Recursos de colección

UCL University College London Eprints (399.377 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 181 - 200 de 2.324

  1. Oropharyngeal carcinoma, incidental findings on magnetic resonance imaging scans for audiovestibular symptoms, penetrating neck trauma and myringoplasty

    Fisher, E; Youngs, R; Hussain, M; Fishman, J

  2. Adenoid cystic carcinoma, dynamic Eustachian tube imaging and a touch of magic

    Fishman, J; Youngs, R; Fisher, E; Hussain, M

  3. The current status of human laryngeal transplantation in 2017: A state of the field review.

    Krishnan, G; Du, C; Fishman, JM; Foreman, A; Lott, DG; Farwell, G; Belafsky, P; Krishnan, S; Birchall, MA
    OBJECTIVES: Human laryngeal allotransplantation has long been contemplated as a surgical option following laryngectomy, but there is a paucity of information regarding the indications, surgical procedure, and patient outcomes. Our objectives were to identify all human laryngeal allotransplants that have been undertaken and reported in the English literature and to evaluate the success of the procedure. DATA SOURCES: MEDLINE, Embase, Current Index to Nursing and Allied Health Literature, Web of Science and Scopus, and the Gray literature. REVIEW METHODS: A comprehensive search strategy was undertaken across multiple databases. Inclusion criteria were case reports of patients who had undergone human laryngeal...

  4. Hsp40 Molecules That Target to the Ubiquitin-proteasome System Decrease Inclusion Formation in Models of Polyglutamine Disease.

    Howarth, JL; Kelly, S; Keasey, MP; Glover, C; Lee, YB; Mitrophanous, K; Chapple, JP; Gallo, JM; Cheetham, ME; Uney, JB
    We studied the ability of heat shock, DnaJ-like-1 (HSJ1) proteins (which contain DnaJ and ubiquitin-interacting motifs) to reduce polyglutamine-mediated inclusion formation. The experiments demonstrated that expression of heat shock protein 70 (hsp70), hsp40, HSJ1a, and HSJ1b significantly reduced protein inclusion formation in a model of spinal and bulbar muscular atrophy (SBMA). HSJ1a also mediated a significant decrease in the number of inclusions formed in a primary neuronal model of protein aggregation. Studies to elucidate the mechanisms underlying these reductions showed that hsp70 and hsp40 increased chaperone-mediated refolding. In contrast, expression of HSJ1 proteins did not promote chaperone activity but caused...

  5. Electrically Pumped Continuous-Wave III-V Quantum Dot Lasers Monolithically Grown On Silicon

    Chen, S; Wu, J; Li, W; Liao, M; Tang, M; Jiang, Q; Shutts, S; Elliott, S; Sobiesierski, A; Ross, I; Smowton, P; Seeds, A; Liu, H

  6. The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2.

    Hartwig, T; Montinaro, A; von Karstedt, S; Sevko, A; Surinova, S; Chakravarthy, A; Taraborrelli, L; Draber, P; Lafont, E; Arce Vargas, F; El-Bahrawy, MA; Quezada, SA; Walczak, H
    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known for specifically killing cancer cells, whereas in resistant cancers, TRAIL/TRAIL-R can promote metastasis via Rac1 and PI3K. It remains unknown, however, whether and to what extent TRAIL/TRAIL-R signaling in cancer cells can affect the immune microenvironment. Here we show that TRAIL-triggered cytokine secretion from TRAIL-resistant cancer cells is FADD dependent and identify the TRAIL-induced secretome to drive monocyte polarization to myeloid-derived suppressor cells (MDSCs) and M2-like macrophages. TRAIL-R suppression in tumor cells impaired CCL2 production and diminished both lung MDSC presence and tumor growth. In accordance, the receptor of CCL2, CCR2,...

