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UCL University College London Eprints (333,922 recursos)
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 181 - 200 de 333,435

181. COMBODY: One-domain antibody multimer with improved avidity - Zhu, X; Wang, L; Liu, R; Ding, J; Tao, H; Liu, C; Flutter, B; Li, S; Sun, M; Gao, B
Antibodies (Abs) have been engineered into small antigen-binding fragments and rebuilt into multivalent high-avidity molecules for improving in vivo pharmacokinetics and efficacy in clinical use. To increase the avidity of a T-cell receptor-like single-domain Ab (sdAb) specific for HLA-A2 complex, we fused the sdAb to a coiled-coil peptide derived from human cartilage oligomeric matrix protein (COMP48) to make an sdAb multimer, termed combody. The combody improved the binding avidity of sdAb significantly, whereas the specificity for the targeted cells was retained. The strategy was also expanded to create a bispecific combody by fusing an sdAb to the N-terminal and an...

182. Fetal tissue engineering: Regenerative capacity of fetal stem cells - Wu, P; Moschidou, D; Fisk, NM
Considerable debate has focused on the contrasting merits of embryonic and adult stem cells. Fetal stem cells represent an intermediate cell type in this controversy. Adult stem cells have limited capacity to differentiate into fully functioning mature cell types of their tissue of origin (multipotent), whereas embryonic stem cells (ESCs) have the advantageous capacity to develop into all tissue types (pluripotent), including trophoblasts (totipotent). However, ESC research has been hampered by both safety concerns and ethical reservations due to requisite destruction of the blastocyst during harvesting. Transplantation of ESCs is almost invariably followed by the development of embryonal teratomas, precluding...

183. Vascularisation is not necessary for gut colonisation by enteric neural crest cells - Delalande, J-M; Natarajan, D; Vernay, B; Thapar, N; Burns, AJ; Finlay, M; Ruhrberg, C
The vasculature and nervous system share striking similarities in their networked, tree-like architecture and in the way they are super-imposed in mature organs. It has previously been suggested that the intestinal microvasculature network directs the migration of enteric neural crest cells (ENCC) along the gut to promote the formation of the enteric nervous system (ENS). To investigate the inter-relationship of migrating ENCC, ENS formation and gut vascular development we combined fate-mapping of ENCC with immunolabelling and intravascular dye injection to visualise nascent blood vessel networks. We found that the enteric and vascular networks initially had very distinct patterns of development....

184. Childhood Epstein-Barr Virus infection and subsequent risk of psychotic experiences in adolescence: A population-based prospective serological study. - Khandaker, GM; Stochl, J; Zammit, S; Lewis, G; Jones, PB
Several studies suggest a link between early-life infection and adult schizophrenia. Cross-sectional studies have reported: (1) increased prevalence of Epstein-Barr Virus (EBV), a member of the Herpesviridae family in schizophrenia; (2) a possible role of Herpes simplex virus in cognitive dysfunction in schizophrenia and healthy controls. We report a longitudinal serological study of early-life EBV infection, childhood IQ, and subsequent risk of psychotic experiences (PE) in adolescence.

185. Differences in risk factors for self-harm with and without suicidal intent: Findings from the ALSPAC cohort. - Mars, B; Heron, J; Crane, C; Hawton, K; Kidger, J; Lewis, G; Macleod, J; Tilling, K; Gunnell, D
There is a lack of consensus about whether self-harm with suicidal intent differs in aetiology and prognosis from non-suicidal self-harm, and whether they should be considered as different diagnostic categories.

186. Outcomes of childhood conduct problem trajectories in early adulthood: findings from the ALSPAC study - Kretschmer, T; Hickman, M; Doerner, R; Emond, A; Lewis, G; Macleod, J; Maughan, B; Munafo, MR; Heron, J

187. Childhood Internalizing Symptoms Are Negatively Associated with Early Adolescent Alcohol Use - Edwards, AC; Latendresse, SJ; Heron, J; Bin Cho, S; Hickman, M; Lewis, G; Dick, DM; Kendler, KS

188. A population-based longitudinal study of childhood neurodevelopmental disorders, IQ and subsequent risk of psychotic experiences in adolescence. - Khandaker, GM; Stochl, J; Zammit, S; Lewis, G; Jones, PB
Schizophrenia has a neurodevelopmental component to its origin, and may share overlapping pathogenic mechanisms with childhood neurodevelopmental disorders (NDs). Nevertheless, longitudinal studies of psychotic outcomes among individuals with NDs are limited. We report a population-based prospective study of six common childhood NDs, subsequent neurocognitive performance and the risk of psychotic experiences (PEs) in early adolescence.

