UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
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Race and ethnicity influences collection of G-CSF mobilized peripheral blood progenitor cells from unrelated donors, a CIBMTR analysis. - Hsu, JW; Wingard, JR; Logan, BR; Chitphakdithai, P; Akpek, G; Anderlini, P; Artz, AS; Bredeson, C; Goldstein, S; Hale, G; Hematti, P; Joshi, S; Kamble, RT; Lazarus, HM; O'Donnell, PV; Pulsipher, MA; Savani, B; Schears, RM; Shaw, BE; Confer, DL
Little information exists on the effect of race and ethnicity on collection of peripheral blood stem cells (PBSC) for allogeneic transplantation. We studied 10776 donors from the National Marrow Donor Program who underwent PBSC collection from 2006-2012. Self-reported donor race/ethnic information included Caucasian, Hispanic, Black/African American (AA), Asian/Pacific Islander (API), and Native American (NA). All donors were mobilized with subcutaneous filgrastim (G-CSF) at an approximate dose of 10 μg/kg/d for 5 days. Overall, AA donors had the highest median yields of mononuclear cells (MNC)/L and CD34(+) cells/L blood processed (3.1 x 10(9) and 44 x 10(6) respectively) while Caucasians had...
The frequency of HLA-B(∗)57:01 and the risk of abacavir hypersensitivity reactions in the majority population of Costa Rica. - Arrieta-Bolaños, E; Madrigal, JA; Marsh, SG; Shaw, BE; Salazar-Sánchez, L
HLA-B(∗)57:01 is a well-known and cost-effective pharmacogenetic marker for abacavir hypersensitivity. As with other HLA alleles, there is widespread variation in its frequency across populations. The Costa Rica Central Valley Population (CCVP) is the major population in this country. The frequency of HLA-B(∗)57:01 in this population has not been described yet. Thus, our aim was to determine the frequency of this allele in the CCVP. 200 unrelated healthy volunteer donors born in the CCVP were typed. HLA-B(∗)57-positive samples identified by HLA intermediate resolution typing methods were further typed by SBT to high resolution. An HLA-B(∗)57:01 carrier frequency of 5.00% was...
Impact of pre-transplant co-morbidities on outcome after alemtuzumab-based reduced intensity conditioning allo-SCT in elderly patients: A British Society of Blood and Marrow Transplantation study. - Nikolousis, E; Nagra, S; Pearce, R; Perry, J; Kirkland, K; Byrne, J; Dignan, F; Tholouli, E; Gilleece, M; Russell, N; Littlewood, T; Cook, M; Peniket, A; Shaw, BE; Cook, G; Craddock, C
The advent of reduced intensity conditioning (RIC) regimens has permitted the extension of allo-SCT to selected patients into their eighth decade but GVHD remains a major cause of morbidity and mortality. Alemtuzumab is increasingly used to reduce the risk of severe GVHD, but there are concerns that T-cell depletion may compromise outcome particularly in older patients. We therefore studied the impact of pre-transplant factors on the outcome of 187 patients with a haematological malignancy over the age of 60 transplanted using an alemtuzumab-based RIC regimen of whom co-morbidity scoring was possible in 169. Of the patients, 120 had a haematopoietic...
Numerical identification of a sparse Robin coefficient - Sun, Z; Jiao, Y; Lu, X; Jin, B
We investigate an inverse problem of identifying a Robin coefficient with a sparse structure in the Laplace equation from noisy boundary measurements. The sparse structure of the Robin coefficient γ is understood as a small perturbation of a reference profile γ in the sense that their difference γ-γ has a small support. This problem is formulated as an optimal control problem with an L-regularization term. An iteratively reweighted least-squares algorithm with an inner semismooth Newton iteration is employed to solve the resulting optimization problem, and the convergence of the iteratively weighted least-squares algorithm is established. Numerical results for two-dimensional problems...
