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PubMed Central (PMC3 - NLM DTD) (2,928,117 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Clinical Epigenetics

Mostrando recursos 1 - 20 de 246

1. Hypomethylation of FAM63B in bipolar disorder patients - Starnawska, Anna; Demontis, Ditte; McQuillin, Andrew; O’Brien, Niamh L.; Staunstrup, Nicklas H.; Mors, Ole; Nielsen, Anders L.; Børglum, Anders D.; Nyegaard, Mette
Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found significant hypomethylation of FAM63B in exon 9. Here, we used iPLEX-based methylation analysis to investigate two CpG sites in FAM63B in blood samples from 459 BD cases and 268 controls. Both sites were significantly hypomethylated in BD cases (lowest p value = 3.94 × 10−8). The methylation levels at the two sites were correlated, and no strong correlation was found with nearby single nucleotide polymorphisms (SNPs), suggesting that methylation differences at these sites are not...

2. RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors - Oronsky, Bryan; Scicinski, Jan; Cabrales, Pedro; Minchinton, Andrew

3. DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease - Zeybel, Müjdat; Vatansever, Sezgin; Hardy, Timothy; Sarı, Ayşegül Akder; Cakalağaoğlu, Fulya; Avcı, Arzu; Zeybel, Gemma Louise; Karahüseyinoğlu, Serçin; Bashton, Matthew; Mathers, John C.; Ünsal, Belkıs; Mann, Jelena

4. Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation - Bohne, Florian; Langer, David; Martiné, Ursula; Eider, Claudia S.; Cencic, Regina; Begemann, Matthias; Elbracht, Miriam; Bülow, Luzie; Eggermann, Thomas; Zechner, Ulrich; Pelletier, Jerry; Zabel, Bernhard Ulrich; Enklaar, Thorsten; Prawitt, Dirk

5. Establishing an analytic pipeline for genome-wide DNA methylation - Wright, Michelle L.; Dozmorov, Mikhail G.; Wolen, Aaron R.; Jackson-Cook, Colleen; Starkweather, Angela R.; Lyon, Debra E.; York, Timothy P.
The need for research investigating DNA methylation (DNAm) in clinical studies has increased, leading to the evolution of new analytic methods to improve accuracy and reproducibility of the interpretation of results from these studies. The purpose of this article is to provide clinical researchers with a summary of the major data processing steps routinely applied in clinical studies investigating genome-wide DNAm using the Illumina HumanMethylation 450K BeadChip. In most studies, the primary goal of employing DNAm analysis is to identify differential methylation at CpG sites among phenotypic groups. Experimental design considerations are crucial at the onset to minimize bias from...

6. Analysis of RET promoter CpG island methylation using methylation-specific PCR (MSP), pyrosequencing, and methylation-sensitive high-resolution melting (MS-HRM): impact on stage II colon cancer patient outcome - Draht, Muriel X. G.; Smits, Kim M.; Jooste, Valérie; Tournier, Benjamin; Vervoort, Martijn; Ramaekers, Chantal; Chapusot, Caroline; Weijenberg, Matty P.; van Engeland, Manon; Melotte, Veerle

7. Defining the criteria for identifying constitutional epimutations - Sloane, Mathew A.; Ward, Robyn L.; Hesson, Luke B.
In the January 2016 issue of Clinical Epigenetics, Quiñonez-Silva et al. (Clin Epigenetics 8:1, 2016) described a possible constitutional epimutation of the RB1 gene as a cause of hereditary predisposition to retinoblastoma. The term constitutional epimutation describes an epigenetic aberration in normal tissues that predisposes to disease. The data presented by Quiñonez-Silva et al. are interesting, but further analysis is required to demonstrate a constitutional epimutation in this family. Here, we define the criteria and describe the experimental approach necessary to identify an epigenetic aberration as a constitutional epimutation.

