Recursos de colección

UCL University College London Eprints (406.551 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 161 - 180 de 53.837

  1. Differences in virological and immunological risk factors for non-Hodgkin lymphoma (NHL) and Hodgkin (HL): the D:A:D study

    Shepherd, L; Ryom, L; Law, M; Hatleberg, C; de Wit, S; Monforte, AD; Battegay, M; Phillips, A; Bonnet, F; Reiss, P; Pradier, C; Grulich, A; Sabin, C; Lundgren, J; Mocroft, A

  2. Improved kidney function in patients who switch their protease inhibitor from atazanavir or lopinavir to darunavir

    Jose, S; Nelson, M; Phillips, A; Chadwick, D; Trevelion, R; Jones, R; Williams, D; Hamzah, L; Sabin, C; Post, F

  3. Modelling the in-utero initation of ETV6-RUNX1 in childhood acute lymphoblastic leukaemia using human pluripotent stem cells

    Richardson, S; Boiers, C; Zriwil, A; Turati, V; Brown, J; Wang, D; Herrero, J; Smith, A; Jacobsen, SE; Enver, T

  4. Positive and Negative Experiences of Social Support and Risk of Dementia in Later Life: An Investigation Using the English Longitudinal Study of Ageing.

    Khondoker, M; Rafnsson, SB; Morris, S; Orrell, M; Steptoe, A
    BACKGROUND: Having a network of close relationships may reduce the risk of developing dementia. However, social exchange theory suggests that social interaction entails both rewards and costs. The effects of quality of close social relationships in later life on the risk of developing dementia are not well understood. OBJECTIVE: To investigate the effects of positive and negative experiences of social support within key relationships (spouse or partner, children, other immediate family, and friends) on the risk of developing dementia in later life. METHODS: We analyzed 10-year follow up data (2003/4 to 2012/13) in a cohort of 10,055 dementia free (at...

  5. Anti-inflammatory effects of Streptococcus pneumoniae toxin pneumolysin

    Periselneris, J; Noursadeghi, M; Brown, J

  6. Modular deconvolution of tissue transcriptomes: pitfalls and solutions

    Pollara, G; Murray, MJ; Heather, J; Chain, BM; Noursadeghi, M

  7. Seasonal variation of heavy metals (cd, pb and hg) in sediments and in mullet, mugil cephalus (Mugilidae), from the ghar el melh lagoon (Tunisia)

    Chouba, L; Kraiem, M; Njimi, W; Tissaoui, CH; Thompson, JR; Flower, RJ
    This study investigates the toxic contaminants cadmium (Cd), lead (Pb) and mercury (Hg) in surface sediments and in the fish species Mugil cephalus of the lagoon of Ghar El Melh (GEM), Tunisia. Sampling was conducted seasonally during 2003 and 2004. The results of this study indicated that levels of Cd and Pb varied in sediment from 0.4 to 0.9μgg-1dw and 25 to 70μgg -1dw, respectively. Mercury concentrations in sediment were generally below 1μgg-1dw. The highest level was observed in the northeast of lagoon. In fish muscle, concentrations of Cd, Pb and Hg varied between 0.013 to 0.025μgg-1dw, 0.048 to 0.422μgg-1dw...

  8. Nonconvulsive Status Epilepticus and Leucoencephalopathy After High-Dose Methotrexate

    Patterson, DM; Aries, J; Hyare, H; Holder, D; Rees, J; Lee, SM

  9. Investigation of dosimetric differences between the TMR 10 and convolution algorithm for Gamma Knife stereotactic radiosurgery

    Rojas-Villabona, A; Kitchen, N; Paddick, I

  10. Borderline intellectual functioning and psychosis: Adult Psychiatric Morbidity Survey evidence.

    Hassiotis, A; Noor, M; Bebbington, P; Afia, A; Wieland, J; Qassem, T
    Borderline intellectual functioning (BIF) is associated with several neuropsychological deficits. We used national data to establish the prevalence of psychosis and psychotic symptoms, and the role of potential mediators. The BIF group were more than twice as likely to have probable psychosis (adjusted odds ratio (OR) = 2.3, 95% CI 1.4-4.0) and to report hallucinations (adjusted OR = 2.9, 95% CI 1.9-4.4) but not persecutory ideation. Salient mediators were depressive symptoms and the cumulative total of life events. Our findings suggest mechanisms other than drug use that are contributing to the strong relationship between BIF and severe mental illness and...

