UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
Sensory, psychological and metabolic dysfunction in HIV-Associated Peripheral Neuropathy. A cross sectional deep profiling study. - Phillips, TJ; Brown, M; Ramirez, JD; Perkins, J; Woldeamanuel, YW; de C Williams, AC; Orengo, C; Bennett, DL; Bodi, I; Cox, S; Maier, C; Krumova, EK; Rice, AS
HIV-associated Sensory Neuropathy (HIV-SN) is a frequent complication of HIV infection and a major source of morbidity. A cross-sectional deep profiling study examining HIV-SN was conducted in people living with HIV in a high resource setting, using a battery of measures which included: parameters of pain and sensory symptoms (7 day pain diary, Neuropathic Pain Symptom Inventory (NPSI) and Brief Pain Inventory (BPI)), sensory innervation (structured neurological examination, quantitative sensory testing (QST) and intra-epidermal nerve fibre density (IENFD)), psychological state (Pain Anxiety Symptoms Scale-20 (PASS-20), Depression Anxiety and Positive Outlook Scale (DAPOS), and Pain Catastrophizing Scale (PCS), insomnia (Insomnia Severity...
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis - Zigmond, E; Bernshtein, B; Yona, S; Kim, K-W; Krauthgamer, R; Jung, S; Varol, C; Friedlander, G; Walker, CR; Müller, W; Brenner, O
Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and sensed by most hematopoietic cells. Genome-wide association studies and experimental animal models point at a central role of the IL-10 axis in inflammatory bowel diseases. Here we investigated the importance of intestinal macrophage production of IL-10 and their IL-10 exposure, as well as the existence of an IL-10-based autocrine regulatory loop in the gut. Specifically, we generated mice harboring IL-10 or IL-10 receptor (IL-10Rα) mutations in intestinal lamina propria-resident chemokine receptor CXCR1-expressing macrophages. We found macrophage-derived IL-10 dispensable for gut homeostasis and maintenance of colonic T regulatory cells. In contrast, loss...
Publication Trends of Medical Anthropology in the Biomedical and Life Sciences Literature - Ruiz, M
OBJECTIVES: The goal of this paper is to measure the success of medical anthropology in its inclusion within the biomedical and life sciences discourse. The paper will establish a publication timeline for medical anthropology to identify high and low productivity rates. Articles will be classified to determine the linguistic and geographical clustering of the literature, as well as the distribution of journals in which they are published and the institutions that produce them. METHODS: PubMed, an electronic database, was used to identify MEDLINE-indexed articles in biomedical and life sciences journals. The query searched for the phrase “medical anthropology” in the...
Childhood social disadvantage and health and development in later life: the DRIVERS Project - Pikhart, H; Morrison, J; Ruiz, M; Goldblatt, P
INTRODUCTION: The evidence suggests that early childhood is the most crucial period of development. The socioeconomic environment in which children live has been shown to be related to many outcomes in childhood and later life. The aim of EU FP7-funded DRIVERS project is to (1) systematically review the available evidence on associations between socioeconomic factors and early childhood health and development in Europe, (2) summarise existing intervention research on unequal development and health to enable identifying effective intervention approaches, and (3) conduct data analysis on selected Europe-based studies focusing on early childhood. METHODS: Several databases were searched in order to...
Attitudes and beliefs of non-participants in a population-based screening programme for colorectal cancer - Hall, NJ; Rubin, GP; Dobson, C; Weller, D; Wardle, J; Ritchie, M; Rees, CJ
Background: Uptake of colorectal cancer screening programmes needs to be improved or at least maintained in order to achieve projected reductions in mortality and morbidity. Understanding the origins of non-participation in screening is therefore important. Objective: To explore the beliefs and experiences of individuals who had not responded either to their screening invitation or reminder. Design: A qualitative study using in-depth interviews with non-participants from England's population-based colorectal cancer screening programme. Data collection and analysis were carried out using a grounded theory approach, with an emphasis on the constant comparison method, and continued until saturation (27 interviews). Findings: The interviews...