PubMed Central (PMC3 - NLM DTD)
(2,081,148 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
Mostrando recursos 181 - 200 de 3,096
181.
Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender - Xu, Xiangru; Zhan, Ming; Duan, Wenzhen; Prabhu, Vinayakumar; Brenneman, Randall; Wood, William; Firman, Jeff; Li, Huai; Zhang, Peisu; Ibe, Carol; Zonderman, Alan B; Longo, Dan L; Poosala, Suresh; Becker, Kevin G; Mattson, Mark P
The transcriptional profiles of five regions of the central nervous system (CNS) of mice varying in age, gender and dietary intake were measured by microarray. The resulting data provide insights into the mechanisms of age-, diet- and gender-related CNS plasticity and vulnerability in mammals.
182.
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases - Bergholdt, Regine; Størling, Zenia M; Lage, Kasper; Karlberg, E Olof; Ólason, Páll Í; Aalund, Mogens; Nerup, Jørn; Brunak, Søren; Workman, Christopher T; Pociot, Flemming
An integrative analysis combining genetic interactions and protein interactions can be used to identify candidate genes/proteins for type 1 diabetes and other complex diseases.
183.
Nose thyself: individuality in the human olfactory genome - Zhang, Xiaohong; Firestein, Stuart
A link between a genetic polymorphism in an odorant receptor and variability in perception of the smell of the steroid androstenone.
184.
The global landscape of sequence diversity - Peregrín-Álvarez, José Manuel; Parkinson, John
Comparison of genomic and EST sequences reveals a greater genetic diversity within eukaryotes than prokaryotes and enables identification of taxon-specific sequences.
185.
Shaken not stirred: a global research cocktail served in Hinxton - Marguerat, Samuel; Wilhelm, Brian T; Bähler, Jürg
A report of the 2007 Cold Spring Harbor Laboratory/Wellcome Trust Conference on Functional Genomics and Systems Biology, Hinxton, UK, 10-13 October 2007.
186.
The distributions, mechanisms, and structures of metabolite-binding riboswitches - Barrick, Jeffrey E; Breaker, Ronald R
Phylogenetic analyses revealed insights into the distribution of riboswitch classes in different microbial groups, and structural analyses led to updated aptamer structure models and insights into the mechanism of these non-coding RNA structures.
188.
GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silico dissection of mixed phenotypes - Lu, Shi-Jiang; Hipp, Jennifer A; Feng, Qiang; Hipp, Jason D; Lanza, Robert; Atala, Anthony
Transcriptional profiling of human embryonic stem cells differentiating into blast cells reveals that erythroblasts are the predominant cell type in the blast cell population. In silico comparisons with publicly available data sets revealed the presence of endothelia, cardiomyocytes and hematopoietic lineages.
189.
Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study - Bhutkar, Arjun; Gelbart, William M; Smith, Temple F
A simple, fast, and biologically-inspired computational approach to infer genome-scale rearrangement phylogeny and ancestral gene order has been developed and applied to eight Drosophila genomes, providing insights into evolutionary chromosomal dynamics.
192.
Sequence and functional analyses of Haemophilus spp. genomic islands - Juhas, Mario; Power, Peter M; Harding, Rosalind M; Ferguson, David JP; Dimopoulou, Ioanna D; Elamin, Abdel RE; Mohd-Zain, Zaini; Hood, Derek W; Adegbola, Richard; Erwin, Alice; Smith, Arnold; Munson, Robert S; Harrison, Alistair; Mansfield, Lucielle; Bentley, Stephen; Crook, Derrick W
Comparative analysis of genomic islands of Haemophilus species shows that they are co-evolving as semi-autonomous genomes within the host genome.
193.
An idea whose time has come - Banci, Lucia; Baumeister, Wolfgang; Heinemann, Udo; Schneider, Gunter; Silman, Israel; Stuart, David I; Sussman, Joel L
A response to An idea whose time has gone by Gregory A Petsko, Genome Biology 2007, 8:107.
194.
Determinants of protein function revealed by combinatorial entropy optimization - Reva, Boris; Antipin, Yevgeniy; Sander, Chris
A new algorithm is presented allows protein specificity residues to be assigned from multiple sequence alignments alone. This information can be used, amongst other things, to infer protein functions.
195.
What if Watson had said "Apes evolved from man"? - Petsko, Gregory A
Our status as genome biologists gives us both ammunition and a powerful line of attack when we are confronted with ignorance, prejudice, and bigotry.
196.
Termites in the woodwork - Chaffron, Samuel; von Mering, Christian
Metagenomic analysis of termite gut flora reveals a diversity of wood-degrading enzymes.
199.
Quantification of ortholog losses in insects and vertebrates - Wyder, Stefan; Kriventseva, Evgenia V; Schröder, Reinhard; Kadowaki, Tatsuhiko; Zdobnov, Evgeny M
Comparison of the gene repertoires of 5 vertebrates and 5 insects showed that the rate of losses correlates well with the species' rates of molecular evolution and radiation times and suggests that the Urbilateria genome contained more than 7,000 genes.
200.
Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa - Loscher, Carol J; Hokamp, Karsten; Kenna, Paul F; Ivens, Alasdair C; Humphries, Peter; Palfi, Arpad; Farrar, G Jane
MicroRNA expression profiling showed that the retina of mice carrying a rhodopsin mutation that leads to retinitis pigmentosa have notably different microRNA profiles from wildtype mice; further in silico analyses identified potential retinal targets for differentially regulated microRNAs.
181.
