ORBi Open Repository and Bibliography
In may 2007, the ULg's Administrative Board (joined in June 2007 by the FUSAGx) decided to create an institutional repository and defined a strong institutional self-archiving policy to increase the visibility, accessibility and impact of the University's publications (Board's decision).
This decision led to the official launch, in November 2008, of the ORBi platform including both the Academic Bibliography and the Institutional Repository of the Wallonia-Europe University Academy.
Haematological modifications in counterpulsation - de Leval, M.; Fourny, J.; Fillet, Georges; Honoré, D.
Haematological modifications during counterpulsation (Sisma pump) are studied in the dog. An improved technique for collection of blood samples in the dog is first described. Three haematological syndromes are studies : 1) erythrocyte trauma, 2) intravascular clotting and 3) fibrinolysis. The more striking features are a diminution of apparent half life of the erythrocytes Cr51) reaching one third to one half; biologic signs of intravascular clotting without thrombi in the capillaries and a low activation of the fibrinolytic system.
Utilisation en scintillation liquide du Triton X-100 pour le comptage à haut rendement du radiofer plasmatique - Fillet, Georges
A new method for liquid scintillation counting of plasma 59Fe is presented. Using Triton X-100 as an emulsifying agent at 4°C, the efficiency is in the 81-83% range and is five times greater than that achieved with crystal sytems. Without previous manipulation, volumes as great as 4 ml of plasma may be directly incorporated into the scintillation medium and counted with good reproducibility. Bleaching procedure and quench correction are discussed. The method allows a more precise study of iron kinetics and erythropoiesis in humans.
Storage Iron Kinetics. VII. A biologic Model for Reticulo-Endothelial Iron Transport - Fillet, Georges; Cook, J-D.; Finch, C.A.
The processing of erythrocyte iron by the reticuloendothelial cell has been characterized by kinetic measurements of blood radioactivity made after the intravenous injection of heat-damaged erythrocytes labeled with 59Fe and of transferrin-bound 55Fe. The early reticuloendothelial release of iron, a matter of hours, was calculated from the plasma turnover rate of 55Fe and the plasma reappearance of 59Fe. Late release was calculated from the ratio of the cumulative incorporation of both tracers into the circulating red cell mass over a period of 2wk. There was an initial processing period within the reticuloendothelial cell, after which radioiron either rapidly returned to...
Effects of transfusion on serum iron, serum lactate dehydrogenase and platelets in megaloblastic anemia - Fillet, Georges; Andrien, J-M.; Bury, Jean
In 11 patients with megaloblastic anemia, transfusion of packed erythrocytes or washed erythrocytes invariably resulted in a decline in plasma iron concentration to a range of 20-90 µg/dl (3.6 - 16 µmol/l) after 36 or 48 hours. The same phenomenon was observed in two of six cases of ineffective erythropoiesis without megaloblastosis and in none of five cases of aplastic anemia. The observed changes did not result from a specific hematinic response or from iron uptake by a non-erythroid compartment. In megaloblastic anemia, alteration in marrow function in response to transfusion was reflected by plasma iron kinetics and serum lactate...
Diagnostic et traitement des maladies de surcharge en fer - Fillet, Georges
La toxicité des dépôts de fer est fonction de leur localisation dans les cellules réticulo-endothéliales ou parenchymateuses. Cette localisation dépend de la voie d'entrée du fer dans l'organisme (absorption digestive ou transfusion), et de l'activité du système réticulo-endothélial. A l'échelle moléculaire, la ferritine se comporte comme un réservoir qui maintient la concentration du fer libre intracellulaire dans certaines limites, et prévient la toxicité du métal. Le dosage de la ferritine dans le sérum donne une mesure quantitative de l'importance des réserves de fer, et permet le diagnostic rapide d'une surcharge en fer. Le traitement de fond de l'hémochromatose idiopathique reste...