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UCL University College London Eprints (396.156 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 141 - 160 de 398.603

  1. Genetic improvement of GPU software

    Langdon, WB; Lam, BYH; Modat, M; Petke, J; Harman, M
    We survey genetic improvement (GI) of general purpose computing on graphics cards. We summarise several experiments which demonstrate four themes. Experiments with the gzip program show that genetic programming can automatically port sequential C code to parallel code. Experiments with the StereoCamera program show that GI can upgrade legacy parallel code for new hardware and software. Experiments with NiftyReg and BarraCUDA show that GI can make substantial improvements to current parallel CUDA applications. Finally, experiments with the pknotsRG program show that with semi-automated approaches, enormous speed ups can sometimes be had by growing and grafting new code with genetic programming...

  2. Particle-based simulation of ellipse-shaped particle aggregation as a model for vascular network formation

    Palachanis, D; Szabó, A; Merks, RMH
    Computational modeling is helpful for elucidating the cellular mechanisms driving biological morphogenesis. Previous simulation studies of blood vessel growth based on the cellular Potts model proposed that elongated, adhesive or mutually attractive endothelial cells suffice for the formation of blood vessel sprouts and vascular networks. Because each mathematical representation of a model introduces potential artifacts, it is important that model results are reproduced using alternative modeling paradigms. Here, we present a lattice-free, particle-based simulation of the cell elongation model of vasculogenesis. The new, particle-based simulations confirm the results obtained from the previous cellular Potts simulations. Furthermore, our current findings suggest...

  3. The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 1: olaparib

    Miller, RE; Ledermann, JA
    Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors have shown promising clinical activity in epithelial ovarian cancer. Following the observation in vitro that PARP inhibition is synthetically lethal in tumors with BRCA mutations, PARP inhibition has become the first genotype-directed therapy for BRCA1- and BRCA2-associated ovarian cancer. However, it is becoming clear that PARP inhibition also may have clinical utility in cancers associated with defects or aberrations in DNA repair that are unrelated to BRCA mutations. Deficient DNA repair mechanisms are present in approximately 30% to 50% of high-grade serous ovarian cancers, the most common histologic subtype. Olaparib is the best-studied PARP inhibitor...

  4. Stabilisation of metastable polymorphs: the case of paracetamol form III

    Telford, R; Seaton, CC; Clout, A; Buanz, A; Gaisford, S; Williams, GR; Prior, TJ; Okoye, CH; Munshi, T; Scowen, IJ
    The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.

  5. Nomenclature for factors of the HLA system, update December 2015

    Marsh, SG; WHO Nomenclature Committee for Factors of the HLA System, .

  6. Nomenclature for factors of the HLA system, update November 2015

    Marsh, SG; WHO Nomenclature Committee for Factors of the HLA System, .

  7. Nomenclature for factors of the HLA system, update October 2015

    Marsh, SG; WHO Nomenclature Committee for Factors of the HLA System, .

  8. HLA Immunogenotype Determines Persistent Human Papillomavirus Virus Infection in HIV-Infected Patients Receiving Antiretroviral Treatment

    Meys, R; Purdie, KJ; de Koning, MNC; Quint, KD; Little, A-M; Baker, F; Francis, N; Asboe, D; Hawkins, D; Marsh, SGE; Harwood, CA; Gotch, FM; Bunker, CB
    A proportion of human immunodeficiency virus (HIV)–infected patients develop persistent, stigmatizing human papillomavirus (HPV)–related cutaneous and genital warts and anogenital (pre)cancer. This is the first study to investigate immunogenetic variations that might account for HPV susceptibility and the largest to date to categorize the HPV types associated with cutaneous warts in HIV-positive patients. The HLA class I and II allele distribution was analyzed in 49 antiretroviral (ART)–treated HIV-positive patients with persistent warts, 42 noninfected controls, and 46 HIV-positive controls. The allele HLA-B*44 was more frequently identified in HIV-positive patients with warts (P = .004); a susceptible haplotype (HLA-B*44, HLA-C*05; P...

  9. Perspectives on the role and synergies of architecture, social and built environment in enabling active healthy ageing.

    Chrysikou, E; Rabnett, R; Tziraki, C
    Research has demonstrated active and healthy aging can be enhanced by enabling societal infrastructure, urban planning, architecture of healthcare facilities and personal accommodations throughout the life span. Yet, there is a paucity of research on how to bring together the various disciplines involved in a multi-domain synergistic collaboration to create new living environments for aging throughout the life span. This paper aims to explore the key domains of skills and knowledge that need to be considered in order to generate a conceptual prototype of an enabling educational process and environment where healthcare professionals, architects, planners and entrepreneurs may establish a...

  10. Simulating the universe(s) Ill: observables for the full bubble collision spacetime

    Johnson, MC; Wainwright, CL; Aguirre, A; Peiris, HV
    This is the third paper in a series establishing a quantitative relation between inflationary scalar field potential landscapes and the relic perturbations left by the collision between bubbles produced during eternal inflation. We introduce a new method for computing cosmological observables from numerical relativity simulations of bubble collisions in one space and one time dimension. This method tiles comoving hypersurfaces with locally-perturbed Friedmann-Robertson-Walker coordinate patches. The method extends previous work, which was limited to the spacetime region just inside the future light cone of the collision, and allows us to explore the full bubble-collision spacetime. We validate our new methods...

  11. Gaining approval for clinical research.

    Cobb, V; Srinivasan, N; Lambiase, P
    Set-up and delivery of a clinical research project can be complicated and difficult. This article introduces the regulatory processes involved in gaining approval for clinical research and discusses the obstacles that may be encountered.

