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UCL University College London Eprints (339,766 recursos)
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 181 - 200 de 339,647

181. Understanding drivers of phylogenetic clustering in molecular epidemiological studies of HIV. - Frost, SD; Pillay, D

182. After the RCT: who comes to a family-based intervention for childhood overweight or obesity when it is implemented at scale in the community? - Fagg, J; Cole, TJ; Cummins, S; Goldstein, H; Morris, S; Radley, D; Sacher, P; Law, C
When implemented at scale, the impact on health and health inequalities of public health interventions depends on who receives them in addition to intervention effectiveness.

183. Functional/psychogenic movement disorders: Do we know what they are? - Edwards, MJ; Stone, J; Lang, AE

184. Massive Pulmonary Carcinoid Tumor Deemed Inoperable until (68)Ga DOTATATE Positron Emission Tomography/Magnetic Resonance Imaging. - Ordidge, KL; Brown, JM; Succony, L; Navani, N; Hardavella, G; Lawrence, DR; Fraioli, F; Groves, A; Janes, SM

185. Influence of lidocaine hydrochloride and penetration enhancers on the barrier function of human skin. - Hirata, K; Mohammed, D; Hadgraft, J; Lane, ME
Skin penetration enhancers (SPEs) are commonly employed in pharmaceutical and personal care products. These compounds transiently alter the barrier properties of the skin and we have previously investigated the effects of specific SPEs on skin barrier function in vivo. In the present study the effects of incorporation of an active pharmaceutical ingredient (API), lidocaine hydrochloride (LID HCl) in the SPEs previously studied were investigated. Solutions of LID HCl were prepared and applied to the volar forearm of human subjects with occlusion for 24h. Subsequently, tape stripping and trans epidermal water loss (TEWL) measurements were conducted for treated and control sites....

186. Rotigotine: The first new chemical entity for transdermal drug delivery. - McAfee, DA; Hadgraft, J; Lane, ME
Rotigotine is the first, and to date, the only new chemical entity to be formulated for transdermal delivery. Although first approved for the management of Parkinson's disease in Europe in 2007 and Restless Leg Syndrome in 2008, the story of rotigotine began more than twenty years earlier. In this review we outline the historical development of this molecule and its route to licensed medicine status. It has very favourable physicochemical properties for transdermal delivery but it took a significant period to develop from concept to market. The stability problems which led to the temporary withdrawal of the patch are examined...

187. Don't Bet on It! Wagering as a Measure of Awareness in Decision Making Under Uncertainty. - Konstantinidis, E; Shanks, DR
Can our decisions be guided by unconscious or implicit influences? According to the somatic marker hypothesis, emotion-based signals can guide our decisions in uncertain environments outside awareness. Postdecision wagering, in which participants make wagers on the outcomes of their decisions, has been recently proposed as an objective and sensitive measure of conscious content. In 5 experiments we employed variations of a classic decision-making assessment, the Iowa Gambling Task, in combination with wagering in order to investigate the role played by unconscious influences. We examined the validity of postdecision wagering by comparing it with alternative measures of conscious knowledge, specifically confidence...

188. The failure to degrade JunB contributes to Collagen type I over-production and dermal fibrosis in Scleroderma. - Ponticos, M; Papaioannou, I; Xu, S; Holmes, AM; Khan, K; Denton, CP; Bou Gharios, G; Abraham, DJ
Objectives: The excessive deposition of extracellular matrix including collagen type I is a key aspect in the pathogenesis of connective tissue diseases such as Scleroderma (SSc). To further our understanding of the mechanisms governing the dysregulation of type I collagen production in SSc, we investigated the role of the activator protein 1 (AP1) family of transcription factors in regulating collagen gene (COL1A2) transcription. Methods: The expression and nuclear localization of AP1 family members (c-Jun, JunB, JunD, Fra 1 and 2 and c-Fos) was examined in dermal biopsies and explanted skin fibroblasts from diffuse cutaneous SSc and healthy controls by immunohistochemistry...

189. Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis. - Ponticos, M; Smith, BD
Extracellular matrix (ECM) within the vascular network provides both a structural and regulatory role. The ECM is a dynamic composite of multiple proteins that form structures connecting cells within the network. Blood vessels are distended by blood pressure and, therefore, require ECM components with elasticity yet with enough tensile strength to resist rupture. The ECM is involved in conducting mechanical signals to cells. Most importantly, ECM regulates cellular function through chemical signaling by controlling activation and bioavailability of the growth factors. Cells respond to ECM by remodeling their microenvironment which becomes dysregulated in vascular diseases such hypertension, restenosis and atherosclerosis....

190. Function of monocytes and monocyte-derived macrophages in α1-antitrypsin deficiency. - Van't Wout, EF; van Schadewijk, A; Lomas, DA; Stolk, J; Marciniak, SJ; Hiemstra, PS
α1-antitrypsin deficiency is the most widely recognised genetic disorder causing chronic obstructive pulmonary disease (COPD). Mutant Z α1-antitrypsin expression has previously been linked to intracellular accumulation and polymerisation of this proteinase inhibitor. Subsequently, this has been described to underlie an exaggerated endoplasmic reticulum stress response and enhanced nuclear factor-κB signalling. However, whether monocyte-derived macrophages display the same features remains unknown. Monocytes from homozygous PiZZ α1-antitrypsin deficiency patients and PiMM controls were cultured for 6 days in the presence of granulocyte-macrophage or macrophage colony-stimulating factor to obtain pro- and anti-inflammatory macrophages (mφ-1 and mφ-2, respectively). We first showed that, in contrast...

