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PubMed Central (PMC3 - NLM DTD) (2,728,859 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Microbial Cell Factories

Mostrando recursos 1 - 20 de 894

1. Development of a multi-gene expression system in Xanthophyllomyces dendrorhous - Hara, Kiyotaka Y; Morita, Toshihiko; Mochizuki, Masao; Yamamoto, Keisuke; Ogino, Chiaki; Araki, Michihiro; Kondo, Akihiko

2. Metabolic engineering of microorganisms for the production of L-arginine and its derivatives - Shin, Jae Ho; Lee, Sang Yup
L-arginine (ARG) is an important amino acid for both medicinal and industrial applications. For almost six decades, the research has been going on for its improved industrial level production using different microorganisms. While the initial approaches involved random mutagenesis for increased tolerance to ARG and consequently higher ARG titer, it is laborious and often leads to unwanted phenotypes, such as retarded growth. Discovery of L-glutamate (GLU) overproducing strains and using them as base strains for ARG production led to improved ARG production titer. Continued effort to unveil molecular mechanisms led to the accumulation of detailed knowledge on amino acid metabolism,...

3. Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea - Wu, Hang; Chen, Meng; Mao, Yongrong; Li, Weiwei; Liu, Jingtao; Huang, Xunduan; Zhou, Ying; Ye, Bang-Ce; Zhang, Lixin; Weaver, David T; Zhang, Buchang

4. Se (IV) triggers faster Te (IV) reduction by soil isolates of heterotrophic aerobic bacteria: formation of extracellular SeTe nanospheres - Bajaj, Mini; Winter, Josef

5. An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines - Jong, Wouter SP; Daleke-Schermerhorn, Maria H; Vikström, David; ten Hagen-Jongman, Corinne M; de Punder, Karin; van der Wel, Nicole N; van de Sandt, Carolien E; Rimmelzwaan, Guus F; Follmann, Frank; Agger, Else Marie; Andersen, Peter; de Gier, Jan-Willem; Luirink, Joen

6. High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10 - Zhong, Yongjun; Yang, Lu; Guo, Yugang; Fang, Fang; Wang, Dong; Li, Rui; Jiang, Ming; Kang, Wenyao; Ma, Jiajia; Sun, Jie; Xiao, Weihua

7. Antisense knockdown of pyruvate dehydrogenase kinase promotes the neutral lipid accumulation in the diatom Phaeodactylum tricornutum - Ma, Yu-Han; Wang, Xiang; Niu, Ying-Fang; Yang, Zhi-Kai; Zhang, Meng-Han; Wang, Zhong-Ming; Yang, Wei-Dong; Liu, Jie-Sheng; Li, Hong-Ye

8. Improving itaconic acid production through genetic engineering of an industrial Aspergillus terreus strain - Huang, Xuenian; Lu, Xuefeng; Li, Yueming; Li, Xia; Li, Jian-Jun

9. Metabolic pathway for degradation of 2-chloro-4-aminophenol by Arthrobacter sp. SPG - Arora, Pankaj Kumar; Mohanta, Tapan Kumar; Srivastava, Alok; Bae, Hanhong; Singh, Vijay Pal
A degradation pathway of 2-chloro-4-aminophenol (2C4AP) was studied in an Arthrobacter sp. SPG that utilized 2C4AP as its sole source of carbon and energy. The 2C4AP degradation was initiated by a 2C4AP-deaminase that catalyzed the conversion of 2C4AP into chlorohydroquinone (CHQ) with removal of ammonium ion. In the next step, a CHQ-dehalogenase dehalogenated CHQ to hydroquinone (HQ) that cleaved into γ-hydroxymuconic semialdehyde by a HQ-dioxygenase. The 2C4AP degradation was also investigated in sterile and non-sterile soil microcosms using strain SPG. The results show that the SPG cells degraded 2C4AP more rapidly in sterile soil than non-sterile soil. Our studies showed...

