ORBi Open Repository and Bibliography
In may 2007, the ULg's Administrative Board (joined in June 2007 by the FUSAGx) decided to create an institutional repository and defined a strong institutional self-archiving policy to increase the visibility, accessibility and impact of the University's publications (Board's decision).
This decision led to the official launch, in November 2008, of the ORBi platform including both the Academic Bibliography and the Institutional Repository of the Wallonia-Europe University Academy.
Human health sciences => Radiology, nuclear medicine & imaging
Hormonosubstitution postmenopausique et risque de cancer mammaire: une mise a jour. - van den Brule, F.; LIFRANGE, Eric; Pintiaux, A.; Foidart, Jean-Michel; Gaspard, Ulysse
Numerous studies have examined the risk of breast cancer in patients with postmenopausal hormone substitution. Most of these studies are retrospective, and a few recent studies are prospective. The observed results present with weak variations from baseline and major heterogeneity. Some studies highlight a slightly increased relative risk of breast cancer. A reanalysis of 51 studies demonstrates a relative risk of 1.35 for developing breast cancer during hormone substitution, with a 2.3% increased risk per year of use. Recently, the results of the WHI study have shown a slight increase of some risks of disease, including breast cancer (relative risk,...
En Bloc Excision of Nonpalpable Breast Lesions Using the Advanced Breast Biopsy Instrumentation System: An Alternative to Needle Guided Surgery? - Lifrange, Eric; Dondelinger, R. F.; Fridman, Viviana; Colin, Claude
This study was prospectively conducted to evaluate the clinical potential of the advanced breast biopsy instrumentation (ABBI) system as an alternative to needle localization and open surgery in the management of nonpalpable breast lesions (NPBL). One hundred and eighty-six consecutive patients were referred for management of NPBL. Thirty-six underwent an ABBI procedure, offered as a first step before possible surgery for lesions which would in any case have required complete excision. The 18 patients with a malignant ABBI biopsy underwent re-excision of the biopsy site and axillary dissection was carried out in cases of infiltrating carcinoma. The other 150 patients...
Single photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice. - JOURET, François; Walrand, Stephan; Parreira, Kleber S.; Courtoy, Pierre J.; Pauwels, Stanislas; Devuyst, Olivier; Jamar, Francois
Noninvasive analysis of renal function in conscious mice is necessary to optimize the use of mouse models. In this study, we evaluated whether single photon emission-computed tomography (SPECT) using specific radionuclear tracers can be used to analyze changes in renal proximal tubule functions. The tracers included (99m)TC- dimercaptosuccinic acid ((99m)Tc-DMSA), which is used for cortex imaging; (99m)Tc-mercaptoacetyltriglycine ((99m)Tc-MAG3), used for dynamic renography; and (123)I-beta(2)-microglobulin, which monitors receptor-mediated endocytosis. (99m)Tc-DMSA SPECT imaging was shown to delineate the functional renal cortex with a approximately 1-mm spatial resolution and accumulated in the cortex reaching a plateau 5 h after injection. The cortical uptake...
Positron-emission computed tomography in cyst infection diagnosis in patients with autosomal dominant polycystic kidney disease. - JOURET, François; Lhommel, Renaud; Beguin, Claire; Devuyst, Olivier; Pirson, Yves; Hassoun, Ziad; Kanaan, Nada
BACKGROUND: Cyst infection remains a challenging issue in patients with autosomal dominant polycystic kidney disease (ADPKD). In most patients, conventional imaging techniques are inconclusive. Isolated observations suggest that (18)fluorodeoxyglucose ((1)(8)FDG) positron-emission computed tomography (PET/CT) might help detect cyst infection in ADPKD patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Comparative assessment of administrative databases from January 2005 to December 2009 identified 27 PET/CT scans performed in 24 ADPKD patients for suspicion of abdominal infection. Cyst infection was definite if confirmed by cyst fluid analysis. Cyst infection was probable if all four of the following criteria were met: temperature of >38 degrees C...
Neural correlates of hypokinetic gait in Parkinson’s disease: An fMRI study - Cremers, Julien; Stamatakis, Julien; D'Ostilio, Kevin; Garraux, Gaëtan
Objective: To investigate the neural correlates of hypokinetic gait in Parkinson’s disease (PD) using functional magnetic resonance imaging (fMRI).
Background: Although hypokinetic gait is frequent and has a negative impact on quality of life in PD, its underlying mechanisms remain poorly understood. Assuming that the brain regions recruited during real and imagined gait strongly overlap, mental imagery of brisk gait may be a successful approach to study hypokinetic gait in PD.
