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UCL University College London Eprints (347,687 recursos)
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 181 - 200 de 347,377

181. Use of gaze and gait analysis to assess the effect of footway environmental factors on older pedestrians' accessibility - Cheng, T
Walking in the footway environment is an essential activity of daily living and the physical activity associated can also improve an individual’s quality of life. The possibility and ability for the individual to reach opportunities and participate in activities on foot indicate the accessibility of the footway environment. One of the major hazards in the footway environment that impedes the accessibility is falling. While it may happen to anyone, falling is more common in older people and the consequence of falling could seriously deteriorate their quality of life. Falls among older people is one of the major public health problems....

182. Furthering our understanding of heterogeneous ice nucleation with molecular simulation - Cox, SJ
Ice formation is arguably the most common phase transition on the planet and almost always occurs heterogeneously. Despite the importance of ice formation to the climate, medical and geological sciences, as well as the food and transport industries, a clear understanding of how the properties of a material affect its ability to nucleate ice has remained elusive. This has prevented the rational design of new materials to either inhibit or promote ice nucleation. In this thesis, a wide variety of computational techniques are used to try and further our understanding of heterogeneous ice nucleation. This includes: testing long established theories;...

183. Using a Functional Tagged Calcium Channel to Investigate Trafficking - Cassidy, JS
3 Abstract N - type calcium channels belong to the family of voltage gated calcium channels , which open in response to membrane depolarisation. These channels are responsible for the calcium influx that triggers neurotransmitter release at presynaptic terminals. N - type channels are particularly important in mediating neurotransmitter release at the presynaptic terminals of peripheral sensory neurons and have been implicated i n neuropathic pain. Understanding the regulation of N - type channels is critical to the development of treatments that target these channels. Until now it has been difficult to directly investigate the regulation of their expression at...

184. Exploring the potential for recombinant protein production in microalgae - Braun Galleani, SC
Microalgae are considered as attractive platforms for the synthesis of high-value heterologous proteins due to their many beneficial attributes including ease of cultivation, lack of pathogenic agents, and low-cost downstream processing. However, recombinant protein levels are low compared to microbial platforms and commercial production is not a reality yet. Promising research using the model microalga Chlamydomonas reinhardtii has highlighted this potential, particularly for transgene expression in the chloroplast. The objective of this research was to study different strategies for expression in the C. reinhardtii chloroplast aimed at increasing growth rate and recombinant protein production, by means of cell engineering and...

185. Identification and Characterization of Cancer promoting genes in Breast Stromal fibroblasts - Alrakan, MAA
It is well known now that changes in the cellular microenvironment contribute to tumour genesis through paracrine effects. Fibroblasts, the predominant cells of the stromal breast carcinomas, play an important role in the development and spread of cancer cells. However, the nature, molecular mediators and pathways of the crosstalk between cancer cells and their stromal fibroblasts are still not well defined. There is evidence that normal breast stromal fibroblasts (NBFs) suppress tumor growth while cancer-associated fibroblasts (CAFs) promote tumorogenesis through functional interactions with cancer cells. Little is known about the biology and the carcinogenic potential of stromal fibroblasts present in...

186. Applied synthesis and characterisation of nanoparticles - Bear, JC
This thesis covers three areas of development of nanomaterials synthesis; namely the synthesis of superhydrophobic polymer-nanoparticle composites (chapter 3), the synthesis of doped quantum dots for catalysis and photoluminescence enhancement (chapter 4) and the synthesis of magnetic iron oxide nanoparticles from inexpensive, readily available reagents (chapter 5). Details of characterisation and analytical techniques and synthetic methods used are given in chapter 2, and the thesis summarised in chapter 6. Superhydrophobic polymer-nanoparticle composites represent a class of material which combine the superhydrophobicity of the polymer with the functionality of incorporated nanoparticles. Reactive oxygen species generated by photocatalytic nanoparticles degrade organic matter,...

187. The fission yeast non-coding transcriptome - Atkinson, SR
Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression, although it remains unclear to what extent they contribute overall to the information flow from genotype to phenotype. Using strand-specific RNAsequencing, I identify thousands of novel unstable, or cryptic, lncRNAs in Schizosaccharomyces pombe. The nuclear exosome, the RNAi pathway and the cytoplasmic exonuclease Exo2 represent three key pathways regulating lncRNAs in S. pombe, defining the overlapping classes of CUTs, RUTs and XUTs, respectively. The nuclear exosome and the RNAi pathway act cooperatively to control nuclear lncRNA expression, while the cytoplasmic Exo2 pathway is more distinct. Impairing both the...