8. The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis - Aprelikova, Olga; Chen, Kenny; El Touny, Lara H.; Brignatz-Guittard, Constance; Han, Justin; Qiu, Tinghu; Yang, Howard H.; Lee, Maxwell P.; Zhu, Min; Green, Jeffrey E.

9. Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients - Chen, Duo; Wen, Xianyu; Song, Young Seok; Rhee, Ye-Young; Lee, Tae Hun; Cho, Nam Yun; Han, Sae-Won; Kim, Tae-You; Kang, Gyeong Hoon

10. TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus - Celarain, Naiara; Sánchez-Ruiz de Gordoa, Javier; Zelaya, María Victoria; Roldán, Miren; Larumbe, Rosa; Pulido, Laura; Echavarri, Carmen; Mendioroz, Maite

11. Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model - Zhao, Quan-Yi; Lei, Pin-Ji; Zhang, Xiaoran; Zheng, Jun-Yi; Wang, Hui-Yi; Zhao, Jiao; Li, Yi-Ming; Ye, Mei; Li, Lianyun; Wei, Gang; Wu, Min

12. Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis - Kamdar, Shivani N.; Ho, Linh T.; Kron, Ken J.; Isserlin, Ruth; van der Kwast, Theodorus; Zlotta, Alexandre R.; Fleshner, Neil E.; Bader, Gary; Bapat, Bharati

13. 5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma - Barazeghi, Elham; Gill, Anthony J.; Sidhu, Stan; Norlén, Olov; Dina, Roberto; Palazzo, F. Fausto; Hellman, Per; Stålberg, Peter; Westin, Gunnar

14. Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn’s disease-associated fibrosis - Sadler, Tammy; Bhasin, Jeffrey M.; Xu, Yaomin; Barnholz-Sloan, Jill; Chen, Yanwen; Ting, Angela H.; Stylianou, Eleni

15. Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3 - Boers, A.; Wang, R.; van Leeuwen, R. W.; Klip, H. G.; de Bock, G. H.; Hollema, H.; van Criekinge, W.; de Meyer, T.; Denil, S.; van der Zee, A. G J.; Schuuring, E.; Wisman, G. B. A.

16. Hsa-miR-375 is a predictor of local control in early stage breast cancer - Zehentmayr, Franz; Hauser-Kronberger, Cornelia; Zellinger, Barbara; Hlubek, Falk; Schuster, Claudia; Bodenhofer, Ulrich; Fastner, Gerd; Deutschmann, Heinz; Steininger, Philipp; Reitsamer, Roland; Fischer, Thorsten; Sedlmayer, Felix

17. Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review - Jia, Min; Gao, Xu; Zhang, Yan; Hoffmeister, Michael; Brenner, Hermann
Contradictory results were reported for the prognostic role of CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients. Differences in the definitions of CIMP were the most common explanation for these discrepancies. The aim of this systematic review was to give an overview of the published studies on CRC prognosis according to the different definitions of CIMP. A systematic literature search was performed in MEDLINE and ISI Web of Science for articles published until 3 April 2015. Data extraction included information about the study population, the definition of CIMP, and investigated outcomes. Thirty-six studies were included in this systematic...

18. Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant, and malignant ascites - Jung, Maria; Pützer, Svenja; Gevensleben, Heidrun; Meller, Sebastian; Kristiansen, Glen; Dietrich, Dimo

19. Epigenetic associations of type 2 diabetes and BMI in an Arab population - Al Muftah, Wadha A.; Al-Shafai, Mashael; Zaghlool, Shaza B.; Visconti, Alessia; Tsai, Pei-Chien; Kumar, Pankaj; Spector, Tim; Bell, Jordana; Falchi, Mario; Suhre, Karsten

20. Insulin-like growth factor axis in pregnancies affected by fetal growth disorders - Nawathe, Aamod R.; Christian, Mark; Kim, Sung Hye; Johnson, Mark; Savvidou, Makrina D.; Terzidou, Vasso

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