Recursos de colección

ORBi Open Repository and Bibliography (279.266 recursos)

In may 2007, the ULg's Administrative Board (joined in June 2007 by the FUSAGx) decided to create an institutional repository and defined a strong institutional self-archiving policy to increase the visibility, accessibility and impact of the University's publications (Board's decision). This decision led to the official launch, in November 2008, of the ORBi platform including both the Academic Bibliography and the Institutional Repository of the Wallonia-Europe University Academy.

Human health sciences => Hematology

Mostrando recursos 601 - 620 de 1.053

  1. Increased synovial fluid levels of soluble CD23 are associated with an erosive status in rheumatoid arthritis (RA).

    Ribbens, Clio; Bonnet, V; Kaiser, Marie-Joëlle; Andre, Béatrice; Kaye, O; Franchimont, N.; De Groote, D; Beguin, Yves; Malaise, Michel
    Synovial fluid (SF) levels of soluble CD23 (sCD23) were determined in 96 patients presenting with an inflammatory knee effusion (73 with RA and 23 with reactive arthritis (ReA) serving as a control inflammatory non-erosive group) and were correlated with the degree of joint destruction, with local immune parameters (IL-1beta, IL-3, IL-4, IL-6, IL-8, IL-10, IL-12 and sCD25) and with serum markers of inflammation, C-reactive protein and erythrocyte sedimentation rate. RA patients, classified as erosive or not according to Larsen's grade, were separated as follows: (i) 13 patients with non-erosive RA; (ii) 16 RA patients with erosions in hands but not...

  2. Alone or in concert with glucocorticoids, genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts

    Relic, Biserka; Zeddou, Mustapha; Desoroux, Aline; Beguin, Yves; De Seny, Dominique; Malaise, Michel
    It was shown recently that synovial fibroblast transformation into adipocytes reduced the expression of interleukin-6 (IL-6) and IL-8. However, the synovial fibroblast adipogenesis was inhibited in inflammatory conditions induced by the tumor necrosis factor-alpha (TNF-alpha). Furthermore, adipogenesis is often accompanied by leptin production, a proinflammatory adipokine in rheumatic diseases. In this study, we tested the phytohormone genistein for adipogenic and anti-inflammatory properties on human synovial fibroblasts. Results showed that genistein was able to transform synovial fibroblasts into adipocytes that expressed perilipin-A and produced adiponectin, but not leptin. Furthermore, genistein enhanced glucocorticoid-mediated synovial fibroblast adipogenesis and, in parallel, downregulated glucocorticoid-induced leptin and...

  3. Alone or in concert with glucocorticoids, genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts

    Relic, Biserka; Zeddou, Mustapha; Desoroux, Aline; Beguin, Yves; De Seny, Dominique; Malaise, Michel
    It was shown recently that synovial fibroblast transformation into adipocytes reduced the expression of interleukin-6 (IL-6) and IL-8. However, the synovial fibroblast adipogenesis was inhibited in inflammatory conditions induced by the tumor necrosis factor-alpha (TNF-alpha). Furthermore, adipogenesis is often accompanied by leptin production, a proinflammatory adipokine in rheumatic diseases. In this study, we tested the phytohormone genistein for adipogenic and anti-inflammatory properties on human synovial fibroblasts. Results showed that genistein was able to transform synovial fibroblasts into adipocytes that expressed perilipin-A and produced adiponectin, but not leptin. Furthermore, genistein enhanced glucocorticoid-mediated synovial fibroblast adipogenesis and, in parallel, downregulated glucocorticoid-induced leptin and...

  4. Association of acute leukemia and autoimmune polyendocrine syndrome in two kindreds.

    Willems, Evelyne; Valdes Socin, Hernan Gonzalo; Betea, Daniela; Beckers, Albert; Beguin, Yves

  5. Association of acute leukemia and autoimmune polyendocrine syndrome in two kindreds.

    Willems, Evelyne; Valdes Socin, Hernan Gonzalo; Betea, Daniela; Beckers, Albert; Beguin, Yves

  6. Traitement moléculaire du cancer: le STI571, un inhibiteur des tyrosines kinases

    Humblet-Baron, Stéphanie; Baron, Frédéric; Pirson, Laurence; Beguin, Yves; Fillet, Georges

  7. Traitement moléculaire du cancer: le STI571, un inhibiteur des tyrosines kinases

    Humblet-Baron, Stéphanie; Baron, Frédéric; Pirson, Laurence; Beguin, Yves; Fillet, Georges

  8. Effect of a novel thromboxane A(2) inhibitor on right ventricular-arterial coupling in endotoxic shock

    Lambermont, Bernard; Kolh, Philippe; Ghuysen, Alexandre; Segers, P; Dogné, Jean-Michel; Tchana-Sato, Vincent; Morimont, Philippe; Benoit, P; Gérard, Paul; Masereel, B; D'Orio, Vincenzo
    We investigated the effects of a dual thromboxane (TX)A(2) synthase inhibitor and TXA(2) receptor antagonist (BM-573) on right ventricular-arterial coupling in a porcine model of endotoxic shock. Thirty minutes before the onset of 0.5 mg/kg endotoxin infusion, six pigs (Endo group) received an infusion with a placebo solution, and six other pigs (Anta group) with BM-573. Right ventricular pressure-volume loops were obtained by the conductance catheter technique. The slope (E-es) of the end-systolic pressure-volume relationship and its volume intercept at 25 mmHg were calculated as measures of right ventricular systolic function. RV afterload was quantified by pulmonary arterial elastance (E-a),...

