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PubMed Central (PMC3 - NLM DTD) (2,912,029 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Clinical Epigenetics

Mostrando recursos 1 - 20 de 228

1. Epigenetic associations of type 2 diabetes and BMI in an Arab population - Al Muftah, Wadha A.; Al-Shafai, Mashael; Zaghlool, Shaza B.; Visconti, Alessia; Tsai, Pei-Chien; Kumar, Pankaj; Spector, Tim; Bell, Jordana; Falchi, Mario; Suhre, Karsten

2. Insulin-like growth factor axis in pregnancies affected by fetal growth disorders - Nawathe, Aamod R.; Christian, Mark; Kim, Sung Hye; Johnson, Mark; Savvidou, Makrina D.; Terzidou, Vasso

3. The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation - Li-Tempel, Ting; Larra, Mauro F.; Sandt, Estelle; Mériaux, Sophie B.; Schote, Andrea B.; Schächinger, Hartmut; Muller, Claude P.; Turner, Jonathan D.

4. Genome-wide DNA methylation analysis of pseudohypoparathyroidism patients with GNAS imprinting defects - Rochtus, Anne; Martin-Trujillo, Alejandro; Izzi, Benedetta; Elli, Francesca; Garin, Intza; Linglart, Agnes; Mantovani, Giovanna; Perez de Nanclares, Guiomar; Thiele, Suzanne; Decallonne, Brigitte; Van Geet, Chris; Monk, David; Freson, Kathleen

5. Loss of nuclear localization of TET2 in colorectal cancer - Huang, Yuji; Wang, Guanghui; Liang, Zhonglin; Yang, Yili; Cui, Long; Liu, Chen-Ying
5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. Here, we show that nuclear localization of TET2 was lost in a significant portion of CRC tissues, in association with metastasis. In CRC cells, nuclear expression of TET2 were absent but not TET3. Nuclear export inhibitor can increase the 5hmC level in CRC cells, probably through regulating TET2. Our results indicate a new mechanism of TET2 dysregulation in colorectal...

6. DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder - Walker, Rosie May; Christoforou, Andrea Nikie; McCartney, Daniel L.; Morris, Stewart W.; Kennedy, Nicholas A.; Morten, Peter; Anderson, Susan Maguire; Torrance, Helen Scott; Macdonald, Alix; Sussmann, Jessika Elizabeth; Whalley, Heather Clare; Blackwood, Douglas H. R.; McIntosh, Andrew Mark; Porteous, David John; Evans, Kathryn Louise

7. Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs - Roos, Leonie; van Dongen, Jenny; Bell, Christopher G.; Burri, Andrea; Deloukas, Panos; Boomsma, Dorret I.; Spector, Tim D.; Bell, Jordana T.

8. Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families - Mamtani, Manju; Kulkarni, Hemant; Dyer, Thomas D.; Göring, Harald H. H.; Neary, Jennifer L.; Cole, Shelley A.; Kent, Jack W.; Kumar, Satish; Glahn, David C.; Mahaney, Michael C.; Comuzzie, Anthony G.; Almasy, Laura; Curran, Joanne E.; Duggirala, Ravindranath; Blangero, John; Carless, Melanie A.

9. Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm - Han, Yanshuo; Tanios, Fadwa; Reeps, Christian; Zhang, Jian; Schwamborn, Kristina; Eckstein, Hans-Henning; Zernecke, Alma; Pelisek, Jaroslav

10. The influence of menstrual cycle and endometriosis on endometrial methylome - Saare, Merli; Modhukur, Vijayachitra; Suhorutshenko, Marina; Rajashekar, Balaji; Rekker, Kadri; Sõritsa, Deniss; Karro, Helle; Soplepmann, Pille; Sõritsa, Andrei; Lindgren, Cecilia M.; Rahmioglu, Nilufer; Drong, Alexander; Becker, Christian M.; Zondervan, Krina T.; Salumets, Andres; Peters, Maire

11. Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk - Guarrera, Simonetta; Fiorito, Giovanni; Onland-Moret, N. Charlotte; Russo, Alessia; Agnoli, Claudia; Allione, Alessandra; Di Gaetano, Cornelia; Mattiello, Amalia; Ricceri, Fulvio; Chiodini, Paolo; Polidoro, Silvia; Frasca, Graziella; Verschuren, Monique W. M.; Boer, Jolanda M. A.; Iacoviello, Licia; van der Schouw, Yvonne T.; Tumino, Rosario; Vineis, Paolo; Krogh, Vittorio; Panico, Salvatore; Sacerdote, Carlotta; Matullo, Giuseppe

