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UCL University College London Eprints (411.881 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 181 - 200 de 64.279

  1. Contradictory concepts in tortuosity determination in porous media in electrochemical devices

    Tjaden, B; Finegan, DP; Lane, J; Brett, DJL; Shearing, PR
    © 2017Porous media are a vital component in almost every electrochemical device in the form of electrode, support or gas diffusion layers. Microstructural parameters of porous layers such as tortuosity, porosity and pore size diameter are of high importance and crucial for diffusive mass transport calculations. Among these parameters, the tortuosity remains ill-defined in the field of electrochemistry, resulting in a wide range of different calculation approaches. Here, we present a systematic approach of calculating the tortuosity of different porous samples using image and diffusion cell experimental-based methods. Image-based analyses include a selection of geometric and flux-based tortuosity calculation algorithms....

  2. Update on primary ciliary dyskinesia

    Robson, EA; Chetcuti, P; Hirst, RA; Mitchison, H; Moya, E; Peckham, D; Robinson, PJ; Rutman, A; O'Callaghan, C
    © 2017 Elsevier Ltd.PCD is a rare autosomal recessive disorder of ciliary function. It is characterised by progressive sino-pulmonary disease, fertility problems and disorders of organ laterality. Clinical phenotype and disease course can vary significantly. A daily chronic wet cough that never goes away is invariably present, with most suffering from persistent and significant rhinosinusitis. Middle ear effusion and hearing difficulty are seen in a proportion of patients. Bronchiectasis is reported in approximately 70% of children.Diagnosis can be difficult and often requires specialist centre input. In patients with a suggestive clinical phenotype a combination of nasal nitric oxide, high-speed video...

  3. Sexual harassment of students on public transport: An exploratory study in Lucknow, India

    Tripathi, K; Borrion, H; Belur, J

  4. [Keynote] Applications des technologie photoniques pour l’accès aux domaine de fréquence THz

    Renaud, C

  5. [Keynote] Progress in THz technology enabled by photonics

    Renaud, C

  6. The significance of circadian rhythms and dysrhythmias in critical illness

    McKenna, HT; Reiss, IKM; Martin, DS
    © The Intensive Care Society 2017.Many physiological and cellular processes cycle with time, with the period between one peak and the next being roughly equal to 24 h. These circadian rhythms underlie ‘permissive homeostasis’, whereby anticipation of periods of increased energy demand or stress may enhance the function of individual cells, organ systems or whole organisms. Many physiological variables related to survival during critical illness have a circadian rhythm, including the sleep/wake cycle, haemodynamic and respiratory indices, immunity and coagulation, but their clinical significance remains underappreciated. Critically ill patients suffer from circadian dysrhythmia, manifesting overtly as sleep disturbance and delirium,...

  7. Opportunities for system level improvement across antibiotic use in the surgical pathway.

    Charani, E; Ahmad, R; Tarrant, C; Birgand, G; Leather, A; Mendelson, M; Moonesinghe, SR; Sevdalis, N; Singh, S; Holmes, A
    Optimising antibiotic prescribing across the surgical pathway (before, during and after surgery) is a key aspect of tackling important drivers of antimicrobial resistance (AMR), and simultaneously decreasing the burden of infection at global level. In the UK alone, 10 million patients undergo surgery every year, which is equivalent to 60% of the annual hospital admissions having a surgical intervention. The overwhelming majority of surgical procedures require effectively limited delivery of antibiotic prophylaxis to prevent infections. Evidence from around the world indicates that antibiotics for surgical prophylaxis are administered ineffectively, or are extended for an inappropriate duration of time postoperatively. Ineffective...

  8. An alternative promoter in the mouse major histocompatibility complex class II I-Abeta gene: implications for the origin of CpG islands.

    Macleod, D; Ali, RR; Bird, A
    Nonmethylated CpG islands are generally located at the 5' ends of genes, but a CpG island in the mouse major histocompatibility complex class II I-Abeta gene is remote from the promoter and covers exon 2. We have found that this CpG island includes a novel intronic promoter that is active in embryonic and germ cells. The resulting transcript potentially encodes a severely truncated protein which would lack the signal peptide and external beta1 domains. The functional significance of the internal CpG island may be to facilitate gene conversion, thereby sustaining the high level of polymorphism seen at exon 2. Deletions...

  9. Monomeric, porous type II collagen scaffolds promote chondrogenic differentiation of human bone marrow mesenchymal stem cells in vitro.

    Tamaddon, M; Burrows, M; Ferreira, SA; Dazzi, F; Apperley, JF; Bradshaw, A; Brand, DD; Czernuszka, J; Gentleman, E
    Osteoarthritis (OA) is a common cause of pain and disability and is often associated with the degeneration of articular cartilage. Lesions to the articular surface, which are thought to progress to OA, have the potential to be repaired using tissue engineering strategies; however, it remains challenging to instruct cell differentiation within a scaffold to produce tissue with appropriate structural, chemical and mechanical properties. We aimed to address this by driving progenitor cells to adopt a chondrogenic phenotype through the tailoring of scaffold composition and physical properties. Monomeric type-I and type-II collagen scaffolds, which avoid potential immunogenicity associated with fibrillar collagens,...

