Recursos de colección

UCL University College London Eprints (372,813 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 161 - 180 de 376,637

  1. Humoral immunity to human breast cancer: Antigen definition and quantitative analysis of mRNA expression

    Scanlan, MJ; Gout, I; Gordon, CM; Williamson, B; Stockert, E; Gure, AO; Jäger, D; Chen, YT; Mackay, A; O'Hare, MJ; Old, LJ
    The ability of the immune system to recognize structurally altered, amplified or aberrantly expressed proteins can be used to identify molecules of etiologic relevance to cancer and to define targets for cancer immunotherapy. In the current study, ninety-four distinct antigens reactive with serum IgG from breast cancer patients were identified by immunoscreening breast cancer-derived cDNA expression libraries (SEREX). A serological profile was generated for each antigen on the basis of reactivity with allogeneic sera from normal individuals and cancer patients, and mRNA expression profiles for coding sequences were assembled based upon the tissue distribution of expressed sequence tags, Northern blots...

  2. Search and characterization of melanoma antigens with the use of serological identification of antigens by recombinant expression cloning

    Rodnin, MV; Tykhonkova, IO; Filonenko, VV; Drobot, LB; Matsuka, GK; Gout, IT
    Ten positive clones nave been identified during immunoscreening of expressing cDNA libraries by autologous sera. One of the clones encoded for a fragment of Ki-67 protein have been subcloned and the protein expressed in bacteria. Heterologous screening of recombinant Ki-67 protein by allogenic sera have been performed. Statistical analysis indicated significant difference in the level of autoantibodies in cancer sera in comparison with normal ones. The data obtained can be useful for the understanding of the malignance processes, and for the diagnostic and therapeutic purposes as well.

  3. Functional and regulatory properties of p70s6 kinase β

    Valovka, T; Fiionenko, V; Palchevsky, S; Velikiy, M; Drobot, L; Waterfield, M; Matsuka, G; Gout, IT
    © 1999, National Academy of Sciences of Ukraine. All rights reserved.A novel ribosomal S6 kinase, termed p70S6 kinase β, has been recently identified. It is highly homologous to known p70/p85 S6 kinase (p70S6 kinase α) in catalytic, kinase extension and auto-inhibitory domains, but differs significantly in the regulatory N- and C-terminal regions. Here we report the kinetics of serum-induced activation of cytoplasmic isoforms of p70S6 kinase α and β (p70α2 and p70β2) in transiently transfected HEK293. Both kinases exhibit biphasic activation upon serum stimulation, but differ in the appearance of peaks of their S6 specific activity. We also found that...

  4. Beyond a levels: Curriculum 2000 and the reform of 14-19 qualifications

    Hodgson, A; Spours, K
    © Ann Hodgson and Ken Spours, 2003. All rights reserved.Since its introduction over 50 years ago, the A-level has been a constant subject of debate in schools, HE and government. Sometimes hailed as a 'gold standard', there is now intense speculation about the future of the A-level in particular, but also about post-14 qualifications in general. The furore about quality and standards which accompanies each year's A-level results has become an annual fixture in the UK press calendar. With the introduction of Curriculum 2000, and an increasing number of calls for Baccalaureate-style examinations, vocational qualifications and more, the need for...

  5. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

    Salim, K; Bottomley, MJ; Querfurth, E; Zvelebil, MJ; Gout, I; Scaife, R; Margolis, RL; Gigg, R; Smith, CI; Driscoll, PC; Waterfield, MD; Panayotou, G
    Pleckstrin homology (PH) domains may act as membrane localization modules through specific interactions with phosphoinositide phospholipids. These interactions could represent responses to second messengers, with scope for regulation by soluble inositol polyphosphates. A biosensor-based assay was used here to probe interactions between PH domains and unilamellar liposomes containing different phospholipids and to demonstrate specificity for distinct phosphoinositides. The dynamin PH domain specifically interacted with liposomes containing phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and, more weakly, with liposomes containing phosphatidylinositol-4-phosphate [PI(4)P]. This correlates with phosphoinositide activation of the dynamin GTPase. The functional GTPase of a dynamin mutant lacking the PH domain, however, cannot be activated...

