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PubMed Central (PMC3 - NLM DTD) (2,833,227 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Clinical Epigenetics

Mostrando recursos 1 - 20 de 174

1. The GALNT9, BNC1 and CCDC8 genes are frequently epigenetically dysregulated in breast tumours that metastasise to the brain - Pangeni, Rajendra P.; Channathodiyil, Prasanna; Huen, David S.; Eagles, Lawrence W.; Johal, Balraj K.; Pasha, Dawar; Hadjistephanou, Natasa; Nevell, Oliver; Davies, Claire L.; Adewumi, Ayobami I.; Khanom, Hamida; Samra, Ikroop S.; Buzatto, Vanessa C.; Chandrasekaran, Preethi; Shinawi, Thoraia; Dawson, Timothy P.; Ashton, Katherine M.; Davis, Charles; Brodbelt, Andrew R.; Jenkinson, Michael D.; Bièche, Ivan; Latif, Farida; Darling, John L.; Warr, Tracy J.; Morris, Mark R.

2. MicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603 - Villaruz, Liza C.; Huang, Grace; Romkes, Marjorie; Kirkwood, John M.; Buch, Shama C.; Nukui, Tomoko; Flaherty, Keith T.; Lee, Sandra J.; Wilson, Melissa A.; Nathanson, Katherine L.; Benos, Panayiotis V.; Tawbi, Hussein A.

3. Inter- and transgenerational epigenetic inheritance: evidence in asthma and COPD? - Krauss-Etschmann, Susanne; Meyer, Karolin F; Dehmel, Stefan; Hylkema, Machteld N
Evidence is now emerging that early life environment can have lifelong effects on metabolic, cardiovascular, and pulmonary function in offspring, a concept also known as fetal or developmental programming. In mammals, developmental programming is thought to occur mainly via epigenetic mechanisms, which include DNA methylation, histone modifications, and expression of non-coding RNAs. The effects of developmental programming can be induced by the intrauterine environment, leading to intergenerational epigenetic effects from one generation to the next. Transgenerational epigenetic inheritance may be considered when developmental programming is transmitted across generations that were not exposed to the initial environment which triggered the change....

4. Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes - Prattichizzo, Francesco; Giuliani, Angelica; Ceka, Artan; Rippo, Maria Rita; Bonfigli, Anna Rita; Testa, Roberto; Procopio, Antonio Domenico; Olivieri, Fabiola
The development of type-2 diabetes mellitus (T2DM) and its complications is largely due to the complex interaction between genetic factors and environmental influences, mainly dietary habits and lifestyle, which can either accelerate or slow down disease progression. Recent findings suggest the potential involvement of epigenetic mechanisms as a crucial interface between the effects of genetic predisposition and environmental factors. The common denominator of environmental factors promoting T2DM development and progression is that they trigger an inflammatory response, promoting inflammation-mediated insulin resistance and endothelial dysfunction. Proinflammatory stimuli, including hyperglycemia, oxidative stress, and other inflammatory mediators, can affect epigenetic mechanisms, altering the...

5. Tobacco smoking is associated with methylation of genes related to coronary artery disease - Steenaard, Rebecca V; Ligthart, Symen; Stolk, Lisette; Peters, Marjolein J; van Meurs, Joyce B; Uitterlinden, Andre G; Hofman, Albert; Franco, Oscar H; Dehghan, Abbas

6. Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence - Ruiz-Hernandez, Adrian; Kuo, Chin-Chi; Rentero-Garrido, Pilar; Tang, Wan-Yee; Redon, Josep; Ordovas, Jose M; Navas-Acien, Ana; Tellez-Plaza, Maria
Current evidence supports the notion that environmental exposures are associated with DNA-methylation and expression changes that can impact human health. Our objective was to conduct a systematic review of epidemiologic studies evaluating the association between environmental chemicals with DNA methylation levels in adults. After excluding arsenic, recently evaluated in a systematic review, we identified a total of 17 articles (6 on cadmium, 4 on lead, 2 on mercury, 1 on nickel, 1 on antimony, 1 on tungsten, 5 on persistent organic pollutants and perfluorinated compounds, 1 on bisphenol A, and 3 on polycyclic aromatic hydrocarbons). The selected articles reported quantitative...

