Recursos de colección

ORBi Open Repository and Bibliography (300.356 recursos)

In may 2007, the ULg's Administrative Board (joined in June 2007 by the FUSAGx) decided to create an institutional repository and defined a strong institutional self-archiving policy to increase the visibility, accessibility and impact of the University's publications (Board's decision). This decision led to the official launch, in November 2008, of the ORBi platform including both the Academic Bibliography and the Institutional Repository of the Wallonia-Europe University Academy.

Life sciences => Biochemistry, biophysics & molecular biology

Mostrando recursos 1 - 20 de 54

  1. Carte interactomique entre l'oncoprotéine Tax du virus HTLV-1 et les protéines à domaines PDZ.

    Blibek, Karim

  2. Stories from the lab, stories from the field

    Vanderschuren, Hervé


    Vanderschuren, Hervé
    Cassava Mosaic Disease (CMD) is a major constraint to cassava production in Africa and in the Indian sub-continent. CMD is caused by cassava geminiviruses (CGMs), which are bipartite ssDNA viruses. At least 9 CGM species are infecting cassava and CGM diversity is particularly high on the African continent. In order to engineer resistance against African cassava mosaic virus (ACMV), we developed transgenic cassava expressing dsRNA against the ACMV Rep (AC1) sequences that are conserved amongst CGMs. Transgenic dsAC1 cassava lines were selected based on the accumulation of transgene-derived small RNAs. We established a rapid and high-throughput agroinoculation method in order...

  4. Genetic diversity and engineering of selected B vitamins in staple crops

    Vanderschuren, Hervé
    Vitamin B1, in the form thiamin diphosphate (ThDP), serves as an enzymatic cofactor for several enzymes involved in glucose metabolism, the Krebs cycle, and branched-chain amino acid biosynthesis. Vitamin B6 in its form as pyridoxal 5'-phosphate (PLP) is required as a cofactor for more than 140 enzymatic reactions in cells, primarily in amino acid, sugar and fatty acid metabolism. Mammals lack the ability to biosynthesize both vitamins B1 and B6 de novo, and plants represent one of their major sources. Symptoms of severe vitamin B1 deficiency include degeneration in the nerves and heart, a disease known as beriberi, which can...

  5. The Synthesis and Evaluation of [18F]BPAM121: Potential of an AMPA Receptor Positive Allosteric Modulator

    Manos-Turvey, Alexandra
    AMPA receptors (AMPARs), one of three sub-groups of ionotropic glutamate receptors present in the central nervous system, are recognised for their involvement in long-term potentiation (LTP), and learning and memory processes.1 They represent a valid cognitive enhancer target, particularly in the fight against Alzheimer’s disease (AD).2,3 Benzothiadiazine 1,1-dioxides, such as BPAM121, have emerged as important allosteric modulators of AMPARs, working solely in the presence of the endogenous transmitter.4 Synthesis of BPAM121 labelled with fluorine-18 was proposed, to investigate the utility of this molecule as a PET probe in vivo, and evaluate its potential as an AD diagnostic tool (Figure 1)....

  6. Identification of specific posttranslational O-mycoloylations mediating protein targeting to the mycomembrane

    Carel, Clément; Marcoux, J; Réat, V; Latge, Guillaume; Laval, F; Demange, P; Burlet-Schiltz, O; Milon, A; Daffé, M; Tropis, MG; Renault, MAM
    Peer reviewed

  7. Innate signaling by mycolate esters of the cell wall of Mycobacterium tuberculosis and relevance for the development of adjuvants for subunit vaccines

    Tima, Giresse
    Tuberculosis remains among the most deadly health threats to humankind. This povertyrelated disease, caused by bacteria of the Mycobacterium tuberculosis complex, kills each year more than 1.5 million people. It is estimated that a further 2 billion individuals are latently infected with M. tuberculosis. Most of them will never develop any clinical symptoms, although 5 to 10% of these latently infected individuals are at risk to develop TB in their lifetime. During the last decades the situation worsened because of deteriorating socioeconomic conditions, the increased incidence of drug-resistant M.tuberculosis strains and the co-infection with HIV (a major risk factor for development of TB). Currently only one vaccine is...

  8. ROBOTEIN A robotic platform dedicated to high-throughput protein production and analysis

    Vandenameele, Julie; De Meutter, Joëlle; Brans, Alain; Goormaghtigh, Erik; Matagne, André

  9. Functional characterization of novel genes highly expressed and conserved across distant species identified by transcriptome analysis of pancreatic cells.