10. The important ergot alkaloid intermediate chanoclavine-I produced in the yeast Saccharomyces cerevisiae by the combined action of EasC and EasE from Aspergillus japonicus - Nielsen, Curt AF; Folly, Christophe; Hatsch, Anaëlle; Molt, Andrea; Schröder, Hartwig; O’Connor, Sarah E; Naesby, Michael

11. Efficient production of single-chain fragment variable-based N-terminal trimerbodies in Pichia pastoris - Blanco-Toribio, Ana; Lacadena, Javier; Nuñez-Prado, Natalia; Álvarez-Cienfuegos, Ana; Villate, Maider; Compte, Marta; Sanz, Laura; Blanco, Francisco J; Álvarez-Vallina, Luis

12. Mucosal vaccine delivery by non-recombinant spores of Bacillus subtilis - Ricca, Ezio; Baccigalupi, Loredana; Cangiano, Giuseppina; De Felice, Maurilio; Isticato, Rachele
Development of mucosal vaccines strongly relies on an efficient delivery system and, over the years, a variety of approaches based on phages, bacteria or synthetic nanoparticles have been proposed to display and deliver antigens. The spore of Bacillus subtilis displaying heterologous antigens has also been considered as a mucosal vaccine vehicle, and shown able to conjugate some advantages of live microrganisms with some of synthetic nanoparticles. Here we review the use of non-recombinant spores of B. subtilis as a delivery system for mucosal immunizations. The non-recombinant display is based on the adsorption of heterologous molecules on the spore surface without...

13. L-lactic acid production from D-xylose with Candida sonorensis expressing a heterologous lactate dehydrogenase encoding gene - Koivuranta, Kari T; Ilmén, Marja; Wiebe, Marilyn G; Ruohonen, Laura; Suominen, Pirkko; Penttilä, Merja

14. Tuning constitutive recombinant gene expression in Lactobacillus plantarum - Tauer, Christopher; Heinl, Stefan; Egger, Esther; Heiss, Silvia; Grabherr, Reingard

15. The Aspergillus nidulans Zn(II)2Cys6 transcription factor AN5673/RhaR mediates L-rhamnose utilization and the production of α-L-rhamnosidases - Pardo, Ester; Orejas, Margarita

16. Exploiting Issatchenkia orientalis SD108 for succinic acid production - Xiao, Han; Shao, Zengyi; Jiang, Yu; Dole, Sudhanshu; Zhao, Huimin

17. Efficient ammonium uptake and mobilization of vacuolar arginine by Saccharomyces cerevisiae wine strains during wine fermentation - Crépin, Lucie; Sanchez, Isabelle; Nidelet, Thibault; Dequin, Sylvie; Camarasa, Carole

18. Insights into glycogen metabolism in Lactobacillus acidophilus: impact on carbohydrate metabolism, stress tolerance and gut retention - Goh, Yong Jun; Klaenhammer, Todd R
In prokaryotic species equipped with glycogen metabolism machinery, the co-regulation of glycogen biosynthesis and degradation has been associated with the synthesis of energy storage compounds and various crucial physiological functions, including global cellular processes such as carbon and nitrogen metabolism, energy sensing and production, stress response and cell-cell communication. In addition, the glycogen metabolic pathway was proposed to serve as a carbon capacitor that regulates downstream carbon fluxes, and in some microorganisms the ability to synthesize intracellular glycogen has been implicated in host persistence. Among lactobacilli, complete glycogen metabolic pathway genes are present only in select species predominantly associated with...

19. Metabolomic basis of laboratory evolution of butanol tolerance in photosynthetic Synechocystis sp. PCC 6803 - Wang, Yaxing; Shi, Mengliang; Niu, Xiangfeng; Zhang, Xiaoqing; Gao, Lianju; Chen, Lei; Wang, Jiangxin; Zhang, Weiwen

20. Isolation, characterization and application of a cellulose-degrading strain Neurospora crassa S1 from oil palm empty fruit bunch - Li, Qingxin; Ng, Wei Ting; Wu, Jin Chuan

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