ORBi Open Repository and Bibliography
In may 2007, the ULg's Administrative Board (joined in June 2007 by the FUSAGx) decided to create an institutional repository and defined a strong institutional self-archiving policy to increase the visibility, accessibility and impact of the University's publications (Board's decision).
This decision led to the official launch, in November 2008, of the ORBi platform including both the Academic Bibliography and the Institutional Repository of the Wallonia-Europe University Academy.
Human health sciences => Radiology, nuclear medicine & imaging
Cerebral functional connectivity periodically (de)synchronizes with anatomical constraints - Liegeois, Raphaël; Sepulchre, Rodolphe; LAUREYS, Steven
This paper studies the link between resting-state functional connectivity (FC), measured by the correlations of the fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber tractography. Instead of a static analysis based on the correlation between SC and the FC averaged over the entire fMRI time series, we propose a dynamic analysis, based on the time evolution of the correlation between SC and a suitably windowed FC. Assessing the statistical significance of the time series against random phase permutations, our data show a pronounced peak of significance for time window widths around 20-30 TR (40-60 sec). Using the...
Evaluation des états de conscience altérée en IRM multimodale - TSHIBANDA, Luaba
Notre travail s’articule autour de deux axes. D’une part nous participons aux travaux de recherches des membres du ComaScienceGroup utilisant les données de Tenseur de diffusion et de fMRI que nous acquérons en IRM 3 Tesla et d’autre part nous procédons à l’évaluation de l’intérêt de la spectroscopie protonique dans le bilan des états de conscience altérée par rapport au gold standard qu'est le PETScan FDG.
Design and synthesis of high-affinity ligands of AMPA receptors and study of their Fluorine-18 radiolabeling - Deverdenne, François; Goffin, Eric; Plenevaux, Alain; Pirotte, Bernard; Luxen, André; Francotte, Pierre
The AMPA subtype of glutamatergic receptors is the main actor in the excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the maintenance of the long-term potentiation, a phenomenon closely linked to cognitive and memorization processes. Based on experimental data collected in recent years, the use of AMPA potentiators seems to be an interesting approach in the treatment of cognitive deficits (e.g. Alzheimer disease), schizophrenia or depression. Such AMPA signal potentiation could be mediated by positive allosteric modulators (PAMs) of the AMPA receptors, a class of compounds able to produce a fine signal...