Koutaissoff, S [author]; Wellmann, D [author]; COUCKE, Philippe [author]; Ozsahin, M [author]; Pampallona, S [author]; Mirimanoff, R-O [author]
Purpose: To evaluate a hyperfractionated and accelerated radiotherapy (HART) protocol in patients with inoperable non-small cell lung carcinoma (NSCLC) who were ineligible for combination radiochemotherapy
Methods and Materials: From February 1989 through August 1994, 23 patients ineligible for available combined
modality protocols in our institution were enrolled and treated with HART, consisting of 63 Gy given in 42 fractions of 1.5 Gy each, twice daily, with a minimum time interval of 6 h between fractions, 5 days a week, over an elapsed time of 4.2 weeks, or 29 days. There was no planned interruption.
Results: The 1-, 2-, and 3-year survival rates were...
Crompton, Nigel; Miralbell, Raymond; Rutz, Hans-Peter; Ersoy, Fügen; Sanal, Özden; Wellmann, Danielle; Bieri, Sabine; Emery, Gillian; Shi, Yu-Quan; COUCKE, Philippe; OzsahinBlattmann; Ozsahin
Coucke, Philippe [author]; Decosterd, L-A [author]; Li, Y-X [author]; Cottin, E [author]; Chen, X [author]; Sun, L-Q [author]; Stern, S [author]; Paschoud, N [author]; Denekamp, J [author]
(E)-2*-Deoxy-(fluoromethylene)cytidine (FMdC) is known as an inhibitor
of ribonucleoside diphosphate reductase, a key enzyme in the de novo
pathway of DNA synthesis. FMdC was tested as a modifier of radiation
response in vitro on a human colon carcinoma cell line (WiDr), and the
observed radiosensitization was confirmed on two human cervix cancer
cell lines (C33-A and SiHa). Using the clonogenic assay, the effect ratio
(ER) at a clinically relevant dose level of 2 Gy was 2.10 (50 nM FMdC),
1.70 (30 nM FMdC), and 1.71 (40 nM FMdC) for the three cell lines WiDr,
C33-A, and SiHa, respectively. A more detailed analysis of the importance
of timing and concentration...
Lomax, T [author]; Goitein, G [author]; Debus, J [author]; Dykstra, C [author]; Tercier, P-A [author]; COUCKE, Philippe [author]; Mirimanoff, R-O [author]
Purpose: A comparative treatment planning study has been undertaken between standard photon delivery techniques,b intensity modulated photon methods and spot scanned protons in order to investigate the merits and limitations of each of these treatment approaches.
Methods: Plans for each modality were performed using CT scans and planning information for nine patients with varying indications and lesion sites and the results have been analysed using a variety of dose and volume based parameters.
Results: Over all cases, it is predicted that the use of protons could lead to a reduction of the total integral dose by a factor three compared to standard...
Coucke, Philippe [author]; Maingon, P [author]; Ciernik, I [author]; Do, H-P [author]
Background: The treatment outcome of advanced stage uterine cervical carcinoma remains unsatisfactory. In order to elaborate a novel
trial within The Radiotherapy Cooperative Group (RCG) of the European Organization for Research and Treatment of Cancer (EORTC), we
conducted a survey in 1997±1998 to determine the variability of pre-treatment assessment and treatment options. The variability of choosing
surgery, de®ned radiation therapy techniques and chemotherapy are investigated, as well as the center's choices of future treatment strategies.
Methods: Fifty two of 81 RCG centers from the RCG have participated in the survey. As one would expect, there is a large variation in the
techniques used for pretreatment...
Delaloye, J-F [author]; Pampallona, S [author]; COUCKE, Philippe [author]; Megalo, A [author]; Dr Grandi, P [author]
Objective : To analyse the effect of differentiation on disease-free survival (DFS) and overall survival (OS) in patients with stage I adenocarcinoma of the endometrium. Patients and methods : From 1979 to 1995, 350 patients with FIGO stage IA–IC with well (G1), moderately (G2) or poorly (G3) differentiated tumors were treated with surgery and high dose-rate brachytherapy with or without external radiation. Median age was 65 years (39–86 years). Results : The 5-year DFS was 8863% for the G1 tumors, 7764% for the G2 tumors,
and 6767% for the G3 tumors (P50.0049). With regard to the events contributing to DFS, the...
