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PubMed Central (PMC3 - NLM DTD) (2,823,233 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Antioxidants & Redox Signaling

Mostrando recursos 1 - 20 de 856

1. Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats - Bielitza, Max; Belorgey, Didier; Ehrhardt, Katharina; Johann, Laure; Lanfranchi, Don Antoine; Gallo, Valentina; Schwarzer, Evelin; Mohring, Franziska; Jortzik, Esther; Williams, David L.; Becker, Katja; Arese, Paolo; Elhabiri, Mourad; Davioud-Charvet, Elisabeth
Aims: Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum were shown to protect G6PD-deficient populations from severe malaria. Here, we investigated the mechanism of a novel antimalarial series, namely 3-[substituted-benzyl]-menadiones, to understand whether these NADPH-consuming redox-cyclers, which induce oxidative stress, mimic the natural protection of G6PD deficiency. Results: We demonstrated that the key benzoylmenadione metabolite of the lead compound acts as an efficient redox-cycler in NADPH-dependent methaemoglobin reduction, leading to the continuous formation of reactive oxygen species, ferrylhaemoglobin, and subsequent haemichrome precipitation. Structure–activity relationships evidenced that both drug metabolites and haemoglobin catabolites contribute to potentiate drug effects...

2. Simple Biological Systems for Assessing the Activity of Superoxide Dismutase Mimics - Tovmasyan, Artak; Reboucas, Julio S.; Benov, Ludmil

3. SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways - Batinic-Haberle, Ines; Tovmasyan, Artak; Roberts, Emily R. H.; Vujaskovic, Zeljko; Leong, Kam W.; Spasojevic, Ivan

4. Manganese Superoxide Dismutase Is a Promising Target for Enhancing Chemosensitivity of Basal-Like Breast Carcinoma - Kumar, Alan Prem; Loo, Ser Yue; Shin, Sung Won; Tan, Tuan Zea; Eng, Chon Boon; Singh, Rajeev; Putti, Thomas Choudary; Ong, Chee Wee; Salto-Tellez, Manuel; Goh, Boon Cher; Park, Joo In; Thiery, Jean Paul; Pervaiz, Shazib; Clement, Marie Veronique

5. Manganese-Based Superoxide Dismutase Mimics Modify Both Acute and Long-Term Outcome Severity in a Drosophila melanogaster Model of Classic Galactosemia - Jumbo-Lucioni, Patricia P.; Ryan, Emily L.; Hopson, Marquise L.; Bishop, Heather M.; Weitner, Tin; Tovmasyan, Artak; Spasojevic, Ivan; Batinic-Haberle, Ines; Liang, Yongliang; Jones, Dean P.; Fridovich-Keil, Judith L.

6. Manganese Superoxide Dismutase-Mediated Inside-Out Signaling in HaCaT Human Keratinocytes and SKH-1 Mouse Skin - Holley, Aaron K.; Xu, Yong; Noel, Teresa; Bakthavatchalu, Vasudevan; Batinic-Haberle, Ines; St. Clair, Daret K.

7. microRNA–200b as a Switch for Inducible Adult Angiogenesis - Sinha, Mithun; Ghatak, Subhadip; Roy, Sashwati; Sen, Chandan K.

8. Central Role of eNOS in the Maintenance of Endothelial Homeostasis - Heiss, Christian; Rodriguez-Mateos, Ana; Kelm, Malte

9. Cellular Biochemistry Methods for Investigating Protein Tyrosine Phosphatases - Stanford, Stephanie M.; Ahmed, Vanessa; Barrios, Amy M.; Bottini, Nunzio

10. Oxidative Stress-Associated Protein Tyrosine Kinases and Phosphatases in Fanconi Anemia - Li, Jie; Pang, Qishen

11. Hydroxyindole Carboxylic Acid-Based Inhibitors for Receptor-Type Protein Tyrosine Protein Phosphatase Beta - Zeng, Li-Fan; Zhang, Ruo-Yu; Bai, Yunpeng; Wu, Li; Gunawan, Andrea M.; Zhang, Zhong-Yin

