Recursos de colección

UCL University College London Eprints (411.881 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 281 - 300 de 64.304

  1. Energy in the home: everyday life and the effect on time of use

    Cosar-Jorda, P; Buswell, RA; Webb, LH; Leder Mackley, K; Morosanu, R; Pink, S

  2. Making Homes: Ethnography and Design

    Pink, S; Leder Mackley, K; Morosanu, R; Mitchell, V; Bhamra, T

  3. 16 Visual and Sensory Ethnography

    Pink, S; Leder Mackley, K; Hackett, PMW

  4. LEEDR: what are the results? Participant feedback for H99

    Buswell, RA; Webb, LH; Quiggin, D; Cosar-Jorda, P; Marini, D; Osz, K; Morosanu, R; Pink, S; Leder Mackley, K; Wilson, GT; others,

  5. PORTS: an interdisciplinary and systemic approach to studying energy use in the home

    Wilson, GT; Bhamra, T; Leder Mackley, K; Pink, S; Mitchell, V

  6. Framing and educating attention: a sensory apprenticeship in the context of domestic energy research

    Leder Mackley, K; Pink, S

  7. Newcastle University ePrints

    Coughlan, T; Brown, M; Martindale, S; Comber, R; Ploetz, T; Leder Mackley, K

  8. Structure of the WipA protein reveals a novel tyrosine protein phosphatase effector from Legionella pneumophila.

    Pinotsis, N; Waksman, G
    Legionnaires disease is a severe form of pneumonia caused by the bacterium Legionella pneumophila. L. pneumophila pathogenicity relies on secretion of more than 300 effector proteins by a type IVb secretion system. Among these Legionella effectors, WipA has been primarily studied because of its dependence on a chaperone complex, IcmSW, for translocation through the secretion system, but its role in pathogenicity has remained unknown. In this study, we present the crystal structure of a large fragment of WipA, WipA435. Surprisingly, this structure revealed a serine/threonine phosphatase fold that unexpectedly targets tyrosine-phosphorylated peptides. The structure also revealed a sequence insertion that...

  9. Use of Chimeric Type IV Secretion Systems to Define Contributions of Outer Membrane Subassemblies for Contact-Dependent Translocation.

    Gordon, JE; Costa, TRD; Patel, RS; Gonzalez-Rivera, C; Sarkar, MK; Orlova, EV; Waksman, G; Christie, PJ
    Recent studies have shown that conjugation systems of Gram-negative bacteria are composed of distinct inner and outer membrane core complexes (IMCs and OMCCs, respectively). Here, we functionally characterized the OMCC, focusing first on a cap domain that forms a channel across the outer membrane. Strikingly, the OMCC caps of the Escherichia coli pKM101 Tra and Agrobacterium tumefaciens VirB/VirD4 systems are completely dispensable for substrate transfer, but required for formation of conjugative pili. The pKM101 OMCC cap and extended pilus also are dispensable for activation of a Pseudomonas aeruginosa type VI secretion system (T6SS). Chimeric conjugation systems composed of the IMCpKM101...

  10. A comprehensive guide to pilus biogenesis in Gram-negative bacteria.

    Hospenthal, MK; Costa, TRD; Waksman, G
    Pili are crucial virulence factors for many Gram-negative pathogens. These surface structures provide bacteria with a link to their external environments by enabling them to interact with, and attach to, host cells, other surfaces or each other, or by providing a conduit for secretion. Recent high-resolution structures of pilus filaments and the machineries that produce them, namely chaperone-usher pili, type IV pili, conjugative type IV secretion pili and type V pili, are beginning to explain some of the intriguing biological properties that pili exhibit, such as the ability of chaperone-usher pili and type IV pili to stretch in response to...

  11. Prion diseases of humans and animals

    Mead, S; Tabrizi, SJ; Collinge, J

  12. Registration of HIV risk factors in the Electronic Medical Record (EMR): what do GPs in Flanders prefer?

    Vos, J; Deblonde, J; Eynde, SVD; Deveugele, M; Avonts, D
    There is an increase of HIV-diagnoses in Belgium among men who have sex with men. GPs take a key position in discussing sexuality with their patients. They have an overall picture of their patients health, including the health risks (e.g. smoking). Yet it is unclear whether GPs are aware of the (extent of) sexual risk behaviour and the sexual orientation of their patients before problems occur. However, at least the awareness of sexual risk behaviour and/or the sexual orientation of patients seems to be necessary for the prevention of HIV. This study explores the views of GPs in Flanders regarding...

