Recursos de colección

UCL University College London Eprints (394.373 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 141 - 160 de 396.874

  1. Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.

    van Hulzen, KJ; Scholz, CJ; Franke, B; Ripke, S; Klein, M; McQuillin, A; Sonuga-Barke, EJ; PGC ADHD Working Group,; Kelsoe, JR; Landén, M; Andreassen, OA; PGC Bipolar Disorder Working Group,; Lesch, KP; Weber, H; Faraone, SV; Arias-Vasquez, A; Reif, A
    BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BPD) are frequently co-occurring and highly heritable mental health conditions. We hypothesized that BPD cases with an early age of onset (≤21 years old) would be particularly likely to show genetic covariation with ADHD. METHODS: Genome-wide association study data were available for 4609 individuals with ADHD, 9650 individuals with BPD (5167 thereof with early-onset BPD), and 21,363 typically developing controls. We conducted a cross-disorder genome-wide association study meta-analysis to identify whether the observed comorbidity between ADHD and BPD could be due to shared genetic risks. RESULTS: We found a significant single nucleotide polymorphism-based...

  2. Editorial IJCS.

    Lintner, K; Lane, ME
    Four years and several months ago…, Tony Rawlings handed me over the IJCS which by that time had acquired the right of citation in Medline and was about to receive its first impact factor. With Majella Lane at my side, we strived to continue the dynamic of its development, the further building of a reputation of scientific integrity, of interesting content and attractiveness for authors, especially in keeping the turnaround times between submission and decision as short as possible. This became more and more difficult as the number of annual submissions went from ≈ 160 in 2013 to an estimated...

  3. English Stop-Smoking Services: One-Year Outcomes.

    Bauld, L; Hiscock, R; Dobbie, F; Aveyard, P; Coleman, T; Leonardi-Bee, J; McRobbie, H; McEwen, A
    The UK is a global leader in stop-smoking support-providing free behavioral support and cessation medication via stop smoking services (SSS) without charge to smokers. This study aimed to explore the client and service characteristics associated with abstinence 52 weeks after quitting. A prospective cohort study of 3057 SSS clients in nine different areas of England who began their quit attempt between March 2012 and March 2013 was conducted. Important determinants of long-term quitting were assessed through quit rates and multivariable logistic regression. Our results showed that the overall weighted carbon monoxide validated quit rate for clients at 52 weeks was...

  4. Perceptual similarity and the neural correlates of geometrical illusions in human brain structure

    Axelrod, V; Schwarzkopf, DS; Gilaie-Dotan, S; Rees, G

  5. Classification and Reconstruction of Compressed GMM Signals with Side Information

    Renna, F; Wang, L; Yuan, X; Yang, J; Reeves, G; Calderbank, R; Carin, L; Rodrigues, MRD

  6. Genotype 4 and the global challenge of hepatitis C treatment

    Ryder, S; Pett, S; Cooke, GS

  7. Intra-arterial transplantation of HLA-matched donor mesoangioblasts in Duchenne muscular dystrophy.

    Cossu, G; Previtali, SC; Napolitano, S; Cicalese, MP; Tedesco, FS; Nicastro, F; Noviello, M; Roostalu, U; Natali Sora, MG; Scarlato, M; De Pellegrin, M; Godi, C; Giuliani, S; Ciotti, F; Tonlorenzi, R; Lorenzetti, I; Rivellini, C; Benedetti, S; Gatti, R; Marktel, S; Mazzi, B; Tettamanti, A; Ragazzi, M; Imro, MA; Marano, G; Ambrosi, A; Fiori, R; Sormani, MP; Bonini, C; Venturini, M; Politi, LS; Torrente, Y; Ciceri, F

  8. Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy

    Moyle, LA; Blanc, E; Jaka, O; Prueller, J; Banerji, CR; Tedesco, FS; Harridge, SDR; Knight, RD; Zammit, PS
    © Moyle et al.Facioscapulohumeral muscular dystrophy (FSHD) involves sporadic expression of DUX4, which inhibits myogenesis and is pro-apoptotic. To identify target genes, we over-expressed DUX4 in myoblasts and found that the receptor tyrosine kinase Ret was significantly up-regulated, suggesting a role in FSHD. RET is dynamically expressed during myogenic progression in mouse and human myoblasts. Constitutive expression of either RET9 or RET51 increased myoblast proliferation, whereas siRNA-mediated knockdown of Ret induced myogenic differentiation. Suppressing RET activity using Sunitinib, a clinically-approved tyrosine kinase inhibitor, rescued differentiation in both DUX4-expressing murine myoblasts and in FSHD patient-derived myoblasts. Importantly, Sunitinib also increased engraftment...

