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PubMed Central (PMC3 - NLM DTD) (2,081,148 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Mostrando recursos 41 - 60 de 3,096

41. An overview of the serpin superfamily - Law, Ruby HP; Zhang, Qingwei; McGowan, Sheena; Buckle, Ashley M; Silverman, Gary A; Wong, Wilson; Rosado, Carlos J; Langendorf, Chris G; Pike, Rob N; Bird, Philip I; Whisstock, James C
Serpins are protease inhibitors that use a conformational change to inhibit target enzymes and are important in many proteolytic cascades, including the mammalian coagulation and inflammatory-response pathways.

42. Stem cells in the genomic age - Lowell, Sally
A report on the 2006 Joint Spring Meeting of the British Society for Developmental Biology and the British Society for Cell Biology, York, UK, 20-23 March 2006.

43. Histone H4 lysine 16 acetylation breaks the genome's silence - Shia, Wei-Jong; Pattenden, Samantha G; Workman, Jerry L
The acetylation of histone H4 on lysine 16 is a crucial event in switching chromatin from a repressive to a transcriptionally active state.

44. Systems biology of gene regulation fulfills its promise - McKee, Adrienne E; Silver, Pamela A
A report on the meeting 'Systems Biology: Global Regulation of Gene Expression' at Cold Spring Harbor, New York, USA, 23-26 March 2006.

45. RNA interference has a role in regulating Drosophila telomeres - Casacuberta, Elena; Pardue, Mary-Lou
RNA interference is implicated in the maintenance of Drosophila telomeres by retrotransposons.

46. RNA at the steering wheel - Schmitt, Sabine; Paro, Renato
Noncoding RNAs transcribed from control elements in DNA provide an anti-silencing mechanism by targeting chromatin-modifying enzymes to these genes.

47. Splicing bioinformatics to biology - Black, Douglas L; Graveley, Brenton R
A report on the 2nd Symposium on Alternative Transcript Diversity, Heidelberg, Germany, 21-23 March 2006.

48. Chromatin remodeling and genome stability - Barkess, Gráinne
A report on the 12th Tenovus Scotland Symposium 'Stability and Regulation of Genes and Genomes', Glasgow UK, 6-7 April 2006.

49. The elusive yeast interactome - Goll, Johannes; Uetz, Peter
Two comprehensive studies of the total complement of protein complexes in yeast come up with surprisingly different answers.

50. Viruses take center stage in cellular evolution - Claverie, Jean-Michel
Advances in genomics have stimulated new hypotheses that DNA viruses were the origin of the eukaryotic cell nucleus, and that they should be considered as living things.

51. The MAP1 family of microtubule-associated proteins - Halpain, Shelley; Dehmelt, Leif
MAP1-family proteins are classical microtubule-associated proteins (MAPs) that bind along the microtubule lattice and stabilize microtubules.

52. Protein synthesis molecule by molecule - Golding, Ido; Cox, Edward C
Even a seemingly uniform culture of bacteria is made up of cells very different from each other in terms of their levels of a given protein. This individuality has now finally been quantified at single-molecule resolution.

53. Mobile DNA: genomes under the influence - Feschotte, Cédric; Pritham, Ellen J
A report on the American Society for Microbiology Conference on Mobile DNA, Banff, Canada, 24 February-1 March 2006.

54. Is there gold at the top of the beanstalk? - Djordjevic, Michael A; Buer, Charles
A report on the 3rd International Legume Genetics and Genomics Conference, Brisbane, Australia, 9-13 April 2006.

55. The ninth wave - Petsko, Gregory A
New, all-pervading technologies, such as the web and genomics, are like the 'ninth waves' of surfboard riders, washing over our culture with sudden, transforming power. The danger is that quality is reduced as we deal with the flood of data.

56. The subcellular localization of the mammalian proteome comes a fraction closer - Simpson, Jeremy C; Pepperkok, Rainer
A recent study shows the successful application of protein correlation profiling to the subcellular localization of organelle proteins in mammalian cells.

57. An all-round view of eukaryotic transcription - Kim, Tae Hoon; Ren, Bing
A report of the Keystone Symposium 'Regulation of Eukaryotic Transcription: From Chromatin to mRNA', Taos, USA, 21-26 April 2006.

58. Facts and figures - Petsko, Gregory A
If we had genome sequence information for whole populations coupled with epidemiologic information about health and disease and lifestyle, imagine what we could do with such data.

59. Transcriptional control of dendritic patterning in Drosophila neurons - Tassetto, Michel; Gao, Fen-Biao
An RNA interference screen reveals roles for transcription factors in regulating the outgrowth and branching of the dendrites of Drosophila neurons.

60. Anticipating the $1,000 genome - Mardis, Elaine R
New technologies will soon enable re-sequencing of human genomes at a much lower cost. The $1,000 human genome is an important goal for research and clinical diagnostics.

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