  11. Polarimetry at millimeter wavelengths with the NIKA camera: calibration and performance

    Ritacco, A; Ponthieu, N; Catalano, A; Adam, R; Ande, P; Andre, P; Beelen, A; Benoit, A; Bideaud, A; Billot, N; Bourrion, O; Calvo, M; Coiffard, G; Comis, B; Desert, F-X; Doyle, S; Goupy, J; Kramer, C; Leclercq, S; Macias-Perez, JF; Mauskopf, P; Maury, A; Mayet, F; Monfardini, A; Pajot, F; Pascale, E; Perotto, L; Pisano, G; Rebolo-Iglesias, M; Reveret, V; Rodriguez, L; Romero, C; Ruppin, F; Savini, G; Schuster, K; Sievers, A; Thum, C; Triqueneaux, S; Tucker, C; Zylka, R

  12. The impact of level of education on vascular events and mortality in patients with type 2 diabetes mellitus: Results from the ADVANCE study.

    Blomster, JI; Zoungas, S; Woodward, M; Neal, B; Harrap, S; Poulter, N; Marre, M; Williams, B; Chalmers, J; Hillis, GS
    AIMS: The relationship between educational level and the risk of all-cause mortality is well established, whereas the association with vascular events in individuals with type 2 diabetes is not well described. Any association may reflect a link with common cardiovascular or lifestyle-based risk factors. METHODS: The relationships between the highest level of educational attainment and major cardiovascular events, microvascular complications and all-cause mortality were explored in a cohort of 11,140 individuals with type 2 diabetes. Completion of formal education before the age of 16 was categorized as a low level of education. Regional differences between Asia, East Europe and Established...

  13. Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials.

    Böhm, M; Schumacher, H; Teo, KK; Lonn, EM; Mahfoud, F; Mann, JFE; Mancia, G; Redon, J; Schmieder, RE; Sliwa, K; Weber, MA; Williams, B; Yusuf, S
    BACKGROUND: Studies have challenged the appropriateness of accepted blood pressure targets. We hypothesised that different levels of low blood pressure are associated with benefit for some, but harm for other outcomes. METHODS: In this analysis, we assessed the previously reported outcome data from high-risk patients aged 55 years or older with a history of cardiovascular disease, 70% of whom had hypertension, from the ONTARGET and TRANSCEND trials investigating ramipril, telmisartan, and their combination, with a median follow-up of 56 months. Detailed descriptions of randomisation and intervention have already been reported. We analysed the associations between mean blood pressure achieved on...

  14. Monoclonal antibodies to human procoagulant factor VIII.

    Rotblat, F; Goodall, AH; O'Brien, DP; Rawlings, E; Middleton, S; Tuddenham, EG
    VIII:C was purified from intermediate-purity concentrate by adsorption on polyelectrolyte E5 and affinity chromatography on Sepharose/anti-VIIIR:Ag. The highly purified VIII:C preparation (sp. act. 1598 U/mg) was used to immunize Balb-C mice. Spleen cells from a mouse with a serum antibody titer of 963 U/ml were fused with P3 NSI mouse myeloma cells. Hybrid clones were screened by a coagulation inhibition assay and by a four-layer antibody adsorption procedure. Nine monoclonal antibodies specific to VIII:C were produced. Five of these antibodies have been cloned and grown in mouse ascitic fluid. Antibody titers from ascitic fluid ranged from 35 to 82,000 BU/ml....

  15. Crystallization and preliminary X-ray analysis of human tissue factor extracellular domain.

    Boys, CW; Miller, A; Harlos, K; Martin, DM; Tuddenham, EG; O'Brien, DP
    The extracellular domain (residues 1 to 220) of human tissue factor has been cloned and expressed in Escherichia coli and purified to isoelectric homogeneity. Single crystals suitable for X-ray analysis have been obtained by vapour diffusion. They belong to the tetragonal space group P4(1)2(1)2 or P4(3)2(1)2 with a = b = 45.2 A, c = 231.5 A, contain one molecule per asymmetric unit and diffract to 2.6 A resolution. Native and derivative data sets have been collected to 3.6 and 3.9 A, respectively.