  10. Integrating Architecture and Crime Science: A Transdisciplinary Challenge

    Borrion, H; koch, D

  11. Y Dynamic Computed Tomography Myocardial Perfusion Imaging Comparison of Clinical Analysis Methods for the Detection of Vessel-Specific Ischemia

    Rossi, A; Wragg, A; Klotz, E; Pirro, F; Moon, JC; Nieman, K; Pugliese, F

  12. Achieving Sustainable and Liveable Communities: Identifying and addressing barriers

    Cavoli, CM; Jones, P
    This report summarises the findings of a scoping study carried out to investigate the barriers to achieving sustainable and liveable cities, and how these might be overcome. It reports on the analysis of a series of interviews with 11 leading professionals at different levels across the public, voluntary, Non-Governmental-Organisations and academic sectors in the UK.

  13. Liveable Cities A transport perspective

    Cavoli, CM; Jones, P
    There are many pressing urban challenges, particularly regarding the needs of transport and mobility. In order to promote liveable cities, these challenges require progressive policies. This note summarises the outputs from a high-level impact seminar organised by University College London (UCL) in collaboration with the Department for Transport (DfT), in March 2014. The seminar presented recent academic research on the topic and considered its relevance for current policy debates.

  14. Shipping in Changing Climates

    Cavoli, CM; Jones, P
    It is important to understand how the UK and global shipping sectors are being affected by new patterns of demand, technological developments and changes in regulations. This note summarises outputs from a high-level impact seminar organised by University College London (UCL) in collaboration with the Department for Transport (DfT), in May 2014.

  15. Long-term Visual Acuity, Strabismus and Nystagmus Outcomes Following Multimodality Treatment in Group D Retinoblastoma Eyes.

    Fabian, ID; Naeem, Z; Stacey, AW; Chowdhury, T; Duncan, C; Reddy, MA; Sagoo, MS
    PURPOSE: To analyse the long-term visual acuity, strabismus and nystagmus outcomes in Group D retinoblastoma following multimodality treatments in a national retinoblastoma referral centre. DESIGN: Retrospective interventional case series. METHODS: A 13-year retrospective chart review of Group D eyes treated initially with intravenous chemotherapy (IVC) and followed-up for at least 1 year from last treatment. Risk factors for final visual acuity (VA) were analysed, and rate of strabismus and nystagmus at last follow-up visit were calculated. RESULTS: One hundred and four Group D eyes (92 patients) presented to our centre during the study period, of which 32 (27 patients) met...

  16. Atrophin controls developmental signaling pathways via interactions with Trithorax-like

    Yeung, K; Boija, A; Karlsson, E; Holmqvist, P-H; Tstskis, Y; Nisoli, I; Yap, D; Lorzadeh, A; Moksa, M; Hirst, M; Aparicio, S; Fanto, M; Stenberg, P; Mannervik, M; McNeill, H

  17. Introduction

    Drinot, P

  18. Range and Heterogeneity of Outcomes in Randomized Trials of Pediatric Chronic Kidney Disease.

    Chong, LSH; Sautenet, B; Tong, A; Hanson, CS; Samuel, S; Zappitelli, M; Dart, A; Furth, S; Eddy, AA; Groothoff, J; Webb, NJA; Yap, H-K; Bockenhauer, D; Sinha, A; Alexander, SI; Goldstein, SL; Gipson, DS; Raman, G; Craig, JC
    OBJECTIVE: To determine the range and heterogeneity of outcomes reported in randomized controlled trials of interventions for children with chronic kidney disease (CKD). STUDY DESIGN: The Cochrane Kidney and Transplant Specialized Register was searched to March 2016. Randomized trials involving children across all stages of CKD were selected. All outcome domains and measurements were extracted from included trials. The frequency and characteristics of the outcome domains and measures were evaluated. RESULTS: From 205 trials included, 6158 different measurements of 100 different outcome domains were reported, with a median of 22 domains per trial (IQR 13-41). Overall, 52 domains (52%) were...

  19. Performance of van der Waals Corrected Functionals for Guest Adsorption in the M2(dobdc) Metal-Organic Frameworks.

    Vlaisavljevich, B; Huck, J; Hulvey, Z; Lee, K; Mason, JA; Neaton, JB; Long, JR; Brown, CM; Alfè, D; Michaelides, A; Smit, B
    Small-molecule binding in metal-organic frameworks (MOFs) can be accurately studied both experimentally and computationally, provided the proper tools are employed. Herein, we compare and contrast properties associated with guest binding by means of density functional theory (DFT) calculations using nine different functionals for the M2(dobdc) (dobdc(4-) = 2,5-dioxido,1,4-benzenedicarboxylate) series, where M = Mg, Mn, Fe, Co, Ni, Cu, and Zn. Additionally, we perform Quantum Monte Carlo (QMC) calculations for one system to determine if this method can be used to assess the performance of DFT. We also make comparisons with previously published experimental results for carbon dioxide and water and...

  20. Craniosynostosis

    Greig, AVH; Dunaway, DJ
    © 2015 John Wiley & Sons, Ltd. All rights reserved.Craniosynostosis is defined as the premature fusion of cranial sutures, which may be due to primary or secondary causes. Either a single suture or multiple sutures may be involved and these cause a change in head shape. Single suture synostosis is usually non-syndromic but craniosynostosis can be associated with several syndromes, including Apert, Crouzon, Pfeiffer, Saethre-Chotzen, Carpenter and Muenke syndromes. Syndromic craniosynostosis patients may present with elevated intracranial pressure, hydrocephalus, papilloedema, optic atrophy, corneal exposure or ulceration, globe herniation, amblyopia, astigmatism, squints and loss of vision. They may present with hearing...

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