PubMed Central (PMC3 - NLM DTD)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
Muscle regeneration after sepsis - Bouglé, Adrien; Rocheteau, Pierre; Sharshar, Tarek; Chrétien, Fabrice
Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but muscle regeneration has not been investigated to any extent in this context, even though its involvement is suggested by the protracted functional consequences of ICU-AW. Recent data suggest that muscle regeneration could be impaired after sepsis, and that mesenchymal stem cell treatment could improve the post-injury muscle recovery.
An adaptive association test for microbiome data - Wu, Chong; Chen, Jun; Kim, Junghi; Pan, Wei
There is increasing interest in investigating how the compositions of microbial communities are associated with human health and disease. Although existing methods have identified many associations, a proper choice of a phylogenetic distance is critical for the power of these methods. To assess an overall association between the composition of a microbial community and an outcome of interest, we present a novel multivariate testing method called aMiSPU, that is joint and highly adaptive over all observed taxa and thus high powered across various scenarios, alleviating the issue with the choice of a phylogenetic distance. Our simulations and real-data analyses demonstrated...
Naming no names: Comments on the taxonomy of small piroplasmids in canids - Harris, D. James
Based on phylogenetic analyses, various taxonomic changes have recently been proposed for tick-transmitted small piroplasmids, including descriptions of new species. It is however essential that any such changes comply with the International Code of Zoological Nomenclature. Unfortunately, this has not been the case, and some recently proposed names are therefore invalid. The use of informal clade names is necessary until formal valid descriptions are available.