Tuesday, June 30, 2015

 

 



Soy un nuevo usuario

Olvidé mi contraseña

Entrada usuarios

Lógica Matemáticas Astronomía y Astrofísica Física Química Ciencias de la Vida
Ciencias de la Tierra y Espacio Ciencias Agrarias Ciencias Médicas Ciencias Tecnológicas Antropología Demografía
Ciencias Económicas Geografía Historia Ciencias Jurídicas y Derecho Lingüística Pedagogía
Ciencia Política Psicología Artes y Letras Sociología Ética Filosofía
 

rss_1.0 Recursos de colección

UCL University College London Eprints (354,640 recursos)
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 141 - 160 de 354,256

141. The application of isothermal microcalorimetry for studying mixed probiotic cultures - Fredua-Agyeman, M
The main aim of this research was to explore the potential of the isothermal microcalorimeter to detect bacteria in mixed cultures; applied to investigate the antagonistic effect of commercial probiotics against pathogens and each other; and also the prebiotic potential of a substrate. Gastric tolerance of commercial probiotic products was also investigated with an improvement on current methods. An initial mixed culture study with Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli in the microcalorimeter showed that the microcalorimeter could detect their growth in mixed cultures; S. aureus was always outcompeted in growth. Antagonistic activity of probiotic strains, Lactobacillus acidophilus, Bifidobacterium...

142. Neural correlates of encoding pictures into long-term memory: the influence of advance information - Wang, D
It has been shown that neural activity before an event influences the likelihood that the event will later be remembered. This doctoral thesis aimed to clarify the functional role of anticipatory activity in long-term memory by manipulating the amount of advance information that is available about an upcoming pictorial encoding event. The first three studies employed scalp-recorded electrical brain activity. Experiment 1 investigated how advance information about the physical form of an object (a perceptually impoverished outline or detailed photograph) affects encoding-related processes. In the temporal domain, event-related potentials (ERPs) showed encoding-related differences regardless of type of advance information. In...

143. Relentless magnificence: The American urban grid - Major, MD
This thesis is about the urban morphology of American cities. Many see American cities as a radical departure in town planning history due to their planned nature based on geometrical division of the land, but other cities in the world also began as planned towns with geometric layouts so the American city is not unique. Space syntax studies analyzing deformed grid layouts of organic cities show they also have an intrinsic geometry underlying their apparent disorder, and a well-defined spatial pattern governing powerful links between layout and urban function. Why did the regular grid come so pervasively to characterize American...

144. Microalgae as a novel production platform for antibacterial proteins - Stoffels, L
Widespread antibiotic resistance among pathogenic bacteria and the low specificity of these drugs cause a pressing need for the development of novel antibiotics. Endolysins are proteins that are produced by bacteriophage infected cells and digest the bacterial cell wall for phage progeny release. These efficient enzymes are highly specific for the target bacteria without affecting other species. Development of resistance against endolysins is rare, because they evolved to target molecules that are essential for bacterial viability. Taken together, this makes them promising novel antibiotics. The development of recombinant endolysins as antibacterial agents requires an inexpensive and safe production platform. Microalgae...

145. Encouraging sustainable lifestyles: local government, citizens and the impact of pro-environmental behaviour change programmes - Revell, KL
In recent years, it has become apparent that in order to achieve many policy objectives, it is often necessary to stimulate behaviour change on the part of the population. Concurrently, the role of local authorities in tackling unsustainability and reducing carbon emissions has become more prominent. This thesis describes research undertaken in London, UK, to understand how local authorities have worked to tackle unsustainability and encourage pro-environmental behaviour change through sustainability programmes, and what the environmental impact of such programmes is. Overall, this thesis provides a clear picture of how local environmental programmes which require individual behaviour change, can be...

146. Advances in computational ion mobility mass spectrometry; with application to α1-antitrypsin - Sivalingam, GN
A new method for deconvolution of electrospray ionisation mass spectrometry (ESI-MS) spectra was produced, allowing for the masses of overlapping charge state series to be correctly indentified. The algorithm also determines the abundance of individual molecular species with a much higher accuracy for congested spectra. Several new methods for representing TWIM-MS data were developed. The combination of the deconvolution algorithm with travelling wave ion mobility data creates plots with collision cross section (CCS) axes which can be directly compared with X-ray crystallography structures and computational models. Difference plots have allowed multidimensional analysis of changes in condition, and spectral averaging can...

