakistanis. In this thesis I explore social and cultural influences on the relationships and sexual behaviours of Pakistani youth, in order to determine whether there is unmet sexual health need. Methods: I analysed data from the second National Survey of Sexual Attitudes & Lifestyles (Natsal-2), exploring attitudes, learning about sex and first sexual...

154. The design of a synthetic, bioactive dermal scaffold to assist the healing of chronic, non-healing wounds - Gilmartin, DJ
Chronic ulcers are painful, hard-to-heal wounds. To assist the healing of full-thickness ulcers and burns, engineers have designed scaffolds; synthetic skin substitutes intended to act as a temporary structure to support cell growth and wound regeneration. Remarkably few studies have investigated the effect of scaffolds on healing at the cellular level, however. Owing to the lack of clear evidence, the initial project aim was to investigate the function of scaffolds in vivo, with the hypothesis "scaffolds do not promote healing of full-thickness wounds." After applying fabricated collagen scaffolds to full-thickness wounds, scaffolds appeared to integrate with the wound edge poorly....

155. Assessing the Democratic Effects of Groundwater User Associations in Mexico: The Case of Guanajuato - Gomez Gonzalez Cosio, R
The Mexican water polity underwent a deep process of Neo-liberal Statetransformation, oriented at modifying the relationship between the State and society and through the implementation of a range of State-strategies. These Statestrategies produced a number of drawback and contradictions. One of such strategies was the establishment and institutional development of multi-stakeholder platforms for groundwater resources management (MSPs), a form of socio-political governance arrangement allegedly created to enable a more democratic social participation and stakeholder cooperation throughout the water resources management process. As a result of a ‘critical juncture’ two models of MSPs were established, one supported by the central-State and...

156. Privileged and Staphylococcus aureus Impaired Healing: Is there a Connexin Connection? - Davis, NG
Wound healing is a vital process, ensuring re-establishment of homeostasis and protection from pathogens. A few regions exhibit privileged healing, such as buccal mucosa, repairing very rapidly. In contrast, wound healing can be impaired, creating chronic wounds. Connexins (Cx) are a group of proteins that form gap junctions, enabling direct communication between the cytoplasm of connected cells. They play a pivotal role in normal skin wound healing. Cx43 is involved in cell proliferation and migration, but the roles of Cx26 and Cx30 are less well understood. Connexin expression changes in the privileged healing of buccal mucosa have not previously been...

157. The Role of van der Waals Interactions and Nuclear Quantum Effects in Soft Layered Materials - Graziano, G
Recent years have seen a surge of interest in layered materials, mainly because of their numerous applications, prominently in gas sorption. These materials are highly anisotropic, because of the coexistence of covalent bonds within the individual layers and weak van der Waals (vdW) interactions between layers. Although the anisotropy makes layered materials appealing for many technological applications, it also makes their full theoretical and experimental description difficult. This study has addressed some of the major gaps in our understanding of layered materials using a combination of theoretical and experimental techniques. Computationally, newly developed functionals able to treat both short and...

158. Commercial and Sublime: Popular Astronomy Lectures in Nineteenth Century Britain - Huang, H-F
This thesis discusses the practitioners, sites, curriculums, apparatus and audiences of popular astronomy lecturing in nineteenth-century Britain. Lecturers who were active approximately between 1820 and 1860 are the focus. This thesis emphasises popularisers who were not scientific elites, including C. H. Adams (1803-1871), George Bartley (c. 1782-1858), and D. F. Walker (1778-1865). Activities of private popularisers are compared with those in scientific establishments, such as the Royal Institution. Private entrepreneurs were not inferior to institutional competitors and enjoyed popularity among audiences. Until the 1860s, popular astronomy lecturing was a shared arena of institutional and private popularisers. A theatrical turn occurred...

159. Acts of Creation, Acts of Recollection: Postmemories of Wartime in Claudel and Gaudé - Dias-Mercier, AEV
The relationship between memory and imagination is at the heart of twenty-first century war fiction. This literature engages with the unmaking and remaking of a history that has not been experienced at first hand. The concept of postmemory, developed by Marianne Hirsch with photography as a primary source, examines the role of memory in reconstructing and recollecting history imaginatively and creatively. The act of remembering is transformed into a malleable and innovative activity. This dissertation analyses how the concept of postmemory, when applied to fiction as a form through which to experience unlived memories, approaches experiences of war with a...

160. Trapping ultracold argon atoms - Edmunds, PD
This thesis describes the dipole trapping of both metastable and ground state argon atoms. Metastable argon atoms are first Doppler-cooled down to ∼80 μK in a magneto- optical trap (MOT) on the 4s[3/2]2 to 4p[5/2]3 transitions. These were loaded into dipole traps formed both within the focus of a high-power CO2 laser beam and within an optical build-up cavity. The optical cavity’s well depth could be rapidly modulated: allowing efficient loading of the trap, characterisation of trapped atom temperature, and reduction of intensity noise. Collisional properties of the trapped metastable atoms were studied within the cavity and the Penning and...

 

Busque un recurso