UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
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Refeeding Hypophosphatemia in Adolescents With Anorexia Nervosa: A Systematic Review - O'Connor, G; Nicholls, D
The rate of adolescents presenting with anorexia nervosa (AN) is increasing. Medically unstable adolescents are admitted to the hospital for nutrition restoration. A lack of global consensus on appropriate refeeding practices of malnourished patients has resulted in inconsistent refeeding practices. Refeeding hypophosphatemia (RH) is the most common complication associated with refeeding the malnourished patient. This review sought to identify the range of refeeding rates adopted globally and the implication that total energy intake and malnutrition may have on RH while refeeding adolescents with anorexia nervosa. Studies were identified by a systematic electronic search of medical databases from 1980 to September...
Enhanced 3-epi-25-hydroxyvitamin D3 signal leads to overestimation of its concentration and amplifies interference in 25-hydroxyvitamin D LC-MS/MS assays - Flynn, N; Lam, F; Dawnay, A
Background 3-epi-25-hydroxyvitamin D3 (3-epi-25OHD3) interferes in most liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for 25-hydroxyvitamin D (25OHD). The clinical significance of this is unclear, with concentrations from undetectable to 230 nmol/L reported. Many studies have quantified 3-epi-25OHD3 based on 25OHD3 calibrators or other indirect methods, and we speculated that this contributes to the observed variability in reported 3-epi-25OHD3 concentrations.
Methods We compared continuous MS/MS infusions of 3-epi-25OHD3 and 25OHD3 solutions, spiked both analytes into the same serum matrix and analysed patient samples to assess the effect of three different quantitation methods on 3-epi-25OHD3 concentration. Experiments were performed on an LC-MS/MS system...
Parent and self-report health-related quality of life measures in young patients with Tourette syndrome - Cavanna, AE; Luoni, C; Selvini, C; Blangiardo, R; Eddy, CM; Silvestri, PR; Cali', PV; Gagliardi, E; Balottin, U; Cardona, F; Rizzo, R; Termine, C
Tourette syndrome is a neurodevelopmental disorder characterized by tics and comorbid behavioral problems. This study compared child- and parent-reported quality of life and everyday functioning. We assessed 75 children with Tourette syndrome, of which 42 (56%) had comorbid conditions (obsessive-compulsive disorder = 25; attention-deficit hyperactivity disorder = 6; both comorbidities = 4). All patients completed psychometric instruments, including the Gilles de la Tourette Syndrome-Quality of Life Scale for Children and Adolescents (child report) and the Child Tourette's Syndrome Impairment Scale (parent report). Data were compared for patients with pure Tourette syndrome, Tourette syndrome + obsessive-compulsive disorder, Tourette syndrome + attention-deficit...
Participatory budgeting at scale and bridging the rural-urban divide in Chengdu - Cabannes, Y; Ming, Z
This paper describes the development of the participatory budgeting (PB) process in the rural villages and communities of the city of Chengdu in China between 2009 and 2012. During this period, more than 40,000 PB-funded projects were implemented in more than 2,300 communities. These projects addressed the growing divide between urban and rural development and increased security of land use rights, resulting in large improvements in the day-to-day lives of millions of villagers. But PB in Chengdu also introduced democratic changes at the local level through processes of deliberation and greater democratic autonomy for village residents. This paper describes the...
Circadian rhythmicity and light sensitivity of the zebrafish brain - Moore, HA
Light is important for entraining circadian rhythms, which regulate a wide range of biological processes. Zebrafish have directly light responsive tissues (Whitmore et al 2000) and are thus a useful vertebrate model for circadian rhythmicity and light sensitivity. Recent studies show the pineal regulates locomotor rhythms (Li et al 2012). However, there are many unresolved questions concerning the neurobiological basis of the zebrafish clock, such as whether neuronal pacemakers, which drive rhythms in other tissues, are present throughout the brain. In this study, per3-luc zebrafish confirm that both central and peripheral tissues are directly light sensitive and have endogenous circadian...
