UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
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Gender, Public Space and Resistance - Baydar, Gülsüm
On May 27, 2013 at 11:30 pm bulldozers drove into Gezi, a central park in Taksim, Istanbul, to uproot five trees in preparation for future construction. Plans for the redevelopment had been announced two years before by the Prime Minister, Recep Tayyip Erdogan, and in response, two local activist groups had been formed: 'Taksim Solidarity' and the 'Society for the Preservation and Beautification of Gezi Park'. Founded to to publicise the historical status of the park and protect what remains a symbolically important site - and one of the few recreation areas in the central area of Istanbul - members...
Hazing Iran: Satellite Imagery, Human Rights, and City as Camp - Zhang, Amy
As perhaps most obviously evidenced in the political maneuverings that led up to the second Gulf War in 2003, the use of satellite imagery to document spatial terrain is often, and almost instantly, politicized. In the two images presented here, this politicization takes on a two-way relationship and is open to contrasting and inevitably dualistic readings. One way of describing their relationship is as "Target" and "Aftermath". On the left, we have an image of the nuclear plant near the Iranian city of Qom, annotated in this version by the US security services to highlight 'suspicious' activity said to evidence...
Roles of the RNAi pathway in making telomere-free chromosome ends - Begnis, M
The discovery of a new mode of telomerase minus survival, ‘HAATI’, shook the dogma that canonical telomeres are essential to maintain linear chromosomes (Jain et al., 2010). In HAATI cells, telomeric sequences are superseded by blocks of generic heterochromatin, which jump to all chromosome ends and acquire the ability to protect them from fusions and degradation. While they lack of detectable telomeric repeats, these newly acquired termini recruit the canonical end-protection factor Pot1 and guarantee end protection. The amplified elements in HAATI are repetitive sequences associated with heterochromatin. Most commonly, the ribosomal DNA (rDNA) is the preferred substrate for this...
Bayesian statistical modelling of genetic sequence evolution - Angelis, K
Bayesian statistics has been at the heart of phylogenetic inference over the last decade, particularly after the development of powerful programs that implement efficient Markov chain Monte Carlo algorithms, allowing inference from multi-parametric problems in realistic time frames. In this thesis we develop and test Bayesian methods to analyse molecular sequence data to address important biological questions. First, we review some fundamental aspects of Bayesian inference and highlight current Bayesian applications in molecular evolution with particular focus in studying natural selection and estimating species divergence times. Then, we develop a new Bayesian method to estimate the nonsynonymous/synonymous rate ratio and...
Improving outcomes in paediatric heart transplantation - Simmonds, JD
For patients with end-stage heart failure, heart transplantation remains the only viable long-term option. During the last fifty years, the procedure has become more successful, and the majority of candidates can now expect to recover and lead relatively normal day-to-day lives. Unfortunately, however, it is not a perfect cure. Daily lifelong immunosuppression is required to protect against rejection, and current drug regimens have substantial side-effects including infection, renal failure and hypertension, all of which further shorten life expectancy. Current post-transplant graft survival is estimated at 15 to 20 years, after which re-transplantation is indicated; with donation rates decreasing, and potential...
The incidence rate over 10 years of naturally occurring, cancer related mutations in the basal core promoter of hepatitis B virus - Wang, XY; Harrison, TJ; Chen, QY; Li, H; Li, GJ; Liu, MH; Hu, LP; Tan, C; Yang, QL; Fang, ZL
Cross-sectional analyses showed that the prevalence of basal core promoter (BCP) double mutations (nt 1762T, 1764A) of hepatitis B virus (HBV) gradually increases with age. We aimed to determine the incidence rate of the mutations over 10 years. Study subjects were selected from the Long An cohort established in 2004, including 59 with HBV with single mutations at nt 1762 or 1764 in the BCP and 342 with wild type BCP sequences at baseline. Their serum samples for analysis were obtained at the 3rd and 10th annual visits, respectively. The results showed that the annual incidence rate of BCP double...
Should the symptomatic region be included in dissemination in space in MRI criteria for MS? - Brownlee, WJ; Swanton, JK; Miszkiel, KA; Miller, DH; Ciccarelli, O
Objectives: To investigate whether inclusion of lesions in the symptomatic region influences the performance of dissemination in space (DIS) criteria for a diagnosis of clinically-definite MS (CDMS) in patients with a clinically isolated syndrome (CIS). / Methods: We studied 30 CIS patients with brainstem/cerebellar and spinal cord syndromes who had MRI scans at the time of CIS and were followed up for the development of CDMS. We retrospectively applied the McDonald 2010 DIS criteria (excluding all lesions in the symptomatic region) to baseline MRI scans and two modified DIS criteria: (1) the inclusion of asymptomatic lesions in the symptomatic region...
Exploring the interplay between human and machine annotated multimodal learning analytics in hands-on STEM Activities - Spikol, D; Avramides, K; Cukurova, M; Vogel, B; Luckin, R; Mavrikis, M; Ruffaldi, E
This poster explores how to develop a working framework for STEM education that uses both human annotated and machine data across a purpose-built learning environment. Our dual approach is to develop a robust framework for analysis and investigate how to design a learning analytics system to support hands-on engineering design tasks. Data from the first user tests are presented along with the framework for discussion.
