UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
Defective Natural Killer cell antiviral capacity in paediatric HBV infection. - Heiberg, IL; Pallett, LJ; Winther, TN; Høgh, B; Maini, MK; Peppa, D
Natural Killer (NK) cells exhibit dysregulated effector function in adult chronic HBV infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell IFN-γ production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NKp30 on NK cells suggests a role of impaired NK-Dendritic Cell (DC) cellular interactions as a potential mechanism...
Mathematical modeling of the VEGF receptor - Page, KM; Alarcon, T
This chapter is devoted to the formulation and analysis of several models of the VEGF receptor and the initial steps in the signalling cascade following receptor activation. Our models take into consideration different factors and processes such as receptor cross-linking, endocytosis, recycling, degradation and synthesis. The effect of each one of these factors is studied. In particular, we present an analysis of a stochastic model of the vascular endothelial growth factor (VEGF) receptor, which accounts for ligand binding-induced oligomerisation, activation of SH2 domain-carrying kinases and receptor internalization. This is an analysis, based upon a generalisation of a WKB approximation of...
The Immuno-Dynamics of Conflict Intervention in Social Systems - Krakauer, DC; Page, KM; Flack, J
We present statistical evidence and dynamical models for the management of conflict and a division of labor (task specialization) in a primate society. Two broad intervention strategy classes are observed– a dyadic strategy – pacifying interventions, and a triadic strategy –policing interventions. These strategies, their respective degrees of specialization, and their consequences for conflict dynamics can be captured through empirically-grounded mathematical models inspired by immuno-dynamics. The spread of aggression, analogous to the proliferation of pathogens, is an epidemiological problem. We show analytically and computationally that policing is an efficient strategy as it requires only a small proportion of a population...
How Can Nanotechnologies Fulfill the Needs of Developing Countries? - Grimshaw, DJ; Gudza, LD; Stilgoe, J
In an effort to engage citizens in "upstream" dialogues, a number of "experiments in public engagement" with science took place during 2005-2006. This chapter discusses those engagements, with a particular focus on the findings of a "nanodialogue" held in Zimbabwe during July 2006 involving scientists and representatives of two communities that experience real problems with the supply of clean drinking water. Concerns of society often focus on risk and this has been found to be especially true when public engagement is delayed. Upstream engagement appears to encourage the public to focus on imagining positive outcomes for nanotechnologies. We raise issues...