12. The Role of Bacterial Protein Tyrosine Phosphatases in the Regulation of the Biosynthesis of Secreted Polysaccharides - Standish, Alistair J.; Morona, Renato

13. Reactive Nitrogen Species and Hydrogen Sulfide as Regulators of Protein Tyrosine Phosphatase Activity - Heneberg, Petr

14. Redox-Relevant Aspects of the Extracellular Matrix and Its Cellular Contacts via Integrins - Eble, Johannes A.; de Rezende, Flávia Figueiredo
Significance: The extracellular matrix (ECM) fulfills essential functions in multicellular organisms. It provides the mechanical scaffold and environmental cues to cells. Upon cell attachment, the ECM signals into the cells. In this process, reactive oxygen species (ROS) are physiologically used as signalizing molecules. Recent Advances: ECM attachment influences the ROS-production of cells. In turn, ROS affect the production, assembly and turnover of the ECM during wound healing and matrix remodeling. Pathological changes of ROS levels lead to excess ECM production and increased tissue contraction in fibrotic disorders and desmoplastic tumors. Integrins are cell adhesion molecules which mediate cell adhesion and...

15. MICAL-Family Proteins: Complex Regulators of the Actin Cytoskeleton - Giridharan, Sai Srinivas Panapakkam; Caplan, Steve
Significance: The molecules interacting with CasL (MICAL) family members participate in a multitude of activities, including axonal growth cone repulsion, membrane trafficking, apoptosis, and bristle development in flies. An interesting feature of MICAL proteins is the presence of an N-terminal flavo-mono-oxygenase domain. This mono-oxygenase domain generates redox potential with which MICALs can either oxidize proteins or produce reactive oxygen species (ROS). Actin is one such protein that is affected by MICAL function, leading to dramatic cytoskeletal rearrangements. This review describes the MICAL-family members, and discusses their mechanisms of actin-binding and regulation of actin cytoskeleton organization. Recent Advances: Recent studies show...

16. Mitochondria: The Cellular Hub of the Dynamic Coordinated Network - Yin, Fei; Cadenas, Enrique
Mitochondria are the powerhouses of the eukaryotic cell. After billions of years of evolution, mitochondria have adaptively integrated into the symbiont. Such integration is not only evidenced by the consolidation of genetic information, that is, the transfer of most mitochondrial genes into the nucleus, but also manifested by the functional recombination by which mitochondria participate seamlessly in various cellular processes. In the past decade, the field of mitochondria biology has been focused on the dynamic and interactive features of these semiautonomous organelles. Aspects of a complex multilayer quality control system coordinating mitochondrial function and environmental changes are being uncovered and...

17. Regulation of Mitochondrial Biogenesis and Its Intersection with Inflammatory Responses - Cherry, Anne D.; Piantadosi, Claude A.
Significance: Mitochondria play a vital role in cellular homeostasis and are susceptible to damage from inflammatory mediators released by the host defense. Cellular recovery depends, in part, on mitochondrial quality control programs, including mitochondrial biogenesis. Recent Advances: Early-phase inflammatory mediator proteins interact with PRRs to activate NF-κB-, MAPK-, and PKB/Akt-dependent pathways, resulting in increased expression or activity of coactivators and transcription factors (e.g., PGC-1α, NRF-1, NRF-2, and Nfe2l2) that regulate mitochondrial biogenesis. Inflammatory upregulation of NOS2-induced NO causes mitochondrial dysfunction, but NO is also a signaling molecule upregulating mitochondrial biogenesis via PGC-1α, participating in Nfe2l2-mediated antioxidant gene expression and modulating...

18. Stem Cells, Redox Signaling, and Stem Cell Aging - Liang, Raymond; Ghaffari, Saghi

19. Roles of Reactive Oxygen Species in the Fate of Stem Cells - Chaudhari, Pooja; Ye, Zhaohui; Jang, Yoon-Young

20. Iron and Reactive Oxygen Species: Friends or Foes of Cancer Cells? - Bystrom, Laura M.; Guzman, Monica L.; Rivella, Stefano

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