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PubMed Central (PMC3 - NLM DTD) (2.977.438 recursos)

Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

BMJ Case Reports

Mostrando recursos 1 - 20 de 6.518

  1. Erratum: First presentation of Addison's disease as hyperkalaemia in acute kidney injury

  2. Erratum: Cemento-ossifying fibroma of the jaw

  3. A rare complication of transitional cell carcinoma of the renal pelvis: parathyroid hormone-related peptide-induced hypercalcaemia

    O Sullivan, Eoin; Plant, William
    We describe a rare occurrence of parathyroid hormone-related peptide (PTHrp) associated hypercalcaemia with a recurrence of transitional cell carcinoma of the renal pelvis. Our patient presented with serum calcium of 3.9 mmol/L, PTH of 5 ng/L and a PTHrp of 9.8 pmol/L (<2 pmol/L). He had no evidence of metastatic disease. His hypercalcaemia responded to bisphosphonate therapy. He chose to be treated conservatively and died 5 weeks after presentation. This is the seventh such case described in the literature. PTHrp-induced hypercalcaemia is associated with a grave prognosis, with a mean survival of 65 days from presentation.

  4. A rare benign odontogenic neoplasm: peripheral odontogenic fibroma

    Reddy, Sasidhar V; Medikonda, Suresh Kumar; Konda, Amarnath; Natta, Sreelakshmi
    The peripheral odontogenic fibroma is a relatively rare, benign, unencapsulated and gingival mass of fibrous connective tissue, considered to be the extraosseous counterpart of the central odontogenic fibroma. Peripheral odontogenic fibroma was earlier quite commonly confused with peripheral ossifying fibroma, until WHO classification (1992), classified it under odontogenic tumours. Peripheral odontogenic fibroma is seen so infrequently that little is known about this neoplasm; the largest series of cases have been that of Farman who found five cases in the literature and added another 10 cases. Through this case report we try to clarify the features of this condition and attempt...

  5. Neonatal Marfan syndrome: a successful early multidisciplinary approach

    Amado, Marta; Calado, Maria Angelina; Ferreira, Rui; Lourenço, Teresa
    Marfan syndrome (MFS) is a genetic disorder of the connective tissue which rarely manifests in the neonatal period and has an ominous prognosis. A case of a first female offspring of healthy parents is described here. The pregnancy was uneventful and the mother had a term caesarean delivery. At birth, some dysmorphic signs became apparent, such as loose redundant skin, dolichocephaly, frontal bossing, deeply sunken eyes, micrognathia, contractures of the elbows, arachnodactyly and hip dysplasia. The echocardiogram showed a mitral and tricuspid valve regurgitation and a long aortic arch. The diagnosis of neonatal MFS came forward and genetic studies revealed...

  6. Exceptional localisation of an ectopic parathyroid adenoma at the level of the hyoid bone

    Musters, Linde; van Ginhoven, Tessa M; Smit, Casper
    Primary hyperparathyroidism is characterised by high parathyroid hormone (PTH) levels and concomitant hypercalcaemia. Ninety per cent is caused by solitary parathyroid adenomas, 10% by multiple adenomas, hyperplasia and carcinomas. Less than 0.1% of the inferior parathyroid glands are ectopically located. This case is of a 54-year-old woman with hypercalcaemia 3.05 mmol/L and high PTH 22 pmol/L. Scintigraphy and CT scan of the neck in 2009 showed no signs of ectopic tissue. After treatment with Aredia (pamidronate disodium) infusion, calcium decreased to 2.73 mmol/L. In 2010 the serum calcium levels increased again to 3 mmol/L. Repeated CT showed no ectopic tissue. However, revision of the...

  7. Phytobezoar leading to gastric outlet obstruction in a patient with diabetes

    Dhakal, Om Prakash; Dhakal, Mona; Bhandari, Dhurba
    Gastroparesis is a condition which results in delayed gastric emptying without gastric outflow tract obstruction. Gastrointestinal involvement in diabetes can present in various forms such as oesophageal dysmotility, gastro-oesophageal reflux disease, gastroparesis, enteropathy, non-alcoholic fatty liver disease and glycogenic hepatopathy. Gastroparesis is the most common gastric motility disorder complicating long-standing diabetes. It can sometimes lead to mechanical obstruction as a result of formation of bezoars. Phytobezoars are the most common type of bezoar and are composed of indigestible food, vegetable fibre or seeds. Poor pyloric function and decreased acid formation predisposes phytobezoars formation in patients with diabetic gastroparesis. An 80-year-old...