191. Genetic Control of Gene Expression at Novel and Established Chronic Obstructive Pulmonary Disease Loci. - Castaldi, PJ; Cho, MH; Zhou, X; Qiu, W; McGeachie, M; Celli, B; Bakke, P; Gulsvik, A; Lomas, DA; Crapo, JD; Beaty, TH; Rennard, S; Harshfield, B; Lange, C; Singh, D; Tal-Singer, R; Riley, JH; Quackenbush, J; Raby, BA; Carey, VJ; Silverman, EK; Hersh, CP
Genetic risk loci have been identified for a wide range of diseases through genome-wide association studies (GWAS), but the relevant functional mechanisms have been identified for only a small proportion of these GWAS-identified loci. By integrating results from the largest current GWAS of chronic obstructive disease (COPD) with expression quantitative trait locus (eQTL) analysis in whole blood and sputum from 121 subjects with COPD from the ECLIPSE Study, this analysis identifies loci that are simultaneously associated with COPD and the expression of nearby genes (COPD eQTLs). After integrative analysis, 19 COPD eQTLs were identified, including all four previously identified genome-wide...

192. Non-resonant Higgs pair production in the $b\overline{b}b\overline{b}$ final state at the LHC - Wardrope, D; Jansen, E; Konstantinidis, N; Cooper, B; Falla, R; Norjoharuddeen, N
We present a particle-level study of the Standard Model non-resonant Higgs-pair production process in the \bbb\bbb\ final state, at the Large Hadron Collider at $\sqrt{s}=14$\,TeV. Each Higgs boson is reconstructed from a pair of close-by jets formed with the anti-$k_t$ jet clustering algorithm, with radius parameter $R=0.4$. Given the kinematic properties of the produced Higgs bosons, we show that this reconstruction approach is more suitable than the use of two large-radius jets that capture all the decay products of a Higgs boson, as was previously proposed in the literature. We also demonstrate that the sensitivity for observing this final state...

193. Epilepsy surgery in children and adults. - Ryvlin, P; Cross, JH; Rheims, S
Epilepsy surgery is the most effective way to control seizures in patients with drug-resistant focal epilepsy, often leading to improvements in cognition, behaviour, and quality of life. Risks of serious adverse events and deterioration of clinical status can be minimised in carefully selected patients. Accordingly, guidelines recommend earlier and more systematic assessment of patients' eligibility for surgery than is seen at present. The effectiveness of surgical treatment depends on epilepsy type, underlying pathology, and accurate localisation of the epileptogenic brain region by various clinical, neuroimaging, and neurophysiological investigations. Substantial progress has been made in the methods of presurgical assessment, particularly...

194. Setting the scene: definition of prolonged seizures, acute repetitive seizures, and status epilepticus. Do we know why seizures stop? - Cross, JH
Status epilepticus is recognised as an acute emergency requiring urgent intervention. The optimal timing of such an intervention during a prolonged seizure, and the reasons for such, have provided much discussion. For operational purposes, a definition of a prolonged seizure of ≥5 minutes requiring intervention appears justified. However, a definition of status epilepticus of ≥30 minutes should stand, with the proportion of seizures proceeding to this clinical state remaining small. The reasons for this may be inherent to an individual, but an understanding of the mechanisms underlying the predisposition may lead to improved management pathways in the future.

195. Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance. - Stratton, D; Lange, S; Kholia, S; Jorfi, S; Antwi-Baffour, S; Inal, J
Using a Quartz Crystal Microbalance with dissipation monitoring, QCM-D (label-free system) measuring changes in resonant frequency (Δf) that equate to mass deposited on a sensor, we showed the attachment, over a 60min period, of a monolayer of PC3 cells to the gold electrodes of the quartz crystal sensor, which had been rendered hydrophilic. That MVs were released upon BzATP stimulation of cells was confirmed by NTA analysis (average 250nm diameter), flow cytometry, showing high phosphatidylserine exposition and by fluorescent (Annexin V Alexa Fluor® 488-positive) and electron microscopy. Over a period of 1000s (16.7min) during which early apoptosis increased from 4%...

196. Novel aspects of encapsulation and delivery using polymersomes. - Messager, L; Gaitzsch, J; Chierico, L; Battaglia, G
Polymersomes are nanoscopic (e.g. nanometer-sized) vesicles formed by amphiphilic block copolymers. They represent the more robust and versatile macromolecular counterparts to the well-established lipid vesicles or liposomes. Recently, considerable efforts have been made to produce them in a uniform and functional manner. New techniques such as artificial endocytosis and electroporation have also been developed to achieve payload encapsulation. In this mini-review, we discuss these and other recent developments in making polymersomes an actual alternative for biomedical applications.

197. An investigation of the relationship between ethnicity and success in a BSc (Hons) Physiotherapy degree programme in the UK. - Williams, A; Norris, M; Cassidy, E; Naylor, S; Marston, L; Shiers, P
To explore the potential relationship between ethnicity and achievement within undergraduate physiotherapy education.

198. Bronchiectasis. - José, RJ; Brown, JS

199. Propriospinal myoclonus: Clinical reappraisal and review of literature. - van der Salm, SM; Erro, R; Cordivari, C; Edwards, MJ; Koelman, JH; Ende, TV; Bhatia, KP; van Rootselaar, AF; Brown, P; Tijssen, MA
Propriospinal myoclonus (PSM) is a rare disorder with repetitive, usually flexor arrhythmic brief jerks of the trunk, hips, and knees in a fixed pattern. It has a presumed generation in the spinal cord and diagnosis depends on characteristic features at polymyography. Recently, a historical paradigm shift took place as PSM has been reported to be a functional (or psychogenic) movement disorder (FMD) in most patients. This review aims to characterize the clinical features, etiology, electrophysiologic features, and treatment outcomes of PSM.

200. Detecting anxiety and depression in patients diagnosed with an interstitial lung disease. Can we do better? - Russell, AM; Maher, TM

 

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