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UCL University College London Eprints (411.881 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 41 - 60 de 64.304

  1. Imaging plus X: multimodal models of neurodegenerative disease.

    Oxtoby, NP; Alexander, DC; EuroPOND consortium,
    PURPOSE OF REVIEW: This article argues that the time is approaching for data-driven disease modelling to take centre stage in the study and management of neurodegenerative disease. The snowstorm of data now available to the clinician defies qualitative evaluation; the heterogeneity of data types complicates integration through traditional statistical methods; and the large datasets becoming available remain far from the big-data sizes necessary for fully data-driven machine-learning approaches. The recent emergence of data-driven disease progression models provides a balance between imposed knowledge of disease features and patterns learned from data. The resulting models are both predictive of disease progression in...

  2. Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease.

    Brown, BM; Sohrabi, HR; Taddei, K; Gardener, SL; Rainey-Smith, SR; Peiffer, JJ; Xiong, C; Fagan, AM; Benzinger, T; Buckles, V; Erickson, KI; Clarnette, R; Shah, T; Masters, CL; Weiner, M; Cairns, N; Rossor, M; Graff-Radford, NR; Salloway, S; Vöglein, J; Laske, C; Noble, J; Schofield, PR; Bateman, RJ; Morris, JC; Martins, RN; Dominantly Inherited Alzheimer Network,
    INTRODUCTION: The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. METHODS: In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42, and CSF tau levels was evaluated using linear regression. RESULTS: No differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher...

  3. Charge transport and efficiency in photovoltaic devices based on polyfluorene blends

    Snaith, HJ; Malone, IB; Ramsdale, CM; Friend, RH; Greenham, NC
    Polymer blends allow control of microstructure in donor-acceptor photovoltaic devices. Here we present measurements of devices containing polyfluorene blend layers of different thicknesses, and we are able to extract characteristic transport lengths for electrons and holes. We also present analytical and numerical modeling of single-layer and bilayer photovoltaic devices, which demonstrates the importance of bound polaron pairs formed after the initial electron transfer from donor to acceptor. Field-assisted dissociation of these polaron pairs is a critical process in determining device performance.

  4. Establishment of Requirements and Methodology for the Development and Implementation of GreyMatters, a Memory Clinic Information System.

    Tapuria, A; Evans, M; Curcin, V; Austin, T; Lea, N; Kalra, D
    INTRODUCTION: The aim of the paper is to establish the requirements and methodology for the development process of GreyMatters, a memory clinic system, outlining the conceptual, practical, technical and ethical challenges, and the experiences of capturing clinical and research oriented data along with the implementation of the system. METHODS: The methodology for development of the information system involved phases of requirements gathering, modeling and prototype creation, and 'bench testing' the prototype with experts. The standard Institute of Electrical and Electronics Engineers (IEEE) recommended approach for the specifications of software requirements was adopted. An electronic health record (EHR) standard, EN13606 was...

  5. HEMIC Project: Design of a Clinical Information Modelling Tool Based on ISO13972 Technical Specification.

    Moreno-Conde, A; Sanchez-Laguna, F; Marin-Bastida, B; Romero-Tabares, A; Martin-Sánchez, E; Kalra, D; Parra-Calderón, CL
    The Andalusian Health Service is the public healthcare provider for 8.302.923 inhabitants in the South Spain. This organization coordinates primary and specialized care with an IT infrastructure composed by multiple Electronic Health Record Systems. According to the large volume of healthcare professionals involved, there is a need for providing a consistent management of information through multiple locations and systems. The HEMIC project aims to address this need developing and validating a methodology based on a software tool for standardizing information contained within EHR systems. The developed tool has been designed for supporting the participation of healthcare professionals the establishment of...

  6. Brain-Computer Interfaces for Virtual Environment Control

    Edlinger, G; Krausz, G; Groenegress, C; Holzner, C; Guger, C; Slater, M
    A brain-computer interface (BCI) is a new communication channel between the human brain and a digital computer. Furthermore a BCI enables communication without using any muscle activity for a subject. The ambitious goal of a BCI is finally the restoration of movements, communication and environmental control for handicapped people. However, in more recent research also BCI control in combination with Virtual Environments (VE) gains more and more interest. Within this study we present experiments combining BCI systems and control VE for navigation and control purposes just by thoughts. A comparison of the applicability and reliability of different BCI types based...

  7. Tourism and economic growth: Does democracy matter?

    Antonakakis, N; Dragouni, M; Eeckels, B; Filis, G

  8. Sentiment, mood and outbound tourism demand

    Dragouni, M; Filis, G; Gavriilidis, K; Santamaria, D

  9. Tourism and growth: The times they are a-changing

    Antonakakis, N; Dragouni, M; Filis, G

  10. How strong is the linkage between tourism and economic growth in Europe?

    Antonakakis, N; Dragouni, M; Filis, G

  11. [invited] Recent development in integrated photonic solutions for THz systems

    Renaud, C; Balakier, K; Gonzalez Guerrero,; Seddon,; Mohammad, A; Fice,; Seeds,

  12. Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms.

