PubMed Central (PMC3 - NLM DTD) (2.007.146 recursos) Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
4. Clonal expansion is a characteristic feature of the B-cell repertoire of patients with rheumatoid arthritis - Itoh, Kenji; Patki, Varsha; Furie, Richard A; Chartash, Elliot K; Jain, Rita I; Lane, Lewis; Asnis, Stanley E; Chiorazzi, Nicholas The present study was designed to analyze the level of B-cell clonal diversity in patients with rheumatoid arthritis by using HCDR3 (third complementarity determining region of the rearranged heavy chain variable region gene) length as a marker.
9. Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis - Goldbach-Mansky, Raphaela; Lee, Jennifer M; Hoxworth, Joseph M; Smith II, David; Duray, Paul; Schumacher, Ralph H; Yarboro, Cheryl H; Klippel, John; Kleiner, David; El-Gabalawy, Hani S Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients.
10. Specificity of T cells in synovial fluid: high frequencies of CD8+ T cells that are specific for certain viral epitopes - Tan, Linda C; Mowat, Alastair G; Fazou , Chrysoula; Rostron , Tim; Roskell, Helen; Dunbar , P Rod; Tournay, Claire; Romagné, François; Peyrat, Marie-Alix; Houssaint, Elisabeth; Bonneville, Marc; Rickinson, Alan B; McMichael , Andrew J; Callan, Margaret FC CD8+ T cells dominate the lymphocyte population insynovial fluid in chronic inflammatory arthritis.
11. Apoptosis and p53 expression in rat adjuvant arthritis - Tak, Paul P; Klapwijk, Maartje S; Broersen, Sophie FM; van de Geest, Deliana A; Overbeek, Marieke; Firestein, Gary S The kinetics of apoptosis and the apoptosis-regulating gene p53 in adjuvant arthritis (AA) were investigated to assess the value of the AA rat model for testing apoptosis-inducing therapies.
12. Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset - Goldbach-Mansky, Raphaela; Lee, Jennifer; McCoy, Angela; Hoxworth, Joseph; Yarboro, Cheryl; Smolen, Josef S; Steiner, Günter; Rosen, Antony; Zhang, Cindy; Ménard, Henri A; Zhou, Zhi Jie; Palosuo, Timo; Van Venrooij, Walther J; Wilder, Ronald L; Klippel, John H; Schumacher, H Ralph; EI-Gabalawy, Hani S An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical significance of a number of rheumatoid arthritis (RA) associated autoantibodies.
13. Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4 - Kim, Seon Hee; Evans, Christopher H; Kim, Sunyoung; Oligino, Thomas; Ghivizzani, Steven C; Robbins, Paul D To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle joints into mice with established collagen-induced arthritis (CIA).
17. The role of X-chromosome inactivation in female predisposition to autoimmunity - Chitnis, Smita; Monteiro, Joanita; Glass, David; Apatoff, Brian; Salmon, Jane; Concannon, Patrick; Gregersen, Peter K We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed X-chromosome inactivation in the thymus may lead to inadequate thymic deletion.
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