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UCL University College London Eprints (377,998 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 161 - 180 de 377,461

  1. Corrigendum: Changing pattern in the basal ganglia: motor switching under reduced dopaminergic drive.

    Fiore, VG; Rigoli, F; Stenner, MP; Zaehle, T; Hirth, F; Heinze, HJ; Dolan, RJ

  2. Neural processes mediating contextual influences on human choice behaviour.

    Rigoli, F; Friston, KJ; Dolan, RJ
    Contextual influences on choice are ubiquitous in ecological settings. Current evidence suggests that subjective values are normalized with respect to the distribution of potentially available rewards. However, how this context-sensitivity is realised in the brain remains unknown. To address this, here we examine functional magnetic resonance imaging (fMRI) data during performance of a gambling task where blocks comprise values drawn from one of two different, but partially overlapping, reward distributions or contexts. At the beginning of each block (when information about context is provided), hippocampus is activated and this response is enhanced when contextual influence on choice increases. In addition,...

  3. Investigating obesity as a risk factor for influenza-like illness during the 2009 H1N1 influenza pandemic using the Health Survey for England.

    Murphy, R; Fragaszy, EB; Hayward, AC; Warren-Gash, C
    BACKGROUND: Following the 2009 H1N1 influenza pandemic, obesity was shown to be associated with severe influenza outcomes. It remains unclear whether obesity was a risk factor for milder influenza-like illness (ILI). OBJECTIVES: To determine whether obesity was associated with an increased risk of self-reported ILI during the 2009 H1N1 influenza pandemic using Health Survey for England (HSE) 2010 cross-sectional data. METHODS: This study used HSE data collected from English households between January and December 2010. Weight and height measurements were taken by trained fieldworkers to determine obesity. ILI was defined as a positive response to the question "Have you had...

  4. A comparison of CellCollector with CellSearch in patients with neuroendocrine tumours.

    Mandair, D; Vesely, C; Ensell, L; Lowe, H; Spanswick, VJ; Hartley, J; Caplin, M; Meyer, T
    EXTRACT: Circulating tumour cells (CTCs) have been hypothesised to be mediators of metastases (Fidler et al. 2003) but with numbers as low as one per 107 white cells (Alunni-Fabbroni et al.2010), their utility as biomarkers has been limited by low rates of detection and isolation. CTCs have been identified in patients with metastatic neuroendocrine tumours (NETs) using the FDA-cleared CellSearch (Janssen Diagnostics) technology, a semi-automated platform that uses immunomagnetic enrichment of CTCs based on expression of epithelial cell adhesion molecule (EpCAM) ...

  5. Rydel-Seiffer fork revisited: Beyond a simple case of black and white.

    Panosyan, FB; Mountain, JM; Reilly, MM; Shy, ME; Herrmann, DN

  6. Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.

    Hampras, SS; Sucheston-Campbell, LE; Cannioto, R; Chang-Claude, J; Modugno, F; Dörk, T; Hillemanns, P; Preus, L; Knutson, KL; Wallace, PK; Hong, CC; Friel, G; Davis, W; Nesline, M; Pearce, CL; Kelemen, LE; Goodman, MT; Bandera, EV; Terry, KL; Schoof, N; Eng, KH; Clay, A; Singh, PK; Joseph, JM; Aben, KK; Anton-Culver, H; Antonenkova, N; Baker, H; Bean, Y; Beckmann, MW; Bisogna, M; Bjorge, L; Bogdanova, N; Brinton, LA; Brooks-Wilson, A; Bruinsma, F; Butzow, R; Campbell, IG; Carty, K; Cook, LS; Cramer, DW; Cybulski, C; Dansonka-Mieszkowska, A; Dennis, J; Despierre, E; Dicks, E; Doherty, JA; du Bois, A; Dürst, M; Easton, D; Eccles, D; Edwards, RP; Ekici, AB; Fasching, PA; Fridley, BL; Gao, YT; Gentry-Maharaj, A; Giles, GG; Glasspool, R; Gronwald, J; Harrington, P; Harter, P; Hasmad, HN; Hein, A; Heitz, F; Hildebrandt, MA; Hogdall, C; Hogdall, E; Hosono, S; Iversen, ES; Jakubowska, A; Jensen, A; Ji, BT; Karlan, BY; Kellar, M; Kelley, JL; Kiemeney, LA; Klapdor, R; Kolomeyevskaya, N; Krakstad, C; Kjaer, SK; Kruszka, B; Kupryjanczyk, J; Lambrechts, D; Lambrechts, S; Le, ND; Lee, AW; Lele, S; Leminen, A; Lester, J; Levine, DA; Liang, D; Lissowska, J; Liu, S; Lu, K; Lubinski, J; Lundvall, L; Massuger, LF; Matsuo, K; McGuire, V; McLaughlin, JR; McNeish, I; Menon, U; Moes-Sosnowska, J; Narod, SA; Nedergaard, L; Nevanlinna, H; Nickels, S; Olson, SH; Orlow, I; Weber, RP; Paul, J; Pejovic, T; Pelttari, LM; Perkins, B; Permuth-Wey, J; Pike, MC; Plisiecka-Halasa, J; Poole, EM; Risch, HA; Rossing, MA; Rothstein, JH; Rudolph, A; Runnebaum, IB; Rzepecka, IK; Salvesen, HB; Schernhammer, E; Schmitt, K; Schwaab, I; Shu, XO; Shvetsov, YB; Siddiqui, N; Sieh, W; Song, H; Southey, MC; Tangen, IL; Teo, SH; Thompson, PJ; Timorek, A; Tsai, YY; Tworoger, SS; Tyrer, J; van Altena, AM; Vergote, I; Vierkant, RA; Walsh, C; Wang-Gohrke, S; Wentzensen, N; Whittemore, AS; Wicklund, KG; Wilkens, LR; Wu, AH; Wu, X; Woo, YL; Yang, H; Zheng, W; Ziogas, A; Gayther, SA; Ramus, SJ; Sellers, TA; Schildkraut, JM; Phelan, CM; Berchuck, A; Chenevix-Trench, G; Cunningham, JM; Pharoah, PP; Ness, RB; Odunsi, K; Goode, EL; Moysich, KB
    BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. METHODS: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian...

