Recursos de colección

UCL University College London Eprints (396.185 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 181 - 200 de 398.632

  1. Review of the Conservation Strategy for cheetah and African wild dog in southern Africa

    Groom, R; Durant, S; Breitenmoser-Wursten, C
    At the end of 2007, a workshop was held to develop a Regional Conservation Strategy RCS for cheetah Acinonyx jubatus and African wild dog Lycaon pictus in southern Africa (IUCN/SSC 2007). The strategy was to form a framework for the development of conservation action plans for cheetah and wild dog in all range states. The regional workshop was conducted as a partnership between National Wildlife Authorities, the IUCN/SSC Cat and Canid Specialist Groups and the Range Wide Conservation Program for Cheetah and African Wild Dogs RWCP. Here we report on the revision of the RCS that took place in August...

  2. Planning and implementing a targeted and strategic dissemination plan for a Cochrane review: a case study

    Jones, K; Hollands, GJ; Shemilt, I; Doyle, J; Armstrong, R

  3. Landslide susceptibility modelling applying user-defined weighting and data-driven statistical techniques in Cox's Bazar Municipality, Bangladesh

    Ahmed, B
    Landslides are common geophysical hazards in the highly urbanized hilly areas of Cox’s Bazar Municipality, Bangladesh. Every year, during the monsoon, landslides cause human casualties, property damage, and economic losses. Indiscriminate hill cutting, developing settlements in dangerous hill slopes, and torrential rainfall in short period of time are responsible for triggering landslide disasters. The aim of this paper is to produce landslide susceptibility maps (LSM) to help reduce the risks of landslides. Geographic information system and remote sensing-based techniques were used for LSM considering 12 relevant factor maps (i.e. slope, land cover, NDVI, geology, geomorphology, soil moisture, rainfall pattern, distance...

  4. Evaluation of an Organisational Intervention to Promote Integrated Working between Health Services and Care Homes in the Delivery of End-of-Life Care for People with Dementia: Understanding the Change Process Using a Social Identity Approach

    Amador, S; Goodman, C; Mathie, E; Nicholson, C
    In the United Kingdom, approximately a third of people with dementia live in long-term care facilities for adults, the majority of whom are in the last years of life. Working arrangements between health services and care homes in England are largely ad hoc and often inequitable, yet quality end-of-life care for people with dementia in these settings requires a partnership approach to care that builds on existing practice. This paper reports on the qualitative component of a mixed method study aimed at evaluating an organisational intervention shaped by Appreciative Inquiry to promote integrated working between visiting health care practitioners (i.e. General...

  5. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

    Chouchani, EE; Pell, V; Gaude, E; Aksentijevic, D; Sundier, S; Duchen, M; Shattock, M; Frezza, C; Krieg, T; Murphy, M

  6. Memories of Phil Bryden

    Corballis, MC; McManus, IC; Bulman-Fleming, MB
    Phil Bryden was a seminal figure in the development of the field of cerebral lateralization in the last half of the twentieth century, and a founding editor of this journal. Here his founding co-editors reminisce about their friend and colleague, and reflect on his wide-ranging influence in the field and in their own careers.

  7. The Tapley and Bryden test of performance differences between the hands: the original data, newer data, and the relation to pegboard and other tasks

    McManus, IC; Van Horn, JD; Bryden, PJ
    Tapley and Bryden (T&B)’s 1985 circle-marking task is a group-administered task assessing performance differences between the hands. The bimodal distribution clearly separates self-described right- and left-handers. Using Phil's original datafiles we analyse the test in more detail, providing raw scores for each hands which are useful forensically, and we provide reliability estimates. Van Horn's unpublished 1992 PhD thesis studied T&B tasks and Annett pegboards varying in difficulty. A striking finding, that Phil Bryden called “the Van Horn problem,” was that hand differences (R − L) were unrelated to task difficulty. That result was the starting point for Pamela Bryden's 1998 thesis, firstly...

  8. One Face of Chlamydia trachomatis: The Infectious Elementary Body

    Cossé, MM; Hayward, RD; Subtil, A
    The lifestyle of Chlamydiae is unique: the bacteria alternate between two morphologically distinct forms, an infectious non-replicative elementary body (EB), and a replicative, non-infectious reticulate body (RB). This review focuses on recent advances in understanding the structure and function of the infectious form of the best-studied member of the phylum, the human pathogen Chlamydia trachomatis. Once considered as an inert particle of little functional capacity, the EB is now perceived as a sophisticated entity that encounters at least three different environments during each infectious cycle. We review current knowledge on its composition and morphology, and emerging metabolic activities. These features...

