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PubMed Central (PMC3 - NLM DTD) (1.999.448 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Mostrando recursos 1 - 20 de 59.228

1. Metabolic regulation of ApoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor - Lehmann, David M.; Galloway, Chad A.; Sowden, Mark P.; Smith, Harold C.
Apolipoprotein B (apoB) mRNA editing is a nuclear event that minimally requires the RNA substrate, APOBEC-1 and APOBEC-1 Complementation Factor (ACF).

2. The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins - Zhong, Xuejun; Garg, Parie; Stith, Carrie M.; McElhinny, Stephanie A. Nick; Kissling, Grace E.; Burgers, Peter M. J.; Kunkel, Thomas A.
DNA polymerase zeta (pol ?) participates in several DNA transactions in eukaryotic cells that increase spontaneous and damage-induced mutagenesis.

3. The DnaA box R4 in the minimal oriC is dispensable for initiation of Escherichia coli chromosome replication. - Bates, D B; Asai, T; Cao, Y; Chambers, M W; Cadwell, G W; Boye, E; Kogoma, T
We have developed a genetic system with which to replace oriC+ on the Escherichia coli chromosome with modified oriC sequences constructed on plasmids.

4. RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult - Bosco, Emily E.; Mayhew, Christopher N.; Hennigan, Robert F.; Sage, Julien; Jacks, Tyler; Knudsen, Erik S.
The retinoblastoma tumor suppressor (RB) is crucial for the maintenance of the DNA damage checkpoint function because it elicits cell cycle arrest in response to a variety of genotoxic stresses.

5. Domain mapping of the Rad51 paralog protein complexes - Miller, Kristi A.; Sawicka, Dorota; Barsky, Daniel; Albala, Joanna S.
These proteins have been found to form two distinct complexes in vivo, Rad51B–Rad51C–Rad51D–Xrcc2 (BCDX2) and Rad51C–Xrcc3 (CX3).

6. GenoFrag: software to design primers optimized for whole genome scanning by long-range PCR amplification - Ben Zakour, Nouri; Gautier, Michel; Andonov, Rumen; Lavenier, Dominique; Cochet, Marie-Françoise; Veber, Philippe; Sorokin, Alexei; Le Loir, Yves
Genome sequence data can be used to analyze genome plasticity by whole genome PCR scanning.

7. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner - Zhang, Suisheng; Schlott, Bernhard; Görlach, Matthias; Grosse, Frank
An RNA-dependent association of Ku antigen with nuclear DNA helicase II (NDH II), alternatively named RNA helicase A (RHA), was found in nuclear extracts of HeLa cells by immunoprecipitation and by gel filtration chromatography.

8. Formation of DNA nanoparticles in the presence of novel polyamine analogues: a laser light scattering and atomic force microscopic study - Vijayanathan, Veena; Thomas, Thresia; Antony, Thomas; Shirahata, Akira; Thomas, T. J.
We synthesized a pentamine (3-3-3-3) and two hexamine (3-3-3-3-3 and 3-4-3-4-3) analogues of the natural polyamine, spermine (3-4-3) and studied their effectiveness in condensing pGL3 plasmid DNA, using light scattering and atomic force microscopic (AFM) techniques.

9. Yeast telomerase is capable of limited repeat addition processivity - Bosoy, Dimitry; Lue, Neal F.
Telomerase-mediated sequence addition is dictated by a short ‘template’ region of the RNA component.

10. Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site - Pearson, Colin G.; Shikazono, Naoya; Thacker, John; O’Neill, Peter
The formation of clustered DNA damage sites is a unique feature of ionizing radiation.

11. The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe - Ribar, Balazs; Izumi, Tadahide; Mitra, Sankar
Among two APEs in Saccharomyces cerevisiae, Apn1 provides the major APE activity, and Apn2, the ortholog of the mammalian APE, provides back-up activity.

12. ARAGORN, a program to detect tRNA genes and tmRNA genes in nucleotide sequences - Laslett, Dean; Canback, Bjorn
A computer program, ARAGORN, identifies tRNA and tmRNA genes.

13. A 21-amino acid peptide from the cysteine cluster II of the family D DNA polymerase from Pyrococcus horikoshii stimulates its nuclease activity which is Mre11-like and prefers manganese ion as the cofactor - Shen, Yulong; Tang, Xiao-Feng; Yokoyama, Hideshi; Matsui, Eriko; Matsui, Ikuo
Here we report the characterization of the nuclease activity of PolD from Pyrococcus horikoshii.

14. Interactions between the 2.4 and 4.2 regions of ?S, the stress-specific ? factor of Escherichia coli, and the –10 and –35 promoter elements - Checroun, Claire; Bordes, Patricia; Leroy, Olivier; Kolb, Annie; Gutierrez, Claude
The ?s subunit of Escherichia coli RNA polymerase holoenzyme (E?S) is a key factor of gene expression upon entry into stationary phase and in stressful conditions.

15. Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1 - Liberzon, Arthur; Ridner, Gabriela; Walker, Michael D.
PDX1 is a homeodomain transcription factor essential for pancreatic development and mature beta cell function.

16. Polyamine derivatives as selective RNaseA mimics - Fouace, Sandra; Gaudin, Cyril; Picard, Sylvie; Corvaisier, Sophie; Renault, Jacques; Carboni, Bertrand; Felden, Brice
Site-selective scission of ribonucleic acids (RNAs) has attracted considerable interest, since RNA is an intermediate in gene expression and the genetic material of many pathogenic viruses.

17. Complementarity-directed RNA dimer-linkage promotes retroviral recombination in vivo - Mikkelsen, Jacob Giehm; Rasmussen, Søren Vestergaard; Pedersen, Finn Skou
To investigate if hairpin loop–loop-complementarity is the primary determinant for this recombination preference, we have devised a novel 5.

18. Characterization of cytosine methylated regions and 5-cytosine DNA methyltransferase (Ehmeth) in the protozoan parasite Entamoeba histolytica - Fisher, Ohad; Siman-Tov, Rama; Ankri, Serge
The DNA methylation status of the protozoan parasite Entamoeba histolytica was heretofore unknown.

19. Automatic extraction of mutations from Medline and cross-validation with OMIM - Rebholz-Schuhmann, Dietrich; Marcel, Stephane; Albert, Sylvie; Tolle, Ralf; Casari, Georg; Kirsch, Harald
Mutations help us to understand the molecular origins of diseases.

20. Domainal organization of the lower eukaryotic homologs of the yeast RNA polymerase II core subunit Rpb7 reflects functional conservation - Singh, Sunanda R.; Rekha, Nambudiry; Pillai, Beena; Singh, Vijender; Naorem, Aruna; Sampath, Vinaya; Srinivasan, N.; Sadhale, Parag P.
The subcomplex of Rpb4 and Rpb7 subunits of RNA pol II in Saccharomyces cerevisiae is known to be an important determinant of transcription under a variety of physiological stresses.

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