  7. Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer.

    Sundar, S; Rick, C; Dowling, F; Au, P; Snell, K; Rai, N; Champaneria, R; Stobart, H; Neal, R; Davenport, C; Mallett, S; Sutton, A; Kehoe, S; Timmerman, D; Bourne, T; Van Calster, B; Gentry-Maharaj, A; Menon, U; Deeks, J; ROCkeTS study group,
    INTRODUCTION: Ovarian cancer (OC) is associated with non-specific symptoms such as bloating, making accurate diagnosis challenging: only 1 in 3 women with OC presents through primary care referral. National Institute for Health and Care Excellence guidelines recommends sequential testing with CA125 and routine ultrasound in primary care. However, these diagnostic tests have limited sensitivity or specificity. Improving accurate triage in women with vague symptoms is likely to improve mortality by streamlining referral and care pathways. The Refining Ovarian Cancer Test Accuracy Scores (ROCkeTS; HTA 13/13/01) project will derive and validate new tests/risk prediction models that estimate the probability of having...

  8. Biomarkers of intestinal fibrosis - one step towards clinical trials for stricturing inflammatory bowel disease.

    Giuffrida, P; Pinzani, M; Corazza, GR; Di Sabatino, A
    Intestinal fibrosis, caused by an excessive deposition of extracellular matrix components, and subsequent stricture development are a common complication of inflammatory bowel disease. However, currently there are no biomarkers which reliably predict the risk of developing intestinal strictures or identify early stages of fibrosis prior to clinical symptoms. Candidate biomarkers of intestinal fibrosis, including gene variants (i.e. nucleotide-binding oligomerization domain-2 gene), serum microRNAs (miR-19, miR-29), serum extracellular matrix proteins (i.e. collagen, fibronectin) or enzymes (i.e. tissue inhibitor of matrix metalloproteinase-1), serum growth factors (i.e. basic fibroblast growth factor, YKL-40), serum anti-microbial antibodies (i.e. anti-Saccharomyces cerevisiae) and circulating cells (i.e. fibrocytes)...

  9. Association between glycaemic control and common infections in people with Type 2 diabetes: a cohort study.

    Hine, JL; de Lusignan, S; Burleigh, D; Pathirannehelage, S; McGovern, A; Gatenby, P; Jones, S; Jiang, D; Williams, J; Elliot, AJ; Smith, GE; Brownrigg, J; Hinchcliffe, R; Munro, N
    AIM: To investigate the impact of glycaemic control on infection incidence in people with Type 2 diabetes. METHODS: We compared infection rates during 2014 in people with Type 2 diabetes and people without diabetes in a large primary care cohort in the UK (the Royal College of General Practitioners Research and Surveillance Centre database). We performed multilevel logistic regression to investigate the impact of Type 2 diabetes on presentation with infection, and the effect of glycaemic control on presentation with upper respiratory tract infections, bronchitis, influenza-like illness, pneumonia, intestinal infectious diseases, herpes simplex, skin and soft tissue infections, urinary tract...

