PubMed Central (PMC3 - NLM DTD)
(2,081,148 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
Mostrando recursos 21 - 40 de 141,942
21.
Influenza in Tropical Regions - Viboud, Cécile; Alonso, Wladimir J; Simonsen, Lone
Viboud and colleagues discuss the implications of a new study by Peiris et al. that assesses the burden of influenza in Hong Kong.
23.
Stage-Specific Action of Matrix Metalloproteinases Influences Progressive Hereditary Kidney Disease - Zeisberg, Michael; Khurana, Mona; Rao, Velidi H; Cosgrove, Dominic; Rougier, Jean-Philippe; Werner, Michelle C; Shield, Charles F; Werb, Zena; Kalluri, Raghu
In a mouse model of Alport disease, matrix metalloproteinases appear to have a crucial dual role in disease progression, with an early pathogenic function and a later protective action.
24.
Influenza-Associated Hospitalization in a Subtropical City - Wong, Chit Ming; Yang, Lin; Chan, King Pan; Leung, Gabriel M; Chan, Kwok H; Guan, Yi; Lam, Tai Hing; Hedley, Anthony Johnson; Peiris, Joseph S. M
Influenza was found to have a major impact on hospitalization in Hong Kong due to respiratory diseases, cardiovascular disease, and diabetes. Previously, little was known about this impact in the tropics and subtropics.
32.
Modeling the Impact of Antiretroviral Use in Developing Countries - Bertozzi, Stefano M; Bautista-Arredondo, Sergio
Bertozzi and Bautista-Arredondo discuss the implications of a new
PLoS Medicine study that models the impact of antiretroviral drugs upon HIV transmission in developing countries.
33.
Modelling the Impact of Antiretroviral Use in Resource-Poor Settings - Baggaley, Rebecca F; Garnett, Geoff P; Ferguson, Neil M
Modelling results suggest that antiretrovirals will not work as direct prevention tools, and that concurrent promotion of safe sex practices is essential to prevent increased transmission.
35.
Relaxed Phylogenetics and Dating with Confidence - Drummond, Alexei J; Ho, Simon Y. W; Phillips, Matthew J; Rambaut, Andrew
In phylogenetics, the unrooted model of phylogeny and the strict molecular clock model are two extremes of a continuum. Despite their dominance in phylogenetic inference, it is evident that both are biologically unrealistic and that the real evolutionary process lies between these two extremes. Fortunately, intermediate models employing relaxed molecular clocks have been described. These models open the gate to a new field of relaxed phylogenetics. Here we introduce a new approach to performing relaxed phylogenetic analysis. We describe how it can be used to estimate phylogenies and divergence times in the face of uncertainty in evolutionary rates and calibration...
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