Recursos de colección

ORBi Open Repository and Bibliography (285.497 recursos)

In may 2007, the ULg's Administrative Board (joined in June 2007 by the FUSAGx) decided to create an institutional repository and defined a strong institutional self-archiving policy to increase the visibility, accessibility and impact of the University's publications (Board's decision). This decision led to the official launch, in November 2008, of the ORBi platform including both the Academic Bibliography and the Institutional Repository of the Wallonia-Europe University Academy.

Human health sciences => Hematology

Mostrando recursos 601 - 620 de 1.063

  1. Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients.

    De Bruyne, Elke; Andersen, TL; De Raeve, Hendrik; Van Valckenborgh, Els; Caers, Jo; Van Camp, Ben; Delaisse, JM; Van Riet, Ivan; Vanderkerken, Karin

  2. Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells

    Caers, Jo; Deleu, S; Belaid, Zakia; De Raeve, H; Van Valckenborgh, E; De Bruyne, E; Defresne, Marie-Paule; Van Riet, I; Van Camp, B; Vanderkerken, K
    Groupe Interdisciplinaire de Génoprotéomique appliquée

  3. Antitumor and anti-angiogenic effects of aplidin in the 5T33MM model, syngeneic model of multiple myeloma

    Caers, Jo; De Raeve, Hendrik; Lepage, Doreen; Van Valckenborgh, Els; Menu, Eline; Alvarez, Enrique; Van Camp, Ben; Vanderkerken, Karin

  4. Multiple Myeloma, an update on diagnosis and treatment.

    Caers, Jo; Vande Broek, Isabelle; De Raeve, Hendrik; Michaux, Lucienne; Trullemans, Fabienne; Schots, Rik; Van Camp, Ben; Vanderkerken, Karin

  5. Thymosin beta4 in multiple myeloma: friend or foe

    Caers, Jo; Otjacques, Eléonore; Hose, Dirk; Klein, Bernard; Vanderkerken, Karin

  6. Thymosin Beta 4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma

    Caers, Jo; Hose, Dirk; Kuijpers, Ine; Bos, Tomas; Van Valckenborgh, Els; Menu, Eline; De Bruyne, Elke; Goldschmidt, Harmut; Van Camp, Ben; Klein, Bernard; Vanderkerken, Karin

  7. Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion.

    Bisig, Bettina; Copie-Bergman, Christiane; Baia, Maryse; Gaulard, Philippe; Delbecque, Katty; Fassotte, Marie-France; Boniver, Jacques; de Leval, Laurence
    The genetic alterations underlying extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type are heterogeneous and show variation according to the tumor site. Here, we report a case of mucosa-associated lymphoid tissue lymphoma of the gallbladder with genetic characterization. This lymphoma, diagnosed in a 75-year-old woman who underwent cholecystectomy for suspected acute cholecystitis, presented as diffuse thickening of the gallbladder wall. The morphology was typical of mucosa-associated lymphoid tissue lymphoma, and by immunophenotype, the tumor cells were CD20+ CD5- CD10- CD23- CD43- BCL6- BCL2+ IgM+ IgD- lambda+, with moderate nuclear expression of BCL10. Interphase fluorescence in situ hybridization analysis...

  8. Developmental and evolutionary aspects of thymic T-cell education to neuroendocrine self

    Geenen, Vincent
    Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS

  9. Soluble CD23 and other receptors (CD4, CD8, CD25, CD71) in serum of patients with chronic lymphocytic leukemia.

    Beguin, Yves; Lampertz, S; De Groote, D; Igot, D; Malaise, Michel; Fillet, Georges
    We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL) and evaluated them in relation to clinical and biological parameters of the disease, as well as serum immunoglobulin E (IgE). Compared to 31 normal individuals, 42 CLL patients had increased levels of sCD23 (98.4 +/- 127.7 versus 0.9 +/- 0.3 U/ml, p < 0.001), sIL-2R (6080 +/- 7030 versus 1420 +/- 640 pg/ml, p < 0.001), sTfR (12,100 +/- 11,250 versus 5000 +/- 1050 ng/ml, p < 0.001), and sCD8 (510...

  10. Effective treatment of Jo-1-associated polymyositis with T-cell-depleted autologous peripheral blood stem cell transplantation.

    Baron, Frédéric; Ribbens, Clio; Kaye, O; Fillet, Georges; Malaise, Michel; Beguin, Yves
    A patient with Jo-1 antibody-associated polymyositis (Jo-1 PM) had a Karnofsky score of 40% and severe muscle, liver and lung damage that was refractory to standard therapy. The female patient received an autologous T-cell-depleted haematopoietic stem cell transplant (HSCT) after myeloablative conditioning. The transplant procedure was complicated by severe adult respiratory distress syndrome (ARDS) and adenovirus-associated haemorrhagic cystitis as well as cytomegalovirus (CMV) reactivation. The patient's creatinine phosphokinase (CPK) and alanine transaminase (ALT) values were normal on day 21. The patient's strength has improved remarkably and her dyspnoea is subjectively improved. At 15 months after the transplant, the patient was...

  11. Increased synovial fluid levels of soluble CD23 are associated with an erosive status in rheumatoid arthritis (RA).

    Ribbens, Clio; Bonnet, V; Kaiser, Marie-Joëlle; Andre, Béatrice; Kaye, O; Franchimont, N.; De Groote, D; Beguin, Yves; Malaise, Michel
    Synovial fluid (SF) levels of soluble CD23 (sCD23) were determined in 96 patients presenting with an inflammatory knee effusion (73 with RA and 23 with reactive arthritis (ReA) serving as a control inflammatory non-erosive group) and were correlated with the degree of joint destruction, with local immune parameters (IL-1beta, IL-3, IL-4, IL-6, IL-8, IL-10, IL-12 and sCD25) and with serum markers of inflammation, C-reactive protein and erythrocyte sedimentation rate. RA patients, classified as erosive or not according to Larsen's grade, were separated as follows: (i) 13 patients with non-erosive RA; (ii) 16 RA patients with erosions in hands but not...