  12. Review of the Conservation Strategy for cheetah and African wild dog in southern Africa

    Groom, R; Durant, S; Breitenmoser-Wursten, C
    At the end of 2007, a workshop was held to develop a Regional Conservation Strategy RCS for cheetah Acinonyx jubatus and African wild dog Lycaon pictus in southern Africa (IUCN/SSC 2007). The strategy was to form a framework for the development of conservation action plans for cheetah and wild dog in all range states. The regional workshop was conducted as a partnership between National Wildlife Authorities, the IUCN/SSC Cat and Canid Specialist Groups and the Range Wide Conservation Program for Cheetah and African Wild Dogs RWCP. Here we report on the revision of the RCS that took place in August...

  13. Planning and implementing a targeted and strategic dissemination plan for a Cochrane review: a case study

    Jones, K; Hollands, GJ; Shemilt, I; Doyle, J; Armstrong, R

  14. Landslide susceptibility modelling applying user-defined weighting and data-driven statistical techniques in Cox's Bazar Municipality, Bangladesh

    Ahmed, B
    Landslides are common geophysical hazards in the highly urbanized hilly areas of Cox’s Bazar Municipality, Bangladesh. Every year, during the monsoon, landslides cause human casualties, property damage, and economic losses. Indiscriminate hill cutting, developing settlements in dangerous hill slopes, and torrential rainfall in short period of time are responsible for triggering landslide disasters. The aim of this paper is to produce landslide susceptibility maps (LSM) to help reduce the risks of landslides. Geographic information system and remote sensing-based techniques were used for LSM considering 12 relevant factor maps (i.e. slope, land cover, NDVI, geology, geomorphology, soil moisture, rainfall pattern, distance...

  15. Evaluation of an Organisational Intervention to Promote Integrated Working between Health Services and Care Homes in the Delivery of End-of-Life Care for People with Dementia: Understanding the Change Process Using a Social Identity Approach

    Amador, S; Goodman, C; Mathie, E; Nicholson, C
    In the United Kingdom, approximately a third of people with dementia live in long-term care facilities for adults, the majority of whom are in the last years of life. Working arrangements between health services and care homes in England are largely ad hoc and often inequitable, yet quality end-of-life care for people with dementia in these settings requires a partnership approach to care that builds on existing practice. This paper reports on the qualitative component of a mixed method study aimed at evaluating an organisational intervention shaped by Appreciative Inquiry to promote integrated working between visiting health care practitioners (i.e. General...

  16. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

    Chouchani, EE; Pell, V; Gaude, E; Aksentijevic, D; Sundier, S; Duchen, M; Shattock, M; Frezza, C; Krieg, T; Murphy, M

  17. Memories of Phil Bryden

    Corballis, MC; McManus, IC; Bulman-Fleming, MB
    Phil Bryden was a seminal figure in the development of the field of cerebral lateralization in the last half of the twentieth century, and a founding editor of this journal. Here his founding co-editors reminisce about their friend and colleague, and reflect on his wide-ranging influence in the field and in their own careers.

  18. The Tapley and Bryden test of performance differences between the hands: the original data, newer data, and the relation to pegboard and other tasks

    McManus, IC; Van Horn, JD; Bryden, PJ
    Tapley and Bryden (T&B)’s 1985 circle-marking task is a group-administered task assessing performance differences between the hands. The bimodal distribution clearly separates self-described right- and left-handers. Using Phil's original datafiles we analyse the test in more detail, providing raw scores for each hands which are useful forensically, and we provide reliability estimates. Van Horn's unpublished 1992 PhD thesis studied T&B tasks and Annett pegboards varying in difficulty. A striking finding, that Phil Bryden called “the Van Horn problem,” was that hand differences (R − L) were unrelated to task difficulty. That result was the starting point for Pamela Bryden's 1998 thesis, firstly...

  19. One Face of Chlamydia trachomatis: The Infectious Elementary Body

    Cossé, MM; Hayward, RD; Subtil, A
    The lifestyle of Chlamydiae is unique: the bacteria alternate between two morphologically distinct forms, an infectious non-replicative elementary body (EB), and a replicative, non-infectious reticulate body (RB). This review focuses on recent advances in understanding the structure and function of the infectious form of the best-studied member of the phylum, the human pathogen Chlamydia trachomatis. Once considered as an inert particle of little functional capacity, the EB is now perceived as a sophisticated entity that encounters at least three different environments during each infectious cycle. We review current knowledge on its composition and morphology, and emerging metabolic activities. These features...

  20. Results from a multicentre comparison of cryoballoon vs. radiofrequency ablation for paroxysmal atrial fibrillation: is cryoablation more reproducible?

    Providencia, R; Defaye, P; Lambiase, PD; Pavin, D; Cebron, JP; Halimi, F; Anselme, F; Srinivasan, N; Albenque, JP; Boveda, S
    AIM: Cryoballoon ablation (Cryoballoon) has emerged as a new alternative for the treatment of symptomatic drug-refractory atrial fibrillation (AF). Whether the results of Cryoballoon are more reproducible than those of radiofrequency (RF) ablation remains to be proved. METHODS AND RESULTS: A total of 860 consecutive patients undergoing a first ablation procedure for paroxysmal AF (467 treated with RF and 393 treated with Cryoballoon) were selected from a prospective multicentre survey of AF ablation (FrenchAF). Radiofrequency and Cryoballoon were compared regarding mid-term efficacy and safety. During a median follow-up of 14 months (interquartile range 8-23), patients treated with Cryoballoon displayed similar...

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