  6. Education for all: The future of education and training for 14-19 year olds

    Pring, R; Hayward, G; Hodgson, A; Johnson, J; Keep, E; Oancea, A; Rees, G; Spours, K; Wilde, S
    © 2009 Richard Pring, Geoff Hayward, Ann Hodgson, Jill Johnson, Ewart Keep, Alis Oancea, Gareth Rees, Ken Spours and Stephanie Wilde.There are two key questions at the heart of the ongoing debate about education and training for all young people, irrespective of background, ability or attainment• What counts as an educated 19 year old today?• Are the models of education we have inherited from the past sufficient to meet the needs of all young people, as well as the social and economic needs of the wider community?Education for All addresses these questions in the light of evidence collected over five...

  7. Decision-making resources for embedding theory into practice

    Conole, G; Oliver, M
    This paper illustrates a way in which practitioners can be supported in the process of engaging with theory in order to underpin practical applications in the use of information and communication technologies (ICT). This approach involves the use of decision-making resources ('toolkits'); three examples are described. The ways in which this embeds specific theoretical assumptions are discussed, and a model for toolkit specification, design and evaluation is described. © 2001 IEEE.

  8. An integrated approach to evaluating learning technologies

    Conole, G; Oliver, M; Harvey, J
    This paper describes the development of a Web-based evaluation toolkit, which supports practitioners in the effective and appropriate use and evaluation of learning technology. The paper defines the term 'toolkit' within this context and illustrates the concept with some existing examples. It provides a review of resources for supporting decision making, with a particular emphasis on learning technology evaluation research. An outline of the basic toolkit architecture and design is described. © 2000 IEEE. © 2000 IEEE.

  9. Evaluating online teaching and learning

    Oliver, M
    Evaluation is becoming increasingly important, both as a part of the design of online courses and as a mechanism for quality assurance. In this paper, the issues facing the evaluation of online teaching and learning are considered. Different motivations for evaluation are identified, and strategies for addressing these needs are illustrated.

  10. What impact does teaching music informally in the classroom have on teachers, and their pedagogy?

    Hallam, S; Creech, A; McQueen, H
    © 2015 Taylor & FrancisThe aim of this research was to explore the impact of the adoption of the Musical Futures (MF) approach on secondary school music teachers working in MF Champion schools. The research took place over 3 years in 3 phases with 28 teachers completing questionnaires exploring the impact on their confidence, skills and pedagogy and 30 being interviewed individually. Data from the interviews provided greater insights into the questionnaire responses. Most teachers reported that MF had helped them to become a more effective teacher, more confident in teaching music and had increased their enjoyment. MF changed the...

  11. Education and training 14-19: Curriculum, qualifications and organization

    Hodgson, A; Spours, K
    © Ann Hodgson and Ken Spours 2008.The authors provide an overview of current policy in the 14-19 area. They cover changes to 14-19 education, diplomas, and work-based learning in the context of new developments. They provide a comprehensive and up-to-date account of the new 14-19 phase with a focus on A levels and GCSEs, the new 14-19 Diplomas vocational learning and institutional collaboration. Drawing on international and historical analysis, recent research and practice and interveiws with policy actors, the authors set out the case for a more unified and strongly collaborative approach to the organisation of upper secondary education in...

  12. Reading

    Daly, C

  13. Improving learning, skills and inclusion: The impact of policy on post-compulsory education

    Coffield, F; Edward, S; Finlay, I; Hodgson, A; Spours, K; Steer, R
    © 2008 Frank Coffield, Sheila Edward, Ian Finlay, Ann Hodgson, Ken Spours and Richard Steer. All rights reserved.How can opportunities for teaching and learning be improved to ensure that many more people participate, gain qualifications and obtain decent jobs? Will government policies enable us to achieve these goals? What new ideas do we need to ensure a more inclusive, equitable and efficient learning system? These are some of the main concerns which underlie this thought-provoking book coming from a major research project looking at how policies affect learners, tutors, managers and institutional leaders in Further Education Colleges, Adult and Community...