    Bernard, Alice; Tarifeno, Estefania; Lavergne, Arnaud; Peers, Bernard; Voz, Marianne

  10. The frd3 Arabidopsis mutant phenotype: new level of complexity

    Scheepers, Maxime; Spielmann, Julien; Boulanger, Madeleine; De Pauw, Edwin; Goormaghtigh, Erik; Motte, Patrick; Hanikenne, Marc

  11. Designing artificial (β/α)8-barrel proteins from scratch: the Octarellin model

    Martina, Cristina Elisa
    De novo protein design is a growing field in protein chemistry, where artificial proteins are first designed in silico and then validated experimentally. Our group has a long tradition in the design of artificial (β/α)8-barrel proteins, known as Octarellins [1]. This fold, also known as TIM-barrel, is widespread in nature, particularly in enzymes, and represent an interesting target for therapeutic or biological applications. Here we present a novel protocol for the de novo design of TIM-barrels. Both Rosetta and Modeller modeling softwares were used to create the backbone structure of a TIM-barrel fold and to generate more than 10.000 artificial amino...

  12. Antagonist activities of the FtsQLB complex and FtsN on peptidoglycan synthesis suggests a regulation mechanism of the divisome

    Boes, Adrien; Terrak, Mohammed

  13. Characterisation of a secondary carotenoid producer microalga of the genus Coelastrella

    Corato, Amélie; Franck, Fabrice; Jacques, Philippe
    Some green microalgae synthesize secondary carotenoids as protecting agents under stress. These pigments have high value as feed supplement for aquaculture and as health products. The most promising pigment is astaxanthin, because of its antioxidant, antitumoral and anti-inflamatory properties. The most used natural source of this pigment is the microalga Haematococcus pluvialis. However this species grows slowly and lacks robustness for easy cultivation. Therefore, other species are investigated for astaxanthin production. Here, we identified a locally isolated strain as Coelastrella sp. that is a secondary carotenoid producer. [1] A known typical feature of this genus, that we could observed in...

  14. étude fonctionnelle des facteurs d’épissage SR (Ser/Arg-rich) au cours du développement embryonnaire de Danio rerio.

    Joris, Marine
    Ser/Arg-rich (SR) proteins constitute a phylogenetically conserved family of RNA binding proteins characterized by one or two RNA-recognition motifs (RRMs) at the N-terminus and a C-terminal domain enriched in Ser/Arg dipeptides. They are important regulators of constitutive and alternative splicing. Moreover, SR proteins are involved in many other aspects of RNA metabolism, including transcription, non-sense mediated decay, mRNA export, translational control as well as maintenance of genome stability. While the roles of SR splicing factors have been widely studied at a molecular level, their functions during animal cell differentiation and development are still largely undetermined. In this study, we decided to...

  15. Effects of a failure versus a submaximal low load blood flow-restriction training protocol on the Heat Shock Proteins responses

    Hody, Stéphanie; Cumming, Kristoffer T.; Wernbom, Mathias; Bjørnsen, T; Paulsen, Goran; Raastad, Truls
    Peer reviewed

  16. Effects of a failure versus a submaximal low load blood flow-restriction training protocol on the Heat Shock Proteins responses

    Hody, Stéphanie; Cumming, Kristoffer T.; Wernbom, Mathias; Bjørnsen, Thomas; Paulsen, Goran; Raastad, Truls
    Peer reviewed

  17. INPP5E Preserves Genomic Stability through Regulation of Mitosis

    Sierra Potchanant, EA; Cerabona, D; Sater, ZA; He, Y; Sun, Z; Gehlhausen, J; Schurmans, Stéphane; Gayral, S; Nalepa, G
    Peer reviewed

  18. Vitamin B1 diversity and characterization of biosynthesis genes in cassava

    Mangel, N.; Fudge, J.; Fitzpatrick, T.B.; Gruissem, W; Vanderschuren, Hervé
    Peer reviewed

  19. Cassava Mosaic and Brown Streak Diseases: Current Perspectives and Beyond

    Rey, M.E.C.; Vanderschuren, Hervé
    Peer reviewed

  20. Cassava Mosaic and Brown Streak Diseases: Current Perspectives and Beyond

    Rey, M.E.C.; Vanderschuren, Hervé
    Peer reviewed

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