PubMed Central (PMC3 - NLM DTD)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).
Future of microbial polyesters - Lee, Gi Na; Na, Jonguk
Numerous microorganisms accumulate polyesters classified as polyhydroxyalkanoates (PHAs) as carbon and energy storage material when the growth condition is unfavorable in the presence of excess carbon source. Natural PHAs typically consist of various (R)-hydroxycarboxylic acids, and exhibit different material properties depending on the monomer composition. Such diversity comes from different metabolic pathways operating in the cell, and thus generating different monomers. Even more diverse PHAs can be produced by metabolically engineered microorganisms, which leads to the biosynthesis of non-natural polyesters containing lactate as a monomer. In order to make PHAs as useful polymers in our daily life, their production cost...
Catabolic flexibility of mammalian-associated lactobacilli - O’Donnell, Michelle M; O’Toole, Paul W; Ross, Reynolds Paul
Metabolic flexibility may be generally defined as “the capacity for the organism to adapt fuel oxidation to fuel availability”. The metabolic diversification strategies used by individual bacteria vary greatly from the use of novel or acquired enzymes to the use of plasmid-localised genes and transporters. In this review, we describe the ability of lactobacilli to utilise a variety of carbon sources from their current or new environments in order to grow and survive. The genus Lactobacillus now includes more than 150 species, many with adaptive capabilities, broad metabolic capacity and species/strain variance. They are therefore, an informative example of a...