Coucke, Philippe; PHUOC DO, Hu; Pica, Alessia; Urban, Filip; Pache, Gilbert
Endovascular brachytherapy after percutaneous coronary intervention (PCI), is becoming a standard approach for the treatment and prevention of restenosis. A variety of technical approaches are currently available to deliver ionizing irradiation to the vascular target. Basically two kinds of radioactive isotopes are available that emit gamma radiation (photons) or beta radiation (electrons). The pitfalls and solutions for the optimization of dosimetry are discussed. As might be expected, the inhomogeneous dose distribution across the target volume
results in recurrence by underdosage or in complications because of overdosage. Moreover, uniformization of the target definition and reporting of the dose distribution in endovascular brachytherapy...
The one-and-a-half day Young Investigators Workshop was
held in the Holiday Inn, Bethesda, August 1–2, 2000. Using
the SCAROP mailing list and recommendations from department
chiefs, approximately 55 “early-career” physicianscientists
were invited to attend the workshop. Table 1
includes the participants.
The goals of the meeting were:
c To bring together radiation oncology physician-scientists
who were in the early part of their career to discuss
research ideas and opportunities as well as potential barriers
to progress for the field and for young-investigator
c To help develop camaraderie among and a critical-mass
of a new generation of physician-scientists with interests
ranging from technology development, to basic and translational
research, to outcomes research and analysis.
Zouhair, A [author]; COUCKE, Philippe [author]; Jeanneret, W [author]; Douglas, P [author]; Do, H-P [author]; Jichlinski, P [author]; Mirimanoff, R-O [author]; Ozsahin, M [author]
To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of
41 consecutive patients with non-metastatic invasive carcinoma of the penis, treated between 1962 and 1994, was performed. The
median age was 59 years (range: 35±76 years). According to the International Union Against Cancer (UICC) 1997 classi®cation,
there were 12 (29%) T1, 24 (59%) T2, 4 (10%) T3 and 1 TX (2%) tumours. The N-classi®cation was distributed as follows: 29
(71%) patients with N0, 8 (20%) with N1, 3 (7%) with N2 and 1 (2%) with N3. Forty-four per cent (n=18) of the patients
Gervaz, Pascal [author]; Rotholtz, Nicolas [author]; Pisano, Michele [author]; Kaplan, Edward [author]; Secic, Michele [author]; COUCKE, Philippe [author]; Pikarsky, Alon [author]; Efron, Jonathan [author]; Wexner, Steven [author]
Hypothesis: Pelvic irradiation adversely affects anal
sphincter function after proctectomy with coloanal anastomosis
for low rectal and middle rectal (,10 cm from
the anal verge) tumors.
Design: Case-control study.
Setting: Private, tertiary care referral center.
Patients: Patients treated for low rectal adenocarcinoma
between January 1, 1994, and October 31, 1999.
Interventions: Anal manometric data were prospectively
collected at the time of initial diagnosis and before
Main Outcome Measures: Mean and maximum resting
pressures (RPs) and squeeze pressures, threshold volume
for sensation, and maximal tolerable volume.
Results: Twenty-three patients in the surgery group and
19 in the chemoradiotherapy group were considered for
Gervaz, P [author]; COUCKE, Philippe [author]; Gillet, M [author]
Le traitement adjuvant des cancers du rectum a pour buts
de stériliser la maladie résiduelle infra-clinique et
d’améliorer le contrôle local. Depuis plus de 20 ans, des
milliers de malades ont été inclus dans des études randomisées,
visant d’abord à mettre en évidence un gain de survie et une
réduction des récidives loco-régionales, en relation avec la
radiothérapie pré- ou postopératoire, combinée ou non à la
chimiothérapie. Les conséquences en termes de qualité de vie de
ces traitements ont pourtant été peu étudiées, et la tolérance
fonctionnelle du néo-rectum et de l’appareil sphinctérien à la
radiothérapie restent mal connues . Les difficultés liées à
l’étude des effets de l’irradiation sur les...
