UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
Two-stage first-trimester screening for trisomy 21 by ultrasound assessment and biochemical testing - Kagan, KO; Staboulidou, I; Cruz, J; Wright, D; Nicolaides, KH
Objectives This study was carried out to examine the performance of a contingent policy in first-trimester screening for trisomy 21, in which the estimated risk was first derived by a combination of maternal age, fetal nuchal translucency (NT) thickness, presence/absence of the nasal bone, blood flow in the ductus venosus or flow across the tricuspid valve, and biochemical testing was carried out only in those who were found to have an intermediate risk. We also examined the performance of a policy in which the estimated risk was first derived by a combination of maternal age and biochemical testing, and ultrasound...
Pregenesys pre-eclampsia markers consensus meeting: What do we require from markers, risk assessment and model systems to tailor preventive strategies? - Cetin, I; Huppertz, B; Burton, G; Cuckle, H; Gonen, R; Lapaire, O; Mandia, L; Nicolaides, K; Redman, C; Soothill, P; Spencer, K; Thilaganathan, B; Williams, D; Meiri, H
The Pregenesys Consensus Meeting held in Cambridge on 13 July 2009 was organized by the Pregenesys Consortium to review and critically discuss current knowledge regarding early markers of preeclampsia, to identify priorities and opportunities for future research, to consider issues that may need to be addressed in future recommendations and to highlight key issues in cost effectiveness and national policies concerning prediction and early screening for the risk of developing preeclampsia.This report summarizes the outcome of the Consensus Meeting and draws attention to issues for further investigation with specific regard to single versus multiple markers, early versus late risk identification,...
ANTENATAL MANAGEMENT OF FETOMATERNAL ALLOIMMUNE THROMBOCYTOPENIA - REPORT OF 15 AFFECTED PREGNANCIES - MURPHY, MF; WATERS, AH; DOUGHTY, HA; HAMBLEY, H; MIBASHAN, RS; NICOLAIDES, K; RODECK, CH
The recognition that spontaneous intracranial haemorrhage (ICH) may occur in utero in fetomaternal alloimmune thrombocytopenia (FMAIT) led us to attempt to prevent this in 15 pregnancies of 11 women who had previously affected infants with FMAIT due to anti-HPA-1a. The antenatal management included fetal platelet transfusions and maternal steroids and/or high-dose intravenous immunoglobulin (IVIgG).In the first pregnancy, ICH occurred between 32 and 35 weeks' gestation before any treatment had been given, emphasizing the need for earlier intervention.Five of the 14 subsequent pregnancies in this study were considered to be severely affected (severe haemorrhagic complications in a previous infant and initial...
Audit of prenatal diagnosis for haemoglobin disorders in the United Kingdom: the first 20 years - Modell, B; Petrou, M; Layton, M; Varnavides, L; Slater, C; Ward, RHT; Rodeck, C; Nicolaides, K; Gibbons, S; Fitches, A; Old, J
Objectives: To audit services for prenatal diagnosis for haemoglobin disorders in the United Kingdom.Design: Comparison of the annual number of cases recorded in a United Kingdom register of prenatal diagnoses for haemoglobin disorders, with the annual number of pregnancies at risk of these disorders, by ethnic group and regional health authority The number of pregnancies at risk was estimated using data on ethnic group from the 1991 census and data from the United Kingdom thalassaemia register, which records the number of babies born with thalassaemia.Setting: The three national prenatal diagnosis centres for haemoglobin disorders.Subjects: 2068 cases of prenatal diagnosis for...
Empowering Egypt - Raslan, RM
The past summer has seen something that many Egyptians had long forgotten: rolling power blackouts. Reports have cited that these month-long power cuts have affected everyday life for Egyptians in many ways. The outages stranded passengers on the Cairo Metro, raised concerns about night time safety and contributed to water supply interruption. Over a period of over a month the frequency of power cuts increased dramatically and were mapped by the crowd-mapping website, Kahrabtak. Power outages in some areas lasted 18 hours a day, hitting poorer residential districts especially hard and prompting protests in Fayoum, Gharbiya and Giza among others....
Public law after the Human Rights Act - Hickman, T
The book articulates in novel ways the relationship between the Act and administrative and constitutional law. It suggests that the Human Rights Act has built on the common law constitution.