188. $rec.titulo - Uzoh, OG

189. The Immunomodulatory Effects of Vitamin D on Mononuclear Phagocytes - Evans, R
Expression of the vitamin D receptor on mononuclear phagocytes renders them susceptible to modulation by 1,25(OH)2D3, which is metabolised from its precursor 25(OH)D3 by the enzyme CYP27B1. Modulation of dendritic cells (DC) with 1,25(OH)2D3 has been shown in vitro to suppress their ability to prime proinflammatory T cells responses, suggesting extra renal synthesis of 1,25(OH)2D3 from the precursor 25(OH)D3 may promote tolerance in vivo. I sought to gain a greater mechanistic understanding of these phenomena at molecular, cellular and intercellular levels in the human system. I found that 1,25(OH)2D3 stimulation of DC results in a selective preservation of NFκB-mediated transcriptional...

190. Dopamine and oculomotor impulsivity in health and disease. - Adam, RJ
The role of subcortical pathology in altered cognition is increasingly recognised. However, measurement and monitoring of impairments in motivation and behaviour due to subcortical disease is challenging. Basal ganglia – cortico-thalamo-cortical loops and the neurotransmitter, dopamine, are recognised to be important in modulating both reward learning and oculomotor performance. This thesis considers the use of novel and adapted oculomotor (saccadic) tasks as a means of interrogating these dynamic circuits as measures of rewarded decision-making under risk and time pressure. I first describe a novel rewarded oculomotor task, the Traffic Light Task, which provokes two distributions of saccades – one anticipatory,...

191. Impact of basin tectonics and climate change on the timing of sediment flux to the Ainsa Basin, Middle Eocene, Spanish Pyrenees - Cantalejo Lopez, B
This thesis integrates sedimentological, geochemical, magnetostratigraphic and spectral work from field and core data from the Middle Eocene, deep-marine siliciclastic sediments in the Ainsa Basin, Spanish Pyrenees. The deep-marine sediments of the Ainsa Basin comprise an alternation of coarse-grained sandbodies (submarine fans) and fine-grained packages of fan lateral-margin and interfan deposits. Time-series analysis performed on spectral gamma-ray and sandstone turbidite intensity data from 10 fine-grained interfan stratigraphic sections covering ~ 1.5 km of stratigraphy, and using multiple geochemical proxies (including high-resolution elemental XRF scanning, total organic carbon and carbon stable isotopes), all show that the interfan sediments contain a strong...

192. Separation of VOCl3 from TiCl4 using soya oil - Crane, JH
This thesis investigated the reactivity of the metal chlorides TiCl4, VOCl3 and VCl4 with different organic ligands. The chosen ligands were based around the chemical structure of soya oil due to its relevance to the industrial chlorine process used to manufacture TiO2. This thesis primarily used nuclear magnetic resonance (NMR)spectroscopy to characterise the reactions of the metal chlorides with soya oil and component parts, namely the glycerol and the alkene. This thesis goes on to investigate the coordination chemistry of the metal chlorides with ligands including diester groups. The chemical properties of the metal chlorides are known to be similar...

193. PAC'nPost: A Peer-to-Peer Micro-blogging Social Network - Asthana, H
In this thesis we provide a framework for a micro-blogging social network in an unstructured peer-to-peer network. At a user level, a micro-blogging service provides (i) a means for publishing a micro-blog, (ii) a means to follow a micro-blogger, and (iii) a means to search for micro-blogs containing keywords. Since unstructured peer-to-peer networks do not bind either the data or the location of data to the nodes in the network, search in an unstructured network is necessarily probabilistic. Using the probably approximately correct (PAC) search architecture, the search of an unstructured network is based on a probabilistic search that queries...

