Recursos de colección

ORBi Open Repository and Bibliography (324.361 recursos)

In may 2007, the ULg's Administrative Board (joined in June 2007 by the FUSAGx) decided to create an institutional repository and defined a strong institutional self-archiving policy to increase the visibility, accessibility and impact of the University's publications (Board's decision). This decision led to the official launch, in November 2008, of the ORBi platform including both the Academic Bibliography and the Institutional Repository of the Wallonia-Europe University Academy.

Life sciences => Biochemistry, biophysics & molecular biology

Mostrando recursos 1 - 20 de 332

  1. Activité antimicrobienne des huiles essentielles du juniperus pheonicea

    Harhour, Aicha; Brada, Moussa; Fauconnier, Marie-Laure; Lognay, Georges

  2. Contribution à l'étude de la composition chimique et de l'activité antimicrobienne des huiles essentielles du juniperus oxycedrus

    Harhour, Aicha; Brada, Moussa; Fauconnier, Marie-Laure; Lognay, Georges

  3. The atypical chemokine receptor ACKR3/CXCR7 displays distinct binding and activation modes for its endogenous agonists

    Meyrath, Max Marc Roger; Szpakowska, Martyna; Counson, Manuel; Reynders, Nathan; Julien, Hanson; Ollert, Markus; Chevigné, Andy
    Background The atypical chemokine receptor ACKR3, formerly CXCR7, binds the endogenous chemokines CXCL12 and CXCL11, as well as the virus-encoded chemokine vCCL2. ACKR3 is crucially involved in various physiological processes but also in viral infection and cancer development, making it a promising drug target, yet a potent antagonist for this receptor is still lacking. Acting as a scavenging receptor, ACKR3 internalizes chemokines without activating the canonical G-protein signaling. ACKR3 extracellular domains present three disulfide bridges, two being conserved among chemokine receptors and one being exclusive to ACKR3, forming a four-residue loop of so far unknown function in the receptors’ N terminus....

  4. Atypical Ligand Binding and Activation Modes of ACKR3/CXCR7

    Meyrath, Max Marc Roger; Szpakowska, Martyna; Reynders, Nathan; Counson, Manuel; Hanson, Julien; Steyaert, Jan; Chevigné, Andy
    The atypical chemokine receptor ACKR3/CXCR7 plays crucial roles in numerous physiological processes but also in viral infection and cancer. ACKR3 shows strong propensity for activation and, unlike classical chemokine receptors, can respond to chemokines from both the CXC and CC families as well as to the endogenous peptides BAM22 and adrenomedullin. Moreover, despite belonging to the G protein coupled receptor family, its function appears to be mainly dependent on β-arrestin. ACKR3 has also been shown to continuously cycle between the plasma membrane and the endosomal compartments, suggesting a possible role as a scavenging receptor. So far, the molecular basis accounting...

  5. Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists

    Szpakowska, Martyna; Meyrath, Max Marc Roger; Reynders, Nathan; Counson, Manuel; Hanson, Julien; Steyaert, Jan; Chevigné, Andy
    Peer reviewed

  6. Distinct binding and activation modes of the atypical chemokine receptor ACKR3/CXCR7 by chemokine and endogenous non-chemokine agonists

    Meyrath, Max Marc Roger; Szpakowska, Martyna; Reynders, Nathan; Counson, Manuel; Hanson, Julien; Steyaert, Jan; Chevigné, Andy
    The atypical chemokine receptor ACKR3/CXCR7 plays crucial roles in numerous physiological processes but also in viral infection and cancer. ACKR3 shows strong propensity for activation and, unlike classical chemokine receptors, can respond to chemokines from both the CXC and CC families as well as to the endogenous peptides BAM22 and adrenomedullin. Moreover, despite belonging to the G protein coupled receptor family, its function appears to be mainly dependent on β-arrestin. ACKR3 has also been shown to continuously cycle between the plasma membrane and the endosomal compartments, suggesting a possible role as a scavenging receptor. So far, the molecular basis accounting...