12. MicroRNA-100 and microRNA-21 as markers of survival and chemotherapy response in pancreatic ductal adenocarcinoma UICC stage II - Dhayat, Sameer Abdallah; Abdeen, Baha; Köhler, Gabriele; Senninger, Norbert; Haier, Jörg; Mardin, Wolf Arif

13. Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer - Sahnane, Nora; Magnoli, Francesca; Bernasconi, Barbara; Tibiletti, Maria Grazia; Romualdi, Chiara; Pedroni, Monica; Ponz de Leon, Maurizio; Magnani, Giulia; Reggiani-Bonetti, Luca; Bertario, Lucio; Signoroni, Stefano; Capella, Carlo; Sessa, Fausto; Furlan, Daniela;

14. MicroRNA profiling of primary pulmonary enteric adenocarcinoma in members from the same family reveals some similarities to pancreatic adenocarcinoma—a step towards personalized therapy - Garajová, Ingrid; Funel, Niccola; Fiorentino, Michelangelo; Agostini, Valentina; Ferracin, Manuela; Negrini, Massimo; Frassineti, Giovanni Luca; Gavelli, Giampaolo; Frampton, Adam Enver; Biasco, Guido; Giovannetti, Elisa

15. The integrative epigenomic-transcriptomic landscape of ER positive breast cancer - Gao, Yang; Jones, Allison; Fasching, Peter A.; Ruebner, Matthias; Beckmann, Matthias W.; Widschwendter, Martin; Teschendorff, Andrew E.

16. CpG island methylation profile in non-invasive oral rinse samples is predictive of oral and pharyngeal carcinoma - Langevin, Scott M.; Eliot, Melissa; Butler, Rondi A.; Cheong, Agnes; Zhang, Xiang; McClean, Michael D.; Koestler, Devin C.; Kelsey, Karl T.

17. Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer - Alonso, Sergio; González, Beatriz; Ruiz-Larroya, Tatiana; Durán Domínguez, Mercedes; Kato, Takaharu; Matsunaga, Akihiro; Suzuki, Koichi; Strongin, Alex Y.; Gimènez-Bonafé, Pepita; Perucho, Manuel

18. Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci - Eggermann, Thomas; Perez de Nanclares, Guiomar; Maher, Eamonn R.; Temple, I. Karen; Tümer, Zeynep; Monk, David; Mackay, Deborah J. G.; Grønskov, Karen; Riccio, Andrea; Linglart, Agnès; Netchine, Irène
Congenital imprinting disorders (IDs) are characterised by molecular changes affecting imprinted chromosomal regions and genes, i.e. genes that are expressed in a parent-of-origin specific manner. Recent years have seen a great expansion in the range of alterations in regulation, dosage or DNA sequence shown to disturb imprinted gene expression, and the correspondingly broad range of resultant clinical syndromes. At the same time, however, it has become clear that this diversity of IDs has common underlying principles, not only in shared molecular mechanisms, but also in interrelated clinical impacts upon growth, development and metabolism. Thus, detailed and systematic analysis of IDs...

19. Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders - Jawahar, Magdalene C.; Murgatroyd, Chris; Harrison, Emma L.; Baune, Bernhard T.
Stressor exposure during early life has the potential to increase an individual’s susceptibility to a number of neuropsychiatric conditions such as mood and anxiety disorders and schizophrenia in adulthood. This occurs in part due to the dysfunctional stress axis that persists following early adversity impairing stress responsivity across life. The mechanisms underlying the prolonged nature of this vulnerability remain to be established. Alterations in the epigenetic signature of genes involved in stress responsivity may represent one of the neurobiological mechanisms. The overall aim of this review is to provide current evidence demonstrating changes in the epigenetic signature of candidate gene(s)...

20. Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health - Stuppia, Liborio; Franzago, Marica; Ballerini, Patrizia; Gatta, Valentina; Antonucci, Ivana
The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and female gametes. In the present review, we focused our attention to the role played by epigenetics on male reproduction, evidencing at least four different levels at which sperm epigenetic modifications could affect reproduction: (1) spermatogenesis failure; (2) embryo development; (3) outcome of assisted reproduction technique (ART) protocols, mainly as concerning genomic imprinting; and (4) long-term effects during the offspring lifetime. The environmental agents responsible for epigenetic modifications are also examined, suggesting that...

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