The View from The Blimp - Urban Image and the Telegenic Iconography of Sports Venues - Clarke, Paul Walker
Architecture_MPS is the academic journal of the research group AMPS (Architecture, Media, Politics, Society). It addresses the growing interest in the social and political interpretation of the built environment from a multi-disciplinary perspective. It engages with architecture, urbanism, planning, sociology, economics, cultural studies, visual culture, new medias and technologies. It draws on experts who bring emerging issues of international importance to the reader. Its publications are linked with a wide range of research programmes and conferences to further raise awareness of the social importance of architecture.
Ethics, Emotion, and Aesthetics: Architecture After the Crisis of Modern Science - Pérez Gómez, Alberto
Alberto Pérez Gómez first came to prominence as an architectural theorist and historian with his 1983 publication, Architecture and the Crisis of Modern Science; a book that won the Alice Davis Hitchcock Award for distinguished scholarship in architectural history the following year. Having established himself as one of the architecture world's leading thinkers and most original historical theorists, he offered a book that completely broke all norms of either academic or architectural discourse; his 1992 treatise Polyphilo, or, The Dark Forest Revisited: An Erotic Epiphany of Architecture. The author and editor of numerous publications since, in 2007 he coauthored Towards...
The City as a Laboratory of Shadows: Exposing Secret Histories While Thinking of the Future. - MacDonald, Robert G
This paper lays out a particular way of 'seeing' or looking at cities – one that allows us to see beneath the physical surface of buildings and infrastructure and which thus opens the door to considering the 'shadows' of a city as a source of inspiration. In these shadows, it suggests, we can see the city as a 'laboratory of ideas.' Specifically, the paper examines the city of Liverpool but its themes are applicable worldwide. It aims to expose Liverpool's 'poetic' qualities and suggests that those best placed to understand it, and guide its development, may not be architects or...
On the "Falsation" of Deceitful Architectures - Miranda, Antonio
Professor Antonio Miranda Regojo-Borges is a polymath; an architectural critic whose knowledge base covers centuries, reaches across disciplines and informs his polemic thoughts. He writes quixotic and "antiquarian" prose - in the style of Wollflin's principles of art history, Kant's theories on taste, and William Gilpin's Eighteenth Century tour journals. In its enumerative tendencies, it is reminiscent of the analytical theorists Edmund Burke, whilst in its examination of architecture in the cultural industry context it reminds us of Theodore Adorno. At times ironic, at times bombastic, and at times mocking, his writing style will alienate as many as it enthuses....
Hidden Power and Built Form: The Politics Behind the Architecture - Chomsky, Noam; Cairns, Graham
Emeritus Professor in the Department of Linguistics & Philosophy at MIT, Avram Noam Chomsky is amongst the world's most cited living scholars. Lauded as the 'father' of modern linguistics and instigator of the 'cognitive revolution' he was voted the "world's top public intellectual" in 2005. He is, however, best known, and at his most controversial, in the fields of political criticism and activism. Perhaps the most prolific author alive today he has engaged with issues ranging from the Vietnam War, US policy in South and Central America, what he calls the 'US-Palestinian-Israeli problem', the Spanish Civil War and the Indonesian...
No Longer and Not Yet - Hollis, Edward
The forest of Kilmahew, around twenty miles west of Glasgow, conceals an architectural cautionary tale. In the 1960's, the landscape was radically transformed by a building. St Peter's seminary was built to house around a hundred catholic novices. Its plan and section, the work of the architects Gillespie Kidd and Coia, were a rigorous statement of the modernist maxim that form follows function. But within a decade, there were not enough priests to fill it; and St Peter's became a form without a function. That was 1987, and since then it has resisted numerous attempts to provide it with a...
Identity and Conflict: Cultural Heritage, Reconstruction and National Identity in Kosovo - Morel, Anne-Françoise
The year 1989 marked the six hundredth anniversary of the defeat of the Christian Prince of Serbia, Lazard I, at the hands of the Ottoman Empire in the "Valley of the Blackbirds," Kosovo. On June 28, 1989, the very day of the battle's anniversary, thousands of Serbs gathered on the presumed historic battle field bearing nationalistic symbols and honoring the Serbian martyrs buried in Orthodox churches across the territory. They were there to hear a speech delivered by Slobodan Milosevic in which the thenpresident of the Socialist Republic of Serbia revived Lazard's mythic battle and martyrdom. It was a symbolic...
Driving on the Left: Sorkin's View of the Street, the City and architecture - Sorkin, Michael
Sardonic, cutting, insightful, provocative: Michael Sorkin is one of today's most radical architectural commentators with a staunch leaning to the political left and a literary bent for framing painful truths in ironic, and sometimes hilarious, verse. However, he should not be dismissed as a radical, isolated, or lone and unhindered voice however. He is a Distinguished Professor of Architecture and Director of the Graduate Program in Urban Design at the City College of New York, and he has been Professor of Urbanism and Director of the Institute of Urbanism at the Academy of Fine Arts, Vienna. In addition, he has...
Branding Stratford: Social Representation and the Re-making of Place - Desiderio, Antonio
As part of the societal world, architecture and urban space do not have any 'objective' quality. They are representations. Their meaning is produced through the negotiation and interaction of individuals, groups and classes. Yet, such 'subjective' meanings do have a 'material' relevance, as they reflect a dialectical process between the functions, forms, ownership and practices of space. They reveal construal and construction: the way in which architectural spaces are represented on the one hand, and the way in which they are physically constructed and used on the other. Nowhere does this become more evident in our current society than in...