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PubMed Central (PMC3 - NLM DTD) (2,081,148 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Mostrando recursos 141 - 160 de 262

141. RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice - Yang, Baichun; Trump, Ryan P; Shen, Ying; McNulty, Judi A; Clifton, Lisa G; Stimpson, Stephen A; Lin, Peiyuan; Pahel, Greg L

142. Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line - Bopp, Stephanie K; Lettieri, Teresa

143. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells - Baker, Jillian G

144. Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives - Volvert, Marie-Laure; Seyen, Sandrine; Piette, Marie; Evrard, Brigitte; Gangolf, Marjorie; Plumier, Jean-Christophe; Bettendorff, Lucien

145. Pharmacological Properties of DOV 315,090, an ocinaplon metabolite - Berezhnoy, Dmytro; Gravielle, Maria C; Downing, Scott; Kostakis, Emmanuel; Basile, Anthony S; Skolnick, Phil; Gibbs, Terrell T; Farb, David H

146. Methoxylation enhances stilbene bioactivity in Caenorhabditis elegans - Wilson, Mark A; Rimando, Agnes M; Wolkow, Catherine A

147. Pharmacokinetics and transcriptional effects of the anti-salmon lice drug emamectin benzoate in Atlantic salmon (Salmo salar L.) - Olsvik, Pål A; Lie, Kai K; Mykkeltvedt, Eva; Samuelsen, Ole B; Petersen, Kjell; Stavrum, Anne-Kristin; Lunestad, Bjørn T

148. Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration - Deupree, Jean D; Burke, William J; Bylund, David B

149. Bioequivalence study of three ibuprofen formulations after single dose administration in healthy volunteers - Bramlage, Peter; Goldis, Adrian

150. Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1 - Deck, Lorraine M; Hunsaker, Lucy A; Gonzales, Amanda M; Orlando, Robert A; Vander Jagt, David L

151. Conformational changes in α7 acetylcholine receptors underlying allosteric modulation by divalent cations - McLaughlin, James T; Barron, Sean C; See, Jennifer A; Rosenberg, Robert L
Allosteric modulation of membrane receptors is a widespread mechanism by which endogenous and exogenous agents regulate receptor function. For example, several members of the nicotinic receptor family are modulated by physiological concentrations of extracellular calcium ions. In this paper, we examined conformational changes underlying this modulation and compare these with changes evoked by ACh. Two sets of residues in the α7 acetylcholine receptor extracellular domain were mutated to cysteine and analyzed by measuring the rates of modification by the thiol-specific reagent 2-aminoethylmethane thiosulfonate. Using Ba2+ as a surrogate for Ca2+, we found a divalent-dependent decrease the modification rates of cysteine...

152. AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts - Adamo, Luigi; Zhang, Yuzhi; García-Cardeña, Guillermo

153. The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis - Burgess, Ian F

154. Bioinformatic characterizations and prediction of K+ and Na+ ion channels effector toxins - Soli, Rima; Kaabi, Belhassen; Barhoumi, Mourad; El-Ayeb, Mohamed; Srairi-Abid, Najet

155. Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats - Schweitzer, A; Hasler-Nguyen, N; Zijlstra, J

156. N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes - Shi, Rong; Huang, Chuan-Chin; Aronstam, Robert S; Ercal, Nuran; Martin, Adam; Huang, Yue-Wern

157. Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models - Lee, Nancy; Woodrum, Chelsey L; Nobil, Alison M; Rauktys, Aubrey E; Messina, Michael P; Dabora, Sandra L

158. Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells - Jiang, Lin; Saetre, Peter; Jazin, Elena; Carlström, Eva Lindholm

159. A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen - Roof, Rebecca A; Roman, David L; Clements, Samuel T; Sobczyk-Kojiro, Katarzyna; Blazer, Levi L; Ota, Shodai; Mosberg, Henry I; Neubig, Richard R

160. Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells - Vik-Mo, Audun O; Fernø, Johan; Skrede, Silje; Steen, Vidar M

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