  9. A propos d'un cas de rhabdomyolyse aigue

    Rorive, Andrée; Fraipont, V; Quatresooz, Pascale; Cataldo, Didier; Dubois, Bernard; Fillet, Georges
    A 83 years old patient was admitted with a complex clinical picture including cutaneous rash, muscular pain, rhabdomyolysis and renal failure. The clinical picture suggests a dermatopolymyositis. Despite of high dose corticotherapy, the patient died on day 22. The anatomical examination shows a cholangiocarcinoma disseminated locally as well as in the lungs and bones.

  10. Contribution of glycoproteomics in the search for accessible biomarkers in human lymphoma

    Kischel, Philippe; Greffe, Yannick; Waltregny, David; Chrétien, N; Mazzucchelli, Gabriel; De Pauw, Edwin; de Leval, Laurence; Castronovo, Vincenzo
    FNRS Contact Group Proteomics (GCProt) 4th annual meeting: Chromatin Modifications and Protein Glycosylation

  11. L’érythropoïèse tardive : une mort avortée ?

    Courtois, Geneviève; Vandekerchove, julie; Dussiot, Michael; Kersual, Joöelle; Coulon, Séverine; Belaid, Zakia; Zermati, Yael; Ribeil, Jean-Antoine; Hermine, Olivier
    La survie et la prolifération des progéniteurs et précurseurs érythroïdes se trouvent sous le contrôle de l’érythropoïétine (Epo), qui est le principal régulateur de l’érythropoïèse. La différenciation érythroïde s’effectue sous la dépendance du facteur de transcription GATA-1 qui active l’expression des gènes de différenciation et de survie. La production des globules rouges est finement régulée par l’inhibition ou au contraire par l’induction de l’apoptose des progéniteurs et des précurseurs érythroïdes. La baisse du taux d’Epo circulante ou l’induction de la voie Fas aboutissent à l’activation de la caspase-3 qui entraîne la protéolyse de GATA-1, l’arrêt de maturation et l’apoptose des...

  12. Human erythroleukemia: is the two-hit model of mouse leukemogenesis valid in human disease?

    Coulon, Séverine; Vandekerckhove, Julie; Dussiot, Michael; Callens, Céline; Suarez, Frédéric; Kersual, Joelle; Asnafi, Vahid; Belaid, Zakia; Courtois, Geneviève; Giraudier, S; Dubreil, Patrice; Lepelletier, Yves; Moura, Ivan Cruz; Hermine, Olivier

  13. Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells

    Caers, Jo; Deleu, Sara; Belaid, Zakia; De Raeve, H.; Van Valckenborgh, E.; De Bruyne, Elke; Defresne, Marie-Paule; Van Riet, Ivan; Van Camp, Benjamin; Vanderkerken, Karin
    Peer reviewed

  14. Despite inhibition of hematopoietic progenitor cell growth in vitro, the tyrosine kinase inhibitor STI571 does not impair engraftment of human CD34+ cells into NOD/SCIDB2mNull mice

    Pirson, Laurence; Baron, Frédéric; Giet, Olivier; Meuris, Nathalie; Bours, Vincent; Fillet, Georges; Gothot, André; Beguin, Yves
    18th general meeting of the Belgian Hematological Society

  15. Despite inhibition of hematopoietic progenitor cell growth in vitro, the tyrosine kinase inhibior STI571 does not impair engraftment of human CD34+ cells into NOD/SCIDB2mNull mice

    Pirson, Laurence; Baron, Frédéric; Giet, Olivier; Meuris, Nathalie; Bours, Vincent; Fillet, Georges; Gothot, André; Beguin, Yves
    44th annual meeting and exposition of American Society of Hematology

  16. Despite inhibition of hematopoietic progenitor cell growth in vitro, the tyrosine kinase inhibitor STI571 does not impair engraftment of human CD34+ cells into NOD/SCIDB2mNull mice

    Pirson, Laurence; Baron, Frédéric; Giet, Olivier; Meuris, Nathalie; Bours, Vincent; Fillet, Georges; Gothot, André; Beguin, Yves
    32nd annual meeting of the International Society of Experimental Hematology

  17. The tyrosine kinase inhibitor Imatinib increases irradiation toxicity but does not impair engraftment of human CD34+ cells into NOD/SCIDB2mNull mice

    Pirson, Laurence; Baron, Frédéric; Giet, Olivier; Meuris, Nathalie; Bours, Vincent; Fillet, Georges; Gothot, André; Beguin, Yves
    19th general meeting of the Belgian Hematological Society

  18. Despite inhibition of hematopoietic progenitor cell growth in vitro, the tyrosine kinase inhibitor imatinib does not impair engraftment of human CD133+ cells into NOD/SCIDBeta2mNull

    Pirson, Laurence; Baron, Frédéric; Meuris, Nathalie; Giet, Olivier; Castermans, Emilie; Greimers, Roland; Di Stefano, I; Gothot, André; Beguin, Yves
    20th general meeting of the Belgian Hematological Society

  19. Impact of Imatinib on immune function in vitro

    Pirson, Laurence; Baron, Frédéric; Gothot, André; Beguin, Yves
    21th general meeting of the Belgian Hematological Society

  20. Definition of quality standards applicable to the purification and the expansion of mesenchymal stem cells for their use in haematopoietic, immunosuppressive and regenerative cellular therapy

    Briquet, Alexandra
    Université de Liège

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