UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
Mostrando recursos 181 - 200 de 336,821
Ionization of the Venusian atmosphere from Solar and Galactic Cosmic Rays - Nordheim, T; Dartnell, LR; Desorgher, L; Coates, AJ; Jones, GH
The atmospheres of the terrestrial planets are exposed to solar and galactic cosmic rays, the most energetic of which are capable of affecting deep atmospheric layers through extensive nuclear and electromagnetic particle cascades. In the Venusian atmosphere, cosmic rays are expected to be the dominant ionization source below ~100 km altitude. While previous studies have considered the effect of cosmic ray ionization using approximate transport methods, we have for the first time performed full 3D Monte Carlo modelling of cosmic ray interaction with the Venusian atmosphere, including the contribution of high-Z cosmic ray ions (Z=1-28). Our predictions are similar to...
Intentional inhibition of actions in humans - Misirlisoy, E
A crucial component of human behavioural flexibility is the capacity to inhibit actions at the last moment before action execution. This behavioural inhibition is often not an immediate reaction to external stimuli, but rather an endogenous ‘free’ decision. Knowledge about such ‘intentional inhibition’ is currently limited, with most research focused on stimulus-driven inhibition. This thesis will examine intentional inhibition, using several different experimental approaches. The behavioural experiments reported in the initial chapters found that intentional inhibition directly alters sensory processing during decision-making. In addition, there were unique effects of prior event sequences on subsequent decisions to either act or inhibit....
Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases. - Mock, U; Riecken, K; Berdien, B; Qasim, W; Chan, E; Cathomen, T; Fehse, B
TAL-effector nucleases (TALENs) are attractive tools for sequence-specific genome modifications, but their delivery still remains problematic. It is well known that the presence of multiple sequence repeats in TALEN genes hampers the use of lentiviral vectors. We report that lentiviral vectors readily package full-length vector mRNAs encoding TALENs, but recombination during reverse transcription prevents successful delivery. We reasoned that preventing reverse transcription of lentiviral-vector RNA would allow transfer of TALENs as mRNA. We demonstrate that lentiviral particles containing genetically inactivated reverse transcriptase (RT) mediated efficient transduction of cultured cells and supported transient transgene expression. For proof-of-principle, we transferred CCR5- and...
Ceramic biomaterials for tissue engineering - Huang, J; Best, SM
The second edition of Tissue Engineering Using Ceramics and Polymers comprehensively reviews the latest advances in this area rapidly evolving area of biomaterials science. Part one considers the biomaterials used for tissue engineering.
Evaluation of age-related macular degeneration with optical coherence tomography. - Keane, PA; Patel, PJ; Liakopoulos, S; Heussen, FM; Sadda, SR; Tufail, A
Age-related macular degeneration (AMD) is the leading cause of severe visual loss in people aged 50 years or older in the developed world. In recent years, major advances have been made in the treatment of AMD, with the introduction of anti-angiogenic agents, offering the first hope of significant visual recovery for patients with neovascular AMD. In line with these advances, a new imaging modality-optical coherence tomography (OCT)-has emerged as an essential adjunct for the diagnosis and monitoring of patients with AMD. The ability to accurately interpret OCT images is thus a prerequisite for both retina specialists and comprehensive ophthalmologists. Despite...
Dual labeling of neural crest cells and blood vessels within chicken embryos using chickGFP neural tube grafting and carbocyanine dye DiI injection - Delalande, JM; Thapar, N; Burns, AJ
All developing organs need to be connected to both the nervous system (for sensory and motor control) as well as the vascular system (for gas exchange, fluid and nutrient supply). Consequently both the nervous and vascular systems develop alongside each other and share striking similarities in their branching architecture. Here we report embryonic manipulations that allow us to study the simultaneous development of neural crest-derived nervous tissue (in this case the enteric nervous system), and the vascular system. This is achieved by generating chicken chimeras via transplantation of discrete segments of the neural tube, and associated neural crest, combined with...
Ophthalmic imaging. - Ilginis, T; Clarke, J; Patel, PJ
The last two decades have seen a revolution in ophthalmic imaging. In this review we present an overview of the breadth of ophthalmic imaging modalities in use today and describe how the role of ophthalmic imaging has changed from documenting abnormalities visible on clinical examination to the detection of clinically silent abnormalities which can lead to an earlier and more precise diagnosis.
Choroidal assessment in idiopathic panuveitis using optical coherence tomography. - Karampelas, M; Sim, DA; Keane, PA; Zarranz-Ventura, J; Patel, PJ; Tufail, A; Westcott, M; Lee, R; Pavesio, CE
Idiopathic panuveitis is a diagnosis of exclusion that lacks distinguishing features on fluorescein and indocyanine green angiography. Choroidal hypoperfusion or ischaemia has been implicated in panuveitis of different aetiologies. In this study, we use enhanced depth imaging optical coherence tomography (OCT) to examine the choroid and its vasculature in patients with this disease.
Gene Therapy for Haemophagocytic Lymphohistiocytosis. - Booth, C; Carmo, M; Gaspar, HB
Haemophagocytic lymphohistiocytosis (HLH) describes a severe and often fatal immunodysregulatory disorder caused primarily by the uncontrolled activation and proliferation of T cells and macrophages. A number of genetic defects mainly involving defective granule exocytosis and effector cell cytotoxicity have been identified and well characterised at the molecular and cellular level. These conditions have limited therapeutic options and given the predominant restriction of the causative gene to the haematopoietic system, they have become attractive targets for ex vivo haematopoietic cell therapy. Pre clinical studies in murine models of HLH due to perforin deficiency have shown correction of the disease phenotype as...
package AOfamilies - Dehbi, HM; Cortina-Borja, M; Geraci, M
This package implements the Aranda-Ordaz (AO) transformation families for binary response variables in Generalised Linear Models and Quantile Regression models.
Child sexual abuse - The child's experience - Vizard, E
This paper looks at child sexual abuse from a child's viewpoint, and postulates three levels at which the child experiences the abuse, both at the time of its occurrence and during later development. It is suggested that the greater the child's difficulty in integrating the experiences from these three different levels the poorer the healing process after abuse and the worse the effect will be on the child's subsequent mental health. Clinical examples are given of some of the concepts described.