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PubMed Central (PMC3 - NLM DTD) (3.020.751 recursos)

Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Clinical Epigenetics

Mostrando recursos 1 - 20 de 278

  1. The emerging role of lysine methyltransferase SETD8 in human diseases

    Milite, Ciro; Feoli, Alessandra; Viviano, Monica; Rescigno, Donatella; Cianciulli, Agostino; Balzano, Amodio Luca; Mai, Antonello; Castellano, Sabrina; Sbardella, Gianluca
    SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20) in vivo. Lysine residues of non-histone proteins including proliferating cell nuclear antigen (PCNA) and p53 are also monomethylated. As a consequence, the methyltransferase activity of the enzyme is implicated in many essential cellular processes including DNA replication, DNA damage response, transcription modulation, and cell cycle regulation. This review aims to provide an overview of the roles of SETD8 in physiological and pathological pathways and to discuss the progress made to date in inhibiting the activity of SETD8 by small molecules, with an emphasis on...

  2. DNA methylation and smoking in Korean adults: epigenome-wide association study

    Lee, Mi Kyeong; Hong, Yoonki; Kim, Sun-Young; London, Stephanie J.; Kim, Woo Jin

  3. MSP-HTPrimer: a high-throughput primer design tool to improve assay design for DNA methylation analysis in epigenetics

    Pandey, Ram Vinay; Pulverer, Walter; Kallmeyer, Rainer; Beikircher, Gabriel; Pabinger, Stephan; Kriegner, Albert; Weinhäusel, Andreas

  4. Antidepressant medication during pregnancy and epigenetic changes in umbilical cord blood: a systematic review

    Viuff, Anne-Cathrine F.; Pedersen, Lars Henning; Kyng, Kasper; Staunstrup, Nicklas Heine; Børglum, Anders; Henriksen, Tine Brink

  5. Aberrant methylation of cell-free circulating DNA in plasma predicts poor outcome in diffuse large B cell lymphoma

    Kristensen, Lasse Sommer; Hansen, Jakob Werner; Kristensen, Søren Sommer; Tholstrup, Dorte; Harsløf, Laurine Bente Schram; Pedersen, Ole Birger; De Nully Brown, Peter; Grønbæk, Kirsten

  6. DNA methylation: conducting the orchestra from exposure to phenotype?

    Leenen, Fleur A. D.; Muller, Claude P.; Turner, Jonathan D.
    DNA methylation, through 5-methyl- and 5-hydroxymethylcytosine (5mC and 5hmC), is considered to be one of the principal interfaces between the genome and our environment, and it helps explain phenotypic variations in human populations. Initial reports of large differences in methylation level in genomic regulatory regions, coupled with clear gene expression data in both imprinted genes and malignant diseases, provided easily dissected molecular mechanisms for switching genes on or off. However, a more subtle process is becoming evident, where small (<10 %) changes to intermediate methylation levels are associated with complex disease phenotypes. This has resulted in two clear methylation paradigms. The...

  7. Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation

    Spólnicka, Magdalena; Piekarska, Renata Zbieć; Jaskuła, Emilia; Basak, Grzegorz W.; Jacewicz, Renata; Pięta, Agnieszka; Makowska, Żanetta; Jedrzejczyk, Maciej; Wierzbowska, Agnieszka; Pluta, Agnieszka; Robak, Tadeusz; Berent, Jarosław; Branicki, Wojciech; Jędrzejczak, Wiesław; Lange, Andrzej; Płoski, Rafał

  8. Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy

    Kernohan, Kristin D.; Cigana Schenkel, Laila; Huang, Lijia; Smith, Amanda; Pare, Guillaume; Ainsworth, Peter; ; Boycott, Kym M.; Warman-Chardon, Jodi; Sadikovic, Bekim

  9. p38-MAPK/MSK1-mediated overexpression of histone H3 serine 10 phosphorylation defines distance-dependent prognostic value of negative resection margin in gastric cancer

    Khan, Shafqat Ali; Amnekar, Ramchandra; Khade, Bharat; Barreto, Savio George; Ramadwar, Mukta; Shrikhande, Shailesh V.; Gupta, Sanjay

  10. Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells

    Sanders, Katherine A.; Benton, Miles C.; Lea, Rod A.; Maltby, Vicki E.; Agland, Susan; Griffin, Nathan; Scott, Rodney J.; Tajouri, Lotti; Lechner-Scott, Jeannette

