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NEU - Artigos

Mostrando recursos 1 - 20 de 69

  1. Suicidal behaviour in frontotemporal dementia patients-a retrospective study

    Fonseca, L; Duarte, J; Machado, A; Sotiropoulos, I; Lima, C; Sousa, N

  2. Delay in hospital admission of patients with cerebral vein and dural sinus thrombosis

    Ferro, JM; Lopes, MG; Rosas, MJ; Fontes, J; VENOPORT Investigators
    Factors influencing early hospital admission have been described for several stroke types but not for cerebral vein and dural sinus thrombosis (CVT). CVT is more difficult to diagnose than arterial stroke; delay in hospital admission may postpone CVT treatment. The purposes of this study were: (1) to describe the delay between the onset of symptoms and hospital admission of patients with CVT, and (2) to identify the variables that influence that delay. We registered the interval (days) between the onset of symptoms and hospital admission in 91 consecutive patients admitted to 20 Portuguese hospitals between June 1995 and June 1998....

  3. Kalirin: a novel genetic risk factor for ischemic stroke

    Krug, T; Manso, H; Gouveia, L; Sobral, J; Xavier, JM; Albergaria, I; Gaspar, G; Correia, M; Viana-Baptista, M; Simões, RN; Pinto, AN; Taipa, R; Ferreira, C; Fontes, JR; Silva, MR; Gabriel, JP; Matos, I; Lopes, G; Ferro, JM; Vicente, AM; Oliveira, SA
    Cerebrovascular and cardiovascular diseases are the leading causes of death and disability worldwide. They are complex disorders resulting from the interplay of genetic and environmental factors, and may share several susceptibility genes. Several recent studies have implicated variants of the Kalirin (KALRN) gene with susceptibility to cardiovascular and metabolic phenotypes, but no studies have yet been performed in stroke patients. KALRN is involved, among others, in the inhibition of inducible nitric oxide synthase, in the regulation of ischemic signal transduction, and in neuronal morphogenesis, plasticity, and stability. The goal of the present study was to determine whether SNPs in the...

  4. Psychogenic Movement Disorder After a Venlafaxine-Induced Dystonia

    Fonseca, L; Rodrigues, M; Machado, A

  5. Late-onset Lennox-Gastaut syndrome as a phenotype of 15q11.1q13.3 duplication

    Rocha, J; Guerra, C; Oliveira, R; Dória, S; Rego, R; Rosas, MJ
    The clinical symptoms associated with chromosome 15q duplication syndrome manifest through a heterogeneous group of symptoms characterised by hypotonia, delay in motor skills and language development, cognitive and learning disabilities, autism spectrum disorder and refractory epilepsy. The late development of Lennox-Gastaut syndrome in patients with 15q11q13 duplication is a possibility that physicians should be aware of. We report the case of a 27-year-old man with a neurodevelopmental syndrome due to a 15q duplication, with intellectual disability, psychiatric disturbances, and an epileptic phenotype diagnosed as late-onset Lennox-Gastaut syndrome.

  6. A whole genome screen for association with multiple sclerosis in Portuguese patients

    Santos, M; Pinto-Basto, J; Rio, ME; Sá, MJ; Valença, A; Sá, A; Dinis, J; Figueiredo, J; Bigotte de Almeida, L; Coelho, I; Sawcer, S; Setakis, E; Compston, A; Sequeiros, J; Maciel, P
    Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.

  7. Stroke and Cardiac Papillary Fibroelastoma: Mechanical Thrombectomy after Thrombolytic Therapy

    Santos, AF; Pinho, J; Ramos, V; Pardal, F; Rocha, J; Ferreira, C
    We describe a case of a 34-year-old man with a sudden development of right hemiparesis and aphasia because of infarction of the left middle cerebral artery that was submitted to intravenous (IV) recombinant tissue plasminogen activator and mechanical thrombectomy. Transesophageal echocardiogram showed a small mass on the anterior leaflet of the mitral valve. Cardiac surgery was performed, and histological examination of the removed material was consistent with cardiac papillary fibroelastoma (CPF). Experience in using IV thrombolysis for the treatment of embolic stroke because of CPF is limited. To the best of our knowledge, only 3 patients are reported in literature...

  8. Hemangioma intracraniano

    Rocha, J; Marques, C; Adams, A; Rodrigues, J
    A case of intracranial hemangioma in a neonate is described by the authors. The rarity of the condition raised differential diagnosis problems.

  9. Caracterização dos antecedentes psiquiátricos nos doentes com demência: relação da depressão com a demência

    Fonseca, L; Machado, A; Duarte, J
    Depression has been reported as the most frequent neuropsychiatric diagnostic on the clinical background of demented patients, mainly with Alzheimer dementia (AD). Several studies have showed that this relation is not occasional. In this work we present the results of the statistical analysis made on the characterization of the psychiatric background of demented patients from the memory consultation of the Braga Hospital.