  7. Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases

    Blomme, A.; van Simaeys, G.; Doumont, G.; Costanza, Brunella; Bellier, Justine; Otaka, Y.; Sherer, F.; LOVINFOSSE, Pierre; Boutry, S.; Palacios, A. P.; De Pauw, Edwin; Hirano, T.; Yokobori, T.; Hustinx, Roland; Bellahcene, Akeila; Delvenne, Philippe; Detry, Olivier; Goldman, S.; Nishiyama, M.; Castronovo, Vincenzo; Turtoi, A.
    Peer reviewed

  8. Study of the crosstalk between VEGF and BMP9 pathways: implications in HHT

    Pollenus, Thomas; Struman, Ingrid
    Peer reviewed

  9. When the Arabidopsis sr45-1 mutant meets environmental challenges

    Fanara, Steven; Hanikenne, Marc; Motte, Patrick

  10. When the Arabidopsis sr45-1 mutant meets environmental challenges

    Fanara, Steven; Hanikenne, Marc; Motte, Patrick

  11. Insight into the Molecular Mechanisms of Pancreatic Beta Cell Regeneration from the Ducts in Zebrafish

    Massoz, Laura; Bergemann, David; Lavergne, Arnaud; Bourdouxhe, Jordane; Carril, Claudio; Voz, Marianne; Peers, Bernard; Manfroid, Isabelle
    Peer reviewed

  12. Varicella Zoster Virus ORF9p binding to cellular adaptor protein complex-1 is important for viral infectivity.

    Lebrun, Marielle; Lambert, Julien; Riva, Laura; Thelen, Nicolas; Rambout, Xavier; Blondeau, Caroline; Thiry, Marc; Snoeck, Robert; Twizere, Jean-Claude; Dequiedt, Franck; Andrei, Graciela; Delvaux-Sadzot, Catherine
    Peer reviewed

  13. Lung Interstitial Macrophages: Past, Present, and Future

    Schyns, Joey; Bureau, Fabrice; Marichal, Thomas
    Peer reviewed

  14. Pancreatic delta cells could be a new source of beta cells in adult zebrafish

    Carril Pardo, Claudio Andrès; Bergemann, David; Massoz, Laura; Lavergne, Arnaud; Bourdouxhe, Jordane; Peers, Bernard; Voz, Marianne; Manfroid, Isabelle
    Diabetes occurs under insulin resistance/deficiency and when insulin-producing pancreatic beta-cell mass is dramatically reduced. Besides therapeutic strategies to preserve beta-cell mass and function and improve insulin treatments, beta-cell replacement constitutes a promising alternative to replenish the pancreas with functional beta-cells. Several observations of pancreatic cell plasticity has led to the hope that triggering beta-cell regeneration within the pancreas could be harnessed in future therapies. Notably, endocrine alpha- and delta-cells have been shown in mouse to convert or transdifferentiate into beta-cell after massive destruction in adult and juvenile, respectively [1] [2]. Due to its potent regenerative capabilities, zebrafish, unlike mammals, is a...

  15. Interplay between platelets, neutrophils and coagulation in bleeding in a mouse model of inflammatory bowel disease

    Wéra, Odile; Delierneux, Céline; Servais, Laurence; Hego, Alexandre; LECUT, Christelle; DELVENNE, Philippe; Nchimi Longang, Alain; LANCELLOTTI, Patrizio; Oury, Cécile
    Peer reviewed

  16. Innovative methods for biomarker discovery in the evaluation and development of cancer precision therapies.

    Umelo, Ijeoma Adaku; Costanza, Brunella; Castronovo, Vincenzo
    Peer reviewed

  17. Thyroid hormone action and disruption in the brain: Xenopus as a model to study disruption of thyroid hormone availability on early brain development

    Mughal, Bilal Babar
    Thyroid hormones (TH) are essential for normal brain development in vertebrates. Disruption of TH action, either due to genetic and/or environmental factors, has been implicated in neurological defects such as autism, attention deficit hyperactivity disorders (ADHD) and IQ loss. On average, over 30 anthropogenic chemicals are present in all American women, with 15 being ubiquitous, including in pregnant women. Many of these chemicals are demonstrated or suspected TH disruptors. A representative mixture of these 15 common chemicals was established at concentrations reported in human amniotic fluid and an in vivo larval reporter (GFP) assay was used to determine integrated TH...

  18. Functional Characterization of Xenopus Thyroid Hormone Transporters mct8 and oatp1c1.

    Mughal, Bilal Babar; Leemans, Michelle; Lima de Souza, Elaine C.; le Mevel, Sebastien; Spirhanzlova, Petra; Visser, Theo J.; Fini, Jean-Baptiste; Demeneix, Barbara A.
    Peer reviewed

  19. Endocrine disruptors: Flame retardants and increased risk of thyroid cancer.

    Mughal, Bilal Babar; Demeneix, Barbara A.
    Peer reviewed

  20. Thyroid-disrupting chemicals and brain development: an update.

    Mughal, Bilal Babar; Fini, Jean-Baptiste; Demeneix, Barbara A.
    Peer reviewed

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.