  11. Erratum to: MSRE-HTPrimer: a high-throughput and genome-wide primer design pipeline optimized for epigenetic research

    Pandey, Ram Vinay; Pulverer, Walter; Kallmeyer, Rainer; Beikircher, Gabriel; Pabinger, Stephan; Kriegner, Albert; Weinhäusel, Andreas

  12. Tobacco smoking differently influences cell types of the innate and adaptive immune system—indications from CpG site methylation

    Bauer, Mario; Fink, Beate; Thürmann, Loreen; Eszlinger, Markus; Herberth, Gunda; Lehmann, Irina

  13. Genome-wide DNA methylation profiling with MeDIP-seq using archived dried blood spots

    Staunstrup, Nicklas H.; Starnawska, Anna; Nyegaard, Mette; Christiansen, Lene; Nielsen, Anders L.; Børglum, Anders; Mors, Ole

  14. Increased global placental DNA methylation levels are associated with gestational diabetes

    Reichetzeder, C.; Dwi Putra, S. E.; Pfab, T.; Slowinski, T.; Neuber, C.; Kleuser, B.; Hocher, B.

  15. Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes

    Day, Samantha E.; Coletta, Richard L.; Kim, Joon Young; Campbell, Latoya E.; Benjamin, Tonya R.; Roust, Lori R.; De Filippis, Elena A.; Dinu, Valentin; Shaibi, Gabriel Q.; Mandarino, Lawrence J.; Coletta, Dawn K.

  16. Studying epigenetic complexes and their inhibitors with the proteomics toolbox

    Weigt, David; Hopf, Carsten; Médard, Guillaume
    Some epigenetic modifier proteins have become validated clinical targets. With a few small molecule inhibitors already approved by national health administrations and many more in the pharmaceutical industry pipelines, there is a need for technologies that can promote full comprehension of the molecular action of these drugs. Proteomics, with its relatively unbiased nature, can contribute to a thorough understanding of the complexity of the megadalton complexes, which write, read and erase the histone code, and it can help study the on-target and off-target effect of the drugs designed to modulate their action. This review on the one hand gathers the...

  17. Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas

    Lim, Annette M.; Wong, Nicholas C.; Pidsley, Ruth; Zotenko, Elena; Corry, June; Dobrovic, Alexander; Clark, Susan J.; Rischin, Danny; Solomon, Benjamin

  18. Recent developments on the role of epigenetics in obesity and metabolic disease

    van Dijk, Susan J.; Tellam, Ross L.; Morrison, Janna L.; Muhlhausler, Beverly S.; Molloy, Peter L.
    The increased prevalence of obesity and related comorbidities is a major public health problem. While genetic factors undoubtedly play a role in determining individual susceptibility to weight gain and obesity, the identified genetic variants only explain part of the variation. This has led to growing interest in understanding the potential role of epigenetics as a mediator of gene-environment interactions underlying the development of obesity and its associated comorbidities. Initial evidence in support of a role of epigenetics in obesity and type 2 diabetes mellitus (T2DM) was mainly provided by animal studies, which reported epigenetic changes in key metabolically important tissues...

  19. PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns

    Côté, Sandra; Gagné-Ouellet, Valérie; Guay, Simon-Pierre; Allard, Catherine; Houde, Andrée-Anne; Perron, Patrice; Baillargeon, Jean-Patrice; Gaudet, Daniel; Guérin, Renée; Brisson, Diane; Hivert, Marie-France; Bouchard, Luigi

  20. A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers

    Diesch, Jeannine; Zwick, Anabel; Garz, Anne-Kathrin; Palau, Anna; Buschbeck, Marcus; Götze, Katharina S.
    The azanucleosides azacitidine and decitabine are currently used for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in patients not only eligible for intensive chemotherapy but are also being explored in other hematologic and solid cancers. Based on their capacity to interfere with the DNA methylation machinery, these drugs are also referred to as hypomethylating agents (HMAs). As DNA methylation contributes to epigenetic regulation, azanucleosides are further considered to be among the first true “epigenetic drugs” that have reached clinical application. However, intriguing new evidence suggests that DNA hypomethylation is not the only mechanism of action for...

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