  12. Alone or in concert with glucocorticoids, genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts

    Relic, Biserka; Zeddou, Mustapha; Desoroux, Aline; Beguin, Yves; De Seny, Dominique; Malaise, Michel
    It was shown recently that synovial fibroblast transformation into adipocytes reduced the expression of interleukin-6 (IL-6) and IL-8. However, the synovial fibroblast adipogenesis was inhibited in inflammatory conditions induced by the tumor necrosis factor-alpha (TNF-alpha). Furthermore, adipogenesis is often accompanied by leptin production, a proinflammatory adipokine in rheumatic diseases. In this study, we tested the phytohormone genistein for adipogenic and anti-inflammatory properties on human synovial fibroblasts. Results showed that genistein was able to transform synovial fibroblasts into adipocytes that expressed perilipin-A and produced adiponectin, but not leptin. Furthermore, genistein enhanced glucocorticoid-mediated synovial fibroblast adipogenesis and, in parallel, downregulated glucocorticoid-induced leptin and...

  13. Alone or in concert with glucocorticoids, genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts

    Relic, Biserka; Zeddou, Mustapha; Desoroux, Aline; Beguin, Yves; De Seny, Dominique; Malaise, Michel
    It was shown recently that synovial fibroblast transformation into adipocytes reduced the expression of interleukin-6 (IL-6) and IL-8. However, the synovial fibroblast adipogenesis was inhibited in inflammatory conditions induced by the tumor necrosis factor-alpha (TNF-alpha). Furthermore, adipogenesis is often accompanied by leptin production, a proinflammatory adipokine in rheumatic diseases. In this study, we tested the phytohormone genistein for adipogenic and anti-inflammatory properties on human synovial fibroblasts. Results showed that genistein was able to transform synovial fibroblasts into adipocytes that expressed perilipin-A and produced adiponectin, but not leptin. Furthermore, genistein enhanced glucocorticoid-mediated synovial fibroblast adipogenesis and, in parallel, downregulated glucocorticoid-induced leptin and...

  14. Association of acute leukemia and autoimmune polyendocrine syndrome in two kindreds.

    Willems, Evelyne; Valdes Socin, Hernan Gonzalo; Betea, Daniela; Beckers, Albert; Beguin, Yves

  15. Association of acute leukemia and autoimmune polyendocrine syndrome in two kindreds.

    Willems, Evelyne; Valdes Socin, Hernan Gonzalo; Betea, Daniela; Beckers, Albert; Beguin, Yves

  16. Traitement moléculaire du cancer: le STI571, un inhibiteur des tyrosines kinases

    Humblet-Baron, Stéphanie; Baron, Frédéric; Pirson, Laurence; Beguin, Yves; Fillet, Georges

  17. Traitement moléculaire du cancer: le STI571, un inhibiteur des tyrosines kinases

    Humblet-Baron, Stéphanie; Baron, Frédéric; Pirson, Laurence; Beguin, Yves; Fillet, Georges

  18. Effect of a novel thromboxane A(2) inhibitor on right ventricular-arterial coupling in endotoxic shock

    Lambermont, Bernard; Kolh, Philippe; Ghuysen, Alexandre; Segers, P; Dogné, Jean-Michel; Tchana-Sato, Vincent; Morimont, Philippe; Benoit, P; Gérard, Paul; Masereel, B; D'Orio, Vincenzo
    We investigated the effects of a dual thromboxane (TX)A(2) synthase inhibitor and TXA(2) receptor antagonist (BM-573) on right ventricular-arterial coupling in a porcine model of endotoxic shock. Thirty minutes before the onset of 0.5 mg/kg endotoxin infusion, six pigs (Endo group) received an infusion with a placebo solution, and six other pigs (Anta group) with BM-573. Right ventricular pressure-volume loops were obtained by the conductance catheter technique. The slope (E-es) of the end-systolic pressure-volume relationship and its volume intercept at 25 mmHg were calculated as measures of right ventricular systolic function. RV afterload was quantified by pulmonary arterial elastance (E-a),...

  19. A propos d'un cas de rhabdomyolyse aigue

    Rorive, Andrée; Fraipont, V; Quatresooz, Pascale; Cataldo, Didier; Dubois, Bernard; Fillet, Georges
    A 83 years old patient was admitted with a complex clinical picture including cutaneous rash, muscular pain, rhabdomyolysis and renal failure. The clinical picture suggests a dermatopolymyositis. Despite of high dose corticotherapy, the patient died on day 22. The anatomical examination shows a cholangiocarcinoma disseminated locally as well as in the lungs and bones.

  20. Contribution of glycoproteomics in the search for accessible biomarkers in human lymphoma

    Kischel, Philippe; Greffe, Yannick; Waltregny, David; Chrétien, N; Mazzucchelli, Gabriel; De Pauw, Edwin; de Leval, Laurence; Castronovo, Vincenzo
    FNRS Contact Group Proteomics (GCProt) 4th annual meeting: Chromatin Modifications and Protein Glycosylation

Aviso de cookies: Usamos cookies propias y de terceros para mejorar nuestros servicios, para análisis estadístico y para mostrarle publicidad. Si continua navegando consideramos que acepta su uso en los términos establecidos en la Política de cookies.