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PubMed Central (PMC3 - NLM DTD) (2,924,057 recursos)
Archive of life sciences journal literature at the U.S. National Institutes of Health (NIH), developed and managed by NIH's National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM).

Clinical Epigenetics

Mostrando recursos 1 - 20 de 240

1. Defining the criteria for identifying constitutional epimutations - Sloane, Mathew A.; Ward, Robyn L.; Hesson, Luke B.
In the January 2016 issue of Clinical Epigenetics, Quiñonez-Silva et al. (Clin Epigenetics 8:1, 2016) described a possible constitutional epimutation of the RB1 gene as a cause of hereditary predisposition to retinoblastoma. The term constitutional epimutation describes an epigenetic aberration in normal tissues that predisposes to disease. The data presented by Quiñonez-Silva et al. are interesting, but further analysis is required to demonstrate a constitutional epimutation in this family. Here, we define the criteria and describe the experimental approach necessary to identify an epigenetic aberration as a constitutional epimutation.

2. The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis - Aprelikova, Olga; Chen, Kenny; El Touny, Lara H.; Brignatz-Guittard, Constance; Han, Justin; Qiu, Tinghu; Yang, Howard H.; Lee, Maxwell P.; Zhu, Min; Green, Jeffrey E.

3. Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients - Chen, Duo; Wen, Xianyu; Song, Young Seok; Rhee, Ye-Young; Lee, Tae Hun; Cho, Nam Yun; Han, Sae-Won; Kim, Tae-You; Kang, Gyeong Hoon

4. TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus - Celarain, Naiara; Sánchez-Ruiz de Gordoa, Javier; Zelaya, María Victoria; Roldán, Miren; Larumbe, Rosa; Pulido, Laura; Echavarri, Carmen; Mendioroz, Maite

5. Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model - Zhao, Quan-Yi; Lei, Pin-Ji; Zhang, Xiaoran; Zheng, Jun-Yi; Wang, Hui-Yi; Zhao, Jiao; Li, Yi-Ming; Ye, Mei; Li, Lianyun; Wei, Gang; Wu, Min

6. Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis - Kamdar, Shivani N.; Ho, Linh T.; Kron, Ken J.; Isserlin, Ruth; van der Kwast, Theodorus; Zlotta, Alexandre R.; Fleshner, Neil E.; Bader, Gary; Bapat, Bharati

7. 5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma - Barazeghi, Elham; Gill, Anthony J.; Sidhu, Stan; Norlén, Olov; Dina, Roberto; Palazzo, F. Fausto; Hellman, Per; Stålberg, Peter; Westin, Gunnar

8. Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn’s disease-associated fibrosis - Sadler, Tammy; Bhasin, Jeffrey M.; Xu, Yaomin; Barnholz-Sloan, Jill; Chen, Yanwen; Ting, Angela H.; Stylianou, Eleni

9. Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3 - Boers, A.; Wang, R.; van Leeuwen, R. W.; Klip, H. G.; de Bock, G. H.; Hollema, H.; van Criekinge, W.; de Meyer, T.; Denil, S.; van der Zee, A. G J.; Schuuring, E.; Wisman, G. B. A.

10. Hsa-miR-375 is a predictor of local control in early stage breast cancer - Zehentmayr, Franz; Hauser-Kronberger, Cornelia; Zellinger, Barbara; Hlubek, Falk; Schuster, Claudia; Bodenhofer, Ulrich; Fastner, Gerd; Deutschmann, Heinz; Steininger, Philipp; Reitsamer, Roland; Fischer, Thorsten; Sedlmayer, Felix

11. Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review - Jia, Min; Gao, Xu; Zhang, Yan; Hoffmeister, Michael; Brenner, Hermann
Contradictory results were reported for the prognostic role of CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients. Differences in the definitions of CIMP were the most common explanation for these discrepancies. The aim of this systematic review was to give an overview of the published studies on CRC prognosis according to the different definitions of CIMP. A systematic literature search was performed in MEDLINE and ISI Web of Science for articles published until 3 April 2015. Data extraction included information about the study population, the definition of CIMP, and investigated outcomes. Thirty-six studies were included in this systematic...

12. Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant, and malignant ascites - Jung, Maria; Pützer, Svenja; Gevensleben, Heidrun; Meller, Sebastian; Kristiansen, Glen; Dietrich, Dimo

13. Epigenetic associations of type 2 diabetes and BMI in an Arab population - Al Muftah, Wadha A.; Al-Shafai, Mashael; Zaghlool, Shaza B.; Visconti, Alessia; Tsai, Pei-Chien; Kumar, Pankaj; Spector, Tim; Bell, Jordana; Falchi, Mario; Suhre, Karsten

14. Insulin-like growth factor axis in pregnancies affected by fetal growth disorders - Nawathe, Aamod R.; Christian, Mark; Kim, Sung Hye; Johnson, Mark; Savvidou, Makrina D.; Terzidou, Vasso

15. The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation - Li-Tempel, Ting; Larra, Mauro F.; Sandt, Estelle; Mériaux, Sophie B.; Schote, Andrea B.; Schächinger, Hartmut; Muller, Claude P.; Turner, Jonathan D.

16. Genome-wide DNA methylation analysis of pseudohypoparathyroidism patients with GNAS imprinting defects - Rochtus, Anne; Martin-Trujillo, Alejandro; Izzi, Benedetta; Elli, Francesca; Garin, Intza; Linglart, Agnes; Mantovani, Giovanna; Perez de Nanclares, Guiomar; Thiele, Suzanne; Decallonne, Brigitte; Van Geet, Chris; Monk, David; Freson, Kathleen

17. Loss of nuclear localization of TET2 in colorectal cancer - Huang, Yuji; Wang, Guanghui; Liang, Zhonglin; Yang, Yili; Cui, Long; Liu, Chen-Ying
5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. Here, we show that nuclear localization of TET2 was lost in a significant portion of CRC tissues, in association with metastasis. In CRC cells, nuclear expression of TET2 were absent but not TET3. Nuclear export inhibitor can increase the 5hmC level in CRC cells, probably through regulating TET2. Our results indicate a new mechanism of TET2 dysregulation in colorectal...

18. DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder - Walker, Rosie May; Christoforou, Andrea Nikie; McCartney, Daniel L.; Morris, Stewart W.; Kennedy, Nicholas A.; Morten, Peter; Anderson, Susan Maguire; Torrance, Helen Scott; Macdonald, Alix; Sussmann, Jessika Elizabeth; Whalley, Heather Clare; Blackwood, Douglas H. R.; McIntosh, Andrew Mark; Porteous, David John; Evans, Kathryn Louise

19. Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs - Roos, Leonie; van Dongen, Jenny; Bell, Christopher G.; Burri, Andrea; Deloukas, Panos; Boomsma, Dorret I.; Spector, Tim D.; Bell, Jordana T.

20. Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families - Mamtani, Manju; Kulkarni, Hemant; Dyer, Thomas D.; Göring, Harald H. H.; Neary, Jennifer L.; Cole, Shelley A.; Kent, Jack W.; Kumar, Satish; Glahn, David C.; Mahaney, Michael C.; Comuzzie, Anthony G.; Almasy, Laura; Curran, Joanne E.; Duggirala, Ravindranath; Blangero, John; Carless, Melanie A.

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