‘I’m there right now. Call me’: Unstable identities and irregular distances from Raymond Chandler to David Lynch - Pavey, AJ
David Lynch’s Lost Highway (1997) and Raymond Chandler’s The High Window (1942) each contain scenes in which ambiguous distances and fluid identities disorientate the protagonists. The principle of incrimination that underpins modern criminal investigation demands a rationalisation of time, space and identity. But these three categories can be undermined, intentionally by individual action, or inherently by the technologies and systems of modernity itself. In both Chandler and Lynch, audio-visual media, particularly the telephone, demonstrate the fragility of any rigid, rationalised conception of distance and proximity, undermining the possibility of the stable knowledge by which the detective might solve the case,...
Distance, Proximity and Hannah Höch's radical imagination - Tabernacle, A
In her pioneering photomontage Hannah Hoch demonstrates her ambition to transform the viewer's perception through imagination, both hers and theirs. In the process of making photomontage complex relationships between the artist, viewer, and original source material arise in which the displacements involved create distance. Her use of the idea of the cross-section by contrast allows otherwise disparate elements to be brought into close proximity. This paper explores Höch's use of the spatial metaphors of the bridge and the abyss in relation to Salomo Friedländer's concept of Creative Indifference, the Die Brücke group and the influence of Nietzsche's use of the...
Refracted Truths: Mediating Constructions of Identity through the Illness and Healing Experience of Homeless Native American Men along the Wasatch Front, Utah. - Stolfi, D
The thesis investigates how homeless Native American men in Salt Lake City, Utah navigate their experience of homelessness, as well as the social suffering it gives rise to, in order to affirm a sense of personhood and personal identity. It examines how this experience is constructed, presented, and mediated through a series of ambivalent spatial and agentic practices that contribute to shaping a contemporary and localized expression of Native American masculine identity. The thesis argues that, for Native Americans, the notions of personhood and identity are deeply rooted in a culturally and spiritually embodied sense of place. When this bond...
‘That’s unscientific!’: Science as the arbitrator of ‘truth’ in (German) feminist linguistic debates - Luck, C
The feminist critique of language has been contested from its very inception. Opponents have distanced themselves from feminist proposals by arguing, for example, that language and reality are separate entities; that linguistic disparity is insignificant in comparison to other forms of discrimination; and most of all, that feminist approaches are ‘unscientific’. In this paper, I explore the late 1970s dispute between Senta Trömel-Plötz, Hartwig Kalverkämper and Luise F. Pusch as a particular example of the feminist vs. ‘scientific’ position. These three linguists are prominent voices in the German-language context and their arguments provide a valuable insight into the nature of...
Archaeogenetic study of prehistoric rice remains from Thailand and India: Evidence of early japonica in South and Southeast Asia - Castillo, C; Tanaka, K; Sato, Y; Ishikawa, R; Bellina, B; Higham, C; Chang, N; Mohanty, R; Kajale, M; Fuller, DQ
We report successful extraction and sequencing of ancient DNA from carbonised rice grains (Oryza sativa) from six archaeological sites, including two from India and four from Thailand, ranging in age from ca. 2500 to 1500 BP. In total, 221 archaeological grains were processed by PCR amplification and primary-targeted fragments were sequenced for comparison with modern sequences generated from 112 modern rice populations, including crop and wild varieties. Our results include the genetic sequences from both the chloroplast and the nuclear genomes, based on 4 markers from the chloroplast and 6 from the nuclear genome. These markers allow differentiation of indica...
Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes. - Bestembayeva, A; Kramer, A; Labokha, AA; Osmanović, D; Liashkovich, I; Orlova, EV; Ford, IJ; Charras, G; Fassati, A; Hoogenboom, BW
The nuclear pore complex (NPC) is the gate for transport between the cell nucleus and the cytoplasm. Small molecules cross the NPC by passive diffusion, but molecules larger than ∼5 nm must bind to nuclear transport receptors to overcome a selective barrier within the NPC. Although the structure and shape of the cytoplasmic ring of the NPC are relatively well characterized, the selective barrier is situated deep within the central channel of the NPC and depends critically on unstructured nuclear pore proteins, and is therefore not well understood. Here, we show that stiffness topography with sharp atomic force microscopy tips can...
