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UCL University College London Eprints (354,676 recursos)
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 181 - 200 de 354,316

181. Investigating catalytic activity at oxide surfaces using a QM/MM methodology - Downing, CA
A set of complementary studies has been undertaken to investigate the interaction of CO2 with metal oxide surfaces. Beginning with the simple and well-studied magnesium oxide surface, work progressed to include a manganese dopant near the MgO active site before shifting to manganese oxide. All work made use of the Quantum Mechanical/Molecular Mechanical (QM/MM) methodology implemented within the ChemShell code, which combines information from an electronic structure calculation on atoms in the vicinity of the adsorption site with relaxation effects from a large component of the surrounding catalyst system. Initial findings showed that CO2 interacts favourably with the MgO (100)...

182. Muslims in Europe - the public engagement of young German Muslims - Soliman, A
This study examines qualitatively several case studies of young Muslims in Germany who strongly identify with Islam and Germany and who are publicly active. It analyses the ways in which the research participants use the public sphere in the context of German Muslim identity. It focuses on three main fields within the public sphere, namely media, the arts and culture, and civil society. Various forms of engagement as well as different contents are investigated. Two theoretical frameworks are used. The first one deals with identity, looking at theories of minority identity, hybrid identity, multiculturalism and secularism. Secondly, the concept of...

183. Adolescent Twins’ Mental Representations of Self and Other in Relation with Zygosity, Attachment Patterns and Psychological Disturbances - Zhou, Y
Abstract Introduction: Based on a theoretical integration of cognitive development psychology, psychoanalytic theory and attachment theory, Blatt and his colleagues formulated a systematic psychodynamic model of mental representation of self and other emphasizing internalization, differentiation and integration of self and object representations in normal and disrupted personality development. During the development process, adolescence is a critical transformational stage to determine either the construction of an integrated self-identity and more mature expressions of relatedness within a wider social context, or emergence or consolidation of many forms of psychopathology. This study used a twin design to examine the degree of articulation, differentiation...

184. The Time and Space of Greek-Cypriot Cinema: A Deleuzian Reading - Socrates, L
This study traces the emergence of Greek-Cypriot Cinema in Cyprus since 1974, arguing that it is the product of a historical moment. 1974 marks a watershed in the island’s protracted political conflict which culminated in ethnic violence, a coup and war. Whilst the war has been the subject of wide ranging scholarly research its impact in forging a distinctive national cinema remains unexamined. This thesis attempts to re-address this absence. My approach is interdisciplinary, drawing on historiographical studies as well as Film Studies, Cultural Theory and Film Philosophy. Primary research includes extensive dialogues with filmmakers. All of the films examined...

185. Action control in uncertain environments - Smittenaar, P
A long-standing dichotomy in neuroscience pits automatic or reflexive drivers of behaviour against deliberate or reflective processes. In this thesis I explore how this concept applies to two stages of action control: decision-making and response inhibition. The first part of this thesis examines the decision-making process itself during which actions need to be selected that maximise rewards. Decisions arise through influences from model-free stimulus-response associations as well as model-based, goal-directed thought. Using a task that quantifies their respective contributions, I describe three studies that manipulate the balance of control between these two systems. I find that a pharmacological manipulation with...

186. The Role of the Neurokinin-1 Receptor in Behaviour and Cognition: an interaction with the Brain Renin Angiotensin System and its implications for Attention Deficit Hyperactivity Disorder - Porter, AJ
Mice lacking functional neurokinin-1 receptors (NK1R-/-) display several behavioural abnormalities that resemble Attention Deficit Hyperactivity Disorder (ADHD), including locomotor hyperactivity (which is alleviated by ADHD medication), impulsivity and inattentiveness. These findings prompted the proposal that NK1R-/- mice offer a novel murine model of ADHD. The first aim of this thesis was to investigate the influence of non-genetic (epigenetic/environmental) factors on the behaviour of NK1R-/- mice by comparing animals from two different breeding protocols. These studies revealed that certain elements of their impulsivity are influenced by non-genetic factors, but other behaviours are not. The second aim was to compare the behaviour...