147. Incorporation of Developability into Cell Line Selection - Betts, JPJ
The pharmaceutical industry is under increasing pressure to deliver new medicines quickly and cost effectively; traditional small molecule product pipelines have dried up and companies are increasingly investing into biopharmaceuticals. To date, the most successful biopharmaceuticals have been monoclonal antibodies. The ability to construct common manufacturing platforms for a range of antibody products has underpinned this interest. Antibodies are most often produced as heterologous proteins at large scale in stirred tank reactors. However, at manufacturing scale there is limited opportunity to undertake process development and optimisation. If a manufacturing process can be ‘scaled down’ experiments could be carried out at...

148. Synthesis of Truncated Analogues of ProTx-II as a Novel Form of Pain Relief - Wright, ZVF
Chronic pain affects almost 10 million people in the UK but despite this, few effective treatments exist. Research has shown that targeting the Nav1.7 ion channel provides a novel approach to treatment. ProTx-II, a 30 amino acid peptide isolated from Tarantula venom, is highly selective for the channel (IC50 value - 0.3nm in vitro) but in vivo results were less promising. ProTx-II contains three interlocking disulfide bonds connected in a distinctive pattern. To investigate the structure-activity relationship between the peptide and the ion channel, truncated analogues based on the individual cysteine rings were synthesised. This thesis investigates the effect of...

149. When can social media lead financial markets? - Zheludev, IN
Social media analytics is showing promise for the prediction of financial markets. The research presented here employs linear regression analysis and information theory analysis techniques to measure the extent to which social media data is a predictor of the future returns of stock-exchange traded financial assets. Two hypotheses are proposed which investigate if the measurement of social media data in real-time can be used to pre-empt – or lead – changes in the prices of financial markets. Using Twitter as the social media data source, this study firstly investigates if geographically-filtered Tweets can lead the returns of UK and US...

150. Effects of remote ischaemic preconditioning on peri-operative myocardial injury and clinical outcomes in patients undergoing elective cardiac bypass surgery - Candilio, L
Ischaemic heart disease (IHD) is a major cause of morbidity and mortality in the world. Coronary artery bypass graft (CABG) surgery is the revascularisation strategy of choice in a significant number of patients, particularly those with diabetes mellitus and complex coronary disease. During cardiac surgery, the myocardium is subjected to peri-operative myocardial injury (PMI), which has been associated with worse short and long-term clinical outcomes. Higher-risks patients are currently being operated on with subsequent higher risk of PMI and worse prognosis: therefore new strategies are required to potentiate the innate mechanisms of cardioprotection. In this regard, remote ischaemic preconditioning (RIPC)...

151. Folding during ribosomal biosynthesis of yellow fluorescent protein: Investigations by fluorescence spectroscopy and NMR spectroscopy - Tajima, T
During biosynthesis on the ribosome, the nascent polypeptide chain emerges in a vectorial fashion, one amino acid at a time and it has its first opportunity to sample conformational space. Study of structural and molecular biology has shown that nascent chains (NC) can co-translationally acquire its native structure, however how an emerging NC forms the native conformation is a fundamental question in modern biology. Yellow fluorescent protein (YFP), a red shifted yellow emission variant of green fluorescent protein (GFP) that is consisted of 238 amino acid residues is highly distinct because of its fast maturation of fluorophore and its rapid...

152. Factors affecting outcome after autologous chondrocyte implantation for the treatment of osteochondral defects of the knee - Jaiswal, PK
Some studies on autologous chondrocyte implantation (ACI) have demonstrated little benefit over other techniques and few have demonstrated a lasting benefit. A number of factors can contribute to failure and a scientific approach to elucidate these variables has not been reported. This thesis reports on the use of a statistical approach - the Generalised Linear Model (GLM) to quantify the effect each factor has whilst considering the interplay of other variables. Data from a randomised controlled trial and several case-controlled studies will assess the efficacy of 2 different types of ACI, the influence of smoking, BMI, and physical activity. Non-modifiable...

153. Methods affecting neuronal differentiation of human adult and pluripotent stem cells - Thwaites, JW
Stem cells have significant potential to treat many age-related degenerative disorders that affect increasing numbers of people globally. This thesis investigated the capacity for omnicytes and human pluripotent stem cells (hPSC) to undergo directed differentiation towards neuronal cell types for the treatment of ischemic stroke and Parkinson’s disease respectively. Omnicytes express a range of markers related to pluripotency and plasticity; however they are a challenging cell source to use in the development of cell therapies. Variability in omnicyte quality was associated with patient source, disease type and cryopreservation, all of which affected the reproducibility of data. Successful generation of dopaminergic...

