UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
Brain MRI to personalise atrial fibrillation therapy: Current evidence and perspectives - Haeusler, KG; Fiebach, JB; Wilson, D; Werring, DJ; Kirchhof, P
Advances in the access to and in the performance of brain MRI have led to an increased detection of asymptomatic abnormalities in the brain of patients with cardiovascular diseases. These may have prognostic impact and could influence management in the future. In this review, we summarise the main findings of brain MRI in patients with atrial fibrillation (AF) and explore the available evidence to better quantify the risk for intracerebral haemorrhage and (recurrent) ischaemic stroke based on brain MRI findings. Treatment decisions in the majority of patients with AF should still be based on data from established validated risk scores...
Effect of hydrogen-diesel fuel co-combustion on exhaust emissions with verification using an in-cylinder gas sampling technique - Talibi, M; Hellier, P; Balachandran, R; Ladommatos, N
The paper presents an experimental investigation of hydrogen-diesel fuel co-combustion carried out on a naturally aspirated, direct injection diesel engine. The engine was supplied with a range of hydrogen-diesel fuel mixture proportions to study the effect of hydrogen addition (aspirated with the intake air) on combustion and exhaust emissions. The tests were performed at fixed diesel injection periods, with hydrogen added to vary the engine load between 0 and 6 bar IMEP. In addition, a novel in-cylinder gas sampling technique was employed to measure species concentrations in the engine cylinder at two in-cylinder locations and at various instants during the...
Rapid assembly of functionalised spirocyclic indolines by palladium-catalysed dearomatising diallylation of indoles with allyl acetate - Dhankher, P; Benhamou, L; Sheppard, TD
Herein, we report the application of allyl acetate to the palladium-catalysed dearomatising diallylation of indoles. The reaction can be carried out by using a readily available palladium catalyst at room temperature, and can be applied to a wide range of substituted indoles to provide access to the corresponding 3,3-diallylindolinines. These compounds are versatile synthetic intermediates that readily undergo Ugi reactions or proline-catalysed asymmetric Mannich reactions. Alternatively, acylation of the 3,3-diallylindolinines with an acid chloride or a chloroformate, followed by treatment with aluminium chloride, enables 2,3-diallylindoles to be prepared. By using ring-closing metathesis, functionalised spirocyclic indoline scaffolds can be accessed from...
Robust real-time visual odometry for stereo endoscopy using dense quadrifocal tracking - Chang, P-L; Handa, A; Davison, AJ; Edwards, PE; Stoyanov, D
Visual tracking in endoscopic scenes is known to be a difficult task due to the lack of textures, tissue deformation and specular reflection. In this paper, we devise a real-time visual odometry framework to robustly track the 6-DoF stereo laparoscope pose using the quadrifocal relationship. The instant motion of a stereo camera creates four views which can be constrained by the quadrifocal geometry. Using the previous stereo pair as a reference frame, the current pair can be warped back by minimising a photometric error function with respect to a camera pose constrained by the quadrifocal geometry. Using a robust estimator...
Deblurring multispectral laparoscopic images - Jones, G; Arridge, S; Stoyanov, D; Clancy, N; Elson, D
Multispectral imaging is an optical modality that can provide real-time in vivo information about tissue characteristics and function through signal sensitivity to chromophores in the tissue. In this paper, we present a deblurring strategy that enables imaging of dynamic tissues at wavelengths where the required acquisition time can cause significant motion blur and obscure the image. We use deconvolution for spatially varying kernels to process multispectral information obtained by using a novel laparoscopic imaging device. The trinocular design of the system allows visible light images provide information about the tissue morphology and motion that we use to construct a per...
Herbal medicines in Brazil: pharmacokinetic profile and potential herb-drug interactions. - Mazzari, AL; Prieto, JM
A plethora of active compounds found in herbal medicines can serve as substrate for enzymes involved in the metabolism of xenobiotics. When a medicinal plant is co-administered with a conventional drug and little or no information is known about the pharmacokinetics of the plant metabolites, there is an increased risk of potential herb-drug interactions. Moreover, genetic polymorphisms in a population may act to predispose individuals to adverse reactions. The use of herbal medicines is rapidly increasing in many countries, particularly Brazil where the vast biodiversity is a potential source of new and more affordable treatments for numerous conditions. Accordingly, the...