  10. De encefalopatia e orelhas duras ao síndrome de Sheehan: caso clínico

    Machado, A; Ferreira, C; Lopes, M; Pereira, T; Pardal, F

  11. Acidente Vascular Cerebral em Doente com Anemia de Células Falciformes

    Caridade, S; Machado, A; Ferreira, C
    Stroke in patients with sickle cell anemia is multifactorial but occurs mainly by 2 mechanisms: occlusive arteriopathy and obliteration of small vessels with plugs of sickle cells. The high individual risk can be assessed by simple and well-defined strategies such as ultrasounds with transcranial and cervical Doppler Ultrasonography. The authors report the clinical case of a 25 year-old black female patient with sickle cell anemia, who was admitted with right hemiparesis. Cerebral MRI showed small recent fronto-temporo-parietal cortical-subcortical infarcts and several, older, posterior periventricular lacunae of left preponderance. A brief discussion is made, with particular emphasis on the proper treatment and prevention...

  12. A whole genome screen for association with multiple sclerosis in Portuguese patients

    Santos, M; Pinto-Basto, J; Rio, ME; Sá, MJ; Valença, A; Sá, A; Dinis, J; Figueiredo, J; Bigotte de Almeida, L; Coelho, I; Sawcer, S; Setakis, E; Compston, A; Sequeiros, J; Maciel, P
    Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.

  13. IgE-mediated hypersensitivity after ibuprofen administration

    Bluth, MH; Beleza, P; Hajee, F; Jordão, MJ; Figueiredo, J; Almeida, F; Smith-Norowitz, T
    Although many immunoglobulin-related drug sensitivities have been described, there is a paucity of reports regarding IgE-related drug sensitivities. Here we describe a case of a patient who demonstrated IgE-mediated sensitivity to ibuprofen.

  14. From juvenile parkinsonism to encephalitis lethargica, a new phenotype of post-streptococcal disorders: case report.

    Beleza, P; Soares-Fernandes, J; Jordão, MJ; Almeida, F
    We report the case of a 16-year-old boy presented with a mild akinetic-rigid parkinsonism shortly after a post-streptococcal infection. After stopping corticoids, he had a rapid neurological deterioration to a fatal encephalitis lethargica-like syndrome. Serum analysis demonstrated consistently elevated anti-streptolysin-O. This case illustrates a new severe phenotype in the spectrum of the post-streptococcal disorders. This etiology should be considered in the differential diagnosis of a movement disorder with a rapid detrimental evolution.

  15. Ictal SPECT in Sturge-Weber syndrome

    Bilgin, O; Vollmar, C; Peraud, A; la Fougere, C; Beleza, P; Noachtar, S
    We report on a patient with right-sided Sturge-Weber syndrome (SWS), in whom earlier functional hemispherectomy failed. Subtraction of ictal and interictal single-photon-emission-computed-tomography (SPECT) superimposed on individual MRI showed a right fronto-orbital hyperperfusion, with a left-sided EEG seizure pattern. Ictal SPECT supported our assumption that right frontal originated seizure pattern propagated to left hemisphere via the remaining right frontal bridge. Right orbito-frontal resection and disconnection from corpus callosum resulted in seizure freedom.

  16. Interictal rhythmical midline theta differentiates frontal from temporal lobe epilepsies

    Beleza, P; Bilgin, O; Noachtar, S
    PURPOSE: We evaluated the role of interictal rhythmical midline theta (RMT) in the identification of frontal lobe epilepsy (FLE) and its differentiation from temporal lobe epilepsy (TLE) and nonepileptic controls. METHODS: We included 162 individuals in the study: 54 FLE patients, 54 TLE patients, and 54 nonepileptic controls. Continuous electroencephalographic (EEG)-video monitoring was performed in all individuals. Interictal RMT was included only if it occurred during definite awake states. RMT associated with drowsiness or mental activation and ictal RMT was excluded. RESULTS: We identified RMT significantly more frequently in FLE patients (48.1%, 26 of 54) than in TLE patients (3.7%, 2 of 54) (p <...

  17. Diversity in anti-N-methyl-D-aspartate receptor encephalitis: case-based evidence

    Pinho, J; Rocha, J; Rodrigues, M; Pereira, J; Maré, R; Ferreira, C; Lourenço, E; Beleza, P
    Antibodies against N-methyl-D-aspartate receptor (NMDAR) are identified in the form of immune-mediated encephalitis in which typical manifestations include neuropsychiatric symptoms, seizures, abnormal movements, dysautonomia and hypoventilation. The authors report two cases of anti-NMDAR encephalitis with different presentations and patterns of progression. The first patient presented with status epilepticus and later developed psychosis, pyramidal signs and diffuse encephalopathy. The second patient presented with acute psychosis followed a week later by seizures, dystonia, rigidity, oromandibular dyskinesias and dysautonomia. Possible mechanisms responsible for the clinical manifestations of this disease are discussed in light of recently described additional clinical and laboratory findings.

  18. Sjögren-Larsson syndrome due to a novel mutation in the FALDH gene

    Botelho-Gomes, JM; Veira, AP; Navarro, J; Maré, R; Tavares, P; Brito, C

  19. Takotsubo cardiomyopathy: a rare, but serious, complication of epileptic seizures

    Rocha, J; Gonçalves, E; Vieira, C; Almeida, F; Pereira, J

  20. Recurrent post-ictal hyperthermia

    Rocha, S; Sousa, F; Pinho, J; Maré, R; Machado, A

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