187. Cardiovascular Morbidity in Juvenile-Onset Systemic Lupus Erythematosus - Quinlan, CT
Cardiovascular disease (CVD) is a leading cause of mortality in adults with systemic lupus erythematosus (SLE). As children with conditions such as chronic kidney disease have been shown to have a risk of CVD similar to their adult counterparts, clinicians have become concerned that paediatric patients with SLE are at increased risk of CVD. The aim of this project was to examine the vascular phenotype of a British paediatric population with SLE and gain mechanistic insights into this process. Structural changes in vessels were measured using carotid intima media thickness (cIMT) and function was assessed using pulse wave velocity (PWV)....

188. Between buildings and streets: a study of the micromorphology of the London terrace and the Manhattan row house 1880-2013 - Palaiologou, G
This thesis examines the role of building morphology and street networks in shaping street activity and transformations in the historical built form. The core inquiry applies a configurational analysis to the street, viewing it as a complex entity which interfaces with both buildings and the urban street network. The research is founded on the identification of two theoretical and methodological gaps in the canon of urban design: how generic building morphology properties relate to street liveability; and, how urban diversity emerges as the result of diachronic processes. The thesis looks at architecture beyond function, geometry and aesthetics, focusing on the...

189. High speed ice friction and its application to the winter sport of skeleton - Seymour-Pierce, AI
Abstract removed.

190. Retinotectal projections influence optic tectum growth in zebrafish - Rouse, H
In the zebrafish visual system, the retina and optic tectum grow in register throughout life. Both regions add new neurons from proliferation zones at their margins, with newly differentiated retinal ganglion cells projecting to, and making new synapses in the tectum. Retinal ganglion cell axon innervation appears to regulate size of the target tissue, because the contralateral tectum is reduced in size when an eye is removed. The mechanisms by which the retina affects cell proliferation and/or survival in the optic tectum remain to be elucidated. In this thesis I use the atoh7 mutant, lakritz, and unilateral eye enucleations to...

191. Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase. - Deszcz, D; Affaticati, P; Ladkau, N; Gegel, A; Ward, JM; Hailes, HC; Dalby, PA
We have analysed the natural evolution of transaminase structure and sequence between an α-transaminase serine-pyruvate aminotransferase, and an ω-transaminase from Chromobacterium violaceum with <20% sequence identity, and identified the active-site regions which are least conserved structurally. We also show that these structural changes correlate strongly with transaminase substrate specificity during evolution and therefore might normally be presumed to be essential determinants of substrate specificity. However, key residues are often conserved spatially during evolution and yet come from within a different region of the sequence via structural reorganisations. Here we also show that α-transaminase-type serine-pyruvate aminotransferase activity, can be engineered into...

192. Structure and Dynamics of the E. coli Chaperone, Trigger Factor, and its Interaction with Ribosome-Nascent Chain Complexes - Wentink, AS
The de novo folding of newly synthesised polypeptide chains, exposed in a vectorial manner to the crowded cellular environment, often requires the assistance of molecular chaperones. The ribosome-associated molecular chaperone, trigger factor (TF), facilitates the early folding events of such nascent chains at the ribosomal exit tunnel. The investigation of the structural and dynamic properties of this interaction, at high resolution, presents a challenge due to the dynamic nature of the interaction and the intrinsic conformational heterogeneity of nascent chains. Additional complexity comes from the competition between TF self-association into a dimeric state, the interaction with ribosome-nascent chain complexes (RNCs)...

193. A Cascade of Molecular Events During Neural Induction - Trevers, KE
Neural induction is the process by which a region of ectoderm acquires a neural identity and forms the neural plate. A popular explanation for neural induction is the “default model”. This proposes that non-neural cells are specified as epidermal by BMP expression and that inhibition of this signal at the end of gastrulation is sufficient to induce neural fate. Although this model is attractive in its simplicity, accumulating evidence suggests a more complex scenario, where neural induction comprises a series of sequential events and multiple signals. However the details of this hierarchy are unclear, as are the specific contributions of...

