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ORBi Open Repository and Bibliography (263,662 recursos)

In may 2007, the ULg's Administrative Board (joined in June 2007 by the FUSAGx) decided to create an institutional repository and defined a strong institutional self-archiving policy to increase the visibility, accessibility and impact of the University's publications (Board's decision). This decision led to the official launch, in November 2008, of the ORBi platform including both the Academic Bibliography and the Institutional Repository of the Wallonia-Europe University Academy.

Human health sciences => Hematology

Mostrando recursos 601 - 620 de 1,007

  1. Timing effect of combined radioimmunotherapy and radiotherapy on a human solid tumor in nude mice.

    Coucke, Philippe [author]; Lin-Quan, Sun [author]; Vogel, Charles-André [author]; Mirimanoff, René-Olivier [author]; COUCKE, Philippe [author]; Slosman, D-O [author]; Buchegger, F [author]
    Timing effects of radioimmunotherapy (HIT) combined with external beam radiotherapy (RT) were assessed In human colon carcinoma xe nografts. Initially, dose effects offractlonated RT and RIT were evaluated separately. Then, 30 Gy RT (10 fractions over 12 days) were combined with three weekly Lv. injections of 200 g@Ci of 131I-labeled anti-carcino embryonic antigen monoclonal antibodies in four different treatment schedules. RIT was given either prior to, concurrently, Immediately after, or 2 weeks after RT administration. The longest regrowth delay (RD) of 105 days was observed in mice treated by concurrent administration of RT and lilT, whereas the RDs of RT and RIT alone were 34 and 20 days, respectively. The...

  2. Radiation therapy duration influences overall survival in patients with cervix carcinoma.

    Coucke, Philippe [author]; Delaloye, J-F [author]; Pampallona, S [author]; Peltecu, G [author]; De Grandi, P [author]
    of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation and brachytherapy as first line therapy. Median therapy duration was 45 days. Patients were classified according to the duration of the therapies, taking 60 days (the 75th percentile) as an arbitrary cut-off. Results: The 5-year survival was 61% (SE. = 3%) for the therapy duration group of less than 60 days and 53% (SE. = 7%) for the group of more than 60 days. In terms of univariate hazard ratio (HR), the relative difference between...

  3. Information transfer between angiographic films and CT images: a tool to delineate the target volume

    Tercier, P-A [author]; COUCKE, Philippe [author]; Fankhauser, H [author]; Mirimanoff, R-O [author]; Uske, A [author]; Valley, J-F [author]
    Abstract Background and purpose: This work was undertaken to improve the definition of target volumes for radiosurgery using the angiographic and CT data. Materials and methods: The basis of this new method is to combine both imaging modalities and to compare them in each representation, i.e. to plot the volume obtained by angiography on CT images and also the contours defined by the CT on angiographic films. To obtain the angiographic volume, the radiographs are taken at several incidence angles. The X-ray sources position and the position of the films are determined using rectangular markers, then the intersection of all the loci...

  4. Radiotherapy of choroidal metastases.

    Rosset, A [author]; Zografos, L [author]; COUCKE, Philippe [author]; Monney, M [author]; Mirimanoff, R-O [author]
    Abstract Purpose: This retrospective study was undertaken to clarify the role of high energy external beam radiation therapy (EBRT) and to determine its safety and efficacy on local control and visual acuity in patients suffering from choroidal metastases (CM). Materials and methods: The records of 58 consecutive patients treated with EBRT between 1970 and 1993 were analyzed. The female to male ratio was 2.9 and the median age was 59 years (range 40–81 years). Thirty-six patients (62%) had unilateral CM and 22 patients had bilateral CM. The mean number of lesions per eye was two. Retinal detachment was present in 65% of cases. The primary...

  5. Primary non-Hodgkin's lymphoma of the nasal cavity: prognostic significance of paranasal extension and role of radiotherapy and chemotherapy

    Li, Y-X [author]; COUCKE, Philippe [author]; Li, J-Y [author]; Gu, D-Z [author]; Liu, X-F [author]; Mirimanoff, R-O [author]; Huang, Y-R [author]
    BACKGROUND. This study was conducted to determine whether the paranasal extension of a primary non-Hodgkin’s lymphoma (NHL) of the nasal cavity has any deleterious effect on patient outcome. METHODS. One hundred and seventy-five patients with previously untreated nasal NHL were reviewed. There were 2 with low grade, 107 with intermediate grade, 17 with high grade, and 49 with unclassifiable lymphomas. In 48 cases the immunophenotype was available and 46 were T-cell lymphoma. According to the Ann Arbor system, there were 133 patients with Stage IE, 28 with Stage IIE, 4 with Stage IIIE, and 10 with Stage IVE lymphomas. Stage IE was subdivided into limited Stage IE (i.e., confined...