  9. A brief intervention for weight control based on habit-formation theory delivered through primary care: Results from a randomised controlled trial.

    Beeken, RJ; Leurent, B; Vickerstaff, V; Wilson, R; Croker, H; Morris, S; Omar, RZ; Nazareth, I; Wardle, J
    BACKGROUND: Primary care is the 'first port of call' for weight control advice, creating a need for simple, effective interventions that can be delivered without specialist skills. Ten Top Tips (10TT) is a leaflet based on habit-formation theory that could fill this gap. The aim of the current study was to test the hypothesis that 10TT can achieve significantly greater weight loss over three months than 'usual care'. METHODS: A two-arm, individually-randomised, controlled trial in primary care. Adults with obesity were identified from 14 primary care providers across England. Patients were randomised to either 10TT or 'usual care' and followed-up...

  10. A propensity matched case-control study comparing efficacy, safety and costs of the subcutaneous vs. transvenous implantable cardioverter defibrillator.

    Honarbakhsh, S; Providencia, R; Srinivasan, N; Ahsan, S; Lowe, M; Rowland, E; Hunter, RJ; Finlay, M; Segal, O; Earley, MJ; Chow, A; Schilling, RJ; Lambiase, PD
    BACKGROUND: Subcutaneous implantable cardioverter defibrillators (S-ICD) have become more widely available. However, comparisons with conventional transvenous ICDs (TV-ICD) are scarce. METHODS: We conducted a propensity matched case-control study including all patients that underwent S-ICD implantation over a five-year period in a single tertiary centre. Controls consisted of all TV-ICD implant patients over a contemporary time period excluding those with pacing indication, biventricular pacemakers and those with sustained monomorphic ventricular tachycardia requiring anti-tachycardia pacing. Data was collected on device-related complications and mortality rates. A cost efficacy analysis was performed. RESULTS: Sixty-nine S-ICD cases were propensity matched to 69 TV-ICD controls. During...

  11. Adenosine-guided pulmonary vein isolation versus conventional pulmonary vein isolation in patients undergoing atrial fibrillation ablation: An updated meta-analysis.

    Papageorgiou, N; Providência, R; Srinivasan, N; Bronis, K; Costa, FM; Cavaco, D; Adragão, P; Tousoulis, D; Hunter, RJ; Schilling, RJ; Segal, OR; Chow, A; Rowland, E; Lowe, M; Lambiase, PD
    BACKGROUND: Recurrent atrial fibrillation episodes following pulmonary vein isolation (PVI) are frequently due to reconnection of PVs. Adenosine can unmask dormant conduction, leading to additional ablation to improve AF-free survival. We performed a meta-analysis of the literature to assess the role of adenosine testing in patients undergoing atrial fibrillation (AF) ablation. METHODS: PubMed, EMBASE, and Cochrane databases were searched through until December 2015 for studies reporting on the role of adenosine guided-PVI versus conventional PVI in AF ablation. RESULTS: Eleven studies including 4099 patients undergoing AF ablation were identified to assess the impact of adenosine testing. Mean age of the...

  12. Efficacy and safety of ablation for people with non-paroxysmal atrial fibrillation.

    Nyong, J; Amit, G; Adler, AJ; Owolabi, OO; Perel, P; Prieto-Merino, D; Lambiase, P; Casas, JP; Morillo, CA
    BACKGROUND: The optimal rhythm management strategy for people with non-paroxysmal (persistent or long-standing persistent) atrial fibrilation is currently not well defined. Antiarrhythmic drugs have been the mainstay of therapy. But recently, in people who have not responded to antiarrhythmic drugs, the use of ablation (catheter and surgical) has emerged as an alternative to maintain sinus rhythm to avoid long-term atrial fibrillation complications. However, evidence from randomised trials about the efficacy and safety of ablation in non-paroxysmal atrial fibrillation is limited. OBJECTIVES: To determine the efficacy and safety of ablation (catheter and surgical) in people with non-paroxysmal (persistent or long-standing persistent)...