Platelet Counts and Coagulation Tests Prior to Neuraxial Anesthesia in Patients With Preeclampsia: A Retrospective Analysis - Sultan, P; Butwick, A
This retrospective, descriptive study aimed to assess hematologic testing practices in 100 patients with preeclampsia undergoing neuraxial blockade (NB). Prior to NB, platelet (PLT) count was performed in 61 (98%) of 62 women in labor and in 37 (97%) of 38 women undergoing cesarean delivery (CD). No patients had a pre-NB PLT count <70 × 109/L. Pre-NB tests for prothrombin time (PT) and activated partial thromboplastin time (APTT) were less common and varied among laboring patients (15 [24%] of 62) and patients prior to CD (18 [47%] of 38). Prior to NB, PT and APTT values were within normal limits...
Meridians: the poem as a place of encounter in Paul Celan and J. H. Prynne - Thomas, Nicola
In his 1960 Büchner Prize acceptance speech, the poet Paul Celan used a series of spatial metaphors to assess the various ways in which the poem enables literary ‘encounters’. Celan’s speech is full of reflections
on how language shapes relationships of distance and proximity, crystallised in the speech’s concluding image of poetic language as a ‘meridian’ which serves both as a measure of distance and a marker of connection. This article compares treatments of the motif of the
poem as a place of encounter in the work of Celan himself and his near-contemporary, the British poet J. H. Prynne. Although both poets...
Language or Dialect?: The Politicisation of Language in Central and Eastern Europe - Gibson, Catherine
Language formed the ideological foundation of many national movements in Central and Eastern Europe during the nineteenth and twentieth centuries. The decision on whether a people spoke a language or a dialect was not
based on arguments about linguistic proximity or distance, but rather on political definitions of who constituted the ethno-linguistic nation. This led to languages being combined or split in accordance with nation-building
projects. Often overlooked is the impact of this politicisation of language on sub-national and regional dialects, which are today not accorded the status
of languages. This paper focuses on the case study of Latgalian, which is used...
Delivering Diabetes Care in the Philippines and Vietnam: Policy and Practice Issues - Beran, D; Higuchi, M
The aim of this study is the comparison of 2 studies looking at the barriers to access of diabetes care and medicines in the Philippines and Vietnam. These studies used the Rapid Assessment Protocol for Insulin Access. Diabetes care is provided in specialized facilities and appropriate referral systems are lacking. In Vietnam, no problems were reported with regard to diagnostic tools, whereas this was a concern in the public sector in the Philippines. Both countries had high prices for medicines in comparison to international standards. Availability of medicines was better in Vietnam than in the Philippines, especially with regard to...
Big data, smart cities and city planning - Batty, M
I define big data with respect to its size but pay particular attention to the fact that the data I am referring to is urban data, that is, data for cities that are invariably tagged to space and time. I argue that this sort of data are largely being streamed from sensors, and this represents a sea change in the kinds of data that we have about what happens where and when in cities. I describe how the growth of big data is shifting the emphasis from longer term strategic planning to short-term thinking about how cities function and can...
Traversing Racial Distance in Hip-hop Culture: The Ethics and Politics of Listening - Ganesh, B
Hip-hop is often studied as a ‘political’ culture. Listeners, however, often contest the attachment of a political nature to hip-hop. After the ‘dilution’ of “real” hip-hop by record labels seeking to package the sound for mainstream consumption, is it fair to say that hip-hop retains political relevance? To address this question I make two moves. In the first, I approach hip-hop from a perspective that moves beyond lyrics, seeking to understand what the music ‘does’ rather than what it represents. In the second, I take this approach to the study of race in hip-hop culture, examining how phenotypical variation affects...