PubMed Central (PMC3 - NLM DTD)
(2,081,148 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
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Transphosphorylation of kinase-dead HER3 and breast cancer progression: a new standpoint or an old concept revisited? - Menendez, Javier A; Lupu, Ruth
Although neither kinase-dead human epidermal growth factor receptor (HER)3 nor orphan HER2 can be activated by HER-related ligands on their own, the formation of HER2/HER3 heterodimers creates the most mitogenic and transforming receptor complex within the HER (erbB) family of transmembrane receptor tyrosine kinases. The incorporation of markers such as HER3 transactivation, HER2/HER3 dimer, or others that may provide information regarding the level of HER pathway engagement has been demonstrated to allow identification of patients who respond to or escape HER-targeted therapies. Pioneering studies showed that high expression of kinase-dead HER3 can predict early escape from the anti-HER2 monoclonal antibody...
104.
P-cadherin expression in breast cancer: a review - Paredes, Joana; Correia, Ana Luísa; Ribeiro, Ana Sofia; Albergaria, André; Milanezi, Fernanda; Schmitt, Fernando C
P-cadherin is frequently over-expressed in high-grade invasive breast carcinomas and has been reported to be an enhancer of migration and invasion of breast cancer cells, being correlated with tumour aggressiveness. In addition, expression of P-cadherin is well established as an indicator of poor prognosis in human breast cancer, which has stimulated our interest in studying its role in this setting. This review describes the most important findings on P-cadherin expression and function in normal mammary tissue and breast cancer cells, emphasizing that further research is required to elucidate the role played by this protein in human mammary tumours.
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Live or let die: oestrogen regulation of survival signalling in endocrine response - Butt, Alison J; Sutherland, Robert L; Musgrove, Elizabeth A
The growth of both normal and neoplastic tissues is determined by a balance between cell proliferation and cell death. Thus, understanding how these processes not only drive tumour growth dynamics but also influence therapeutic responsiveness may aid in the development of more effective cancer treatments. Oestrogen is a major aetiological factor in the development and progression of breast cancer, and its effects in driving breast cancer cell proliferation have been extensively studied. What is less well understood is how oestrogen's role as a survival factor influences breast tumour growth and response to therapy. Recent gene expression profiling studies in breast...
115.
Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes - Nordgard, Silje H; Johansen, Fredrik E; Alnæs, Grethe IG; Naume, Bjørn; Børresen-Dale, Anne-Lise; Kristensen, Vessela N
Recently, genome-wide association studies of breast cancer revealed single nucleotide polymorphisms (SNPs) in five genes with novel association to susceptibility. While there is little doubt that the novel susceptibility markers produced from such highly powered studies are true, the mechanisms by which they cause the susceptibility remain undetermined. We have looked at the expression levels of the identified genes in tumours and found that they are highly significantly differentially expressed between the five established breast cancer subtypes. Also, a significant association between SNPs in these genes and their expression in tumours was seen as well as a significantly different frequency...
116.
Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer - Mastracci, Teresa L; Boulos, Fouad I; Andrulis, Irene L; Lam, Wan L
Advances in genomic technology have improved our understanding of the genetic events that parallel breast cancer development. Because almost all mammary carcinomas develop in the terminal duct lobular units of the breast, understanding the events involved in mammary gland development make it possible to recognize those events that, when altered, contribute to breast neoplasia. In this review we focus on lobular carcinomas, discussing the pathology, development, and progression of premalignant lobular lesions from a genomic point of view. We highlight studies utilizing genomic approaches and describe how these investigations have furthered our understanding of the complexity of premalignant breast lesions.
118.
The promise and limitations of genome-wide association studies to elucidate the causes of breast cancer - Ambrosone, Christine B
With the characterization of the human genome, as well as advances in technology to determine genetic variability across the genomes of populations, there has been focused effort on the identification of cancer susceptibility alleles through the use of genome-wide association studies. These efforts have recently resulted in identification of a susceptibility locus for breast cancer by several groups, although the increases in risk are modest. While genome-wide association studies will probably lead to discoveries of potentially important previously unstudied pathways in cancer etiology, the role of the environment, particularly geneenvironment interactions, in breast cancer etiology should not be overlooked.
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