  16. Synthesis and characterization of wild-type and variant gamma-carboxyglutamic acid-containing domains of factor VII.

    Martin, DM; O'Brien, DP; Tuddenham, EG; Byfield, PG
    Synthetic peptides corresponding to portions of the wild-type and variant sequences of the human factor VII gamma-carboxyglutamic acid (Gla)-containing domain have been prepared by direct peptide synthesis using the Fmoc-based protection strategy. Peptides were purified by ion-exchange and reversed-phase chromatography and characterized as the correct products. A peptide comprising residues 1-49 (GP 1-49) inhibited the activation of factor X (FX) by soluble tissue factor (sTF) and recombinant activated factor VII (rFVIIa). In the absence of phospholipid, no inhibition by this peptide was observed. GP 1-49 did not inhibit the hydrolysis of a peptidyl substrate by rFVIIa in the presence of...

  17. High-level production of human blood coagulation factors VII and XI using a new mammalian expression vector.

    Kemball-Cook, G; Garner, I; Imanaka, Y; Nishimura, T; O'Brien, DP; Tuddenham, EG; McVey, JH
    Recombinant human proteins are generally recovered in low yields from mammalian tissue culture following transfection with commercially available vectors. We have constructed a novel vector containing both the neomycin-resistance-encoding gene (neo) as a dominant selectable marker, and the dihydrofolate reductase-encoding gene (DHFR) to enable amplification of transfected DNA followed by stable expression in mammalian cell lines. Levels of 5 micrograms/ml of the coagulation proteins, factor VII (FVII) and factor XI (FXI), have been achieved in serum-free media. N-terminal sequencing of the purified proteins, and of their separated chains after proteolytic activation, demonstrated correct processing of the recombinant products. In addition,...

  18. Factor VIII S373L: mutation at P1' site confers thrombin cleavage resistance, causing mild haemophilia A.

    Johnson, DJ; Pemberton, S; Acquila, M; Mori, PG; Tuddenham, EG; O'Brien, DP
    A novel CRM+ mutation, factor VIII position 373 serine to leucine substitution (FVIII 373-Leu) was identified during a survey of Factor VIII (FVIII) mutations. We have purified the variant protein from the patient's plasma in order to allow further characterisation of the molecule. The CRM+ plasma contained 120% Factor VIII antigen (FVIII:Ag) and 6% Factor VIII coagulant activity (FVIII:C). After purification the mutant FVIII was subjected to thrombin proteolysis, and was thereby activated 5.6-fold compared with 7-fold for wild type molecule. Subsequently, spontaneous inactivation of the mutant was much slower than noted for wild type FVIII. Western blot analysis using...

  19. Crystal structure of the extracellular region of human tissue factor.

    Harlos, K; Martin, DM; O'Brien, DP; Jones, EY; Stuart, DI; Polikarpov, I; Miller, A; Tuddenham, EG; Boys, CW
    Tissue factor is a cell-surface glycoprotein receptor which initiates the blood coagulation cascade after vessel injury by interacting with blood clotting factor VII/VIIa and which is implicated in various pathological processes. When bound to tissue factor, factor VII is readily converted to the active protease factor VIIa by trace amounts of factors Xa, IXa or VIIa. Human tissue factor consists of 263 residues, the first 219 of which comprise the extracellular region. We have determined the crystal structure of the extracellular region at a resolution of 2.2 A. Tissue factor consists of two immunoglobulin-like domains associated through an extensive, novel,...

  20. EXPRESSION OF FACTOR-VII BY MUSCLE-CELLS IN-VITRO AND IN-VIVO FOLLOWING DIRECT GENE-TRANSFER - A MODEL FOR HEMOPHILIA

    MILLER, G; STEINBRECHER, R; MURDOCK, P; PASI, J; TUDDENHAM, E; LEE, C; GOLDSPINK, G

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