ORBi Open Repository and Bibliography
In may 2007, the ULg's Administrative Board (joined in June 2007 by the FUSAGx) decided to create an institutional repository and defined a strong institutional self-archiving policy to increase the visibility, accessibility and impact of the University's publications (Board's decision).
This decision led to the official launch, in November 2008, of the ORBi platform including both the Academic Bibliography and the Institutional Repository of the Wallonia-Europe University Academy.
Une étude des staphylocoques coagulase positifs isolés à partir de grands brûlés - Biver, A.; Fillet, Georges; Demelenne, A.
Par des prélèvements quotidiens sytématiques, les auteurs ont étudié la colonisation des brûlures graves par les staphylocoques producteurs de coagulase. Ils démontrent la complexité du mécanisme de cette colonisation. Ils ont établi la sensibilité de ces staphylocoques à six antibiotiques courants, comparativement pour les périodes de 1964 à 1967 et 1968 à 1969. Ils soulignent l'efficacité de l'oxygénothérapie hyperbare comme moyen de prévention de l'infection des brûlures.
A study of Staphylococcus Aureus infection in burns - Fillet, Georges; Hanquet, M.; Castermans, A.
The bacteriological control tests regularly carried out reveal the complexity of staphylococcal infection in burned patients. It is not uncommon to find several different strains which succeed one another or coexist in the same patient in the course of his hospital stay. In 5 of the 10 cases of infection of burns, an infection or superinfection of hospital origin was undoubtedly involved. Sometimes, the staphylococcus colonizes the burn furst, and subszquently tends to settle on the skin and in the nose. In other cases, the organism appears to be restricted initially to the nasal fossae, from which it subszquently spreads...
Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response. - Lagneaux, Laurence; Gillet, Nicolas; Stamatopoulos, Basile; Delforge, Alain; Dejeneffe, Marielle; Massy, Martine; Meuleman, Nathalie; Kentos, Alain; Martiat, Philippe; Willems, Luc; Bron, Dominique
OBJECTIVE: Chronic lymphocytic leukemia (CLL) cells develop chemoresistance over time associated with defects in apoptosis pathway. Novel treatment strategies are required to overcome resistance of cells to commonly used agents. The effects of valproic acid (VPA), an antiepileptic drug with histone deacetylase inhibitory activity, on mononuclear cells isolated from 40 CLL patients were evaluated. METHODS: CLL cells were treated with increasing doses of VPA (0.5, 1, 2, and 5 mM). The mode of cytotoxic drug action was determined by annexin binding, DNA fragmentation, and caspase activation. RESULTS: Exposure of CLL cells to VPA resulted in dose-dependent cytotoxicity and apoptosis in...
Actualités thérapeutiques en oncologie sénologique: place actuelle et perspectives des traitements cibles - Jerusalem, Guy; Rorive, Andrée; Gennigens, Christine; Sautois, Brieuc; Mievis, C; Fillet, Georges
The introduction of targeted therapies has largely modified the treatment strategies in oncology. Two targets are currently used for defining the systemic treatment of breast cancer: hormone receptors and HER2 overexpression. Trastuzumab, a monoclonal antibody, is the only registered antiHER2 treatment in Belgium. The association of trastuzumab with chemotherapy is now the recommended adjuvant treatment for early breast cancer overexpressing HER2. Other antiHER2 medications are available and some will probably be registered soon. Angiogenesis is another potential target for improving the treatment results. The CHU Liege, as a reference center for the systemic treatment of solid tumors, participates in many...
La radiothérapie du cancer du sein - Meyns, Mia
Le traitement du cancer du sein est un des exemples les plus probants de l'approche multidisciplinaire oncologique. Dans ce contexte, la radiothérapie a renforcé sa place et son importance, même si certaines incertitudes persistent, comme la prise en charge du creux axillaire, de la chaîne mammaire interne et de la paroi thoracique. La tendance constatée depuis plusieurs années est celle d'une approche moins agressive.
Evolution over a 10 year period of the epidemiological profile of 1,726 newly diagnosed HCV patients in Belgium. - Gerard, Christiane; Delwaide, Jean; Vaira, Dolorès; Bastens, Boris; Servais, Benoit; Wain, Etienne; Bataille, Christian; Daenen, Guy; Belaiche, Jacques
In order to evaluate the future burden of hepatitis C, there is a need to quantify the evolution with time of some crucial parameters such as disease frequency and age, modes of infection and infecting genotypes of patients presenting for the first time at consultation. The yearly evolution of these parameters was analyzed retrospectively in a cohort of 1,726 patients living in Belgium, who were diagnosed as hepatitis C virus (HCV) carriers by polymerase chain reaction (PCR) between 1992 and 2002. The epidemiological profile of HCV patients showed significant changes during this period. The number of new patients increased with...
Treatment of acute nonlymphocytic leukemia in young and elderly patients. - Beguin, Yves; Bury, Jean; Fillet, Georges; Lennes
Among 95 consecutive patients with acute nonlymphocytic leukemia (ANLL), 61 were treated with a high-dose chemotherapeutic induction regimen consisting of daunorubicin, vincristine, and cytosine arabinoside (DOA). The complete remission (CR) rate was 66%. Although young patients responded better than older patients, only sex was found to be of prognostic significance for achieving CR (84% CR in men versus 47% in women, P less than 0.005, independent of age). Patients in CR received consolidation, monthly maintenance therapy, and late intensification for a period of 2 years. Median remission duration was 57 weeks and median survival, 93 weeks. Projected CR rate at...