De Benedetti, E [author]; Latchem, D [author]; Roguelov, C [author]; COUCKE, Philippe [author]; Seydoux, C [author]; Goy, J-J [author]; Urban, P [author]; Eeckhout, E [author]
More than 70% of percutaneous coronary interventions are followed by a stent implantation.
In-stent restenosis still occurs in 20-30% of patients and remains a therapeutic
challenge. At present only vascular brachytherapy has been shown to be an effective
treatment option. We report here one case of recurrent in-stent restenosis after vascular
brachytherapy that was successfully treated by a second beta radiation treatment.
Cathet Cardiovasc Intervent 2002;55:233–236. © 2002 Wiley-Liss, Inc.
Egger, J-F [author]; Coindre, J-M [author]; Benhattar, J [author]; COUCKE, Philippe [author]; Guillou, L [author]
Development of a soft-tissue sarcoma is an infrequent
but well-known long-term complication of
radiotherapy. Malignant fibrous histiocytomas, extraskeletal
osteosarcomas, fibrosarcomas, malignant
peripheral nerve sheath tumors, and angiosarcomas
are most frequently encountered. Radiationassociated
synovial sarcomas are exceptional. We
report the clinicopathologic, immunohistochemical,
and molecular features of two radiationassociated
synovial sarcomas. One tumor developed
in a 42-year-old female 17 years after external irradiation
was given for breast carcinoma; the other
occurred in a 34-year-old female who was irradiated
at the age of 7 years for a nonneoplastic condition of
the left hand. Both lesions showed morphologic features
of monophasic spindle cell synovial sarcoma,
were immunoreactive for cytokeratins, epithelial
membrane antigen, CD99, CD117 (c-kit), and bcl-2
and bore the t(X;18) (SYT-SSX1)...
Bouzourene, Hanifa; Bosman, Fred; Seelentag, Walter; Matter, Maurice; COUCKE, Philippe
BACKGROUND: Locally advanced rectal carcinoma has a poor prognosis. However,
since the introduction of preoperative radiotherapy, the outcome of patients with
rectal carcinoma has been reported to have improved. Nevertheless, to the authors’
knowledge few data are available regarding the histopathologic response to
radiotherapy as assessed on surgical specimens as a potential predictive factor for
METHODS: To estimate the effect of radiotherapy on rectal carcinoma, the authors
retrospectively reviewed the surgical specimens of 102 patients with T3-4, N0 or
N1 rectal carcinoma and 1 patient with T2 but N1 rectal carcinoma. All patients
were treated preoperatively with a...
Bouzourene, H [author]; Chabert, P [author]; Gebhardt, S [author]; Bosman, F-T [author]; COUCKE, Philippe [author]
BACKGROUND. Metallothioneins (MT) are low-molecular weight, metal-binding
proteins that play a role in cellular proliferation and differentiation, as well as in
cellular defense mechanisms. They act as scavengers of free radicals produced by
irradiation. A number of in vitro and in vivo studies have linked overexpression of
cellular MT with tumor cell resistance to radiation. This is the first study that
investigates whether MT expression is involved in the radioresistance of rectal
METHODS. Using a mouse monoclonal antibody, MT expression was analyzed by
immunohistochemistry on surgical samples (n 85) from 85 patients with locally
advanced rectal carcinoma who were treated preoperatively with a hyperfractionated
and accelerated radiotherapy schedule and...
