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UCL University College London Eprints (411.881 recursos)

UCL Eprints collects the work of UCL researchers and makes it freely available over the web, helping the worldwide scholarly community to discover UCL research. Institutional repositories like UCL Eprints complement the traditional academic publishing and scholarly communications processes. They raise the visibility of research and help to maximise its impact. UCL researchers are encouraged to deposit a copy of each journal article, conference paper, working paper, and any other research output, in the UCL Eprints at the earliest opportunity, ensuring that their research reaches as wide an audience as possible.

Mostrando recursos 81 - 100 de 64.304

  1. Sleep apnea, disability pension and cause-specific mortality: a nationwide register linkage study.

    Hulvej Rod, N; Kjeldgård, L; Åkerstedt, T; Ferrie, JE; Salo, P; Vahtera, J; Alexanderson, K
    Sleep apnea is a common problem affecting daily functioning and health. We evaluated associations between sleep apnea and disability pension and mortality in a prospective study of 74,543 cases of sleep apnea (60,125 outpatient; 14,418 inpatient) from the Swedish Patient Register; 2000-2009 inclusive. Cases were matched to five non-cases (n = 371,592) and followed from diagnosis/inclusion via nationwide registers until Dec 31 2010. During a mean (standard deviation) follow-up of 5.1 (2.7) years, 13% men and 21% women with inpatient sleep apnea were disability pensioned. Inpatient sleep apnea was associated with higher total mortality (HR = 1.71; 95% CI: 1.59, 1.84 men; 2.33; 95%...

  2. The future of epidemiology: methods or matter?

    Ebrahim, S; Ferrie, JE; Davey Smith, G

  3. Comparison of positronium, positron and electron collisions with hydrogen at low velocities

    Van Reeth, P; Woods, D; Ward, SJ; Humberston, JW

  4. Identifying the science and technology dimensions of emerging public policy issues through horizon scanning.

    Parker, M; Acland, A; Armstrong, HJ; Bellingham, JR; Bland, J; Bodmer, HC; Burall, S; Castell, S; Chilvers, J; Cleevely, DD; Cope, D; Costanzo, L; Dolan, JA; Doubleday, R; Feng, WY; Godfray, HCJ; Good, DA; Grant, J; Green, N; Groen, AJ; Guilliams, TT; Gupta, S; Hall, AC; Heathfield, A; Hotopp, U; Kass, G; Leeder, T; Lickorish, FA; Lueshi, LM; Magee, C; Mata, T; McBride, T; McCarthy, N; Mercer, A; Neilson, R; Ouchikh, J; Oughton, EJ; Oxenham, D; Pallett, H; Palmer, J; Patmore, J; Petts, J; Pinkerton, J; Ploszek, R; Pratt, A; Rocks, SA; Stansfield, N; Surkovic, E; Tyler, CP; Watkinson, AR; Wentworth, J; Willis, R; Wollner, PKA; Worts, K; Sutherland, WJ
    Public policy requires public support, which in turn implies a need to enable the public not just to understand policy but also to be engaged in its development. Where complex science and technology issues are involved in policy making, this takes time, so it is important to identify emerging issues of this type and prepare engagement plans. In our horizon scanning exercise, we used a modified Delphi technique. A wide group of people with interests in the science and policy interface (drawn from policy makers, policy adviser, practitioners, the private sector and academics) elicited a long list of emergent policy...

  5. Constructing Identity: The Post Keynesians and the Capital Controversies

    Mata, T

  6. Pathways linking car transport for young adults and the public health in Northern Ireland: a qualitative study to inform the evaluation of Graduated Driver Licensing

    Christie, N; Steinbach, R; Green, J; Mulllan, P; Prior, L

  7. Psychological morbidity and return to work after injury: multicentre cohort study

    Kendrick, D; Dhiman, P; Kellezi, B; Coupland, C; Whitehead, J; Beckett, K; Christie, N; Sleney, J; Barnes, J; Joseph, S; Morriss, R
    Background: The benefits of work for physical, psychological and financial wellbeing are well documented. Return to work (RTW) after unintentional injury is often delayed, and psychological morbidity may contribute to this delay. The impact of psychological morbidity on RTW after a wide range of unintentional injuries in the UK has not been adequately quantified. Aims: To quantify the role of psychological factors including anxiety, depression and post-traumatic distress on RTW following unintentional injuries. Design and Setting: Longitudinal multi-centre prospective study in Nottingham, Bristol, Leicester and Guildford, UK Method: Participants (n=273) were 16-69 year olds admitted to hospital following unintentional injury...