194. Flushing Ballast Tanks - Qi, Z
The non-indigenous species (NIS) transported by ships’ ballast water lead to destructive failure of the main ecologies giving rise to economic implications of many countries dependent on aquatic organisms. The International Maritime Organisation currently requires that ballast tanks are flushed three times with far ocean water. New protocols for cleaning technologies are still in discussion internationally. Current lacking is the science to understand how ballast tanks geometry and ballast water composition affect the NIS removal rate. This thesis describes a major contribution to this effort and identifies key engineering principles that should be taken into account to improve flushing efficiency....

195. Characterisation of the Metabolic Phenotype of the Fmo5 Knockout Mouse - Scott, FH
Through the use of a knockout mouse line, we have identified flavin-containing monooxygenase 5 (FMO5) as a regulator of energy homeostasis. The characterisation of the FMO5 knockout (FMO5 KO) phenotype reveals the mutant animals are resistant to age-related and diet-induced weight gain when compared to age-matched wild-type (WT) controls. The FMO5 KO mice exhibit higher insulin sensitivity and need lower circulating insulin to maintain normal glycaemia. The knockout mice are also more responsive to an exogenous dose of insulin and they do not gain weight when fed a high fat diet. FMO5 is expressed in the murine digestive tract of WT...

196. Systemic Amyloidosis – Insights by Cardiovascular Magnetic Resonance - Banypersad, SM
Systemic amyloidosis is the exemplar infiltrative, extracellular disease. Although it is a multi-organ disorder, cardiac involvement drives prognosis. Survival is worst in the AL amyloidosis subtype. It can affect any age and any race. There is no direct test for amyloid burden and there is no treatment for amyloidosis, there is only treatment for the underlying condition. Earlier diagnosis permits prompt treatment and improves survival. A number of imaging modalities exist to non-invasively detect cardiac disease but all have limitations. Cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging provides the highest sensitivity for early detection. However, this also...

197. Translation and the Aesthetics of Prose Poetry - Muris-Prime, CFE
Translation is generally understood as the transformation of text from one language into another. But translation is also a dialogue between two languages, between two versions of a text, and between author and translator. Such dialogue involves thought on language, its usage and potential, and on literary creation itself. Poetry also involves attention to, and experimentation with, language and contains a constant analysis of its own expression. This dissertation examines this coincidence of translation and poetry and seeks to explore how translation, both in theory and in practice, illuminates the understanding of a key development in modern French poetry: the...

198. The derivation of bioprocess understanding from mechanistic models of chromatography - Close, EJ
This thesis, completed in collaboration with Purification Process Development of Pfizer Biotherapeutics, is concerned with how mechanistic models of chromatographic bioseparations can be applied in industry to accelerate development and increase robustness of industrial protein purification processes, whilst also realising the benefits of a systematic development approach based on fundamental process and product understanding. The first results chapter considers the application of mechanistic models to provide a link between high throughput screening (HTS) and scouting runs conducted during early process development. The chapter focuses on an anion exchange (AEX) weak partitioning chromatography (WPC) polishing step in a platform monoclonal antibody...

199. Pathophysiology of functional (psychogenic) movement disorders - Parees Moreno, I
This thesis describes a series of studies involving healthy subjects, carefully selected patients with functional movement disorders and organic movement disorders, in which different aspect of the mechanism underlying functional movement disorders were explored: 1. The presence of physical precipitating factors at onset of functional movement disorder by using semistructured interviews. I found that most patients with functional movement disorder have a clear physical event prior to the onset of functional symptoms. 2. The presence of a “jumping to conclusions” reasoning style that may predispose patients with functional movement disorder to accept new hypothesis on the basis of less evidence....

200. Novel algorithms for the understanding of the chemical cosmos - Makrymallis, A
Molecular data from the interstellar medium (ISM) contain information that holds the key to understanding our chemically controlled cosmos and to unlocking the secrets of our universe. Observational data, as well as synthetic data from chemical codes, provide a cornucopia of digital information that conceals knowledge of the ISM. Astrochemistry studies the chemical interactions in the ISM and translates this information into knowledge of the physical characteristics of the ISM. As larger datasets and more complex models are being employed in astrochemistry, the need for intelligent data mining algorithms wil increase. Machine learning algorithms provide novel methods for human-driven analysis...

 

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