UCL University College London Eprints
UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.
A comprehensive diagnostic approach using galactomannan, targeted β-d-glucan, baseline computerized tomography and biopsy yields a significant burden of invasive fungal disease in at risk haematology patients. - Ceesay, MM; Desai, SR; Berry, L; Cleverley, J; Kibbler, CC; Pomplun, S; Nicholson, AG; Douiri, A; Wade, J; Smith, M; Mufti, GJ; Pagliuca, A
Invasive fungal disease (IFD) is difficult to diagnose. We investigated the incidence of IFD and risk factors using the revised European Organization for Research and Treatment of Cancer (EORTC) and the Mycoses Study Group (MSG) definitions. Patients (N = 203) undergoing intensive therapy with expected neutropenia ≥10 d were recruited prospectively and followed for a median (range) of 556 (12-730) d. Baseline chest computerized tomography (CT) was performed pre-therapy. Twice-weekly surveillance with galactomannan (GM) was combined with targeted β-d-glucan (BDG) testing on patients with possible IFD or who were GM-positive. Tissue diagnosis was obtained whenever possible. The cumulative incidence of proven/probable IFD among the...
Development of the Performance of the Upper Limb module for Duchenne muscular dystrophy - Mayhew, A; Eagle, M; Mazzone, ES; Bianco, F; Mercuri, E; Duong, T; Ash, M; Main, M; Ricotti, V; Decostre, V; Servais, L; Vandenhauwe, M; Goemans, N; Klingels, K; Florence, J; Henrikson, E; Mcdonald, C; Campion, G; Vroom, E
Aim: An international Clinical Outcomes Group consisting of clinicians, scientists, patient advocacy groups, and industries identified a need for a scale to measure motor performance of the upper limb. We report the steps leading to the development of the Performance of the Upper Limb (PUL), a tool specifically designed for assessing upper limb function in ambulant and non-ambulant patients with Duchenne muscular dystrophy (DMD). Method: The development of the PUL followed a number of steps, from the systematic review and a preliminary study exploring the suitability of the existing measures, to the application of a pilot version in a multicentric...
Development of the Performance of the Upper Limb module for Duchenne muscular dystrophy. - Mayhew, A; Mazzone, ES; Eagle, M; Duong, T; Ash, M; Decostre, V; Vandenhauwe, M; Klingels, K; Florence, J; Main, M; Bianco, F; Henrikson, E; Servais, L; Campion, G; Vroom, E; Ricotti, V; Goemans, N; McDonald, C; Mercuri, E; Performance of the Upper Limb (PUL) working group,
An international Clinical Outcomes Group consisting of clinicians, scientists, patient advocacy groups, and industries identified a need for a scale to measure motor performance of the upper limb. We report the steps leading to the development of the Performance of the Upper Limb (PUL), a tool specifically designed for assessing upper limb function in ambulant and non-ambulant patients with Duchenne muscular dystrophy (DMD).
Parasitic ecologies - algorithmic space through diffusion-limited aggregation of truncated octahedrons - Kachri, G; Hanna, S
Parasitic architecture allows the creation of flexible structures that feed off existing infrastructure. Additionally, self-organised models that grow in response to environmental forces and adapt to their context introduce new ways for intervening in architectural design. This paper investigates the properties of self-organised parasitic structures that evolve by creating aggregation forms in the context of simulated structural environments. The growth process of the parasitic structures is inspired by the fungal colonies and is based on the rules of diffusion-limited aggregation (DLA) extended to support real-time force analysis and aggregation of space-filling geometry. The results of the simulations demonstrate that the...