  9. Results from a multicentre comparison of cryoballoon vs. radiofrequency ablation for paroxysmal atrial fibrillation: is cryoablation more reproducible?

    Providencia, R; Defaye, P; Lambiase, PD; Pavin, D; Cebron, JP; Halimi, F; Anselme, F; Srinivasan, N; Albenque, JP; Boveda, S
    AIM: Cryoballoon ablation (Cryoballoon) has emerged as a new alternative for the treatment of symptomatic drug-refractory atrial fibrillation (AF). Whether the results of Cryoballoon are more reproducible than those of radiofrequency (RF) ablation remains to be proved. METHODS AND RESULTS: A total of 860 consecutive patients undergoing a first ablation procedure for paroxysmal AF (467 treated with RF and 393 treated with Cryoballoon) were selected from a prospective multicentre survey of AF ablation (FrenchAF). Radiofrequency and Cryoballoon were compared regarding mid-term efficacy and safety. During a median follow-up of 14 months (interquartile range 8-23), patients treated with Cryoballoon displayed similar...

  10. Self-Critical Perfectionism, Dependency, and Symptomatic Distress in Patients With Personality Disorder During Hospitalization-based Psychodynamic Treatment: A Parallel Process Growth Modeling Approach

    Lowyck, B; Luyten, P; Vermote, R; Verhaest, Y; Vansteelandt, K
    There is growing evidence for the efficacy and effectiveness of psychotherapy in patients with personality disorder (PD), but very little is known about the factors underlying these effects. Two-polarities models of personality development provide an empirically supported approach to studying therapeutic change. Briefly, these models argue that personality pathology is characterized by an imbalance between development of the capacity for self-definition and for relatedness, with an exaggerated emphasis on issues regarding self-definition and relatedness being expressed in high levels of self-critical perfectionism (SCP) and dependency, respectively. This study used data from a study of 111 patients with PD who received...

  11. EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase

    Gudkova, D; Panasyuk, G; Nemazanyy, I; Zhyvoloup, A; Monteil, P; Filonenko, V; Gout, I
    Coenzyme A synthase (CoAsy) is a bifunctional enzyme which facilitates the last two steps of Coenzyme A biogenesis in higher eukaryotes. Here we describe that CoAsy forms a complex with enhancer of mRNA-decapping protein 4 (EDC4), a central scaffold component of processing bodies. CoAsy/EDC4 complex formation is regulated by growth factors and is affected by cellular stresses. EDC4 strongly inhibits the dephospho-CoA kinase activity of CoAsy in vitro. Transient overexpression of EDC4 decreases cell proliferation, and further co-expression of CoAsy diminishes this effect. Here we report that EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold...

  12. Clinical Approach to Progressive Supranuclear Palsy

    Ling, H
    Sixty years ago, Steele, Richardson and Olszewski designated progressive supranuclear palsy (PSP) as a new clinicopathological entity in their seminal paper. Since then, in addition to the classic Richardson's syndrome (RS), different clinical phenotypic presentations have been linked with this four-repeat tauopathy. The clinical heterogeneity is associated with variability of regional distribution and severity of abnormal tau accumulation and neuronal loss. In PSP subtypes, the presence of certain clinical pointers may be useful for antemortem prediction of the underlying PSP-tau pathology. Midbrain atrophy on conventional MRI correlates with the clinical phenotype of RS but is not predictive of PSP pathology....

  13. In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri

    Porro, LB; Ross, CF; Iriarte-Diaz, J; O'Reilly, JC; Evans, SE; Fagan, MJ
    In vivo bone strain data are the most direct evidence of deformation and strain regimes in the vertebrate cranium during feeding and can provide important insights into skull morphology. Strain data have been collected during feeding across a wide range of mammals; in contrast, in vivo cranial bone strain data have been collected from few sauropsid taxa. Here we present bone strain data recorded from the jugal of the herbivorous agamid lizard Uromastyx geyri along with simultaneously recorded bite force. Principal and shear strain magnitudes in Uromastyx geyri were lower than cranial bone strains recorded in Alligator mississippiensis, but higher...

  14. NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma

    Wan, WY; Hollins, F; Haste, L; Woodman, L; Hirst, RA; Bolton, S; Gomez, E; Sutcliffe, A; Desai, D; Chachi, L; Mistry, V; Szyndralewiez, C; Wardlaw, A; Saunders, R; O'Callaghan, C; Andrew, PW; Brightling, CE
    BACKGROUND: Bronchial epithelial ciliary dysfunction is an important feature of asthma. We sought to determine the role in asthma of neutrophilic inflammation and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases in ciliary dysfunction. METHODS: Bronchial epithelial ciliary function was assessed by using video microscopy in fresh ex vivo epithelial strips from patients with asthma stratified according to their sputum cell differentials and in culture specimens from healthy control subjects and patients with asthma. Bronchial epithelial oxidative damage was determined by 8-oxo-dG expression. Nicotinamide adenine dinucleotide phosphate oxidase (NOX)/dual oxidase (DUOX) expression was assessed in bronchial epithelial cells by using microarrays, with NOX4...

