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UCL University College London Eprints (323,547 recursos)
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 181 - 200 de 323,135

181. Hereditary myopathy with early respiratory failure: Occurrence in various populations - Palmio, J; Udd, B; Evilä, A; Hackman, P; Chapon, F; Tasca, G; Xiang, F; Bradvik, B; Eymard, B; Laforêt, P; Echaniz-Laguna, A; Laporte, J; Kärppä, M; Mahjneh, I; Quinlivan, R; Damian, M; Berardo, A; Bueri, JA; Taratuto, AL; Tommiska, J; Raivio, T; Tuerk, M; Gölitz, P; Chevessier, F; Schröder, R; Sewry, C; Norwood, F; Hedberg, C; Oldfors, A; Edström, L
Objective Several families with characteristic features of hereditary myopathy with early respiratory failure (HMERF) have remained without genetic cause. This international study was initiated to clarify epidemiology and the genetic underlying cause in these families, and to characterise the phenotype in our large cohort. Methods DNA samples of all currently known families with HMERF without molecular genetic cause were obtained from 12 families in seven different countries. Clinical, histopathological and muscle imaging data were collected and five biopsy samples made available for further immunohistochemical studies. Genotyping, exome sequencing and Sanger sequencing were used to identify and confirm sequence variations. Results...

182. Depressive disorder, coronary heart disease, and stroke: Dose-response and reverse causation effects in the Whitehall II cohort study - Brunner, EJ; Shipley, MJ; Britton, AR; Singh-Manoux, A; Kivimaki, M; Stansfeld, SA; Heuschmann, PU; Rudd, AG; Wolfe, CDA
Background: Systematic reviews examining associations of depressive disorder with coronary heart disease and stroke produce mixed results. Failure to consider reverse causation and dose-response patterns may have caused inconsistencies in evidence. Design: This prospective cohort study on depressive disorder, coronary heart disease, and stroke analysed reverse causation and dose-response effects using four 5-year and three 10-year observation cycles (total follow up 24 years) based on multiple repeat measures of exposure. Methods: Participants in the Whitehall II study (n=10,036, 31,395 person-observations, age at start 44.4 years) provided up to six repeat measures of depressive symptoms via the 30-item General Health Questionnaire...

183. Health inequalities in Japan: The role of material, psychosocial, social relational and behavioural factors - Hiyoshi, A; Shipley, MJ; Brunner, EJ; Fukuda, Y
The extent that risk factors, identified in Western countries, account for health inequalities in Japan remains unclear. We analysed a nationally representative sample (Comprehensive Survey of Living Conditions surveyed in 2001 (n=40,243)). The cross-sectional association between self-rated fair or poor health and household income and a theory-based occupational social class was summarised using the relative index of inequality [RII]. The percentage attenuation in RII accounted for by candidate contributory factors - material, psychosocial, social relational and behavioural - was computed. The results showed that the RII for household income based on self-rated fair or poor health was reduced after including...

184. Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children. - McWilliam, SJ; Antoine, DJ; Sabbisetti, V; Pearce, RE; Jorgensen, AL; Lin, Y; Leeder, JS; Bonventre, JV; Smyth, RL; Pirmohamed, M
Aim: The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers of acute kidney injury, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Materials & Methods: Urinary biomarkers were determined in samples from children in the UK (n = 120) and the USA (n = 171) using both Meso Scale Discovery (MSD) and Luminex-based analytical approaches. Results: 95% reference intervals for each biomarker in each cohort are presented and stratified by sex or ethnicity where necessary, and age-related variability is explored using quantile regression. We identified consistently higher NGAL concentrations in...

185. Chemical variability along the value chains of turmeric (Curcuma longa): A comparison of nuclear magnetic resonance spectroscopy and high performance thin layer chromatography - Booker, A; Umealajekwu, C; Heinrich, M; Frommenwiler, D; Reich, E; Johnston, D
Ethnopharmacological relevance Herbal medicine value chains have generally been overlooked compared with food commodities. Not surprisingly, revenue generation tends to be weighted towards the end of the chain and consequently the farmers and producers are the lowest paid beneficiaries. Value chains have an impact both on the livelihood of producers and on the composition and quality of products commonly sold locally and globally and consequently on the consumers. In order to understand the impact of value chains on the composition of products, we studied the production conditions for turmeric (Curcuma longa) and the metabolomic composition of products derived from it....

186. Back pain in a previously healthy teenager - Fitzgerald, F; Howard, J; Bailey, F; Soleimanian, S

187. Development of Antiretroviral Resistance in Children With HIV in Low- and Middle-Income Countries - Fitzgerald, F; Penazzato, M; Gibb, D

188. Mother-to-child transmission of HIV in a community-based antiretroviral clinic in South Africa - Fitzgerald, FCS; Bekker, LG; Kaplan, R; Myer, L; Lawn, SD; Wood, R
OBJECTIVE: To examine the uptake of ART among pregnant women referred to an ART service and the associated rates and risk factors for vertical HIV transmission. METHOD: Retrospective analysis of an observational cohort at a community ART clinic in Cape Town. RESULTS: Between 2002 and 2008, 367 treatment-naive pregnant women accessed the clinic. The median age was 27.5 years, and median gestation at presentation was 28 weeks. The median baseline CD4 count and viral load were 134 cells/µl and 28 282 copies/ml. Two hundred and sixty-five women (72%) commenced ART before giving birth, 73 women (20%) were referred for prevention...