  13. Registration of sexual orientation in the electronic medical record in family practice: opinions of general practitioners (GPs) in Flanders

    Vos, J; Deblonde, J; Eynde, SVD; Deveugele, M; Avonts, D
    Background: Discussing sexual health is a sensitive issue in family practice, these data are often unknown and it is unclear if GP?s know the sexual orientation of patients[1]. Although homosexuals are a minority, they are prominently present in the HIV-population in Belgium[2]. Sexual culture among gay men is not only an individual matter, but embedded in a broader gay community. GP?s, as leading medical actor of community care, may support the continuity of (primary) health care by identifying patients at risk and develop targeted interventions. Aim: Exploring the view of GP?s in Flanders regarding a systematic registration of the sexual...

  14. Care pathways of non-western immigrant cancer patients in Belgium: having cancer in a foreign country

    Aelbrecht, K; Vos, J; Deveugele, M
    The rising number of immigrants in Western Europe has implications in many areas, including healthcare. This sub-population has difficulties in finding their way into the complexity of the healthcare system, especially when being diagnosed with a life threatening illness such as cancer. Although, there is an urgent need for insight and knowledge about these patients, most research excludes this population, because of the various difficulties it entails. This study intended to capture the meaning of having a life threatening illness in a migration country, and to study the expectations and experiences of non-western immigrant patients about the provided care in...

  15. Beschrijving van de recent ingevoerde maatregelen in de huisartsgeneeskunde

    Willems, S; Maeseneer, JD; Vos, J
    Studie uitgevoerd in opdracht van het RIZIV. Betreft een beschrijving van de recent ingevoerde maatregelen in de huisartsgeneeskunde.

  16. Investigating the potential role of ICT to support older people with multi-morbidity to navigate the care network

    Vos, J; Windle, K; Siriwardena, N; Linehan, C
    Tools are available to help people navigate when they are not quite sure where they should be going (e.g. GPS). In the care system there is (as yet) no available map to guide patients, users or carers to particular health and care services. This poster displays the mixed method research protocol in which we will investigate the potential role of ICT to support older people with multi morbidities to navigate through the care system. Three distinct work streams are set up to explore and analyse the current literature, patients? perspective about their care network and patients? experience about problems in...

  17. Vlaamse prioritaire thema’s met betrekking tot eerstelijnsgezondheidszorg: focus op de Vlaamse huisartsgeneeskunde

    Detollenaere, J; Vos, J; Maeseneer, JD; Willems, S
    Om tegemoet te komen aan belangrijke verschuivingen en uitdagingen binnen de Vlaamse gezondheidszorg (bijvoorbeeld vergrijzing, fragmentatie of vermaatschappelijking van zorg) werden op Vlaams en Federaal niveau een aantal speerpunten geformuleerd. In stap 1 van dit onderzoeksproject werden deze vooropgestelde accenten onder de vorm van zes prioritaire thema?s gesynthetiseerd : - Ondersteunen en versterken van zelfzorg en mantelzorg, en focussen op preventie - Empowerment van patiënten en hun naaste omgeving - Focussen op eerste lijn (gezondheidszorg dichtbij huis garanderen) en verbindingen tussen en binnen eerste lijn en andere zorgniveaus - Versterkte, direct toegankelijke eerstelijnsgezondheidszorg - Kwaliteitsvolle eerstelijnsgezondheidszorg - Focus op alle...

  18. Perceptie en beleving van zorg door oncologische patiënten na migratie: een kwalitatieve analyse: kanker in een vreemd land

    Aelbrecht, K; Vos, J; Deveugele, M
    De toename van het aantal migranten in West-Europa heeft gevolgen op vele gebieden, waaronder de gezondheidszorg. Deze subpopulatie heeft moeilijkheden bij het vinden van hun weg in de complexiteit van onze gezondheidszorg, in het bijzonder wanneer zij de diagnose krijgen van een levensbedreigende ziekte zoals kanker. Hoewel er een dringende nood is aan inzicht en kennis over patienten afkomstig van een andere culturele of etnische entiteit, sluit het meeste onderzoek deze populatie uit, vanwege diverse moeilijkheden die zij met zich meebrengt. In deze studie wordt de zorgbeleving van niet-westerse oncologische patienten in kaart gebracht, meer bepaald worden hun verwachtingen en...

  19. Postgraduate conference 2014

    Hughes, C

  20. Evaluating the Admission Avoidance Programme: final report

    Windle, K; Essam, N; Vos, J; Caballero, ALG; Phung, V-H; Sirdifield, C; Siriwardena, N; McKay, S
    The United Lincolnshire Hospital Trust Admission Avoidance Programme Board was set up in April 2013. Its remit was to identify and implement a range of community-based resources that could reduce emergency admissions by 5,000 finished consultant episodes, (pro-rata), across the winter pressures period (October 2013 to March 2014). Four projects were identified and planned; the Contact Centre, Rapid Response Teams, Enhanced Community Teams and Ambulatory Emergency Care. Funding was made available from the Marginal Resource Tariff (MRT) and ?Readmission? monies to ensure initial implementation. The non-recurring MRT monies have now come to an end. If the projects are to continue...

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