  6. Les associations radiochimiothérapiques dans les cancers du col utérin.

    Maingon, Philippe [author]; COUCKE, Philippe [author]; Haie-Meder, Catherine [author]; Barillot, Isabelle [author]
    Le traitement des cancers du col utérin repose sur la radiothérapie et la chirurgie. Le pronostic des formes évoluées a conduit à proposer différentes modalités d’association dont seuls les traitements concomitants ont montré un intérêt. Les associations de radiothérapie et d’un radiosensibilisant n’ont pas apporté, de bénéfice, voire abouti à des résultats inférieurs à ceux de l’irradiation exclusive. L’Hydroxyurée et la Mitomycine C ont été largement testées, seules ou en association, sans qu’elles puissent être retenues comme efficaces. Des associations modernes et des essais récents, il peut être établi que seul le Cisplatine (et peut-être ses dérivés) peut être retenu dans !es propositions thérapeutiques futures. 1998 Elsevier, Paris

  7. Focalized external radiotherapy for resected solitary brain metastasis: the dogma stands

    Coucke, Philippe [author]; Zouhair, A [author]; Ozsahin, M [author]; De Tribolet, N [author]; Mirimanoff, R-O [author]
    Abstract Purpose: To investigate whether whole brain irradiation might be replaced by focalized irradiation after resection of a single brain metastasis in patients where extracranial tumor control is deemed to be obtained. Patients and methods: Twelve patients were introduced in a phase I/II prospective study of conformal postoperative external irradiation after resection of a solitary brain metastasis. The radiation treatment consisted of 50.4 Gy (1.8 Gy per fraction, five fractions per week). The planning target volume consisted of the tumor bed and a 2 cm safety margin. All treatments were optimized with head immobilization, dedicated tomodensitometry and computer assisted three-dimensional treatment planning. Results:...

  8. Prognostic Factors in Urothelial Renal Pelvis and Ureter Tumours: a Multicentre Rare Cancer Network Study

    Ozsahin, M; Zouhair, A; Villa, S; Storme, G; Chauvet, B; Taussky, D; Gouder, D; Ries, G; Bontemps, P; COUCKE, Philippe; Mirimanoff, R-O
    Peer reviewed

  9. Simultaneous Determination of Deoxyribonucleoside in the Presence of Ribonucleoside Triphosphates in Human Carcinoma Cells by High-Performance Liquid Chromatography

    Decoster, L-A [author]; Chen, X [author]; Lejeune, F [author]; Mirimanoff, R-O [author]; Biolla, J [author]; COUCKE, Philippe [author]
    Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in cells by HPLC is an analytical challenge since the concentration of dNTP present in mammalian cells is several orders of magnitude lower than the corresponding NTP. Hence, the quantitation of dNTP in cells is generally performed after selective oxidation or removal of the major NTP. The procedures reported so far are lengthy and cumbersome and do not enable the simultaneous determination of NTP. We report the development of a simple, direct HPLC method for the simultaneous determination of dNTP and NTP in colon carcinoma WiDr cell extracts using a stepwise gradient elution ion-pairingHPLCwith uv detection at 260 nm and with a minimal chemical manipulation of cells....

  10. Reproducibility of measurements of potential doubling time of tumor cells in the multicenter NCI protocol T92-0045

    Wilson, G-D [author]; Paschoud, N [author]; Pavy, J-J [author]; Weber, K. [author]; Weber, P. [author]; Dubray, B [author]; COUCKE, Philippe [author]
    Summary We compared the flow cytometric measurement and analysis of the potential doubling time ( Tpot) between three centres involved in the National Cancer Institute (NCI) protocol T92-0045. The primary purpose was to understand and minimize the variation within the measurement. A total of 102 specimens were selected at random from patients entered into the trial. Samples were prepared, stained, run and analysed in each centre and a single set of data analysed by all three centres. Analysis of the disc data set revealed that the measurement of labelling index (LI) was robust and reproducible. The estimation of duration of S-phase ( Ts) was...

  11. Potentiation of cytotoxicity and radiosensitization of (E)-2'-deoxy-2' (fluoromethylene) cytidine by pentoxifylline in vitro.