  8. IL-2(high) tissue-resident T cells in the human liver: Sentinels for hepatotropic infection.

    Pallett, LJ; Davies, J; Colbeck, EJ; Robertson, F; Hansi, N; Easom, NJW; Burton, AR; Stegmann, KA; Schurich, A; Swadling, L; Gill, US; Male, V; Luong, T; Gander, A; Davidson, BR; Kennedy, PTF; Maini, MK
    The liver provides a tolerogenic immune niche exploited by several highly prevalent pathogens as well as by primary and metastatic tumors. We have sampled healthy and hepatitis B virus (HBV)-infected human livers to probe for a subset of T cells specialized to overcome local constraints and mediate immunity. We characterize a population of T-bet(lo)Eomes(lo)Blimp-1(hi)Hobit(lo) T cells found within the intrahepatic but not the circulating memory CD8 T cell pool expressing liver-homing/retention markers (CD69(+)CD103(+) CXCR6(+)CXCR3(+)). These tissue-resident memory T cells (TRM) are preferentially expanded in patients with partial immune control of HBV infection and can remain in the liver after the...

  9. Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.

    Colbeck, EJ; Hindley, JP; Smart, K; Jones, E; Bloom, A; Bridgeman, H; McPherson, RC; Turner, DG; Ladell, K; Price, DA; O'Connor, RA; Anderton, SM; Godkin, AJ; Gallimore, AM
    Foxp3(+) regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises largely of CXCR3(+) T-bet(+) 'TH1-like' Tregs which are thymus-derived Helios(+) cells. Whilst IL-2 maintains homeostatic ratios of Tregs in lymphoid organs, we found that the perturbation in Treg frequencies in tumors is IL-2 independent. Moreover, we show that the TH1 phenotype of tumor-infiltrating Tregs is dispensable for their ability to influence tumor progression. We did however find that unlike Tconvs, the majority of intra-tumoral Tregs express the activation markers...

  10. Altered organisation of the intermediate filament cytoskeleton and relocalisation of proteostasis modulators in cells lacking the ataxia protein sacsin.

    Duncan, EJ; Larivière, R; Bradshaw, TY; Longo, F; Sgarioto, N; Hayes, MJ; Romano, LEL; Nethisinghe, S; Giunti, P; Bruntraeger, MB; Durham, HD; Brais, B; Maltecca, F; Gentil, BJ; Paul Chapple, J
    Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is caused by mutations in the gene SACS, encoding the 520 kDa protein sacsin. Although sacsin's physiological role is largely unknown, its sequence domains suggest a molecular chaperone or protein quality control function. Consequences of its loss include neurofilament network abnormalities, specifically accumulation and bundling of perikaryal and dendritic neurofilaments.To investigate if loss of sacsin affects intermediate filaments more generally, the distribution of vimentin was analysed in ARSACS patient fibroblasts and in cells where sacsin expression was reduced. Abnormal perinuclear accumulation of vimentin filaments, which sometimes had a cage-like appearance, occurred in sacsin-deficient cells....