7. MicroRNA-375 plays a dual role in prostate carcinogenesis - Costa-Pinheiro, Pedro; Ramalho-Carvalho, João; Vieira, Filipa Quintela; Torres-Ferreira, Jorge; Oliveira, Jorge; Gonçalves, Céline S; Costa, Bruno M; Henrique, Rui; Jerónimo, Carmen

8. Epigenetic reprogramming of melanoma cells by vitamin C treatment - Gustafson, Christopher B; Yang, Cuixia; Dickson, Kevin M; Shao, Hongwei; Van Booven, Derek; Harbour, J William; Liu, Zhao-Jun; Wang, Gaofeng

9. Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis - Locke, Warwick J; Zotenko, Elena; Stirzaker, Clare; Robinson, Mark D; Hinshelwood, Rebecca A; Stone, Andrew; Reddel, Roger R; Huschtscha, Lily I; Clark, Susan J

10. Effects of phthalate exposure on asthma may be mediated through alterations in DNA methylation - Wang, I-Jen; Karmaus, Wilfried JJ; Chen, Su-Lien; Holloway, John W; Ewart, Susan

11. DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma - Udali, Silvia; Guarini, Patrizia; Ruzzenente, Andrea; Ferrarini, Alberto; Guglielmi, Alfredo; Lotto, Valentina; Tononi, Paola; Pattini, Patrizia; Moruzzi, Sara; Campagnaro, Tommaso; Conci, Simone; Olivieri, Oliviero; Corrocher, Roberto; Delledonne, Massimo; Choi, Sang-Woon; Friso, Simonetta

12. Comparison of HPV genotyping and methylated ZNF582 as triage for women with equivocal liquid-based cytology results - Liou, Yu-Ligh; Zhang, Yu; Liu, Yingzi; Cao, Lanqin; Qin, Chong-Zhen; Zhang, Tao-Lan; Chang, Chi-Feng; Wang, Huei-Jen; Lin, Shu-Yi; Chu, Tang-Yuan; Zhang, Yi; Zhou, Hong-Hao

13. Racial differences in IGF1 methylation and birth weight - Straughen, Jennifer K; Sipahi, Levent; Uddin, Monica; Misra, Dawn P; Misra, Vinod K

14. Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants - Ortega, Francisco José; Moreno, María; Mercader, Josep María; Moreno-Navarrete, José María; Fuentes-Batllevell, Núria; Sabater, Mònica; Ricart, Wifredo; Fernández-Real, José Manuel

15. A statistical method for single sample analysis of HumanMethylation450 array data: genome-wide methylation analysis of patients with imprinting disorders - Rezwan, Faisal I; Docherty, Louise E; Poole, Rebecca L; Lockett, Gabrielle A; Arshad, S Hasan; Holloway, John W; Temple, I Karen; Mackay, Deborah JG

16. Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers - Kuasne, Hellen; Cólus, Ilce Mara de Syllos; Busso, Ariane Fidelis; Hernandez-Vargas, Hector; Barros-Filho, Mateus Camargo; Marchi, Fabio Albuquerque; Scapulatempo-Neto, Cristovam; Faria, Eliney Ferreira; Lopes, Ademar; Guimarães, Gustavo Cardoso; Herceg, Zdenko; Rogatto, Silvia Regina

17. Risk of re-identification of epigenetic methylation data: a more nuanced response is needed - Joly, Yann; Dyke, Stephanie OM; Cheung, Warren A; Rothstein, Mark A; Pastinen, Tomi
In this letter to the editor, we respond to the recent publication by Philibert et al. Methylation array data can simultaneously identify individuals and convey protected health information: an unrecognized ethical concern (Clinical Epigenetics 2014, 6:28). Further discussion of the issues raised by the risk of re-identification of epigenetic methylation data is needed, and a more nuanced approach should be taken with respect to its implications for data sharing policy than the one provided.

18. Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy - Jones, Takako I; King, Oliver D; Himeda, Charis L; Homma, Sachiko; Chen, Jennifer C J; Beermann, Mary Lou; Yan, Chi; Emerson, Charles P; Miller, Jeffrey B; Wagner, Kathryn R; Jones, Peter L

19. Platelet mitochondrial DNA methylation: a potential new marker of cardiovascular disease - Baccarelli, Andrea A; Byun, Hyang-Min

20. DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility - Song, Sisi; Ghosh, Jayashri; Mainigi, Monica; Turan, Nahid; Weinerman, Rachel; Truongcao, May; Coutifaris, Christos; Sapienza, Carmen

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