Methods: Fifteen ‘‘on-drugs’’ PD patients (8 males; mean age 5 65.1 6 9.4 years) and fifteen controls matched for age, gender and mental imagery skills were trained to perform video-taped trials...
Brain activation pattern related to gait disturbances in Parkinson's disease. - Cremers, Julien; D'Ostilio, Kevin; Stamatakis, Julien; DELVAUX, Valérie; GARRAUX, Gaëtan
Gait disturbances represent a therapeutic challenge in Parkinson's disease (PD). To further investigate their underlying pathophysiological mechanisms, we compared brain activation related to mental imagery of gait between 15 PD patients and 15 age-matched controls using a block-design functional MRI experiment. On average, patients showed altered locomotion relatively to controls, as assessed with a standardized gait test that evaluated the severity of PD-related gait disturbances on a 25-m path. The experiment was conducted in the subjects as they rehearsed themselves walking on the same path with a gait pattern similar as that during locomotor evaluation. Imagined walking times were measured...
Quantitative capabilities of four state-of-the-art SPECT-CT cameras - Seret, Alain; Nguyen, Daniel; BERNARD, Claire
Background. Four state-of-the-art single-photon emission computed tomography-computed tomography (SPECT-CT) systems, namely Philips Brightview, General Electric Discovery NM/CT 670 and Infinia Hawkeye 4, and Siemens Symbia T6, were investigated in terms of accuracy of attenuation and scatter correction, contrast recovery for small hot and cold structures, and quantitative capabilities when using their dedicated three-dimensional iterative reconstruction with attenuation and scatter corrections and resolution recovery. Methods. The National Electrical Manufacturers Association (NEMA) NU-2 1994 phantom with cold air, water, and Teflon inserts, and a homemade contrast phantom with hot and cold rods were filled with 99mTc and scanned. The acquisition parameters were...
Echographic Characterization of Carotid Plaques - VAN DAMME, Hendrik; TROTTEUR, Geneviève; Vivario, M.; Limet, Raymond
The histology of the endarterectomy specimen was compared with the preoperative echopattern of 154 plaques. Thirty-four ultrasound images were of poor quality. The 120 adequate echographies revealed 22 dense hyperechogenic homogeneous plaques, 28 soft hypoechogenic homogeneous plaques, 53 inhomogeneous plaques, and 13 mixed plaques. According to the surface, lesions were subdivided as smooth (n = 63) or irregular (n = 57). Echography recognized fibrous plaques (dense homogeneous hyperechogeneous lesions), with a specificity of 87% and a sensitivity of 56%. Recent intraplaque haemorrhage is echographically apparent as a hypoechogenic area in 88% of cases, what corresponds to a specificity of 79%...
Epimerization study on [18F]FDG produced by an alkaline hydrolysis on solid support under stringent conditions - Mosdzianowski, C.; Lemaire, Christian; Simoens, F.; Aerts, Joël; Morelle, J. L.; Luxen, André
Since 1998, routine [18F]FDG syntheses are being carried out by alkaline hydrolysis on a solid support, i.e. the labeled intermediate is trapped on a tC18 solid phase extraction cartridge, purified and finally hydrolyzed within the cartridge, at room temperature, using sodium hydroxide. The present study demonstrated that no epimerization of [18F]FDG to [18F]FDM occurs even when 12 N NaOH is used and when the hydrolysis time is extended up to 1 h. The alkaline hydrolysis on solid support appears to be a simple method leading to [18F]FDG with high purity.
Evaluation of the Solitary Pulmonary Nodule by Positron Emission Tomography Imaging - BURY, Thierry; Dowlati, A.; Paulus, P.; CORHAY, Jean-Louis; Benoit, T.; Kayembe, J. M.; Limet, Raymond; Rigo, P.; RADERMECKER, Marc
Current noninvasive imaging methods are not sufficiently reliable for accurate detection of malignancy in most solitary pulmonary nodules (SPNs). Positron emission tomography (PET) using 18-fluorodeoxyglucose (FDG), showing increased FDG uptake and retention in malignant cells, has proved useful to differentiate malignant from benign tissue and could, therefore, contribute to the evaluation of the SPN. We performed a prospective study of 50 patients referred to the Pneumology Department with unclear diagnoses of SPN after conventional radiological screening. PET study was performed on each subject before an invasive procedure was proposed. Thirty three patients had a malignant nodule and 17 had a...