  13. ASL-incorporated pharmacokinetic modelling of PET data with reduced acquisition time: Application to amyloid imaging

    Scott, CJ; Jiao, J; Melbourne, A; Schott, JM; Hutton, BF; Ourselin, S
    © Springer International Publishing AG 2016.Pharmacokinetic analysis of Positron Emission Tomography (PET) data typically requires at least one hour of image acquisition,which poses a great disadvantage in clinical practice. In this work,we propose a novel approach for pharmacokinetic modelling with significantly reduced PET acquisition time,by incorporating the blood flow information from simultaneously acquired arterial spin labelling (ASL) magnetic resonance imaging (MRI). A relationship is established between blood flow,measured by ASL,and the transfer rate constant from plasma to tissue of the PET tracer,leading to modified PET kinetic models with ASL-derived flow information. Evaluation on clinical amyloid imaging data from an Alzheimer’s...

  14. Nuclear incorporation of iron during the eukaryotic cell cycle

    Robinson, I; Yang, Y; Zhang, F; Lynch, C; Yusuf, M; Cloetens, P

  15. Foxp3 activation within effector T-cells controls the antigen-specific T-cell response in the contact hypersensitivity model

    Bending, D; Martin, PP; Day, H; Boon, NJ; Kumar, AS; Heaton, L; Carus, JA; Crompton, T; Tanaka, R; Ono, M

  16. Interaction between maternal obesity and Hedgehog signalling influences immune cell development in the foetal liver

    Li, J; Solanki, A; Cordero, P; Nguyen, V; Katar, C; Vinciguerra, M; Crompton, T; Oben, JA

  17. Gazelle seasonal mobility in the Jordanian steppe: The use of dental isotopes and microwear as environmental markers, applied to Epipalaeolithic Kharaneh IV.

    Henton, E; Martin, L; Garrard, A; Jourdan, A-L; Thirlwall, M; Boles, O

  18. The "Permanent" Component of NBTI Revisited: Saturation, Degradation-Reversal, and Annealing

    Grasser, T; Waltl, M; Rzepa, G; Goes, W; Wimmer, Y; El-Sayed, A-M; Shluger, AL; Reisinger, H; Kaczer, B

  19. Splicing repression allows the gradual emergence of new Alu-exons in primate evolution.

    Attig, J; Ruiz de Los Mozos, I; Haberman, N; Wang, Z; Emmett, W; Zarnack, K; König, J; Ule, J
    Alu elements are retrotransposons that frequently form new exons during primate evolution. Here, we assess the interplay of splicing repression by hnRNPC and nonsense-mediated mRNA decay (NMD) in the quality control and evolution of new Alu-exons. We identify 3100 new Alu-exons and show that NMD more efficiently recognises transcripts with Alu-exons compared to other exons with premature termination codons. However, some Alu-exons escape NMD, especially when an adjacent intron is retained, highlighting the importance of concerted repression by splicing and NMD. We show that evolutionary progression of 3' splice sites is coupled with longer repressive uridine tracts. Once the 3'...

  20. Flexible head-casts for high spatial precision MEG.

    Meyer, SS; Bonaiuto, J; Lim, M; Rossiter, H; Waters, S; Bradbury, D; Bestmann, S; Brookes, M; Callaghan, MF; Weiskopf, N; Barnes, GR
    BACKGROUND: In combination with magnetoencephalographic (MEG) data, accurate knowledge of the brain's structure and location provide a principled way of reconstructing neural activity with high temporal resolution. However, measuring the brain's location is compromised by head movement during scanning, and by fiducial-based co-registration with magnetic resonance imaging (MRI) data. The uncertainty from these two factors introduces errors into the forward model and limit the spatial resolution of the data. NEW METHOD: We present a method for stabilizing and reliably repositioning the head during scanning, and for co-registering MRI and MEG data with low error. RESULTS: Using this new flexible and...

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