  10. MDM2 binds and ubiquitinates keratin 10 in VZV infection and is required for viral propagation and blister formation

    Tomassi, C; Depledge, D; Otto, R; Tan, W; Duddy, D; Breuer, J; O'Shaughnessy, R

  11. Corrigendum to "Sex hormone measurements using mass spectrometry and sensitive extraction radioimmunoassay and risk of estrogen receptor negative and positive breast cancer: Case control study in UK Collaborative Cancer Trial of Ovarian Cancer Screening (UKCTOCS)" [Steroids 110 (2016) 62-69].

    Fourkala, EO; Blyuss, O; Field, H; Gunu, R; Ryan, A; Barth, J; Jacobs, I; Zaikin, A; Dawnay, A; Menon, U

  12. PCR-based detection of composite transposons and translocatable units from oral metagenomic DNA.

    Tansirichaiya, S; Mullany, P; Roberts, AP
    A composite transposon is a mobile genetic element consisting of two insertion sequences (ISs) flanking a segment of cargo DNA often containing antibiotic resistance (AR) genes. Composite transposons can move as a discreet unit. There have recently been several reports on a novel mechanism of movement of an IS26 based composite transposon through the formation of a translocatable unit (TU), carrying the internal DNA segment of a composite transposon and one copy of a flanking IS. In this study, we determined the presence of composite transposons and TUs in human oral metagenomic DNA using PCR primers from common IS elements....

  13. Hijos de un tiempo perdido La búsqueda de nuestros orígenes

    Bermudez de Castro, JM; Márquez, B; Mateos, A; Martinón-Torres, M; Sarmiento, S
    Los autores de este libro, arqueólogos y antropólogos de las excavaciones de Atapuerca, han añadido a su propia experiencia los resultados de las investigaciones y los descubrimientos más recientes para contarnos esa historia ...

  14. Salivary testosterone levels and health status in men and women in the British general population: findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).

    Clifton, S; Macdowall, W; Copas, AJ; Tanton, C; Keevil, BG; Lee, DM; Mitchell, KR; Field, N; Sonnenberg, P; Bancroft, J; Mercer, CH; Wallace, AM; Johnson, AM; Wellings, K; Wu, F
    CONTEXT: Salivary testosterone (Sal-T) measurement by LC-MS/MS resents the opportunity to examine health correlates of Sal-T in a large-scale population survey. OBJECTIVE: To examine associations between Sal-T and health-related factors in men and women aged 18-74 years. DESIGN & SETTING: Morning saliva samples were obtained from participants in a cross-sectional probability-sample survey of the general British population ('Natsal-3'). Self-reported health and lifestyle questions were administered as part of a wider sexual health interview. PARTICIPANTS: 1,599 men; 2,123 women. METHODS: Sal-T was measured using LC-MS/MS; linear regression was used to examine associations between health factors and mean Sal-T. RESULTS: In men,...

  15. How can we objectively categorise partnership type? A novel classification of population survey data to inform epidemiological research and clinical practice.

    Mercer, CH; Jones, KG; Johnson, AM; Lewis, R; Mitchell, KR; Gravningen, K; Clifton, S; Tanton, C; Sonnenberg, P; Wellings, K; Cassell, JA; Estcourt, CS
    BACKGROUND: Partnership type is a determinant of STI risk; yet, it is poorly and inconsistently recorded in clinical practice and research. We identify a novel, empirical-based categorisation of partnership type, and examine whether reporting STI diagnoses varies by the resulting typologies. METHODS: Analyses of probability survey data collected from 15 162 people aged 16-74 who participated in Britain's third National Survey of Sexual Attitudes and Lifestyles were undertaken during 2010-2012. Computer-assisted self-interviews asked about participants' ≤3 most recent partners (N=14 322 partners/past year). Analysis of variance and regression tested for differences in partnership duration and perceived likelihood of sex again across 21...

  16. RegenVOX - Translational Exploitation Strategy for Stem Cell-Based Tissue-Engineered Laryngeal Implants Undergoing Phase I/II Clinical Trial

    Culme-Seymour, EJ; Carvalho, C; Bain, O; Omakobia, E; Wilson, S; Knowles, H; Tebbs, S; Champion, K; Round, J; Ambler, G; Birchall, MA; Lowdell, MW; Mason, C

  17. Numerical simulation of the loading characteristics of straight and helical-bladed vertical axis tidal turbines

    Marsh, P; Ranmuthugala, D; Penesis, I; Thomas, G

  18. Homo antecessor

    Martinon-Torres, M

  19. Hedgehog Signalling in the Embryonic Mouse Thymus.

    Barbarulo, A; Lau, CI; Mengrelis, K; Ross, S; Solanki, A; Saldaña, JI; Crompton, T
    T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation.

  20. Targeted Gene Addition Strategies for the Treatment of X-Linked Lymphoproliferative Disease

    Houghton, BC; Mussolino, C; Cathomen, T; Gaspar, HB; Booth, C

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