  8. Primary tuberculosis of the palate

    Rosado, Pablo; Fuente, Eduardo; Gallego, Lorena; Calvo, Nicolás
    Tuberculosis (TB) is a life-threatening infectious disease with a high world incidence. However, TB with oral expression is considered rare. The importance of recognising this entity lies in its early diagnosis and treatment, as it can be easily confused with neoplastic or traumatic ulcers. We present a case of a primary TB located in the hard palate and gingiva in an 88-year-old woman.

  9. Cerebral hypoperfusion secondary to radiation arteritis presenting with recurrent syncope

    Bashar, Khalid; McHugh, Seamus; Burke, Paul; Kavanagh, Eamon
    Radiation arteritis can lead to significant extracranial carotid artery stenosis, affecting the circle of Willis. Cerebral hypoperfusion due to arterial insufficiency is often considered as a differential diagnosis in cases of syncope but rarely proven. We present a case of a 61-year-old man with repeated episodes of syncope-negative cardiac investigations. He had a history of cervical radiation therapy for tonsillar squamous cell carcinoma 15 years previously. Carotid duplex revealed bilateral carotid occlusive disease. MR angiography showed severe multilevel extracranial carotid stenosis bilaterally with occluded left vertebral artery. A diagnosis of cerebral hypoperfusion was performed following single-photon emission CT scan. The patient...

  10. Presurgical nasal moulding in a neonate with cleft lip

    Deshpande, Anshula; Shah, Dixit; Macwan, Chirag S
    The concept of presurgical nasoalveolar moulding (PNM) was developed to improve the aesthetic result of surgically corrected cleft lip. This paper presents the method of fabrication of PNM appliance and the case of a 30-day-old neonate with unilateral cleft lip in whom nasal moulding was performed. Treatment was initiated at 30 days and continued for 60 days after which the surgical correction of cleft lip was performed. Significant improvement in aesthetics and symmetry of the nose was achieved at the end of the treatment.

  11. Solid blue dot tumour: minor salivary gland acinic cell carcinoma

    Bavle, Radhika M; Makarla, Soumya; Nadaf, Afreen; Narasimhamurthy, Srinath
    Acinic cell adenocarcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of all primary salivary gland malignancies. In the head and neck region, the parotid gland is the predominant site of origin and ACC is usually more frequent in women than men. Previous radiation exposure and familial predisposition are some of the risk factors for ACC. ACCs rarely involve minor salivary glands constituting only 13–17% of all minor salivary gland tumours. Generally, a slowly enlarging mass lesion in the tail of the parotid gland is the most frequent presentation. ACC has a significant tendency to recur, metastasise...

  12. Peripheral embolisation after an abdominal massage

    Tak, Sandeep; Tak, Shubhanjali; Gupta, Alok
    A 65-year-old man presented with a history of acute onset pain in toes of the right foot immediately after an abdominal massage by a ‘local healer’. General physical examination and systemic examination were normal except for discolouration of the fourth and fifth toes and cold toes. Investigations including complete blood count, erythrocyte sedimentation rate, renal function tests, liver profile, lipid profile, antinuclear antibody, antineutrophil cytoplasmic antibody, ECG, chest X-ray, ultrasound abdomen, cardiac echocardiography, lower limb Doppler and CT scan of the abdomen were normal. The patient was treated with regular heparin infusion, aspirin and tramadol. Recovery was complete in 5 days.

  13. Bedside cardiac testing in acute cor pulmonale

    Ali, Omair M; Masood, Abdul Mannan; Siddiqui, Faisal
    We present a case where an ECG and echocardiogram suggested pulmonary embolism and early treatment led to a positive outcome.

