PubMed Central (PMC3 - NLM DTD)
(2,081,148 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
Mostrando recursos 161 - 180 de 3,096
161.
The ribosomal protein genes and Minute loci of Drosophila melanogaster - Marygold, Steven J; Roote, John; Reuter, Gunter; Lambertsson, Andrew; Ashburner, Michael; Millburn, Gillian H; Harrison, Paul M; Yu, Zhan; Kenmochi, Naoya; Kaufman, Thomas C; Leevers, Sally J; Cook, Kevin R
A combined bioinformatic and genetic approach was used to conduct a systematic analysis of the relationship between ribosomal protein genes and Minute loci in Drosophila melanogaster, allowing the identification of 64 Minute loci corresponding to ribosomal genes.
162.
Transcriptional regulatory network for sexual differentiation in fission yeast - Mata, Juan; Wilbrey, Anna; Bähler, Jürg
Microarray analysis of the transcriptome of fission yeast after genetic perturbation of 6 genes known to have a role in sexual differentiation reveals insights into the regulatory principles controlling the gene expression program driving this process.
164.
Harnessing naturally randomized transcription to infer regulatory relationships among genes - Chen, Lin S; Emmert-Streib, Frank; Storey, John D
An approach is developed that utilizes randomized genotypes to rigorously infer causal regulatory relationships among genes at the transcriptional level. The approach is applied to an experiment in yeast, yielding new insights into the topology of the yeast transcriptional regulatory network.
165.
Responses of hyperthermophilic crenarchaea to UV irradiation - Götz, Dorothee; Paytubi, Sonia; Munro, Stacey; Lundgren, Magnus; Bernander, Rolf; White, Malcolm F
The transcriptional response to UV irradiation was analyzed in two related crenarchaea, Sulfolobus solfataricus and Sulfolobus acidocaldarius, showing a clear response to DNA damage but no increase in the expression of DNA repair genes.
167.
Common gene expression strategies revealed by genome-wide analysis in yeast - García-Martínez, José; González-Candelas, Fernando; Pérez-Ortín, José E
A comprehensive analysis of six variables characterizing gene expression in yeast, including transcription and translation, mRNA and protein amounts, reveals a general tendency for levels of mRNA and protein to be harmonized, and for functionally related genes to have similar values for these variables.
169.
A BAC clone fingerprinting approach to the detection of human genome rearrangements - Krzywinski, Martin; Bosdet, Ian; Mathewson, Carrie; Wye, Natasja; Brebner, Jay; Chiu, Readman; Corbett, Richard; Field, Matthew; Lee, Darlene; Pugh, Trevor; Volik, Stas; Siddiqui, Asim; Jones, Steven; Schein, Jacquie; Collins, Collin; Marra, Marco
Fingerprint Profiling (FPP) is a new method which uses restriction digest fingerprints of bacterial artificial chromosome (BAC) clones for detecting and classifying rearrangements in the human genome.
171.
Surprising complexity of the ancestral apoptosis network - Zmasek, Christian M; Zhang, Qing; Ye, Yuzhen; Godzik, Adam
A comparative genomics approach revealed that the genes for several components of the apoptosis network with single copies in vertebrates have multiple paralogs in cnidarian-bilaterian ancestors, suggesting a complex evolutionary history for this network.
172.
Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo - Yang, Lixin; Kemadjou, Jules R; Zinsmeister, Christian; Bauer, Matthias; Legradi, Jessica; Müller, Ferenc; Pankratz, Michael; Jäkel, Jens; Strähle, Uwe
Microarray profiling of zebrafish embryos exposed to a range of environmental toxicants revealed distinct expression profiles for each of the toxicants tested.
173.
Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization - Marioni, John C; Thorne, Natalie P; Valsesia, Armand; Fitzgerald, Tomas; Redon, Richard; Fiegler, Heike; Andrews, T Daniel; Stranger, Barbara E; Lynch, Andrew G; Dermitzakis, Emmanouil T; Carter, Nigel P; Tavaré, Simon; Hurles, Matthew E
Datasets used for detecting copy number variation (CNV) are shown to be affected by a technical artifact. A novel CNV calling algorithm is presented which removes this artifact and identifies regions of CNV better than existing methods.
174.
Simplified ontologies allowing comparison of developmental mammalian gene expression - Kruger, Adele; Hofmann, Oliver; Carninci, Piero; Hayashizaki, Yoshihide; Hide, Winston
The Developmental eVOC ontologies presented are simplified orthogonal ontologies describing the temporal and spatial distribution of developmental human and mouse anatomy.
175.
On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees - Marques-Bonet, Tomàs; Sànchez-Ruiz, Jesús; Armengol, Lluís; Khaja, Razi; Bertranpetit, Jaume; Lopez-Bigas, Núria; Rocchi, Mariano; Gazave, Elodie; Navarro, Arcadi
Analysis of the genes located in rearranged human and chimpanzee chromosomes identified lower divergence than for those in colinear chromosomes.
176.
Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster - Morozova, Tatiana V; Anholt, Robert RH; Mackay, Trudy FC
Gene-expression profiling combined with selection for genetically divergent Drosophila lines either highly sensitive or resistant to ethanol exposure has been used to identify candidate genes that affect alcohol sensitivity, including 23 novel genes that have human orthologs.
177.
They fought the law and the law won - Petsko, Gregory A
The new science geo-engineering doesn't try to alter a few corn plants; it aims to tinker with the entire planet, based on the notion that ultimately we can actively manipulate the planet to have any climate pattern we want. But there is no way we can ever assess all of the likely consequences.
178.
The determinants of gene order conservation in yeasts - Poyatos, Juan F; Hurst, Laurence D
Current intergene distance is shown to be consistently the strongest predictor of synteny conservation as expected under a simple null model, and other variables are of lesser importance.
161.
