Recursos de colección

ORBi Open Repository and Bibliography (317.084 recursos)

In may 2007, the ULg's Administrative Board (joined in June 2007 by the FUSAGx) decided to create an institutional repository and defined a strong institutional self-archiving policy to increase the visibility, accessibility and impact of the University's publications (Board's decision). This decision led to the official launch, in November 2008, of the ORBi platform including both the Academic Bibliography and the Institutional Repository of the Wallonia-Europe University Academy.

Human health sciences => Hematology

Mostrando recursos 41 - 60 de 60

  1. Role for PARs and thrombin-GPIbα interaction in thrombin induced procoagulant platelet formation

    Bourcy, Morgane; Wang, Samuel; Pasalic, Leonardo; Campbell, Heather; Liang, Helena; Chen, Vivien

  2. Demonstrating GPIbα-thrombin interaction in procoagulant platelet formation leads to identification of potential specific inhibitors.

    Bourcy, Morgane; Pasalic, Leonardo; Wang, Samuel; Campbell, Heather; Liang, Helena; Chen, Vivien
    Procoagulant platelets are a highly activated platelets-subpopulation which support thrombin generation. We previously reported that coronary artery disease (CAD) patients have excess procoagulant platelet response to thrombin. Thrombin directly activates platelets via cleavage of PAR1 and PAR4, but is also known to interact with GPIbα via exosite II. Aim: To understand the mechanism of thrombin induced procoagulant platelets and to generate novel antiplatelet therapies. Hypothesis: Involvement of both PAR-dependent and GPIbα-thrombin interaction pathways. Methods: Procoagulant platelets detected by FACS (GSAO, P-selectin, lactadherin) in whole blood and washed platelets after treatment with PAR, GPIbα, exosite II inhibitors and heparins prior to thrombin...


    VANDERMEULEN, Morgan; MAGGIPINTO, Gianni; JOURET, François; BEGUIN, Yves; DETRY, Olivier
    Peer reviewed

  4. Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group.

    Hillengass, J.; Moulopoulos, L. A.; Delorme, S.; Koutoulidis, V.; Mosebach, J.; Hielscher, T.; Drake, M.; Rajkumar, S. V.; Oestergaard, B.; Abildgaard, N.; Hinge, M.; Plesner, T.; Suehara, Y.; Matsue, K.; Waage, A.; Goldschmidt, H.; Dimopoulos, M. A.; Lentzsch, S.; Durie, B.; Terpos, E.; WITHOFS, Nadia; CAERS, Jo
    Peer reviewed

  5. Molecular mechanisms, current management and next generation therapy in myeloma bone disease.

    Heusschen, Roy; Muller, Joséphine; Duray, Elodie; WITHOFS, Nadia; Bolomsky, Arnold; Baron, Frédéric; Beguin, Yves; Menu, Eline; Ludwig, Heinz; Caers, Jo
    Peer reviewed

  6. L'anémie dans la bronchopneumopathie chronique obstructive sévère: une comorbidité plus fréquente que l'on ne croit

    Pirotte, Michèle; GUIOT, Julien; BEGUIN, Yves; LOUIS, Renaud
    Peer reviewed

  7. Effet of immune modulation in relapsed peripheral T-cell lymphomas after allogeneic stem cell transplantation: a study by the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)

    Mamez; Levy, V; Chevallier, P; Blaise, D; Vigouroux, S; Xhaard, A; Fegueux, N; Contentin, N; BEGUIN, Yves; Ifrah, N; Bulabois, CE; Suarez, F; Yakoub-Agha, I; Turlure, P; Deconink, E; Lamy, T; Cahn, J-Y; Huynh, A; Maury, S; Fornecker, L-M; Ouzegdouh, M; Bay, J-O; Guillerm, G; Maillard, N; Michallet, M; Malfuson, J-V; Bourhis, J-H; Rialland, F; Oumedaly, R; Jubert, C; Leblond, V; Boubaya, M; Mohty, M; Nguyen, S
    Peer reviewed

  8. Allogenic hematopoietic stem cell transplantation after reduced intensity conditioning regimen for elderly patients (60 years and older) with hematologic malignancies using unrelated donors: a retrospective study for the French society for stem cell transplantation (SFGM-TC)

    El Cheikh, J; Sfumato, P; Sobh, M; Fegueux, N; Mohty, M; Vigouroux, S; BEGUIN, Yves; Yakoub-Agha, I; Socié, G; Cornillon, J; Mercier, M; Bay, JO; Blaise, D; Michallet, M; Peffault de Latour, R
    Peer reviewed

  9. Comparative value of post-remission treatment in cytogenetically normal AML subclassified by NPM1 and FLT3-ITD allelic ratio.