    Roberts, I; Edwards, P; Prieto, D; Joshi, M; Mahmood, A; Ker, K; Shakur, H
    BACKGROUND: The CRASH-2 trial showed that tranexamic acid (TXA) administration reduces mortality in bleeding trauma patients. However, the effect appeared to depend on how soon after injury TXA treatment was started. Treatment within 3 h reduced bleeding deaths whereas treatment after 3 h increased the risk. We examine how patient characteristics vary by time to treatment and explore whether any such variations explain the time-dependent treatment effect. METHODS: Exploratory analysis were carried out, including per-protocol analyses, of data from the CRASH-2 trial, a randomised placebo-controlled trial of the effect of TXA on mortality in 20,211 trauma patients with, or at risk of,...

  13. Evaluation of a community-based hypertension improvement program (ComHIP) in Ghana: data from a baseline survey.

    Lamptey, P; Laar, A; Adler, AJ; Dirks, R; Caldwell, A; Prieto-Merino, D; Aerts, A; Pearce, N; Perel, P
    BACKGROUND: Ghana faces an increasing burden of non-communicable disease with rates of hypertension estimated as high as 36% in adults. Despite these high rates, hypertension control remains very poor in Ghana (4%). The current project aims to implement and evaluate a community-based programme to raise awareness, and to improve treatment and control of hypertension in the Eastern Region of Ghana. In this paper, we present the findings of the baseline cross-sectional survey focusing on hypertension prevalence, awareness, treatment, and control. METHODS: To evaluate the ComHIP project, a quasi-experimental design consisted of a before and after evaluations are being implemented in...

  14. ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.

    Carecchio, M; Mencacci, NE; Iodice, A; Pons, R; Panteghini, C; Zorzi, G; Zibordi, F; Bonakis, A; Dinopoulos, A; Jankovic, J; Stefanis, L; Bhatia, KP; Monti, V; R'Bibo, L; Veneziano, L; Garavaglia, B; Fusco, C; Wood, N; Stamelou, M; Nardocci, N
    INTRODUCTION: ADCY5 mutations have been recently identified as an important cause of early-onset hyperkinetic movement disorders. The phenotypic spectrum associated with mutations in this gene is expanding. However, the ADCY5 mutational frequency in cohorts of paediatric patients with hyperkinetic movement disorders has not been evaluated. METHODS: We performed a screening of the entire ADCY5 coding sequence in 44 unrelated subjects with genetically undiagnosed childhood-onset hyperkinetic movement disorders, featuring chorea alone or in combination with myoclonus and dystonia. All patients had normal CSF analysis and brain imaging and were regularly followed-up in tertiary centers for paediatric movement disorders. RESULTS: We identified...

  15. Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?

    Whitwell, JL; Höglinger, GU; Antonini, A; Bordelon, Y; Boxer, AL; Colosimo, C; van Eimeren, T; Golbe, LI; Kassubek, J; Kurz, C; Litvan, I; Pantelyat, A; Rabinovici, G; Respondek, G; Rominger, A; Rowe, JB; Stamelou, M; Josephs, KA; Movement Disorder Society-endorsed PSP Study Group,
    BACKGROUND: PSP is a pathologically defined neurodegenerative tauopathy with a variety of clinical presentations including typical Richardson's syndrome and other variant PSP syndromes. Our aim was to critically evaluate the degree to which structural, functional and molecular neuroimaging metrics fulfill criteria for diagnostic biomarkers of PSP. METHODS: We queried the PubMed, Cochrane, Medline, and PSYCInfo databases for original research articles published in English using postmortem diagnosis or NINDS-SPSP criteria as the diagnostic standard from 1996-2016. We define a five-level theoretical construct for the utility of neuroimaging biomarkers in PSP: group-level findings (level 1), biomarkers with demonstrable individual-level diagnostic utility (level...

  16. Review of Charles Bingham and Gert Biesta, Jacques Rancière: Education, Truth, Emancipation: Continuum, 2010

    Pelletier, C

  17. Aripiprazole treatment for coprophagia in autistic disorder

    Pardini, M; Guida, S; Gialloreti, LE

  18. Teacher education and the new biology

    Reiss, MJ
    Recent years have seen a growth not only in biological knowledge but also, and more significantly for teacher education, in the types of knowledge manifested in biology. No longer, therefore, is it adequate for teachers to retain a Mertonian or a Popperian conception of science. Today's teachers of science need also to be able to help their students discuss bioethics and the societal implications of biology, even when these are controversial and contested. Moreover, practical work can no longer be confined to "pure", "safe", and "confined" activities. These are increasingly rejected by students, validly, as boring or irrelevant. Instead, we...

  19. Autonomy of universities

    Fumasoli, T

  20. Academic work and careers in Europe

    Fumasoli, T

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