Bosset, J. F.; Roelofsen, F.; Morgan, D.A. L.; Budach, V.; Jager, J. J.; Van der Steen-Banasik, E.; Trivière, N.; Stüben, G.; Puyraveau, M.; COUCKE, Philippe; Mercier, M
The European Organization for Research and Treatment of Cancer (EORTC) 22861 randomised trial established that combined
radiochemotherapy is the standard treatment for locally advanced anal cancer. This EORTC phase II study (#22953) tests the
feasibility of reducing the gap between sequences to 2 weeks, to deliver Mitomycin C (MMC) in each radiotherapy sequence and
5-FU continuously during the treatment. The first sequence consisted of 36 Gy over 4 weeks. 5-FU 200 mg/m2/days 1–26, MMC 10
mg/m2/day 1 gap 16 days. Then a second sequence of 23.4 Gy over 17 days, 5-FU 200 mg/m2/days 1–17 and, MMC 10 mg/m2/day 1
was given. 43 patients with a...
Zouhair, A [author]; COUCKE, Philippe [author]; Azria, D. [author]; Pache, P. [author]; Stupp, R. [author]; Moeckli, R. [author]; Mirimanoff, R. O. [author]; Ozsahin, M. [author]
Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell
carcinoma of the head and neck (SCCHN).
Patients and methods. – Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range:
43–81) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary
sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extracapsular infiltration (ECI)
* Auteur correspondant.
Adresse e-mail : firstname.lastname@example.org (A. Zouhair).
Cancer/Radiothérapie 7 (2003) 231–236
© 2003 Éditions scientifiques et médicales Elsevier SAS. Tous droits...
Bouzourene, H [author]; Bosman, F [author]; Matter, M [author]; Coucke, Philippe [author]
This study examines the prognostic significance of pathologic
factors in patients with primary locally advanced rectal cancer treated
prospectively with preoperative radiotherapy. From 1992 to 1998, 104
patients with rectal cancer of grades T3 or T4 and any N underwent
preoperative radiotherapy followed by surgical resection. Survival
curves were estimated according to the Kaplan-Meier method. Correlation
of outcome with clinicopathologic variables (pathologic tumor
and lymph node staging, histology, radial resection margin
[RRM], clearance, vessel involvement, and tumor regression grade
[TRG], quantitated in 5 grades) was evaluated using the Cox proportional
hazards model. None of the patients achieved a histologically
confirmed complete pathologic response, but 79% of the patients
showed partial tumor regression...
Voelter, V [author]; Stupp, R [author]; Matter, M [author]; Gillet, M [author]; Bouzourene, H [author]; Leyvraz, S [author]; COUCKE, Philippe [author]
Purpose: Patients with locally advanced rectal carcinoma are at risk for both local recurrence and distant metastases. We demonstrated the efficacy of preoperative hyperfractionated accelerated radiotherapy (HART).
In this Phase I trial, we aimed at introducing chemotherapy early in the treatment course with both intrinsic antitumor activity and a radiosensitizer effect.
Methods and Materials: Twenty-eight patients (19 males; median age 63, range 28–75) with advanced rectal carcinoma (cT3: 24; cT4: 4; cN : 12; M1: 5) were enrolled, including 8 patients treated at the maximally tolerated dose. Escalating doses of CPT-11 (30–105 mg/m2/week) were given on Days 1, 8, and 15, and...
Coen, V [author]; Serruys, P [author]; Sauerwein, W [author]; Orecchia, R [author]; Von Rottkay, P [author]; COUCKE, Philippe [author]; Ehnert, M [author]; Urban, P [author]; Bonan, R [author]; Levendag, P [author]
Purpose: To assess, by a European registry trial, the clinical event rate in patients with discrete stenotic lesions of coronary arteries (de novo or restenotic) in single or multiple vessels (native or bypass grafts) treated with -radiation.
Methods and Materials: Between April 1999 and September 2000, 1098 consecutive patients treated in 46 centers in Europe and the Middle East with the Novoste Beta-Cath System were included in Registry Novoste (RENO).
Results: Six-month follow-up data were obtained for 1085 patients. Of 1174 target lesions, 94.1% were located in native vessels and 5.9% in a bypass graft; 17.7% were de novo lesions, 4.1% were...