194. Cardiac injury in lupus - Bourke, LT
Systemic lupus erythematosus (SLE) carries a significantly enhanced risk of developing cardiovascular disease (CVD) and remains a leading cause of death in these patients, accounting for ~25% of all causes of mortality. Although there is clear evidence li nking accelerated atherosclerosis to SLE (and consequently an increase in cardiovascular events), another factor that may contribute to CVD related morbidity and mortality is reperfusion injury that occurs post - ischaemia. This is termed ischaemic / reperfu sion (I/R) injury and is a known important contributor to the size of the eventual infarct in the heart, which in animal studies has been...

195. What is the function of the human retrosplenial cortex? - Auger, SD
The retrosplenial cortex (RSC) comprises Brodmann areas 29/30 and is an integral part of a brain system that is engaged by spatial navigation, scene processing, recollection of the past and imagining the future. Damage involving the RSC in humans can result in significant memory and navigation deficits, while the earliest metabolic decline in Alzheimer's disease is centred upon this region. The precise function of the RSC, however, remains elusive. In this thesis I sought to determine the key contribution of the RSC in a series of six studies that each comprised behavioural and functional magnetic resonance imaging (fMRI) experiments. Specifically,...

196. Synthesis of Five-Membered Heterocycles: Novel Allosteric Modulators for Nicotinic Receptors and New Gold-Catalysed Reactions - D'Oyley, JM
The Drug Discovery project is centred on the design, synthesis and characterisation of novel positive allosteric modulators (PAMs) for α7 nicotinic receptors (nAChR). These receptors are widely found in the central and peripheral nervous systems and are involved in a range of physiological processes. They are active targets for the treatment of pain as well as psychiatric and neurodegenerative disorders. Nicotinic receptors are ion channels which open and allow ions to flow in or out of the neuron upon binding of an agonist. Positive allosteric modulators (PAM) enhance the receptor’s response to the binding of the endogenous agonist, giving greater...

197. The E3 Ligase TRIM32 is a Novel Effector of the RAS Family GTPase Rap2 - Demiray, B
Classical RAS oncogenes are mutated in approximately 30% of human tumours and RAP proteins are closely related to classical RAS proteins. RAP1 has an identical effector domain to RAS whereas RAP2 differs by one amino acid. RAP2 not only shares effectors with other classical RAS family members, but it also has its own specific effectors that do not bind to RAP1 or classical RAS family proteins. Thus, although closely related, RAP2 performs distinct functions, although these have been poorly characterised. Using RAP2 as bait in Tandem Affinity Purifications, we have identified several RAP2 interacting proteins including TRIM32; a protein implicated...

198. The Response of the Labour Government to the “Revolution of Carnations” in Portugal, 1974-76 - Cooke, SJ
This thesis examines the response of the Labour Government to events in Portugal following the coup d’état in April 1974. Britain, as Portugal’s traditional ally and largest trading partner, with close partisan ties between the Labour movement and Portuguese Socialist Party, was a leading player in the international response to developments in Lisbon. The Portuguese Revolution also had wider implications for British foreign policy: the presence of communist ministers in government threatened both the cohesion of NATO and detente with the Soviet Union; West European leaders sought to influence events in Lisbon through the new political structures of the EEC;...

199. Internet use, social engagement, and health literacy decline during ageing in a longitudinal cohort of older English adults - Kobayashi, LC; Wardle, J; von Wagner, C
Background: Health literacy skills tend to decline during ageing, which is often attributed to age-related cognitive decline. Whether health literacy skills may be influenced by technological and social factors during ageing is unknown. Methods: We investigated whether internet use and social engagement protect against health literacy decline during ageing, independent of cognitive decline. We used prospective data from 4368 men and women aged ≥52 years in the English Longitudinal Study of Ageing from 2004-11. Health literacy was measured at baseline (2004-5) and follow-up (2010-11) using a reading comprehension test of a fictitious medicine label. The influences of consistent internet use...

200. An experimental study of friction between wet and dry human skin and nonwoven fabrics - Falloon, SS
Many people who have urinary incontinence manage it with the use of absorbent hygiene products, such as pads. Long-term use of these products can lead to abrasion by friction between the topsheet (a nonwoven fabric) and the skin, and is exacerbated when the skin is wet. However, the nature and mechanisms of friction between skin and nonwovens are poorly understood, hindering progress to improve products. Most work on skin friction to date has involved the use of skin surrogates or real skin in the dry state only. Moreover, only a narrow range of different nonwoven fabrics have been investigated. The...

 

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