    LI, Y-X [author]; Sun, L-Q [author]; Paschoud, N [author]; Weber-Johnson, K [author]; COUCKE, Philippe [author]
    (E)-28-deoxy-28-(fluoromethylene) cytidine (FMdC), a novel inhibitor of ribonucleotide-diphosphate reductase, has been shown to have anti-tumor activity against solid tumors and sensitize tumor cells to ionizing radiation. Pentoxifylline (PTX) can potentiate the cell killing induced by DNAdamaging agents through abrogation of DNA-damagedependent G2 checkpoint. We investigated the cytotoxic, radiosensitizing and cell-cycle effects of FMdC and PTX in a human colon-cancer cell line WiDr. PTX at 0.25–1.0 mM enhanced the cytotoxicity of FMdC and lowered the IC50 of FMdC from 79 6 0.1 to 31.2 6 2.1 nM, as determined by MTT assay. Using clonogenic assay, pre-irradiation exposure of exponentially growing WiDr cells to 30 nM FMdC for 48 hr or post-irradiation to 0.5 to...

  12. Radiothérapie externe ou anti-inflammatoire non-stéroïdien pour la prévention des ossifications hétérotopiques après prothèse totale de hanche?

    Zouhair, A [author]; Ozsahin, M [author]; Mouhsine, E [author]; Leyvraz, P-F [author]; Mirimanoff, R-O [author]; COUCKE, Philippe [author]
    External radiotherapy or non-steroid antiinflammatory drugs for prevention of heterotopic ossification following total hip replacement Heterotopic ossification (HO) is defined as the development of abnormal ossification in soft tissues. HO is a common disease after total hip replacement. Many therapeutic modalities have been proposed to prevent HO. The most commonly used modalities are nonsteroidal anti-inflammatory drugs (NSAID) or ionizing radiation administered just before or immediately after total hip replacement. As far as external radiation therapy is concerned, there are several published randomized studies aimed at investigating its efficacy and timing related to surgery, and at comparing ionizing irradiation to NSAID. In this article we review the published data in order to define guidelines which could be used in daily...

  13. Hyperfractionated accelerated radiotherapy (HART) for inoperable, non metastatic non-small-cell lung carcinoma of the lung (NSCLC): result of a phase II study for patients ineligible for combination radio-chemotherapy.

    Koutaissoff, S [author]; Wellmann, D [author]; COUCKE, Philippe [author]; Ozsahin, M [author]; Pampallona, S [author]; Mirimanoff, R-O [author]
    Purpose: To evaluate a hyperfractionated and accelerated radiotherapy (HART) protocol in patients with inoperable non-small cell lung carcinoma (NSCLC) who were ineligible for combination radiochemotherapy studies. Methods and Materials: From February 1989 through August 1994, 23 patients ineligible for available combined modality protocols in our institution were enrolled and treated with HART, consisting of 63 Gy given in 42 fractions of 1.5 Gy each, twice daily, with a minimum time interval of 6 h between fractions, 5 days a week, over an elapsed time of 4.2 weeks, or 29 days. There was no planned interruption. Results: The 1-, 2-, and 3-year survival rates were...

  14. Altered apoptotic profiles in irradiated patients with increased toxicity.

    Crompton, Nigel; Miralbell, Raymond; Rutz, Hans-Peter; Ersoy, Fügen; Sanal, Özden; Wellmann, Danielle; Bieri, Sabine; Emery, Gillian; Shi, Yu-Quan; COUCKE, Philippe; OzsahinBlattmann; Ozsahin
    Peer reviewed

  15. The ribonucleoside diphosphate reductase inhibitor (E)-2'-Deoxy-(fluoromethylene) cytidine, acts as a cytotoxic radiosensitizer on human cancer cell lines in vitro.

    Coucke, Philippe [author]; Decosterd, L-A [author]; Li, Y-X [author]; Cottin, E [author]; Chen, X [author]; Sun, L-Q [author]; Stern, S [author]; Paschoud, N [author]; Denekamp, J [author]
    ABSTRACT (E)-2*-Deoxy-(fluoromethylene)cytidine (FMdC) is known as an inhibitor of ribonucleoside diphosphate reductase, a key enzyme in the de novo pathway of DNA synthesis. FMdC was tested as a modifier of radiation response in vitro on a human colon carcinoma cell line (WiDr), and the observed radiosensitization was confirmed on two human cervix cancer cell lines (C33-A and SiHa). Using the clonogenic assay, the effect ratio (ER) at a clinically relevant dose level of 2 Gy was 2.10 (50 nM FMdC), 1.70 (30 nM FMdC), and 1.71 (40 nM FMdC) for the three cell lines WiDr, C33-A, and SiHa, respectively. A more detailed analysis of the importance of timing and concentration...

