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PubMed Central (PMC3 - NLM DTD) (2,823,233 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

PMC full-text journals

Mostrando recursos 1 - 20 de 433,729

1. Evaluating a variety of text-mined features for automatic protein function prediction with GOstruct - Funk, Christopher S; Kahanda, Indika; Ben-Hur, Asa; Verspoor, Karin M
Most computational methods that predict protein function do not take advantage of the large amount of information contained in the biomedical literature. In this work we evaluate both ontology term co-mention and bag-of-words features mined from the biomedical literature and analyze their impact in the context of a structured output support vector machine model, GOstruct. We find that even simple literature based features are useful for predicting human protein function (F-max: Molecular Function =0.408, Biological Process =0.461, Cellular Component =0.608). One advantage of using literature features is their ability to offer easy verification of automated predictions. We find through manual...

2. In vitro study of the potential protection of sound enamel against demineralization - Montasser, Mona A; El-Wassefy, Noha A; Taha, Mahasen

3. Closing the Mad2 cycle - Musacchio, Andrea
Chromosome separation is regulated by a cycle that involves a protein undergoing an unusual topological conversion.

4. Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein–Protein Interactions - Lao, Brooke Bullock; Drew, Kevin; Guarracino, Danielle A.; Brewer, Thomas F.; Heindel, Daniel W.; Bonneau, Richard; Arora, Paramjit S.

5. Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound - Thomas, James B.; Giddings, Angela M.; Wiethe, Robert W.; Olepu, Srinivas; Warner, Keith R.; Sarret, Philippe; Gendron, Louis; Longpre, Jean-Michel; Zhang, Yanan; Runyon, Scott P.; Gilmour, Brian P.

6. In Vivo Imaging of GLP-1R with a Targeted Bimodal PET/Fluorescence Imaging Agent - Brand, Christian; Abdel-Atti, Dalya; Zhang, Yachao; Carlin, Sean; Clardy, Susan M.; Keliher, Edmund J.; Weber, Wolfgang A.; Lewis, Jason S.; Reiner, Thomas

7. Keratoacanthoma Pathobiology in Mouse Models - Gibson-Corley, Katherine N.; Rogers, Laura M.; Goeken, Adam; Dupuy, Adam J.; Meyerholz, David K.
Recently we described skin tumors driven by skin-specific expression of Zmiz1 and here we define keratoacanthoma pathobiology in this mouse model. Similar to human keratoacanthoma development, we were able to segregate murine keratoacanthomas into three developmental phases: growth, maturation, and regression. These tumors had areas with cellular atypia, high mitotic rate, and minor local invasion in the growth phase, but with development they transitioned to maturation and regression phases with evidence of resolution. The early aggressive appearance could easily be misdiagnosed as a malignant change if the natural pathobiology was not well-defined in the model. To corroborate these findings in...

8. Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer - Farwell, Christopher C.; McIntosh, John A.; Hyster, Todd K.; Wang, Z. Jane; Arnold, Frances H.

9. Phenotypic Mapping of Metabolic Profiles Using Self-Organizing Maps of High-Dimensional Mass Spectrometry Data - Goodwin, Cody R.; Sherrod, Stacy D.; Marasco, Christina C.; Bachmann, Brian O.; Schramm-Sapyta, Nicole; Wikswo, John P.; McLean, John A.

10. Engineering Vascularized Bone Grafts by Integrating a Biomimetic Periosteum and β-TCP Scaffold - Kang, Yunqing; Ren, Liling; Yang, Yunzhi

11. Probing the Non-Native H Helix Translocation in Apomyoglobin Folding Intermediates - Aoto, Phillip C.; Nishimura, Chiaki; Dyson, H. Jane; Wright, Peter E.

12. Mechanisms of Selenomethionine Developmental Toxicity and the Impacts of Combined Hypersaline Conditions on Japanese Medaka (Oryzias latipes) - Kupsco, Allison; Schlenk, Daniel

13. Hydrogen Peroxide Formation in a Surrogate Lung Fluid by Transition Metals and Quinones Present in Particulate Matter - Charrier, Jessica G.; McFall, Alexander S.; Richards-Henderson, Nicole K.; Anastasio, Cort

14. Hydrogen Sulfide Deactivates Common Nitrobenzofurazan-Based Fluorescent Thiol Labeling Reagents - Montoya, Leticia A.; Pluth, Michael D.

15. Intrinsic Conformational Plasticity of Native EmrE Provides a Pathway for Multidrug Resistance - Cho, Min-Kyu; Gayen, Anindita; Banigan, James R.; Leninger, Maureen; Traaseth, Nathaniel J.

16. Enantiospecific Intramolecular Heck Reactions of Secondary Benzylic Ethers - Harris, Michael R.; Konev, Mikhail O.; Jarvo, Elizabeth R.

17. The Redox-Mannich Reaction - Chen, Weijie; Seidel, Daniel

18. Dual-Emissive Difluoroboron Naphthyl-Phenyl β-Diketonate Polylactide Materials: Effects of Heavy Atom Placement and Polymer Molecular Weight - Samonina-Kosicka, Jelena; DeRosa, Christopher A.; Morris, William A.; Fan, Ziyi; Fraser, Cassandra L.

19. Management of anticoagulant-related intracranial hemorrhage: an evidence-based review - Ray, Bappaditya; Keyrouz, Salah G
The increased use of anticoagulants for the prevention and treatment of thromboembolic diseases has led to a rising incidence of anticoagulant-related intracranial hemorrhage (AICH) in the aging western population. High mortality accompanies this form of hemorrhagic stroke, and significant and debilitating long-term consequences plague survivors. Although management guidelines for such hemorrhages are available for the older generation anticoagulants, they are still lacking for newer agents, which are becoming popular among physicians. Supportive care, including blood pressure control, and reversal of anticoagulation remain the cornerstone of acute management of AICH. Prothrombin complex concentrates are gaining popularity over fresh frozen plasma, and...

20. β-blockers in critically ill patients: from physiology to clinical evidence - Coppola, Silvia; Froio, Sara; Chiumello, Davide
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at Further information about the Annual Update in Intensive Care and Emergency Medicine is available from

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