  15. The improvement of the best practice guidelines for preimplantation genetic diagnosis of cystic fibrosis: toward an international consensus

    Girardet, A; Viart, V; Plaza, S; Daina, G; De Rycke, M; Des Georges, M; Fiorentino, F; Harton, G; Ishmukhametova, A; Navarro, J; Raynal, C; Renwick, P; Saguet, F; Schwarz, M; SenGupta, S; Tzetis, M; Roux, A-F; Claustres, M
    Cystic fibrosis (CF) is one of the most common indications for preimplantation genetic diagnosis (PGD) for single gene disorders, giving couples the opportunity to conceive unaffected children without having to consider termination of pregnancy. However, there are no available standardized protocols, so that each center has to develop its own diagnostic strategies and procedures. Furthermore, reproductive decisions are complicated by the diversity of disease-causing variants in the CFTR (cystic fibrosis transmembrane conductance regulator) gene and the complexity of correlations between genotypes and associated phenotypes, so that attitudes and practices toward the risks for future offspring can vary greatly between countries....

  16. Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery

    Hausenloy, DJ; Candilio, L; Evans, R; Ariti, C; Jenkins, DP; Kolvekar, S; Knight, R; Kunst, G; Laing, C; Nicholas, J; Pepper, J; Robertson, S; Xenou, M; Clayton, T; Yellon, DM
    BACKGROUND: Whether remote ischemic preconditioning (transient ischemia and reperfusion of the arm) can improve clinical outcomes in patients undergoing coronary-artery bypass graft (CABG) surgery is not known. We investigated this question in a randomized trial. / METHODS: We conducted a multicenter, sham-controlled trial involving adults at increased surgical risk who were undergoing on-pump CABG (with or without valve surgery) with blood cardioplegia. After anesthesia induction and before surgical incision, patients were randomly assigned to remote ischemic preconditioning (four 5-minute inflations and deflations of a standard blood-pressure cuff on the upper arm) or sham conditioning (control group). Anesthetic management and perioperative...

  17. Mafia and Prostitution in Calabria, c. 1880 - c. 1940

    Dickie, J

  18. An epidemiological modelling study to estimate the composition of HIV-positive populations including migrants from endemic settings

    Nakagawa, Fumiyo
    OBJECTIVE: Migrants account for a significant number of people living with HIV in Europe, and it is important to fully consider this population in national estimates. Using a novel approach with the UK as an example, we present key public health measures of the HIV epidemic, taking into account both in-country infections and infections likely to have been acquired abroad. DESIGN: Mathematical model calibrated to extensive data sources. METHODS: An individual-based stochastic simulation model is used to calibrate to routinely collected surveillance data in the UK. Data on number of new HIV diagnoses, number of deaths, CD4 cell count at...

  19. Surfactants adsorption on crossing stripes and steps

    Suttipong, M; Grady, BP; Striolo, A
    Using coarse-grained dissipative particle dynamics (DPD) simulations, we systematically study the effect of surface heterogeneity on surfactant adsorption. Here we investigate the adsorption and aggregation of surfactants on hydrophobic stripes crossing each other perpendicularly (i.e., crossing stripes) and on hydrophobic steps. The results are compared with those obtained for isolated stripes. We find that on crossing stripes of moderate stripe widths (e.g., L = 0.61LS, 1.22LS and 1.83LS, where LS is the length of one surfactant molecule) the crossing region hinders the formation of defect-free adsorbed surfactant structures. By increasing the stripe width and/or by increasing the length of one...

  20. 'Fooling the Court of the Lord Pope': Dafydd Ap Llywelyn's Petition to the Curia in 1244

    Wiedemann, BEG
    Dafydd ap Llywelyn's approach to Pope Innocent IV in 1244 was classified as an attempt to become a papal 'vassal' by Michael Richter in an article of 1971. It seems more likely, however, both that Dafydd saw his relationship with the papacy as one of protectio , and that the precise form of the relationship was in fact incidental to his appeal. Dafydd took advantage of the routinization of papal administration to have local judges-delegate investigate Henry III's extorted treaties of 1241. The judges' appointment was not an acknowledgement by the papacy that Dafydd had a good case, or whether...

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