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UCL University College London Eprints (356,388 recursos)
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 141 - 160 de 360,201

141. Aspects of Processing in the Visual Thalamus; Context, Correlations, and Re–entrant Signals - Andolina, IM
The act of seeing appears effortless, yet it’s a perceptual sense whose processing occupies a large percentage of the neurons of our central nervous system. One fascinating conundrum of this mass of neurons is the following: the brain region receiving most of the input coming directly from the eyes (the dorsal lateral geniculate nucleus; dLGN) only receives some 6–10% of its input from the eyes! At this very first stage of visual processing, the incoming sensory information is modified and augmented by a whole plethora of connections from other parts of the brain. For the dLGN the numerically dominant inputs...

142. The role of ALS associated genes and c-Jun in neurodegeneration - Acosta Saltos, AD
The molecular pathways mediating motor neuron degeneration in Amyotrophic lateral sclerosis and axonal regeneration following peripheral nerve injury remain elusive. The transcription factor c-Jun, an important orchestrator of axonal regeneration, has been found upregulated in the spinal cord of ALS cases and the SOD1G93A mouse model of the disease. However the functional role of c-Jun in ALS degeneration has not been defined. The current thesis demonstrates that genetic deletion of c-Jun from neurons and neuroglia prolonged the lifespan of SOD1G93A mice. Associated with this effect on survival, motor neuron loss, axonal loss and neuroinflammation were attenuated in c-Jun deficient SOD1G93A...

143. Developmental function of Drosophila RASSF9 and RASSF10 - Banerjee, JJ
Cell polarity is a fundamental property of most living cells, and its disruption is associated with diseases such as cancer. Members of the N-terminal RASSF protein family have been proposed to function as tumour suppressors and oncogenes, but the underlying mechanisms are not well understood. Proteomic approaches have recently linked the human N-terminal RASSFs to PP1 phosphatases, as well as its regulatory subunit ASPP and two RASSFs - RASSF9 and RASSF10 - showed additional associations to both planar cell polarity (PCP) proteins and the apical-basal polarity determinant Par3/Bazooka. This thesis investigates the developmental function of RASSF9 and RASSF10 in Drosophila....

144. The development and testing of an oral health-related quality of life measure for children/adolescents with Down syndrome (OH-QOLADS) - Aljameel, AHM
Background: Down Syndrome is the most common genetic cause of intellectual disabilities. In addition, it is the most common chromosomal anomaly among liveborn infants. Individuals with this condition exhibit special oro-facial characteristics that increase their risk of oral conditions. The impact of oro-facial conditions on individuals may be related closely to their oral health (such as pain, discomfort, and in severe cases tooth loss), but can also extend to broader effects on personal relationships, emotional status and Quality of Life (QoL). However, there is very little research on the way oral health affects QoL of people with Down Syndrome. Aim:...

145. Regulation of adipogenesis and inflammation: role(s) of adipose microRNAs - Al-Jabir, MJMH
Background: Obesity is associated with elevated risk of premature death and a range of co- morbidities. It is multifactorial and heterogeneous in origin, and, stratification of this disease, depending on the range of associated pathogenicities could help identify mediators and in the design of targeted therapies. Recent research has focused on microRNA (miRs) as potential biomarkers of cardiovascular risk, as well as their role as causative agents in the obesity associated pathologies. / Aims of the project were to: / 1. Stratify obese subjects depending on systemic biomarkers of insulin resistance and inflammation. / 2. Identify and validate specific miRs...

146. Innovative solutions and applications for polymer light-emitting diodes - Bausi, F
This work focuses on the development of new technical solutions for polymer light-emitting diodes (PLEDs). Treatments were developed to use innovative materials, such as graphene and carbon nanotubes, as hole-transporting layers and surface modifiers on top of ITO. A processing treatment for the preparation of the polymeric emissive layer of PLEDs was also investigated which allowed the improvement of the on/off switching speed of the devices thus enabling their employment in novel applications for visible light communications. Graphene-based transparent thin films obtained via the exfoliation of graphite in the liquid phase were produced with a view of using them as...

147. Synthesis and catalytic performance of hierarchically structured zeolitic materials - Adedigba, A-LA
The work presented in this dissertation involves the investigation of the synthesis methodology of hierarchically structured zeolite and their catalytic performances. To create these materials, an inert templating agent, chitosan, as macro-template was used along with microporous templating agent to produce titanosilicate, aluminosilicate and titano-aluminosilicate systems with MFI structure. Firstly, synthesis of the titanosilicate (TS-1) system was carried out. It was found that, while the use of chitosan did not affect production of crystalline, phase pure TS-1, the preparation of precursors indeed is an important factor in the insertion of titanium in the silicalite structure. A range of characterisation methods...

