PubMed Central (PMC3 - NLM DTD)
(2,081,148 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
Mostrando recursos 101 - 120 de 3,096
101.
'Chumanzee' evolution: the urge to diverge and merge - Disotell, Todd R
Comparative analysis of primate genomes suggests that the divergence between human and chimpanzee lineages around 6 million years ago was initially not a clean split.
102.
Jumping the shark - Petsko, Gregory A
In popular-culture, 'jumping the shark' refers to an abandoning of core values in an attempt to appeal to dwindling audiences, a metaphor that might be reasonably be applied to some areas of genomics-based research.
103.
Genome re-annotation: a wiki solution? - Salzberg, Steven L
Genome annotation currently tends to represent a static snapshot. Routine re-annotation, perhaps using wiki software, would help.
104.
Signaling netwErks get the global treatment - Yaffe, Michael B; White, Forest M
Two landmark analyses of signaling networks by RNAi and phosphoproteomics provide complementary snapshots of the phosphoproteome.
107.
The Homer family proteins - Shiraishi-Yamaguchi, Yoko; Furuichi, Teiichi
The Homer family of proteins act as adapters for many postsynaptic density proteins. They are alternatively spliced into short and long forms; the long forms probably act as protein signaling complexes, whereas short forms might disrupt Homer complexes by competitive binding to target proteins.
108.
And the second shall be first - Petsko, Gregory A
The retraction of 5 protein crystal structures has held back an entire sub-field for years due to the inordinately persuasive power of the pretty pictures that structural biology produces. All too often the first report is sketchy, superficial in its analysis, and prone to error. The second report is often more thoughtful, more useful, and is essential to the scientific process of validation and self-correction.
109.
Expanding the mitochondrial interactome - Shutt, Timothy E; Shadel, Gerald S
The most comprehensive mitochondrial interactome so far has been revealed by integrating many different studies.
110.
Applying plant genomics to crop improvement - Bevan, Michael; Waugh, Robbie
A report of the European Science Foundation-Wellcome Trust Conference on Crop Genomics, Trait Analysis and Breeding, Hinxton, UK, 8-11 November 2006.
111.
Decoding dosage compensation - Deng, Xinxian; Disteche, Christine M
In C. elegans, clusters of short DNA motifs have been identified as binding sites for the protein complex that mediates dosage compensation.
114.
The ring between ring fingers (RBR) protein family - Eisenhaber, Birgit; Chumak, Nina; Eisenhaber, Frank; Hauser, Marie-Theres
An overview of the large and functionally diverse RBR protein family that mediates protein-protein interactions of various kinds in development and disease.
116.
It can't happen here - can it? - Petsko, Gregory A
If scientific advice is to have any value, it must come from sources that are not under any obligation to any organisation, public or private. Most principal scientific organisations in Western countries have similar ideas about the importance of independence but the independence of American science is being eroded.
117.
Maturation of the mammalian secretome - Simpson, Jeremy C; Mateos, Alvaro; Pepperkok, Rainer
What methodology will define the complete secretome?
118.
New perspectives on an old disease: proteomics in cancer research - Gallego, Oriol; Gavin, Anne-Claude
A report on the American Association for Cancer Research Conference 'Advances in Proteomics in Cancer Research', Amelia Island, USA, 27 February-2 March 2007.
119.
Developing a systems-level understanding of gene expression - Elemento, Olivier
A report on the meeting 'Systems Biology: Global Regulation of Gene Expression' at the Cold Spring Harbor Laboratory, New York, USA, 28 March-1 April 2007.
120.
Searching genomes for ribozymes and riboswitches - Hammann, Christian; Westhof, Eric
A discussion of experimental approaches and theoretical difficulties in the identification of ribozymes with novel catalytic functions.
101.