  11. Effects of ecstasy on autobiographical memories: implications for MDMA assisted psychotherapy

    Curran, HV; Wall, M; Demetriou, L; Carhart-Harris, R; Fergusson, B; Nutt, D

  12. Percutaneous transluminal angioplasty of the internal carotid artery.

    Brown, MM; Crawley, F; Clifton, A; Buckenham, T; Taylor, R

  13. Improvement in cerebral hemodynamics after carotid angioplasty.

    Markus, HS; Clifton, A; Buckenham, T; Taylor, R; Brown, MM
    BACKGROUND AND PURPOSE: Carotid percutaneous transluminal angioplasty ( PTA) may offer an alternative treatment to carotid endarterectomy. However, in contrast to carotid endarterectomy, which has been shown to normalize impaired cerebral hemodynamics, the effects of carotid PTA are unknown. Therefore, we prospectively studied the effect of carotid PTA on both perioperative and postoperative cerebral hemodynamics. METHODS: Eleven patients undergoing carotid PTA for symptomatic carotid artery stenosis were prospectively studied. Transcranial Doppler recordings from the ipsilateral middle cerebral artery (MCA) were performed during the procedure. In addition, MCA blood flow velocity and CO2 reactivity were determined before PTA and at 2...

  14. Investigations of Carotid Stenosis to Identify Vulnerable Atherosclerotic Plaque and Determine Individual Stroke Risk.

    Liem, MI; Kennedy, F; Bonati, LH; van der Lugt, A; Coolen, BF; Nederveen, AJ; Jager, HR; Brown, MM; Nederkoorn, PJ
    Selection of patients with atherosclerotic carotid stenosis for revascularization is mainly based on the degree of luminal narrowing of the carotid artery. However, identification of other features of plaque apart from the degree of stenosis could enable better selection for intervention if they are also associated with the occurrence of stroke. Before these risk factors can possibly play a role in treatment decisions, their prognostic value needs to be proven. The purpose of this narrative review is to summarize current knowledge regarding the risk factors for stroke in patients with carotid stenosis, how they can be determined, and to what...

  15. Scaling aerosol assisted chemical vapour deposition: Exploring the relationship between growth rate and film properties

    Powell, MJ; Potter, DB; Wilson, RL; Darr, JA; Parkin, IP; Carmalt, CJ
    © 2017Thin films of fluorine doped tin oxide were deposited, by an aerosol assisted chemical vapour deposition route, to study the effect of scaling the growth rate. The effect of precursor concentration on the growth rate of the films and the properties of deposited films were compared. The films were characterised by X-ray diffraction, scanning electron microscopy, UV/vis spectroscopy, X-ray photoelectron spectroscopy and Hall effect measurements. A maximum film growth rate of ca. 100 nm min− 1 was observed, which is significantly faster than previously reported aerosol assisted studies. This method shows the ability of aerosol assisted methods to deliver...

  16. Unravelling an allochthonous, subaqueously deposited volcanic–epiclastic to subaerial andesitic lava assemblage in Hong Kong: age, stratigraphy and provenance studies of the Middle Jurassic Tuen Mun Formation

    Sewell, RJ; So, KWF; Tang, DLK; Carter, A

  17. Recent advances in pharmaceutical analysis using transmission Raman spectroscopy

    Griffen, JA; Owen, AW; Andrews, D; Matousek, P
    © 2017 UBM. All rights reserved.This article reviews recent advances in the application of transmission Raman spectroscopy (TRS) to pharmaceutical analysis. The TRS technique overcomes subsampling limitations of conventional Raman spectroscopy and enables rapid noninvasive volumetric analysis of intact pharmaceutical tablets and capsules in a quantitative manner with relevance to quality and process control applications. Although only recently introduced to this area, this technique's uptake and breadth of applications are rapidly growing, with regulatory approvals for its use in quality control of manufactured pharmaceutical products recently being granted.

  18. Predicting PTSD symptoms in victims of violent crime: The role of shame, anger, and childhood abuse.

    Andrews, B; Brewin, CR; Rose, S; Kirk, M

  19. Dilation of fusion pores by crowding of SNARE proteins

    Wu, Z; Bello, OD; Thiyagarajan, S; Auclair, SM; Vennekate, W; Krishnakumar, SS; O'Shaughnessy, B; Karatekin, E

  20. Use of a next generation maleimide in combination with THIOMAB™ antibody technology delivers a highly stable, potent and near homogeneous THIOMAB™ antibody-drug conjugate (TDC)

    Nunes, JPM; Vassileva, V; Robinson, E; Morais, M; Smith, MEB; Pedley, RB; Caddick, S; Baker, JR; Chudasama, V

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