148. A girl who paints - Sheleg, M

149. Polyarteritis nodosa associated with necrosis of the tongue: A rare presentation in an adult patient - Ciurtin, C; Shirodaria, A; Manson, J; Macmillan, R
© 2015 The British Association of Oral and Maxillofacial Surgeons. Polyarteritis nodosa is a rare form of vasculitis of the medium-sized vessels, which leads to the formation of microaneurysms, thrombosis, organ ischaemia, and necrosis. Involvement of the oral cavity is rare. To our knowledge, this is the first case of localised polyarteritis nodosa in an adult with ulceration of the tongue and necrosis at the onset of the disease. The patient made a full recovery after the use of strong immunosuppressants.

150. A case study of an early Islamic city in Transoxiana: Excavations at the medieval citadel in Taraz, Kazakhstan - Dawkes, G; Jorayev, G
© 2015. This report presents a summary of the 2011 and 2012 excavations of the joint UK-Kazakhstani excavations in the medieval citadel of Taraz. The city of Taraz, located near the southern border with Uzbekistan, is one of the most significant historic settlements in Kazakhstan, and the investigations in the central market place have started to reveal the composition of the medieval city. Despite frequent mentions in Arabic and Chinese written sources, the form and evolution of this important Silk Road city remains poorly understood. These excavations, which identified a series of buildings including a bathhouse and a fire shrine,...

151. Determination of physical and chemical stability in pressurised metered dose inhalers: potential new techniques - Ooi, J; Traini, D; Boyd, BJ; Gaisford, S; Young, PM
INTRODUCTION: Pressurised metered dose inhalers (pMDIs) are subject to rigorous physical and chemical stability tests during formulation. Due to the time and cost associated with product development studies, there is a need for online techniques to fast screen new formulations in terms of physical and chemical (physico-chemical) stability. The problem with achieving this is that pMDIs are by their definition, pressurised, making the direct observation of physico-chemical properties in situ difficult. AREAS COVERED: This review highlights the characterisation tools that can enhance the product development process for pMDIs. Techniques investigated include: laser diffraction, Raman spectroscopy, isothermal ampoule calorimetry, titration calorimetry...

152. Should Google's Secret Sauce be Organic? - Wagner-Von Papp, FH
This commentary discusses the European antitrust investigation into Google and the international implications of the case. It focuses on Google's alleged dominance and the allegations concerning Google’s self-preferencing of its Google Shopping results on general web search result pages, which form the subject matter of the Statement of Objections that the Commission sent on 15 April 2015. The EU Commission's international jurisdiction to prescribe is found to be unproblematic. However, the tendency towards overenforcement resulting from the cumulation of national and supranational investigations by competition authorities worldwide counsels caution in borderline cases. And Google is a borderline case. While it...

153. Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations. - Bannister, K; Patel, R; Goncalves, L; Townson, L; Dickenson, AH
Diffuse noxious inhibitory controls (DNICs) utilize descending inhibitory controls through poorly understood brain stem pathways. The human counterpart, conditioned pain modulation, is reduced in patients with neuropathy aligned with animal data showing a loss of descending inhibitory noradrenaline controls together with a gain of 5-HT3 receptor-mediated facilitations after neuropathy. We investigated the pharmacological basis of DNIC and whether it can be restored after neuropathy. Deep dorsal horn neurons were activated by von Frey filaments applied to the hind paw, and DNIC was induced by a pinch applied to the ear in isoflurane-anaesthetized animals. Spinal nerve ligation was the model of...

154. Genome-wide Polygenic Burden of Rare Deleterious Variants in Sudden Unexpected Death in Epilepsy - Leu, C; Balestrini, S; Maher, B; Hernández-Hernández, L; Gormley, P; Hämäläinen, E; Heggeli, K; Schoeler, N; Novy, J; Willis, J; Plagnol, V; Ellis, R; Reavey, E; O'Regan, M; Pickrell, WO; Thomas, RH; Chung, SK; Delanty, N; McMahon, JM; Malone, S; Sadleir, LG; Berkovic, SF; Nashef, L; Zuberi, SM; Rees, MI; Cavalleri, GL; Sander, JW; Hughes, E; Helen Cross, J; Scheffer, IE; Palotie, A; Sisodiya, SM
Sudden unexpected death in epilepsy (SUDEP) represents the most severe degree of the spectrum of epilepsy severity and is the commonest cause of epilepsy-related premature mortality. The precise pathophysiology and the genetic architecture of SUDEP remain elusive. Aiming to elucidate the genetic basis of SUDEP, we analysed rare, protein-changing variants from whole-exome sequences of 18 people who died of SUDEP, 87 living people with epilepsy and 1479 non-epilepsy disease controls. Association analysis revealed a significantly increased genome-wide polygenic burden per individual in the SUDEP cohort when compared to epilepsy (P = 5.7 × 10(- 3)) and non-epilepsy disease controls (P = 1.2 × 10(- 3)). The polygenic burden was driven...

155. Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels – A Strategy for Brain Cancer Treatments - Fisusi, FA; Siew, A; Chooi, KW; Okubanjo, O; Benattayallah, A; Garrett, N; Lalatsa, K; Summers, I; Moger, I; Stapleton, P; Satchi-Fainaro, R; Schatzlein, AG; Uchegbu, IF
Purpose The blood brain barrier compromises glioblastoma chemotherapy. However high blood concentrations of lipophilic, alkylating drugs result in brain uptake, but cause myelosuppression. We hypothesised that nanoparticles could achieve therapeutic brain concentrations without dose-limiting myelosuppression. Methods Mice were dosed with either intravenous lomustine Molecular Envelope Technology (MET) nanoparticles (13 mg kg-1) or ethanolic lomustine (6.5 mg kg-1) and tissues analysed. Efficacy was assessed in an orthotopic U-87 MG glioblastoma model, following intravenous MET lomustine (daily 13 mg kg-1) or ethanolic lomustine (daily 1.2 mg kg-1 - the highest repeated dose possible). Myelosuppression and MET particle macrophage uptake were also investigated....

156. Acetazolamide-responsive paroxysmal dyskinesia in a 12-week-old female golden retriever dog - Royaux, E; Bhatti, S; Harvey, R; Garosi, L; Shelton, GD; Van Ham, L

157. Adolescent Self-Organization and Adult Smoking and Drinking over Fifty Years of Follow-Up: The British 1946 Birth Cohort - Nishida, A; Cadar, D; Xu, MK; Croudace, T; Jones, PB; Kuh, D; Richards, M
Variations in markers of adolescent self-organization predict a range of economic and health-related outcomes in general population studies. Using a population-based birth cohort study we investigated associations between adolescent self-organization and two common factors over adulthood influencing health, smoking and alcohol consumption. The MRC National Survey of Health and Development (the British 1946 birth cohort) was used to test associations between a dimensional measure of adolescent self-organization derived from teacher ratings, and summary longitudinal measures of smoking and alcohol consumption over the ensuing five decades. Multinomial regression models were adjusted for sex, adolescent emotional and conduct problems, occupational social class...

158. Improving trust, improving schools: Findings from a social network analysis of 43 primary schools in England - Brown, C; Daly, A; Liou, YH
Purpose Many governments worldwide are now promoting the importance of research-informed efforts at improvement. At the same time research is yet to make sustained impact on the practices of teachers. Given the importance of the issue and the lack of progress in this area, the purpose of this paper is to examine what drives teachers’ perceptions that their school: first, encourages the use of research evidence to support improvements to teaching; and second, whether school improvement strategies are grounded in research on effective practice. Design/methodology/approach Reviewing extant literature, the authors hypothesize that teachers’ perceptions of research use are related to...

159. The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling - Maiarù, M; Tochiki, KK; Cox, MB; Annan, LV; Bell, CG; Feng, X; Geranton, SM; Hausch, F
Polymorphisms in FKBP51 are associated with stress-related psychiatric disorders and influence the severity of pain symptoms experienced after trauma. Here, we report that FKBP51 (FK506 binding protein 51) is crucial for the full development and maintenance of long-term pain states and that this is independent from its effect on mood. Indeed, FKBP51 knock out mice but also mice with silencing of FKBP51 restricted to the spinal cord showed reduced hypersensitivity in a number of persistent pain models. FKBP51 deletion did not compromise the detection of acute painful stimuli, a critical protective mechanism. Moreover, the specific FKBP51 inhibitor SAFit2 intrathecally administered...

160. Doubly Disadvantaged? Bullying Experiences among Disabled Children and Young People in England - Chatzitheochari, S; Parsons, S; Platt, L
Bullying among school-aged children and adolescents is recognised as an important social problem, and the adverse consequences for victims are well established. However, despite growing interest in the socio-demographic profile of victims, there is limited evidence on the relationship between bullying victimisation and childhood disability. This article enhances our understanding of bullying experiences among disabled children in both early and later childhood, drawing on nationally representative longitudinal data from the Millennium Cohort Study and the Longitudinal Study of Young People in England. We model the association of disability measured in two different ways with the probability of being bullied at...

 

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