154. Mesenteric Fat in Crohn’s Disease - Broadhurst, JF
Crohn’s Disease is a chronic inflammatory disorder of the bowel affecting approximately 1 in 800 people in the UK. The terminal ileum is most commonly affected and the mesentery becomes thickened, a phenomenon known as ‘fat wrapping’. The cause is not understood. Elemental feeding can induce remission in Crohn’s disease and polyunsaturated fatty acid (PUFA) content may be the cause of a reduction in inflammation. Particular attention has focused on n-­‐3 and n-­‐6 PUFA content of elemental feeds. The aim of this study was to further characterize mesenteric fat in Crohn’s disease and to examine the effects of different PUFA...

155. Investigating catalytic activity at oxide surfaces using a QM/MM methodology - Downing, CA
A set of complementary studies has been undertaken to investigate the interaction of CO2 with metal oxide surfaces. Beginning with the simple and well-studied magnesium oxide surface, work progressed to include a manganese dopant near the MgO active site before shifting to manganese oxide. All work made use of the Quantum Mechanical/Molecular Mechanical (QM/MM) methodology implemented within the ChemShell code, which combines information from an electronic structure calculation on atoms in the vicinity of the adsorption site with relaxation effects from a large component of the surrounding catalyst system. Initial findings showed that CO2 interacts favourably with the MgO (100)...

156. Muslims in Europe - the public engagement of young German Muslims - Soliman, A
This study examines qualitatively several case studies of young Muslims in Germany who strongly identify with Islam and Germany and who are publicly active. It analyses the ways in which the research participants use the public sphere in the context of German Muslim identity. It focuses on three main fields within the public sphere, namely media, the arts and culture, and civil society. Various forms of engagement as well as different contents are investigated. Two theoretical frameworks are used. The first one deals with identity, looking at theories of minority identity, hybrid identity, multiculturalism and secularism. Secondly, the concept of...

157. Adolescent Twins’ Mental Representations of Self and Other in Relation with Zygosity, Attachment Patterns and Psychological Disturbances - Zhou, Y
Abstract Introduction: Based on a theoretical integration of cognitive development psychology, psychoanalytic theory and attachment theory, Blatt and his colleagues formulated a systematic psychodynamic model of mental representation of self and other emphasizing internalization, differentiation and integration of self and object representations in normal and disrupted personality development. During the development process, adolescence is a critical transformational stage to determine either the construction of an integrated self-identity and more mature expressions of relatedness within a wider social context, or emergence or consolidation of many forms of psychopathology. This study used a twin design to examine the degree of articulation, differentiation...

158. The Time and Space of Greek-Cypriot Cinema: A Deleuzian Reading - Socrates, L
This study traces the emergence of Greek-Cypriot Cinema in Cyprus since 1974, arguing that it is the product of a historical moment. 1974 marks a watershed in the island’s protracted political conflict which culminated in ethnic violence, a coup and war. Whilst the war has been the subject of wide ranging scholarly research its impact in forging a distinctive national cinema remains unexamined. This thesis attempts to re-address this absence. My approach is interdisciplinary, drawing on historiographical studies as well as Film Studies, Cultural Theory and Film Philosophy. Primary research includes extensive dialogues with filmmakers. All of the films examined...

159. Action control in uncertain environments - Smittenaar, P
A long-standing dichotomy in neuroscience pits automatic or reflexive drivers of behaviour against deliberate or reflective processes. In this thesis I explore how this concept applies to two stages of action control: decision-making and response inhibition. The first part of this thesis examines the decision-making process itself during which actions need to be selected that maximise rewards. Decisions arise through influences from model-free stimulus-response associations as well as model-based, goal-directed thought. Using a task that quantifies their respective contributions, I describe three studies that manipulate the balance of control between these two systems. I find that a pharmacological manipulation with...

160. The Role of the Neurokinin-1 Receptor in Behaviour and Cognition: an interaction with the Brain Renin Angiotensin System and its implications for Attention Deficit Hyperactivity Disorder - Porter, AJ
Mice lacking functional neurokinin-1 receptors (NK1R-/-) display several behavioural abnormalities that resemble Attention Deficit Hyperactivity Disorder (ADHD), including locomotor hyperactivity (which is alleviated by ADHD medication), impulsivity and inattentiveness. These findings prompted the proposal that NK1R-/- mice offer a novel murine model of ADHD. The first aim of this thesis was to investigate the influence of non-genetic (epigenetic/environmental) factors on the behaviour of NK1R-/- mice by comparing animals from two different breeding protocols. These studies revealed that certain elements of their impulsivity are influenced by non-genetic factors, but other behaviours are not. The second aim was to compare the behaviour...

 

Busque un recurso