189. Mother-to-child transmission of HIV in a community-based antiretroviral clinic in South Africa - Fitzgerald, FCS
OBJECTIVE: To examine the uptake of ART among pregnant women referred to an ART service and the associated rates and risk factors for vertical HIV transmission. METHOD: Retrospective analysis of an observational cohort at a community ART clinic in Cape Town. RESULTS: Between 2002 and 2008, 367 treatment-naive pregnant women accessed the clinic. The median age was 27.5 years, and median gestation at presentation was 28 weeks. The median baseline CD4 count and viral load were 134 cells/µl and 28 282 copies/ml. Two hundred and sixty-five women (72%) commenced ART before giving birth, 73 women (20%) were referred for prevention...

190. Bounding quantile demand functions using revealed preference inequalities - Blundell, R; Kristensen, D; Matzkin, R
This paper develops a new approach to the estimation of consumer demand models with unobserved heterogeneity subject to revealed preference inequality restrictions. Particular attention is given to nonseparable heterogeneity. The inequality restrictions are used to identify bounds on counterfactual demand. A nonparametric estimator for these bounds is developed and asymptotic properties are derived. An empirical application using data from the UK Family Expenditure Survey illustrates the usefulness of the methods. © 2014 Elsevier B.V. All rights reserved.

191. Paleoenvironmental conditions for the development of calcareous nannofossil acme during the late Miocene in the Eastern Equatorial Pacific. - Beltran, C; Rousselle, G; Backman, J; Wade, BS; Sicre, MA

192. Can uncertainties in sea ice albedo reconcile patterns of data-model discord for the Pliocene and 20th/21st centuries? - Howell, FW; Haywood, AM; Dolan, AM; Dowsett, HJ; Francis, JE; Hill, DJ; Pickering, SJ; Pope, JO; Salzmann, U; Wade, BS

193. Scanning electron microscope studies of human metaphase chromosomes - Shemilt, LA; Estandarte, AKC; Yusuf, M; Robinson, IK

194. Steve Wilkins 1946-2013 - Olivo, A; Robinson, I; Stevenson, A

195. Optimal least-squares FIR digital filters for compensation of chromatic dispersion in digital coherent optical receivers - Eghbali, A; Johansson, H; Gustafsson, O; Savory, SJ
This paper proposes optimal finite-length impulse response (FIR) digital filters, in the least-squares (LS) sense, for compensation of chromatic dispersion (CD) in digital coherent optical receivers. The proposed filters are based on the convex minimization of the energy of the complex error between the frequency responses of the actual CD compensation filter and the ideal CD compensation filter. The paper utilizes the fact that pulse shaping filters limit the effective bandwidth of the signal. Then, the filter design for CD compensation needs to be performed over a smaller frequency range, as compared to the whole frequency band in the existing...

196. Investigation of the impact of ultra-narrow carrier spacing on the transmission of a 10-carrier 1Tb/s superchannel - Gavioli, G; Torrengo, E; Bosco, G; Carena, A; Curri, V; Miot, V; Poggiolini, P; Belmonte, M; Forghieri, F; Muzio, C; Piciaccia, S; Brinciotti, A; La Porta, A; Lezzi, C; Savory, S; Abrate, S
We investigate the impact of ultra-narrow carrier spacing on the transmission of a 1Tb/s superchannel comprising 10x100Gb/s PM-QPSK carriers. We demonstrate 2200km over installed SMF fibre with a carrier spacing of 1.1 the Baud rate. © 2008 Optical Society of America.

197. REMCARE: reminiscence groups for people with dementia and their family caregivers - effectiveness and cost-effectiveness pragmatic multicentre randomised trial. - Woods, RT; Bruce, E; Edwards, RT; Elvish, R; Hoare, Z; Hounsome, B; Keady, J; Moniz-Cook, ED; Orgeta, V; Orrell, M; Rees, J; Russell, IT
The aim of the REMiniscence groups for people with dementia and their family CAREgivers (REMCARE) study was to assess the effectiveness and cost-effectiveness of joint reminiscence groups for people with dementia and their family caregivers as compared with usual care. A multicentre, pragmatic randomised controlled trial with two parallel arms - an intervention group and a usual-care control group - was carried out. A restricted dynamic method of randomisation was used with an overall allocation ratio of 1 : 1, restricted to ensure intervention groups of a viable size. Assessments, blind to treatment allocation, were carried out at baseline, 3...

198. The Multidisciplinary Team and Day Care Provision - Orrell, M; Ashaye, K
"The multidisciplinary team assessments and treatment of older people with mental health problems enables a holistic approach to care and meet the complex health and social needs this group of patients may present with. Day hospitals with the various health professionals can offer the short-term care required of patients with acute and increasing mental and physical health problems requiring ongoing multidisciplinary team assessments, review of medication and psychological treatments. Day centres with more untrained staff should have the long term goals of ongoing social care support and daytime respite to carers for relatively stable patients with enduring mental health problems....

199. Maintenance cognitive stimulation therapy for dementia: single-blind, multicentre, pragmatic randomised controlled trial. - Orrell, M; Aguirre, E; Spector, A; Hoare, Z; Woods, RT; Streater, A; Donovan, H; Hoe, J; Knapp, M; Whitaker, C; Russell, I
There is good evidence for the benefits of short-term cognitive stimulation therapy for dementia but little is known about possible long-term effects.

200. The importance of music for people with dementia: the perspectives of people with dementia, family carers, staff and music therapists. - McDermott, O; Orrell, M; Ridder, HM
Objectives: Despite the popularity of music-based interventions in dementia care, there is a limited knowledge of how and why people with dementia find music beneficial for their well-being. A qualitative study was conducted to develop further insights into the musical experiences of people with dementia and explore the meaning of music in their lives.Method: Separate focus groups and interviews with (1) care home residents with dementia and their families, (2) day hospital clients with dementia, (3) care home staff, and (4) music therapists, were conducted. The findings of the thematic analysis were investigated further in the light of psychosocial factors...

 

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