  16. A treatment planning intercomparison of proton and intensity modulated photon radiotherapy.

    Lomax, T [author]; Goitein, G [author]; Debus, J [author]; Dykstra, C [author]; Tercier, P-A [author]; COUCKE, Philippe [author]; Mirimanoff, R-O [author]
    Abstract Purpose: A comparative treatment planning study has been undertaken between standard photon delivery techniques,b intensity modulated photon methods and spot scanned protons in order to investigate the merits and limitations of each of these treatment approaches. Methods: Plans for each modality were performed using CT scans and planning information for nine patients with varying indications and lesion sites and the results have been analysed using a variety of dose and volume based parameters. Results: Over all cases, it is predicted that the use of protons could lead to a reduction of the total integral dose by a factor three compared to standard...

  17. A survey on staging and treatment in uterine cervical carcinoma in the Radiotherapy Cooperative Group of the European Organization for Research and Treatment of Cancer

    Coucke, Philippe [author]; Maingon, P [author]; Ciernik, I [author]; Do, H-P [author]
    Abstract Background: The treatment outcome of advanced stage uterine cervical carcinoma remains unsatisfactory. In order to elaborate a novel trial within The Radiotherapy Cooperative Group (RCG) of the European Organization for Research and Treatment of Cancer (EORTC), we conducted a survey in 1997±1998 to determine the variability of pre-treatment assessment and treatment options. The variability of choosing surgery, de®ned radiation therapy techniques and chemotherapy are investigated, as well as the center's choices of future treatment strategies. Methods: Fifty two of 81 RCG centers from the RCG have participated in the survey. As one would expect, there is a large variation in the techniques used for pretreatment...

  18. Effect of grade on disease-free survival and overall survival in FIGO Stage I adenocarcinoma of the endometrium.

    Delaloye, J-F [author]; Pampallona, S [author]; COUCKE, Philippe [author]; Megalo, A [author]; Dr Grandi, P [author]
    Abstract Objective : To analyse the effect of differentiation on disease-free survival (DFS) and overall survival (OS) in patients with stage I adenocarcinoma of the endometrium. Patients and methods : From 1979 to 1995, 350 patients with FIGO stage IA–IC with well (G1), moderately (G2) or poorly (G3) differentiated tumors were treated with surgery and high dose-rate brachytherapy with or without external radiation. Median age was 65 years (39–86 years). Results : The 5-year DFS was 8863% for the G1 tumors, 7764% for the G2 tumors, and 6767% for the G3 tumors (P50.0049). With regard to the events contributing to DFS, the...

  19. Basic rules of dosimetry in endovascular brachytherapy.

    Coucke, Philippe; PHUOC DO, Hu; Pica, Alessia; Urban, Filip; Pache, Gilbert
    Endovascular brachytherapy after percutaneous coronary intervention (PCI), is becoming a standard approach for the treatment and prevention of restenosis. A variety of technical approaches are currently available to deliver ionizing irradiation to the vascular target. Basically two kinds of radioactive isotopes are available that emit gamma radiation (photons) or beta radiation (electrons). The pitfalls and solutions for the optimization of dosimetry are discussed. As might be expected, the inhomogeneous dose distribution across the target volume results in recurrence by underdosage or in complications because of overdosage. Moreover, uniformization of the target definition and reporting of the dose distribution in endovascular brachytherapy...

  20. Young Investigators Workshop participants (P.A Coucke) and N. Coleman : Radiation Research program, Radiation Oncology Sciences Program, National Cancer Institue, Nih, August 1-2, 2000


    INTRODUCTION The one-and-a-half day Young Investigators Workshop was held in the Holiday Inn, Bethesda, August 1–2, 2000. Using the SCAROP mailing list and recommendations from department chiefs, approximately 55 “early-career” physicianscientists were invited to attend the workshop. Table 1 includes the participants. The goals of the meeting were: c To bring together radiation oncology physician-scientists who were in the early part of their career to discuss research ideas and opportunities as well as potential barriers to progress for the field and for young-investigator careers. c To help develop camaraderie among and a critical-mass of a new generation of physician-scientists with interests ranging from technology development, to basic and translational research, to outcomes research and analysis. c To...

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