  7. Pleiotropic effect of a novel mutation in GCNT2 causing congenital cataract and a rare adult i blood group phenotype.

    Cheong, SS; Hull, S; Jones, B; Chana, R; Thornton, N; Plagnol, V; Moore, AT; Hardcastle, AJ
    Mutations in GCNT2 have been associated with the rare adult i blood group phenotype with or without congenital cataract. We report a novel homozygous frameshift mutation c.1163_1166delATCA, p.(Asn388Argfs*20) as the cause of congenital cataract in two affected siblings. Blood group typing confirmed that both affected males have the rare adult i phenotype, supporting the hypothesis that the partial association of I/i phenotype and congenital cataract is due to the differential expression of GCNT2 isoforms.

  8. Pleiotropic effect of a novel mutation in GCNT2 causing congenital cataract and a rare adult i blood group phenotype.

    Cheong, SS; Hull, S; Jones, B; Chana, R; Thornton, N; Plagnol, V; Moore, AT; Hardcastle, AJ
    Mutations in GCNT2 have been associated with the rare adult i blood group phenotype with or without congenital cataract. We report a novel homozygous frameshift mutation c.1163_1166delATCA, p.(Asn388Argfs*20) as the cause of congenital cataract in two affected siblings. Blood group typing confirmed that both affected males have the rare adult i phenotype, supporting the hypothesis that the partial association of I/i phenotype and congenital cataract is due to the differential expression of GCNT2 isoforms.

  9. Camera Calibration Tools

    Stoyanov, D
    Camera Calibration Tools is a Windows application designed to streamline the camera calibration process. It can be used to capture calibration images from a camera attached to your PC, detect the calibration object and calculate the intrinsic and extrinsic camera parameters.

  10. No saturation in the accumulation of alien species worldwide.

    Seebens, H; Blackburn, TM; Dyer, EE; Genovesi, P; Hulme, PE; Jeschke, JM; Pagad, S; Pyšek, P; Winter, M; Arianoutsou, M; Bacher, S; Blasius, B; Brundu, G; Capinha, C; Celesti-Grapow, L; Dawson, W; Dullinger, S; Fuentes, N; Jäger, H; Kartesz, J; Kenis, M; Kreft, H; Kühn, I; Lenzner, B; Liebhold, A; Mosena, A; Moser, D; Nishino, M; Pearman, D; Pergl, J; Rabitsch, W; Rojas-Sandoval, J; Roques, A; Rorke, S; Rossinelli, S; Roy, HE; Scalera, R; Schindler, S; Štajerová, K; Tokarska-Guzik, B; van Kleunen, M; Walker, K; Weigelt, P; Yamanaka, T; Essl, F
    Although research on human-mediated exchanges of species has substantially intensified during the last centuries, we know surprisingly little about temporal dynamics of alien species accumulations across regions and taxa. Using a novel database of 45,813 first records of 16,926 established alien species, we show that the annual rate of first records worldwide has increased during the last 200 years, with 37% of all first records reported most recently (1970-2014). Inter-continental and inter-taxonomic variation can be largely attributed to the diaspora of European settlers in the nineteenth century and to the acceleration in trade in the twentieth century. For all taxonomic...

  11. No saturation in the accumulation of alien species worldwide.

    Seebens, H; Blackburn, TM; Dyer, EE; Genovesi, P; Hulme, PE; Jeschke, JM; Pagad, S; Pyšek, P; Winter, M; Arianoutsou, M; Bacher, S; Blasius, B; Brundu, G; Capinha, C; Celesti-Grapow, L; Dawson, W; Dullinger, S; Fuentes, N; Jäger, H; Kartesz, J; Kenis, M; Kreft, H; Kühn, I; Lenzner, B; Liebhold, A; Mosena, A; Moser, D; Nishino, M; Pearman, D; Pergl, J; Rabitsch, W; Rojas-Sandoval, J; Roques, A; Rorke, S; Rossinelli, S; Roy, HE; Scalera, R; Schindler, S; Štajerová, K; Tokarska-Guzik, B; van Kleunen, M; Walker, K; Weigelt, P; Yamanaka, T; Essl, F
    Although research on human-mediated exchanges of species has substantially intensified during the last centuries, we know surprisingly little about temporal dynamics of alien species accumulations across regions and taxa. Using a novel database of 45,813 first records of 16,926 established alien species, we show that the annual rate of first records worldwide has increased during the last 200 years, with 37% of all first records reported most recently (1970-2014). Inter-continental and inter-taxonomic variation can be largely attributed to the diaspora of European settlers in the nineteenth century and to the acceleration in trade in the twentieth century. For all taxonomic...

