UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
Differential Myocyte Responses in Patients with Cardiac Transthyretin Amyloidosis and Light-Chain Amyloidosis: A Cardiac MR Imaging Study. - Fontana, M; Banypersad, SM; Treibel, TA; Abdel-Gadir, A; Maestrini, V; Lane, T; Gilbertson, JA; Hutt, DF; Lachmann, HJ; Whelan, CJ; Wechalekar, AD; Herrey, AS; Gillmore, JD; Hawkins, PN; Moon, JC
PURPOSE: To investigate cardiac magnetic resonance (MR) imaging measurements of extracellular volume (ECV) and total cell volume in immunoglobulin light-chain amyloidosis (AL) and transthyretin amyloidosis (ATTR) in order to evaluate the amyloid and myocyte volumes. MATERIALS AND METHODS: All ethics were approved, and participants provided written informed consent. Of the 257 subjects who were recruited, 92 had AL (mean age, 62 years ± 10), 44 had mutant ATTR (mean age, 68 years ± 10), and 66 had wild-type ATTR (mean age, 75 years ± 7). In addition, eight healthy subjects with ATTR mutations (mean age, 47 years ± 6) and...
Automatic Measurement of the Myocardial Interstitium: Synthetic Extracellular Volume Quantification Without Hematocrit Sampling. - Treibel, TA; Fontana, M; Maestrini, V; Castelletti, S; Rosmini, S; Simpson, J; Nasis, A; Bhuva, AN; Bulluck, H; Abdel-Gadir, A; White, SK; Manisty, C; Spottiswoode, BS; Wong, TC; Piechnik, SK; Kellman, P; Robson, MD; Schelbert, EB; Moon, JC
OBJECTIVES: The authors sought to generate a synthetic extracellular volume fraction (ECV) from the relationship between hematocrit and longitudinal relaxation rate of blood. BACKGROUND: ECV quantification by cardiac magnetic resonance (CMR) measures diagnostically and prognostically relevant changes in the extracellular space. Current methodologies require blood hematocrit (Hct) measurement-a complication to easy clinical application. We hypothesized that the relationship between Hct and longitudinal relaxation rate of blood (R1 = 1/T1blood) could be calibrated and used to generate a synthetic ECV without Hct that was valid, user-friendly, and prognostic. METHODS: Proof-of-concept: 427 subjects with a wide range of health and disease were divided...
Does participation in research lead to changes in attitudes among clinicians? Report on a survey of those involved in a French practice research network - Thurin, JM; Thurin, M; Midgley, N
Background/Objective: With increasing awareness of some of the limitations of randomised controlled trials as the 'gold standard' of psychotherapy evaluation, researchers at the start of the twenty-first century have focused on a number of new priorities: developing studies in natural conditions; investigating the psychotherapeutic process to better understand the conditions, causes and mechanisms of change; and reducing the gap between clinicians and researchers. Can these three interrelated objectives be combined? Method: A French psychotherapy practice-based research network (PRN) is used as a field of research for these issues. A survey was used to investigate the conditions that encouraged the clinicians...
'A path in the woods': Child psychotherapists' participation in a large randomised controlled trial - Henton, I; Midgley, N
Introduction: Much literature is devoted to the gap between clinical practice and research, particularly outcome research in the form of the randomised controlled trial (RCT). However, the RCT's central role in health services policy has increasingly led to calls for psychotherapists of all theoretical backgrounds to participate in RCT research. Aims: This study explored how actual participation in outcome research may change clinicians' attitudes towards this type of research. The specific focus is on psychoanalytic child psychotherapists' experiences of participation in a large-scale RCT in the UK studying the effectiveness of treatments for adolescent depression. Method: Five child psychotherapists were...
Psychodynamic psychotherapy for children and adolescents: A critical review of the evidence base - Midgley, N; Kennedy, E
For many years psychoanalytic and psychodynamic therapies have been considered to lack a credible evidence-base and have consistently failed to appear in lists of 'empirically supported treatments'. This study systematically reviews the research evaluating the efficacy and effectiveness of psychodynamic psychotherapy for children and young people. The researchers identified 34 separate studies that met criteria for inclusion, including nine randomised controlled trials. While many of the studies reported are limited by sample size and lack of control groups, the review indicates that there is increasing evidence to suggest the effectiveness of psychoanalytic psychotherapy for children and adolescents. The article aims...
Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation. - Wu, C; Hussein, MA; Shrestha, E; Leone, S; Aiyegbo, MS; Lambert, WM; Pourcet, B; Cardozo, T; Gustafson, JA; Fisher, EA; Pineda-Torra, I; Garabedian, MJ
In mouse models of atherosclerosis, normalization of hyperlipidemia promotes macrophage emigration and regression of atherosclerotic plaques in part by liver X receptor (LXR)-mediated induction of the chemokine receptor CCR7. Here we report that LXRα serine 198 (S198) phosphorylation modulates CCR7 expression. Low levels of S198 phosphorylation are observed in plaque macrophages in the regression environment where high levels of CCR7 expression are observed. Consistent with these findings, CCR7 gene expression in human and mouse macrophages cell lines is induced when LXRα at S198 is nonphosphorylated. In bone marrow-derived macrophages (BMDMs), we also observed induction of CCR7 by ligands that promote...