The intelligibility of interrupted speech depends upon its uninterrupted intelligibility. - Ardoint, M; Green, T; Rosen, S
Recognition of sentences containing periodic, 5-Hz, silent interruptions of differing duty cycles was assessed for three types of processed speech. Processing conditions employed different combinations of spectral resolution and the availability of fundamental frequency (F0) information, chosen to yield similar, below-ceiling performance for uninterrupted speech. Performance declined with decreasing duty cycle similarly for each processing condition, suggesting that, at least for certain forms of speech processing and interruption rates, performance with interrupted speech may reflect that obtained with uninterrupted speech. This highlights the difficulty in interpreting differences in interrupted speech performance across conditions for which uninterrupted performance is at ceiling.
A review of the haematopoietic stem cell donation experience: is there room for improvement? - Billen, A; Madrigal, JA; Shaw, BE
Donation of haematopoietic stem cells, either through BM or PBSC collection, is a generally safe procedure for healthy donors although adverse reactions are a definite risk. The invaluable source of donation and its central role in transplantation implies that every effort should be made to alleviate possible difficulties the donor encounters. The physical and psychological reactions to donation have been established for some time, but less is known about the factors that are associated with a poorer donation experience. In this article, we provide an overview of the physical and psychological donation experience and focus attention on demographic, physical and...
Pre-transplant MRD predicts outcome following reduced-intensity and myeloablative allogeneic hemopoietic SCT in AML. - Anthias, C; Dignan, FL; Morilla, R; Morilla, A; Ethell, ME; Potter, MN; Shaw, BE
The presence of minimal residual disease (MRD) by multiparametric flow cytometry (MFC) has been associated with adverse outcomes in AML patients treated with chemotherapy alone, but its impact in the setting of allogeneic hematopoietic SCT (HSCT) is less clear. We studied 88 patients who underwent myeloablative (MA) or reduced-intensity conditioned allogeneic HSCT for AML in first or subsequent remission at our center. MRD status was determined using three-color MFC on pre-HSCT BM aspirates, and patients were stratified by MRD status into MRD-negative, low-level MRD-positive (<1%) or high-level MRD-positive groups (1-4.9%). Two-year survival estimates in these groups were 66.8%, 51% and...
Unrelated adult stem cell donor medical suitability: recommendations from the World Marrow Donor Association Clinical Working Group Committee. - Lown, RN; Philippe, J; Navarro, W; van Walraven, SM; Philips-Johnson, L; Fechter, M; Pawson, R; Bengtsson, M; Beksac, M; Field, S; Yang, H; Shaw, BE
The World Marrow Donor Association (WMDA) fosters collaboration between international registries to facilitate the exchange of hematopoietic stem cell products for unrelated stem cell donor transplantation. As indications for hematopoietic SCT grow, the movement of products across the world will increase. Although competent authorities may regulate products within their country, there is a need to protect the best interests of donors and recipients by identifying universal donor medical suitability criteria. Within this report the WMDA provides a background to unrelated adult donor and recipient safety, recommends a common framework for assessing the health of unrelated adult donors at each stage...
Lower risk of serious adverse events and no increased risk of cancer after PBSC versus bone marrow donation. - Pulsipher, MA; Chitphakdithai, P; Logan, BR; Navarro, WH; Levine, JE; Miller, JP; Shaw, BE; O'Donnell, PV; Majhail, NS; Confer, DL
We compared serious early and late events experienced by 2726 BM and 6768 PBSC donors who underwent collection of peripheral blood stem cells (PBSC) or bone marrow (BM) between 2004 and 2009 as part of a prospective study through the National Marrow Donor Program. Standardized FDA definitions for serious adverse events (SAEs) were used and all events were reviewed by an independent physician panel. BM donors had an increased risk of SAEs (2.38% BM vs. 0.56% PBSC; OR 4.13, p < 0.001), and women were twice as likely to experience an SAE (OR for men 0.50, p=0.005). Restricting the analysis...
Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1. - Fleischhauer, K; Fernandez-Viña, MA; Wang, T; Haagenson, M; Battiwalla, M; Baxter-Lowe, LA; Ciceri, F; Dehn, J; Gajewski, J; Hale, GA; Heemskerk, MB; Marino, SR; McCarthy, PL; Miklos, D; Oudshoorn, M; Pollack, MS; Reddy, V; Senitzer, D; Shaw, BE; Waller, EK; Lee, SJ; Spellman, SR
HLA-DP antigens are beta-alpha heterodimers encoded by polymorphic HLA-DPB1 and -DPA1 alleles, respectively, in strong linkage disequilibrium (LD) with each other. Non-permissive unrelated donor (UD)-recipient HLA-DPB1 mismatches across three different T-cell epitope (TCE) groups are associated with increased mortality after hematopoietic SCT (HCT), but the role of HLA-DPA1 is unclear. We studied 1281 onco-hematologic patients after 10/10 HLA-matched UD-HCT facilitated by the National Marrow Donor Program. Non-permissive mismatches defined solely by HLA-DPB1 TCE groups were associated with significantly higher risks of TRM compared to permissive mismatches (hazard ratio (HR) 1.30, confidence interval (CI) 1.06-1.53; P=0.009) or allele matches. Moreover, non-permissive...
Prevention of fall-related injuries in long-term care: a randomized controlled trial of staff education. - Ray, WA; Taylor, JA; Brown, AK; Gideon, P; Hall, K; Arbogast, P; Meredith, S
Fall-related injuries, a major public health problem in long-term care, may be reduced by interventions that improve safety practices. Previous studies have shown that safety practice interventions can reduce falls; however, in long-term care these have relied heavily on external funding and staff. The aim of this study was to test whether a training program in safety practices for staff could reduce fall-related injuries in long-term care facilities.
Oral erythromycin and the risk of sudden death from cardiac causes. - Ray, WA; Murray, KT; Meredith, S; Narasimhulu, SS; Hall, K; Stein, CM
Oral erythromycin prolongs cardiac repolarization and is associated with case reports of torsades de pointes. Because erythromycin is extensively metabolized by cytochrome P-450 3A (CYP3A) isozymes, commonly used medications that inhibit the effects of CYP3A may increase plasma erythromycin concentrations, thereby increasing the risk of ventricular arrhythmias and sudden death. We studied the association between the use of erythromycin and the risk of sudden death from cardiac causes and whether this risk was increased with the concurrent use of strong inhibitors of CYP3A.
Pharmacy data for tuberculosis surveillance and assessment of patient management - Yokoe, DS; Platt, R; Coon, SW; Iannuzzi, MC; Dokholyan, R; Jones, TF; Meredith, S; Ray, W; Moore, M; Phillips, L; Schech, S; Shatin, D
Underreporting tuberculosis (TB) cases can compromise surveillance. We evaluated the contribution of pharmacy data in three different managed-care settings and geographic areas. Persons with more than two anti-TB medications were identified by using pharmacy databases. Active TB was confirmed by using state TB registries, medical record review, or questionnaires from prescribing physicians. We identified 207 active TB cases, including 13 (6%) missed by traditional surveillance. Pharmacy screening identified 80% of persons with TB who had received their medications through health plan-reimbursed sources, but missed those treated solely in public health clinics. The positive predictive value of receiving more than two...
Cyclic antidepressants and the risk of sudden cardiac death. - Ray, WA; Meredith, S; Thapa, PB; Hall, K; Murray, KT
Tricyclic and other related cyclic antidepressants (TCAs), used frequently for the treatment of depression and several other indications, have cardiovascular effects that may increase the risk of sudden cardiac death. We thus sought to quantify the risk of sudden cardiac death among TCA users, according to dose, as well as among users of selective serotonin reuptake inhibitors (SSRIs).