  12. Effect of topiramate and zonisamide on fMRI cognitive networks.

    Wandschneider, B; Burdett, J; Townsend, L; Hill, A; Thompson, PJ; Duncan, JS; Koepp, MJ
    OBJECTIVE: To investigate the effects of topiramate (TPM), zonisamide (ZNS), and levetiracetam (LEV) on cognitive network activations in patients with focal epilepsy using an fMRI language task. METHODS: In a retrospective, cross-sectional study, we identified patients from our clinical database of verbal fluency fMRI studies who were treated with either TPM (n = 32) or ZNS (n = 51). We matched 62 patients for clinical measures who took LEV but not TPM or ZNS. We entered antiepileptic comedications as nuisance variables and compared out-of-scanner psychometric measures for verbal fluency and working memory between groups. RESULTS: Out-of-scanner psychometric data showed overall...

  13. Effect of topiramate and zonisamide on fMRI cognitive networks.

    Wandschneider, B; Burdett, J; Townsend, L; Hill, A; Thompson, PJ; Duncan, JS; Koepp, MJ
    OBJECTIVE: To investigate the effects of topiramate (TPM), zonisamide (ZNS), and levetiracetam (LEV) on cognitive network activations in patients with focal epilepsy using an fMRI language task. METHODS: In a retrospective, cross-sectional study, we identified patients from our clinical database of verbal fluency fMRI studies who were treated with either TPM (n = 32) or ZNS (n = 51). We matched 62 patients for clinical measures who took LEV but not TPM or ZNS. We entered antiepileptic comedications as nuisance variables and compared out-of-scanner psychometric measures for verbal fluency and working memory between groups. RESULTS: Out-of-scanner psychometric data showed overall...

  14. Automated Classification of Breast Cancer Stroma Maturity from Histological Images.

    Reis, S; Gazinska, P; Hipwell, J; Mertzanidou, T; Naidoo, K; Williams, N; Pinder, S; Hawkes, DJ
    OBJECTIVE: The tumour microenvironment plays a crucial role in regulating tumour progression by a number of different mechanisms, in particular the remodelling of collagen fibres in tumour-associated stroma, which has been reported to be related to patient survival. The underlying motivation of this work is that remodelling of collagen fibres gives rise to observable patterns in Hematoxylin and Eosin (H&E) stained slides from clinical cases of invasive breast carcinoma that the pathologist can label as mature or immature stroma. The aim of this paper is to categorise and automatically classify stromal regions according to their maturity and show that this...

