PubMed Central (PMC3 - NLM DTD) (2.002.009 recursos) Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
Mostrando recursos 1 - 20 de 2.984
1. Partners in dicing - Ketting, René F Recent studies of the protein Dicer, a key enzyme in the RNA interference process, have started to reveal how this single enzyme is targeted to different RNA-silencing pathways.
3. The semaphorins - Yazdani, Umar; Terman, Jonathan R They alter the cytoskeleton and the organization of actin filaments and the microtubule network, and are important in a wide range of functions, including neural connectivity, angiogenesis, immunoregulation, and cancer.
4. Mining the HapMap to dissect complex traits - Kim, Sung K; Borevitz, Justin A report on the Keystone Symposium 'Genome Sequence Variation and the Inherited Basis of Common Disease and Complex Traits', Big Sky, USA, 8-13 January 2006.
5. The dynamic proteome of Lyme disease Borrelia - Norris, Steven J The proteome of the spirochete bacterium Borrelia burgdorferi, the tick-borne agent of Lyme disease, has been characterized by two different approaches using mass spectrometry, providing a launching point for future studies.
6. Small genomes and big science - Edwards, Jeremy A report of the 13th Annual International Conference on Microbial Genomes, Madison, USA, 11-15 September 2005.
7. A cornucopia of genomes - Paterson, Andrew H A report on the Plant and Animal Genome XIV Conference, San Diego, USA, 14-18 January 2006.
8. The system is broken - Petsko, Gregory A When a scientist doing work in genomics, or cell biology, or biochemistry, or immunology submits a grant proposal to the US National Institutes of Health (NIH), the largest supporter of life science research in the world, his or her chance of it being funded are at historic lows.
9. Mining the genome and regulatory networks - Potapov, Anatolij P; Wingender, Edgar A report on the 16th International Conference on Genome Informatics (GIW 2005), Yokohama, Japan, 19-21 December 2005.
10. Genetic control of hippocampal neurogenesis - Pozniak, Christine D; Pleasure, Samuel J Quantitative trait locus analysis of two inbred mouse strains has revealed that cell survival is most highly correlated with neurogenesis.
11. Signals and systems - Krogan, Nevan J; Hughes, Timothy R A report on the 2006 Keystone Conference on Signaling Networks, Vancouver, Canada, 30 January-4 February 2006.
13. Circadian rhythms lit up in Chlamydomonas - Breton, Ghislain; Kay, Steve A A high-throughput luciferase-based assay for circadian gene expression gives a boost to the study of circadian rhythms in Chlamydomonas.
14. Cancer and kinases: reports from the front line - Burley, Stephen K A report on the Keystone Symposium 'Cancer and Kinases: Lessons from the Clinic', Santa Fe, USA, 14-19 February 2006.
15. Plant NBS-LRR proteins: adaptable guards - McHale, Leah; Tan, Xiaoping; Koehl, Patrice; Michelmore, Richard W Plant nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins are a large family involved in disease resistance; they may monitor the status of proteins targeted by pathogens.
16. TANGOing along the protein secretion pathway - Rabouille, Catherine; Kondylis, Vangelis An RNAi screen in Drosophila cells has identified about 100 TANGO proteins, which may regulate protein exocytosis or secretion.
17. Shelling out for genomics - McClintock, Timothy S; Derby, Charles D A report on the symposium 'Genomic and Proteomic Approaches to Crustacean Biology' held as part of the Society for Integrative and Comparative Biology 2006 Annual Meeting, Orlando, USA, 4-8 January 2006.
18. Instructions for repair - Petsko, Gregory A Peer review is the foundation quality in science, but now, in the US, the system is broken.
19. Getting to synaptic complexes through systems biology - Jordan, Bryen A; Ziff, Edward B A systems biology approach using network maps and annotated functions of synaptic components has identified biologically relevant networks within a synaptic neurotransmitter receptor complex.
20. Partners in dicing - Ketting, René F Recent studies of the protein Dicer, a key enzyme in the RNA interference process, have started to reveal how this single enzyme is targeted to different RNA-silencing pathways.
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