UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
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Multifunctional Cytomegalovirus (CMV)-Specific CD8(+) T Cells Are Not Restricted By Telomere-Related Senescence in Young or Old Adults. - Riddell, NE; Griffiths, SJ; Rivino, L; King, DC; Teo, GH; Henson, SM; Cantisan, S; Solana, R; Kemeny, DM; MacAry, PA; Larbi, A; Akbar, AN
Antigen-specific multifunctional T cells that secrete IFNγ, IL-2 and TNFα simultaneously after activation are important for the control of many infections. It is unclear if these CD8(+) T cells are at an early or late stage of differentiation and whether telomere erosion restricts their replicative capacity. We developed a multiparameter flow cytometric method for investigating the relationship between differentiation (CD45RA and CD27 surface phenotype), function (cytokine production) and replicative capacity (telomere length) in individual cytomegalovirus (CMV) antigen specific CD8(+) T cells. This involves surface and intracellular cell staining coupled to fluorescence in situ hybridization to detect telomeres (flow-FISH). The end-stage/senescent...
Sir John Soane and Le Corbusier: modulating light and arresting views - Weber, PM
Four architectural interventions exploring the relationship of two eminent architects - Sir John Soane and Le Corbusier with the design of spaces using both LIGHT and VIEWS. The works draw on the striking similarities between their approaches including their innovations in how spaces are lit, their affiliations with spatial experiences and a specific material pallet. The work presented as part of a wider Le Corbusier exhibition in the Pitzhanger Gallery cosists of four models - two responding to Le Corbusier (cast in concrete) and two responding to Soane (fabricated in brass).
Guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery - O'Kane, M; Barth, J; Batterham, RL; Pinkney, J; Aasheim, E; Welbourn, R
ariatric surgery is now an essential option for the treatment of obesity and its associated comorbidity. Many patients presenting for surgery will have pre-existing vitamin deficiencies and all bariatric surgical procedures compromise nutrition to varying extents, and have the potential to cause clinically significant micronutrient deficiencies. Therefore, long term nutritional monitoring and follow-up are essential components of all bariatric surgical services. However, there are no current standard guidelines in the UK for the biochemical monitoring and replacement of essential micronutrients in patients undergoing different forms of bariatric surgery. Furthermore, a survey of members of BOMSS revealed a wide diversity of...
Obesity: Causes, Consequences and Patient-Centred Therapeutic Approaches - Pucci, A; Batterham, RL; Manning, S
Obesity is one of the greatest 21st century public health challenges. However, government strategies aimed at reducing the unprecedented levels of obesity have been largely unsuccessful to date (Institute of Medicine 2013). Only in 2013 the American Medical Association (AMA) identified the necessity for prevention and medical interventions in the obesity field, suggesting that clinicians are also lagging behind in the fight to halt the obesity epidemic (American Medical Association 2013). Excess weight is the fifth leading risk factor for global deaths. At least 2.8 million adults die each year as a result of being overweight or obese. In addition,...
The delta survey: Minufiyeh province, 2008-9 - Rowland, J; Edinborough, K; Phillipps, R; El-Senussi, A
This fieldwork report presents the results of the ground survey phase of fieldwork of the Minufiyeh Archaeological Survey during the 2008 and 2009 seasons. These seasons also saw the continuation of investigations into the cemetery and Sacred Falcon Necropolis at the Quesna archaeological area and into the archaeological remains at Kom el-Ahmar, Minuf The 2008 season saw the first visit of the ground survey to the region between el-Khatatbah and Kafr Dawud, west of the Rosetta branch of the Nile, as well as further investigation into sites across the province and the continuation of the drill core survey. In 2009...
Paleoindian demography and the extraterrestrial impact hypothesis. - Buchanan, B; Collard, M; Edinborough, K
Recently it has been suggested that one or more large extraterrestrial (ET) objects struck northern North America 12,900 +/- 100 calendar years before present (calBP) [Firestone RB, et al. (2007) Proc Natl Acad Sci USA 104: 16016-16021]. This impact is claimed to have triggered the Younger Dryas major cooling event and resulted in the extinction of the North American megafauna. The impact is also claimed to have caused major cultural changes and population decline among the Paleoindians. Here, we report a study in which approximately 1,500 radiocarbon dates from archaeological sites in Canada and the United States were used to...
Concepts of probability in radiocarbon analysis - Weninger, B; Edinborough, K; Clare, L; Jöris, O
In this paper we explore the meaning of the word probability, not in general terms, but restricted to the field of radiocarbon dating, where it has the meaning of 'dating probability assigned to calibrated C-ages'. The intention of our study is to improve our understanding of certain properties of radiocarbon dates, which - although mathematically abstract - are fundamental both for the construction of age models in prehistoric archaeology, as well as for an adequate interpretation of their reliability.
Talking about quality: exploring how 'quality' is conceptualized in European hospitals and healthcare systems. - Wiig, S; Aase, K; von Plessen, C; Burnett, S; Nunes, F; Weggelaar, AM; Anderson-Gare, B; Calltorp, J; Fulop, N; For QUASER-team,
Conceptualization of quality of care - in terms of what individuals, groups and organizations include in their meaning of quality, is an unexplored research area. It is important to understand how quality is conceptualised as a means to successfully implement improvement efforts and bridge potential disconnect in language about quality between system levels, professions, and clinical services. The aim is therefore to explore and compare conceptualization of quality among national bodies (macro level), senior hospital managers (meso level), and professional groups within clinical micro systems (micro level) in a cross-national study.
Ethnicity, length of time on the register and sex predict donor availability at the confirmatory typing stage. - Lown, RN; Marsh, SG; Switzer, GE; Latham, KA; Madrigal, JA; Shaw, BE
Despite over 20 million unrelated donors being listed worldwide, donor attrition at the confirmatory typing (CT) stage of donor acquisition is a key source of delay. Anthony Nolan undertook a study of CT requests from 2010 to 2011 to identify factors associated with attrition. Of 7541 CT requests, 38.2% were cancelled for donor reasons. Of these, 19.4% were personal, 34.1% medical, 36% no contact, 7.9% emigrated and 2.6% others. African (odds ratio (OR) 2.78, P<0.001), African-Caribbean (OR 3.07, P<0.001), Asian (OR 2.65, P<0.001), Jewish (OR 1.54, P=0.009) and Mediterranean (OR=2.38, P<0.001) donors were more likely not to be available compared...
Towards a global system of vigilance and surveillance in unrelated donors of haematopoietic progenitor cells for transplantation. - Shaw, BE; Chapman, J; Fechter, M; Foeken, L; Greinix, H; Hwang, W; Phillips-Johnson, L; Korhonen, M; Lindberg, B; Navarro, WH; Szer, J
Safety of living donors is critical to the success of blood, tissue and organ transplantation. Structured and robust vigilance and surveillance systems exist as part of some national entities, but historically no global systems are in place to ensure conformity, harmonisation and the recognition of rare adverse events (AEs). The World Health Assembly has recently resolved to require AE/reaction (AE/R) reporting both nationally and globally. The World Marrow Donor Association (WMDA) is an international organisation promoting the safety of unrelated donors and progenitor cell products for use in haematopoietic progenitor cell (HPC) transplantation. To address this issue, we established a...