    Versluis, J.; In 't Hout, F. E. M.; Devillier, R.; van Putten, W. L. J.; Manz, M. G.; Vekemans, M.-C.; Legdeur, M.-C.; Passweg, J. R.; Maertens, J.; Kuball, J.; Biemond, B. J.; Valk, P. J. M.; van der Reijden, B. A.; Meloni, G.; Schouten, H. C.; Vellenga, E.; Pabst, T.; Willemze, R.; Lowenberg, B.; Ossenkoppele, G.; Baron, Frédéric; Huls, G.; Cornelissen, J. J.
    Peer reviewed

  10. Low-dose clofarabine in combination with a standard remission induction in patients aged 18-60 years with previously untreated intermediate and bad-risk acute myeloid leukemia or high-risk myelodysplastic syndrome: Combined phase I/II results of the EORTC/GIMEMA AML-14A trial

    Selleslag, Dominik; Suciu, Stefan; Meloni, Giovanna; Muus, Petra; Halkes, Constantijn J. M.; Venditti, Adriano; Ramadan, Safaa M.; Pruijt, Hans; Meert, Liv; Vignetti, Marco; Marie, Jean-Pierre; Wittnebel, Sebastian; de Witte, Theo; Amadori, Sergio; Willemze, Roelof; Baron, Frédéric
    Peer reviewed

  11. Erratum: Elevated basal levels of circulating activated platelets predict ICU-acquired sepsis and mortality: a prospective study.

    LAYIOS, Nathalie; Delierneux, Céline; Hego, A.; HUART, Justine; Joly, Arnaud; Geurts, Pierre; DAMAS, Pierre; Lecut, C.; Gothot, Andre; Oury, Cécile
    Peer reviewed

  12. Erratum: Prospective immune profiling in critically ill adults: before, during and after severe sepsis and septic shock.

    Layios, N.; GOSSET, Christian; Delierneux, Céline; Hego, A.; HUART, Justine; Joly, Arnaud; Geurts, Pierre; DAMAS, Pierre; Oury, Cécile; Gothot, Andre
    Peer reviewed

  13. Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

    Cuende, Julia; Liénart, Stéphanie; Dedobbeleer, Olivier; van der Woning, Bas; De Boeck, Gitte; Stockis, Julie; Huygens, Caroline; Colau, Didier; Somja, Joan; Delvenne, Philippe; Hannon, Muriel; Baron, Frédéric; Dumoutier, Laure; Renauld, Jean-Christophe; De Haard, Hans; Saunders, Michael; Coulie, Pierre; Lucas, Sophie
    Peer reviewed

  14. The role of mesenchymal stromal cells in the treatment of ulcerative colitis and Crohn’s disease

    GREGOIRE, Céline; Louis, Edouard; BRIQUET, Alexandra; LECHANTEUR, Chantal; BAUDOUX, Etienne; GIET, Olivier; Beguin, Yves; BARON, Frédéric
    Peer reviewed

  15. Multiparameter flow cytometric analysis of composite lymphoma: case report of a mantle cell lymphoma associated with a B-cell chronic lymphocytic leukemia and an aberrant T cell subset

    FOGUENNE, Jacques; SIMUL, Mickael; KEUTGENS, Aurore; TASSIN, Françoise; Bonnet, Christophe; BEGUIN, Yves; JAMAR, Mauricette; LAMBERT, Frédéric; GOTHOT, André
    Peer reviewed

  16. A European patient record study on diagnosis and treatment of chemotherapy-induced anaemia

    Ludwig, Heinz P.; Aapro, Matti S.; Bokemeyer, Carsten; Glaspy, John A.; Hedenus, Michael; Littlewood, Tim James; Osterborg, Anders C.; Rzychon, Beate; Mitchell, Daniell; BEGUIN, Yves
    Peer reviewed

  17. Prognostic importance of exercise-induced changes in mitral regurgitation in patients with chronic ischemic left ventricular dysfunction

    Lancellotti, Patrizio; Troisfontaines, P.; Toussaint, A. C.; PIERARD, Luc
    Peer reviewed

  18. Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts

    Relic, Biserka; Zeddou, Mustapha; Desoroux, Aline; Beguin, Yves; De Seny, Dominique; Malaise, Michel
    It was shown recently that synovial fibroblast transformation into adipocytes reduced the expression of interleukin-6 (IL-6) and IL-8. However, the synovial fibroblast adipogenesis was inhibited in inflammatory conditions induced by the tumor necrosis factor-alpha (TNF-alpha). Furthermore, adipogenesis is often accompanied by leptin production, a proinflammatory adipokine in rheumatic diseases. In this study, we tested the phytohormone genistein for adipogenic and anti-inflammatory properties on human synovial fibroblasts. Results showed that genistein was able to transform synovial fibroblasts into adipocytes that expressed perilipin-A and produced adiponectin, but not leptin. Furthermore, genistein enhanced glucocorticoid-mediated synovial fibroblast adipogenesis and, in parallel, downregulated glucocorticoid-induced leptin and...

  19. Contribution of glycoproteomics in the search for accessible biomarkers in human lymphoma

    Kischel, Philippe; Greffe, Yannick; Waltregny, David; Chrétien, N.; Mazzucchelli, Gabriel; De Pauw, Edwin; de Leval, Laurence; Castronovo, Vincenzo

  20. Simultaneous alteration of de novo and salvage pathway to the deoxynucleoside triphosphate pool by (E)-2′-Deoxy-(fluoromethylene) cytidine (FMdC) and zidovudine (AZT) results in increased radiosensitivity in vitro

    Coucke, Philippe; Cottin, Eliane; Decosterd, Laurent A.
    Peer reviewed

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