  15. UK Mother-to-Child HIV Transmission Rates Continue to Decline: 2012-2014.

    Peters, H; Francis, K; Sconza, R; Horn, A; S Peckham, C; Tookey, PA; Thorne, C

  16. Students' participation in collaborative research should be recognised

    Borakati, A; McLean, K; Bhangu, A; Drake, TM; Fitzgerald, JE; Harrison, EM; Kamarajah, SK; Khatri, C; Woin, E; Glasbey, J; Nepogodiev, D; Abbas, M; Abdalkoddus, M; Abdel-Fattah, A; Abdelgalil, R; Abdikadir, H; Adams, R; Adams, S; Adelaja, I; Adeogun, A; Adjei, H; Adlan, A; Adwan, H; Aeyad, S; Aftab, R; Afzul, A; Agarwal, V; Aglan, H; Agrawal, M; Agrawal, R; Ahmed, F; Akhtar, S; Akpenyi, O; Al-Attar, M; Al-Ausi, M; Al-Khyatt, W; Al-Mousawi, A; Al-Nasser, Z; Alagappan, A; Alberts, J; Alfa-Wali, M; Ali, A; Ali, A; Ali, T; Alkhaffaf, B; Allen, R; Alubaidi, K; Andah, E; Anderson, R; Andrew, K; Ang, A; Ang, E; Anyomih, T; Archer, J; Archer, M; Arnell, S; Arnold, M; Arora, E; Ashraf, N; Ashraf, R; Ashwood, J; Asif, U; Atayi, A; Auckburally, S; Austin, R; Azam, S; Yahaya, AA; Babatunde, F; Bach, S; Bachar, R; Badran, A; Baillie, C; Balai, E; Baldwin, A; Balian, V; Banfield, D; Bannard-Smith, J; Barker, C; Barmayehvar, B; Barnfield, J; Bartlett, D; Bartlett, R; Baryeh, K; Basetti, S; Bateman, K; Bath, M; Beamish, A; Beasley, W; Beecroft, S; Begaj, A; Beghal, G; Belchos, J; Bera, K; Bergara, T; Betts, A; Bhangu, A; Bhaskaran, G; Bhatti, A; Bica, M; Billyard, C

  17. Attention and multisensory modulation argue against total encapsulation

    de Haas, B; Schwarzkopf, DS; Rees, G

  18. Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

    Schütte, M; Risch, T; Abdavi-Azar, N; Boehnke, K; Schumacher, D; Keil, M; Yildiriman, R; Jandrasits, C; Borodina, T; Amstislavskiy, V; Worth, CL; Schweiger, C; Liebs, S; Lange, M; Warnatz, HJ; Butcher, LM; Barrett, JE; Sultan, M; Wierling, C; Golob-Schwarzl, N; Lax, S; Uranitsch, S; Becker, M; Welte, Y; Regan, JL; Silvestrov, M; Kehler, I; Fusi, A; Kessler, T; Herwig, R; Landegren, U; Wienke, D; Nilsson, M; Velasco, JA; Garin-Chesa, P; Reinhard, C; Beck, S; Schäfer, R; Regenbrecht, CR; Henderson, D; Lange, B; Haybaeck, J; Keilholz, U; Hoffmann, J; Lehrach, H; Yaspo, ML
    Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling >4,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate...

  19. Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

    Schütte, M; Risch, T; Abdavi-Azar, N; Boehnke, K; Schumacher, D; Keil, M; Yildiriman, R; Jandrasits, C; Borodina, T; Amstislavskiy, V; Worth, CL; Schweiger, C; Liebs, S; Lange, M; Warnatz, HJ; Butcher, LM; Barrett, JE; Sultan, M; Wierling, C; Golob-Schwarzl, N; Lax, S; Uranitsch, S; Becker, M; Welte, Y; Regan, JL; Silvestrov, M; Kehler, I; Fusi, A; Kessler, T; Herwig, R; Landegren, U; Wienke, D; Nilsson, M; Velasco, JA; Garin-Chesa, P; Reinhard, C; Beck, S; Schäfer, R; Regenbrecht, CR; Henderson, D; Lange, B; Haybaeck, J; Keilholz, U; Hoffmann, J; Lehrach, H; Yaspo, ML
    Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling >4,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate...

  20. A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies.

    Teschendorff, AE; Breeze, CE; Zheng, SC; Beck, S
    BACKGROUND: Intra-sample cellular heterogeneity presents numerous challenges to the identification of biomarkers in large Epigenome-Wide Association Studies (EWAS). While a number of reference-based deconvolution algorithms have emerged, their potential remains underexplored and a comparative evaluation of these algorithms beyond tissues such as blood is still lacking. RESULTS: Here we present a novel framework for reference-based inference, which leverages cell-type specific DNAse Hypersensitive Site (DHS) information from the NIH Epigenomics Roadmap to construct an improved reference DNA methylation database. We show that this leads to a marginal but statistically significant improvement of cell-count estimates in whole blood as well as in...

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.