189. Associations of cannabis and cigarette use with psychotic experiences at age 18: findings from the Avon Longitudinal Study of Parents and Children. - Gage, SH; Hickman, M; Heron, J; Munafò, MR; Lewis, G; Macleod, J; Zammit, S
A clearer understanding of the basis for the association between cannabis use and psychotic experiences (PEs) is required. Our aim was to examine the extent to which associations between cannabis and cigarette use and PEs are due to confounding.

190. Allowing for non-adherence to treatment in a randomized controlled trial of two antidepressants (citalopram versus reboxetine): an example from the GENPOD trial. - Wiles, NJ; Fischer, K; Cowen, P; Nutt, D; Peters, TJ; Lewis, G; White, IR
Meta-analyses suggest that reboxetine may be less effective than other antidepressants. Such comparisons may be biased by lower adherence to reboxetine and subsequent handling of missing outcome data. This study illustrates how to adjust for differential non-adherence and hence derive an unbiased estimate of the efficacy of reboxetine compared with citalopram in primary care patients with depression.

191. Behavioural therapies versus other psychological therapies for depression. - Churchill, R; Caldwell, D; Moore, TH; Davies, P; Jones, H; Lewis, G; Hunot, V
This is the protocol for a review and there is no abstract. The objectives are as follows: To examine the effectiveness and acceptability of all BT approaches compared with all other psychological therapy approaches for acute depressionTo examine the effectiveness and acceptability of different BT approaches (behavioural therapy, behavioural activation, social skills training and relaxation training) compared with all other psychological therapy approaches for acute depression.To examine the effectiveness and acceptability of all BT approaches compared with different psychological therapy approaches (psychodynamic, humanistic, integrative, cognitive-behavioural and third wave CBT) for acute depression.

192. Mindfulness-based 'third wave' cognitive and behavioural therapies versus other psychological therapies for depression. - Hunot, V; Moore, TH; Caldwell, D; Davies, P; Jones, H; Lewis, G; Churchill, R
This is the protocol for a review and there is no abstract. The objectives are as follows: To examine the effectiveness and acceptability of all third wave CBT approaches compared with all other psychological therapy approaches for acute depression.To examine the effectiveness and acceptability of different third wave CBT approaches (ACT,compassionate mind training, functional analytic psychotherapy, extended behavioural activation and meta-cognitive therapy) compared with all other psychological therapy approaches for acute depression.To examine the effectiveness and acceptability of all third wave CBT approaches compared with different psychological therapy approaches (psychodynamic, behavioural, humanistic, integrative, cognitive-behavioural) for acute depression.

193. Mindfulness-based 'third wave' cognitive and behavioural therapies versus treatment as usual for depression. - Churchill, R; Moore, TH; Davies, P; Caldwell, D; Jones, H; Lewis, G; Hunot, V
This is the protocol for a review and there is no abstract. The objectives are as follows: To examine the effectiveness and acceptability of all third wave CBT approaches compared with treatment as usual/waiting list/attention placebo control conditions for acute depression.To examine the effectiveness and acceptability of different third wave CBT approaches (ACT, compassionate mind training, functional analytic psychotherapy, meta-cognitive therapy, dialectical behaviour therapy, MBCT, extended behavioural activation and meta-cognitive therapy) compared with treatment as usual/waiting list/attention placebo control conditions for acute depression.To examine the effectiveness and acceptability of all third wave CBT approaches compared with different types of comparator...

194. 3D printing: for the many, not the few - Fullerton, J; Frodsham, G; Day, R

195. Bone Marrow Derived Kit-positive Cells Colonize the Gut but Fail to Restore Pacemaker Function in Intestines Lacking Interstitial Cells of Cajal. - McCann, CJ; Hwang, SJ; Hennig, GW; Ward, SM; Sanders, KM
Several motility disorders are associated with disruption of interstitial cells of Cajal (ICC), which provide important functions, such as pacemaker activity, mediation of neural inputs and responses to stretch in the gastrointestinal (GI) tract. Restoration of ICC networks may be therapeutic for GI motor disorders. Recent reports have suggested that Kit(+) cells can be restored to the GI tract via bone marrow (BM) transplantation. We tested whether BM derived cells can lead to generation of functional activity in intestines naturally lacking ICC.

196. Regenerative medicine therapies for obstetric trauma-induced fecal incontinence - Parmar, N; Kumar, L; Emmanuel, A; Day, R

197. Development of a Soft Tissue In Vitro Model for Ameloblastoma - Eriksson, T; Fedele, S; Day, R; Salih, V

198. Faecal Incontinence: Innovative Strategies for Treatment and Therapy Evaluation - Parmar, N; Day, R

199. Magnetic Conditioning of the Sphincter Muscle - Angelopoulos, A; Pankhurst, Q; Day, R

200. Retention of Myoblast Differentiation Capacity in 3D Culture on TIPS Microspheres - Parmar, N; Day, R

 

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