  14. An ecological analysis of the dynamics of localities: a 14+ low opportunity progression equilibrium in action

    Hodgson, A; Spours, K
    © 2013 Taylor & Francis.This article uses a multi-level ecological model to explore the dynamics of localities in England and their effects on the 14+ participation, progression and transition (14+ PPT) of young people at a time when nationally and internationally there is a recognition that transitions from education to employment are both more complex and take longer. Drawing on major research programmes, national enquiries and local studies, the article further develops the concept of a ‘local learning ecologies’ (LLEs) that represent localities in the physical, economic and social senses and that function as part of a multi-level ecological framework...

  15. A baccalaureate system for the english context

    Hodgson, A; Spours, K

  16. Exploring formative e-assessment: Using case stories and design patterns

    Daly, C; Pachler, N; Mor, Y; Mellar, H
    This article presents key findings from a Joint Information Systems Committeefunded project, which aimed to identify existing practices where technologies contribute to formative assessment and identify processes that take place around formative assessment where technologies play a significant role. Using a design pattern methodology, the project developed a range of cases of formative eassessment with practitioners across a variety of settings through a series of participant workshops. From a selection of these cases, we identified key elements in how practitioners described the problems and solutions they addressed regarding assessment in relation to learning within their different contexts. The patterns were...

  17. The 'real world' of technologies: What kinds of professional development are needed for English teachers?

    Daly, C

  18. Debates in english teaching

    Davison, J; Daly, C; Moss, J
    © 2011 Jon Davison, Caroline Daly and John Moss for selection and editorial material. All rights reserved.What are the key debates in English teaching today? Debates in English Teaching explores the major issues all English teachers encounter in their daily professional lives. It engages with established and contemporary debates, promotes and supports critical reflection and aims to stimulate both novice and experienced teachers to reach informed judgements and argue their point of view with deeper theoretical knowledge and understanding. Key issues debated include: the professional identity of English teachers. attitudes to correctness in grammar and standard English. the importance of...

  19. Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1.

    Yonezawa, K; Ueda, H; Hara, K; Nishida, K; Ando, A; Chavanieu, A; Matsuba, H; Shii, K; Yokono, K; Fukui, Y
    Monoclonal antibodies raised against the 85-kDa subunit (p85) of bovine phosphatidylinositol (PI) 3-kinase were found to recognize uncomplexed p85 or p85 in the active PI 3-kinase. Immunoprecipitation studies of Chinese hamster ovary cells, which overexpress the human insulin receptor when treated with insulin, showed increased amounts of p85 and PI 3-kinase activity immunoprecipitable with monoclonal anti-p85 antibody and no increase in the tyrosine phosphorylation of p85. Insulin also induced an association of p85 with the tyrosine-phosphorylated insulin receptor substrate 1 (IRS-1) and other phosphorylated proteins ranging in size from 100 to 170 kDa but not with the activated insulin receptor....

  20. International conference "Tumor and host: Novel aspects of old problem"

    Kavetsky, RE; Paton, BE; Chekhun, VF; Jones, PA; Vaupel, P; Friess, H; Klein, G; Klein, E; Horsman, M; Kleeff, J; Osinsky, S; Sica, A; Berezhnaya, N; Molls, M; Volodko, N; Kovelskaya, A; Gerashchenko, B; Florovskaya, N; Ganusevich, I; Gout, I; Kavsan, VM; Belousov, PV; Lazarevich, NL; Sidorenko, SP; Yurchenko, M; Drobot, LB; Nadgornaya, VO; Gluzman, DF; Kravchuk, IN; Pande, NT; Filonenko, VV; Lukianova, NY; Galanta, ES; Gordiyuk,; Shlyakhovenko, VA; Gamaleia, NF; Kaluzhny, DN; Nikolaev, VG; Solyanik, GI; Bilynskyi, BT; Souchelnytskyi, S

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