  14. Staged off-pump coronary artery bypass grafting and radical nephrectomy in a patient with multivessel coronary artery disease and a renal tumour

    Cetin, Erdem; Ozyuksel, Arda; Akay, Ferruh

  15. Three-dimensional spectral domain optical coherence tomography in vitreomacular traction

    Saxena, Sandeep; Manisha,; Meyer, Carsten H; Akduman, Levent
    Spectral domain optical coherence tomography (SD-OCT) is a non-invasive tool providing unprecedented imaging and analysis of vitreomacular interface. Two cases of vitreomacular traction were analysed by advanced three–dimensional (3D) SD-OCT imaging. En-face OCT permitted localisation of the exact point of attachment of vitreous to retina. A comprehensive view of the surface topography and anatomical configuration of vitreomacular affection was revealed by 3D imaging with segmentation technique. Macular change analysis programme revealed progression to full-thickness macular hole in the second case. Non-invasive high-resolution SD-OCT imaging has transformed the understanding and management of vitreomacular traction. Its role is further reinforced by the...

  16. A thalassaemia intermedia case with concomitant left atrial thrombus

    Sahin, Cem; Basaran, Ozcan; Topal, Yasar; Akin, Fatih
    Although marked improvements have been observed in the life expectancy of patients with thalassaemia by regular blood transfusion and strict iron chelation therapies in recent years, these patients still have to deal with several complications, mainly cardiovascular. One of the life-threatening complications is the chronic hypercoagulable state and thromboembolic events which develop due to haemostatic alterations in patients with thalassaemia, although they are more frequently seen in those with thalassaemia intermedia. Many thromboembolic complications, mainly deep venous thrombosis and cerebral thrombosis, have been reported in thalassaemia. However, intracardiac thrombosis is rarely seen. In this manuscript, we presented a case that...

  17. Pseudointernuclear ophthalmoplegia as a presenting feature of ocular myasthenia gravis

    Nijsse, Britta; Wefers Bettink, Marijke; Neuteboom, Rinze F

  18. Penetrating foreign body in the nasal floor through nasolacrimal duct

    Santoro, Roberto; Mannella, Valentina Katia; Freni, Francesco; Galletti, Francesco
    Clinical otolaryngologists frequently encounter nasal foreign bodies (FBs) particularly among children. The removal of nasal FBs is a common otolaryngological practice. However, occasionally trauma results from FBs being lodged in the nasal cavity especially through the nasolacrimal duct. In this article we present an unusual case of a FB that from the left medial canthus went inside the nasolacrimal duct, then through the inferior turbinate and stuck in the floor of the nose. We describe the transnasal endoscopic approach used and we recommend that the treatment be done as soon as possible to avoid complications.

  19. Delayed onset panuveitis following intravitreal aflibercept injection

    Glading, Jodi A; Lake, Stewart R; Craig, Jamie E; Supramaniam, Devaraj
    Aflibercept has been listed on the Australian Pharmaceutical Benefit Scheme for the past year for neovascular age-related macular degeneration. Since that time there have not been any reports of delayed onset panuveitis. We present two cases of anterior and posterior uveitis that have occurred 4 weeks or more after first intravitreal injection of aflibercept. Both patients had received other vascular endothelial growth factor inhibitors prior to aflibercept administration without signs of inflammation and both cases had sterile endophthalmitis. On resolution of the inflammation the patients were recommenced on ranibizumab without further incident.

  20. Transient small bowel intussusception in adults: an overlooked feature of coeliac disease

    Briggs, James Henry; McKean, David; Palmer, Jonathan S; Bungay, Helen
    Coeliac disease is the commonest immunological gastrointestinal disorder in the Western world. The symptoms of coeliac disease in adults are often non-specific, and a high index of suspicion may be required for timely diagnosis. We describe the case of a 46-year-old woman, with known dilated cardiomyopathy and pulmonary hypertension, who presented with non-specific abdominal symptoms, not initially attributed to gastrointestinal disease. Radiological investigations demonstrated transient small bowel intussusception without other abnormality, leading to the suggestion of coeliac disease as a cause, which was subsequently confirmed as the diagnosis.

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