UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
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Cerebral microbleeds as a marker of small vessel disease: new insights from neuro-imaging and clinical studies in stroke patients - Gregoire, SMF
Introduction: A portfolio of studies is presented aimed at understanding the clinical and pathophysiological significance of cerebral microbleeds (CMBs) in stroke patients. CMBs are the radiological marker of microscopic haemosiderin deposits on iron-sensitiveMRI sequences (mainly gradient-recalled echo [GRE] T2* MRI). They are common in patients with cerebrovascular disease and are hypothesised to be a biomarker for brain small vessel diseases, including hypertensive arteriopathy and cerebral amyloid angiopathy (CAA). Important questions relating to CMBs include their use as a prognostic marker for antithrombotic-related intracerebral haemorrhage (ICH) and cognitive impairment. Our aims were to address the pathophysiological and clinical relevance of CMBs...
The foundations of lesion-function inference in the human brain - Mah, Y
Understanding the functional architecture of the brain has long been a challenge in neuroscience with a variety of techniques having been developed to explore this structure-function relationship. However, in order to be able to accurately identify the underlying system we require techniques that have the capabilities of describing the complexities therein. In order to perform lesion-function studies a cohort of brain scans with the location of the lesion identified must be collected. Utilising diffusion weighted magnetic resonance imaging, normally collected in the clinical setting, I propose a new unsupervised lesion segmentation routine. The cohort of brain scans also need to...
First-principles investigation of negative thermal expansion in II-VI semiconductors - Wang, L; Yuan, P-F; Wang, F; Sun, Q; Liang, E-J; Jia, Y; Guo, Z-X
Within the framework of first-principles, all II-VI semiconductors with cubic zinc blende structure have negative thermal expansion (NTE) behavior at low temperatures. Negative mode Grüneisen parameters are found for two transverse acoustic (TA) branches near the Brillouin-zone boundaries. Through the analysis of vibrational modes, it shows that the librational mode which brings about the bond tension effect by atomic motions perpendicular to the bonds can contribute to the NTE. Related thermodynamic properties of II-VI semiconductors have also been studied. It is demonstrated that with increased ionic radius and atomic mass, the variety of electronegativity can cause more covalent character in...
Creating an open geodemographic classification using the UK Census of the Population - Gale, CG
The 2011 Area Classification for Output Areas (2011 OAC) is a new open geodemographic classification of the UK based on 2011 UK Census data. The 2011 OAC, created in partnership with the Office for National Statistics (ONS), supersedes the 2001 Area Classification for Output Areas (2001 OAC) to provide the most current open geodemographic view of the UK. The 2001 OAC was widely used in academia, local government and by commercial organisations, but its reliance on data from the 2001 UK Census has led to a perceived degradation of reliability over time and a decline in users. The release of...
Self-efficacy and health-related quality of life in family carers of people with dementia: A systematic review - Crellin, NE; Orrell, M; McDermott, O; Charlesworth, G
Conclusions: The model might have theoretical implications in guiding future research and advancing theoretical models of caring. It might also have clinical implications in facilitating the development of carer support services aimed at improving SE. The review highlights the need for future research, particularly longitudinal research, and further exploration of domain/task-specific SE beliefs, the influence of carer characteristics, and other mediating/moderating variables.
Oral calorie supplements for cystic fibrosis. - Smyth, RL; Rayner, O
Poor nutrition occurs frequently in people with cystic fibrosis (CF) and is associated with other adverse outcomes. Oral calorie supplements are used to increase total daily calorie intake and improve weight gain. However, they are expensive and there are concerns they may reduce the amount of food eaten and not improve overall energy intake.
Adrenal Responses to a Low Dose Short Synacthen Test in Children with Asthma. - Hawcutt, DB; Jorgensen, AL; Wallin, N; Thompson, B; Peak, M; Lacy, D; Newland, P; Didi, M; Couriel, J; Blair, J; Pirmohamed, M; Smyth, RL
Corticosteroids are known to cause adrenal suppression. The aim of this study was to assess clinical factors affecting responses to a Low Dose Short Synacthen Test (LDSST) in asthmatic children using corticosteroids.